Details for: ROCK2
Associated with
Other Information
Genular Protein ID: 1767328788
Symbol: ROCK2_HUMAN
Name: Rho-associated protein kinase 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9933571
Title: Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24.
PubMed ID: 9933571
PubMed ID: 9734811
Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9734811
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 10579722
Title: Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo.
PubMed ID: 10579722
PubMed ID: 15699075
Title: Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner.
PubMed ID: 15699075
DOI: 10.1084/jem.20031877
PubMed ID: 16574662
Title: Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase.
PubMed ID: 16574662
PubMed ID: 17015463
Title: Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication.
PubMed ID: 17015463
DOI: 10.1128/mcb.01383-06
PubMed ID: 18559669
Title: Regulation of RhoA-dependent ROCKII activation by Shp2.
PubMed ID: 18559669
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19131646
Title: ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells.
PubMed ID: 19131646
PubMed ID: 19997641
Title: Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation.
PubMed ID: 19997641
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20230755
Title: Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.
PubMed ID: 20230755
PubMed ID: 20826462
Title: Src-dependent phosphorylation of ROCK participates in regulation of focal adhesion dynamics.
PubMed ID: 20826462
DOI: 10.1242/jcs.071555
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21084279
Title: BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2.
PubMed ID: 21084279
PubMed ID: 21147781
Title: Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production.
PubMed ID: 21147781
PubMed ID: 12778124
PubMed ID: 20803696
Title: Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.
PubMed ID: 20803696
DOI: 10.1002/cm.20472
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 1388
- Mass: 160900
- Checksum: 876240F410C2487E
- Sequence:
MSRPPPTGKM PGAPETAPGD GAGASRQRKL EALIRDPRSP INVESLLDGL NSLVLDLDFP ALRKNKNIDN FLNRYEKIVK KIRGLQMKAE DYDVVKVIGR GAFGEVQLVR HKASQKVYAM KLLSKFEMIK RSDSAFFWEE RDIMAFANSP WVVQLFYAFQ DDRYLYMVME YMPGGDLVNL MSNYDVPEKW AKFYTAEVVL ALDAIHSMGL IHRDVKPDNM LLDKHGHLKL ADFGTCMKMD ETGMVHCDTA VGTPDYISPE VLKSQGGDGF YGRECDWWSV GVFLYEMLVG DTPFYADSLV GTYSKIMDHK NSLCFPEDAE ISKHAKNLIC AFLTDREVRL GRNGVEEIRQ HPFFKNDQWH WDNIRETAAP VVPELSSDID SSNFDDIEDD KGDVETFPIP KAFVGNQLPF IGFTYYRENL LLSDSPSCRE TDSIQSRKNE ESQEIQKKLY TLEEHLSNEM QAKEELEQKC KSVNTRLEKT AKELEEEITL RKSVESALRQ LEREKALLQH KNAEYQRKAD HEADKKRNLE NDVNSLKDQL EDLKKRNQNS QISTEKVNQL QRQLDETNAL LRTESDTAAR LRKTQAESSK QIQQLESNNR DLQDKNCLLE TAKLKLEKEF INLQSALESE RRDRTHGSEI INDLQGRICG LEEDLKNGKI LLAKVELEKR QLQERFTDLE KEKSNMEIDM TYQLKVIQQS LEQEEAEHKA TKARLADKNK IYESIEEAKS EAMKEMEKKL LEERTLKQKV ENLLLEAEKR CSLLDCDLKQ SQQKINELLK QKDVLNEDVR NLTLKIEQET QKRCLTQNDL KMQTQQVNTL KMSEKQLKQE NNHLMEMKMN LEKQNAELRK ERQDADGQMK ELQDQLEAEQ YFSTLYKTQV RELKEECEEK TKLGKELQQK KQELQDERDS LAAQLEITLT KADSEQLARS IAEEQYSDLE KEKIMKELEI KEMMARHKQE LTEKDATIAS LEETNRTLTS DVANLANEKE ELNNKLKDVQ EQLSRLKDEE ISAAAIKAQF EKQLLTERTL KTQAVNKLAE IMNRKEPVKR GNDTDVRRKE KENRKLHMEL KSEREKLTQQ MIKYQKELNE MQAQIAEESQ IRIELQMTLD SKDSDIEQLR SQLQALHIGL DSSSIGSGPG DAEADDGFPE SRLEGWLSLP VRNNTKKFGW VKKYVIVSSK KILFYDSEQD KEQSNPYMVL DIDKLFHVRP VTQTDVYRAD AKEIPRIFQI LYANEGESKK EQEFPVEPVG EKSNYICHKG HEFIPTLYHF PTNCEACMKP LWHMFKPPPA LECRRCHIKC HKDHMDKKEE IIAPCKVYYD ISTAKNLLLL ANSTEEQQKW VSRLVKKIPK KPPAPDPFAR SSPRTSMKIQ QNQSIRRPSR QLAPNKPS
Genular Protein ID: 991326780
Symbol: Q14DU5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 703
- Mass: 82149
- Checksum: 23BDD34321929F96
- Sequence:
MEIDMTYQLK VIQQSLEQEE AEHKATKARL ADKNKIYESI EEAKSEAMKE MEKKLLEERT LKQKVENLLL EAEKRCSLLD CDLKQSQQKI NELLKQKDVL NEDVRNLTLK IEQETQKRCL TQNDLKMQTQ QVNTLKMSEK QLKQENNHLM EMKMNLEKQN AELRKERQDA DGQMKELQDQ LEAEQYFSTL YKTQVRELKE ECEEKTKLGK ELQQKKQELQ DERDSLAAQL EITLTKADSE QLARSIAEEQ YSDLEKEKIM KELEIKEMMA RHKQELTEKD ATIASLEETN RTLTSDVANL ANEKEELNNK LKDVQEQLSR LKDEEISAAA IKAQFEKQLL TERTLKTQAV NKLAEIMNRK EPVKRGNDTD VRRKEKENRK LHMELKSERE KLTQQMIKYQ KELNEMQAQI AEESQIRIEL QMTLDSKDSD IEQLRSQLQA LHIGLDSSSI GSGPGDAEAD DGFPESRLEG WLSLPVRNNT KKFGWVKKYV IVSSKKILFY DSEQDKEQSN PYMVLDIDKL FHVRPVTQTD VYRADAKEIP RIFQILYANE GESKKEQEFP VEPVGEKSNY ICHKGHEFIP TLYHFPTNCE ACMKPLWHMF KPPPALECRR CHIKCHKDHM DKKEEIIAPC KVYYDISTAK NLLLLANSTE EQQKWVSRLV KKIPKKPPAP DPFARSSPRT SMKIQQNQSI RRPSRQLAPN KPS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.