Details for: CABP1

Gene ID: 9478

Symbol: CABP1

Ensembl ID: ENSG00000157782

Description: calcium binding protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.39
    Marker Score: 4,861
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.38
    Marker Score: 3,994
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.35
    Marker Score: 9,727
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.32
    Marker Score: 2,797
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.26
    Marker Score: 716
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.26
    Marker Score: 2,128
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.16
    Marker Score: 906
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.08
    Marker Score: 31,051
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.06
    Marker Score: 126,701
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.03
    Marker Score: 19,108
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.92
    Marker Score: 18,197
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.85
    Marker Score: 15,916
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8
    Marker Score: 6,968
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.78
    Marker Score: 486
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.66
    Marker Score: 2,565
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.66
    Marker Score: 12,720
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.59
    Marker Score: 60,479
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.5
    Marker Score: 55,443
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169,071
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.34
    Marker Score: 2,535
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.3
    Marker Score: 677
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.27
    Marker Score: 924
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 853
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.22
    Marker Score: 24,224
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 485
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.14
    Marker Score: 11,794
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,046
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.99
    Marker Score: 2,647
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.99
    Marker Score: 15,416
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.95
    Marker Score: 625
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,351
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,286
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 658
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.86
    Marker Score: 1,745
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.83
    Marker Score: 3,487
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.75
    Marker Score: 356
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.73
    Marker Score: 2,976
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 460
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.67
    Marker Score: 352
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.63
    Marker Score: 1,806
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.63
    Marker Score: 605
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.63
    Marker Score: 2,893
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.59
    Marker Score: 799
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.57
    Marker Score: 1,256
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.56
    Marker Score: 2,352
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.55
    Marker Score: 329
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.54
    Marker Score: 617
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.51
    Marker Score: 484
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.5
    Marker Score: 1,187
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.49
    Marker Score: 5,015
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.49
    Marker Score: 594
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.47
    Marker Score: 10,082
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.45
    Marker Score: 224
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.44
    Marker Score: 159
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.43
    Marker Score: 537
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.43
    Marker Score: 430
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 180
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.41
    Marker Score: 116
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.39
    Marker Score: 274
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.37
    Marker Score: 202
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.36
    Marker Score: 2,405
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.35
    Marker Score: 113
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.34
    Marker Score: 154
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.34
    Marker Score: 87
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.32
    Marker Score: 180
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.32
    Marker Score: 303
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.31
    Marker Score: 141
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 124
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.28
    Marker Score: 823
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.26
    Marker Score: 222
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.25
    Marker Score: 211
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.25
    Marker Score: 74
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.25
    Marker Score: 71
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.25
    Marker Score: 162
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.24
    Marker Score: 74
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 69
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.23
    Marker Score: 435
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.23
    Marker Score: 455
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.22
    Marker Score: 129
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.22
    Marker Score: 632
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CABP1 is a calcium-binding protein that exhibits high affinity for calcium ions, allowing it to regulate a wide range of cellular processes. Its expression is significantly enriched in neurons, particularly in GABAergic and glycinergic neurons, which are involved in inhibitory neurotransmission. CABP1 is also expressed in non-neuronal cells, including those in the retina and cochlea, where it plays a crucial role in sensory perception and processing. **Pathways and Functions:** CABP1 is involved in various signaling pathways, including calcium-dependent protein binding, calcium channel regulator activity, and negative regulation of protein import into the nucleus. Its functions include: 1. **Regulation of calcium-dependent signaling**: CABP1 binds to calcium ions, modulating the activity of calcium-dependent kinases and phosphatases, which in turn regulate various cellular processes, including gene expression, protein localization, and synaptic transmission. 2. **Protein binding and regulation**: CABP1 interacts with a wide range of proteins, including enzymes, receptors, and transcription factors, to regulate their activity and localization. 3. **Nuclear localization and regulation**: CABP1 regulates the nuclear localization of proteins by binding to nuclear localization sequences, thereby modulating gene expression and cellular transcription. 4. **Sensory perception and processing**: CABP1 plays a crucial role in sensory perception, particularly in the cochlea, where it regulates the activity of inner hair cells and sensory processing of sound. **Signaling Pathways and Processes:** CABP1 is involved in various signaling pathways, including: 1. **Calcium-dependent protein binding**: CABP1 binds to calcium ions, modulating the activity of calcium-dependent kinases and phosphatases. 2. **Calcium channel regulator activity**: CABP1 regulates the activity of calcium channels, modulating the influx of calcium ions into cells. 3. **Negative regulation of protein import into nucleus**: CABP1 regulates the nuclear localization of proteins by binding to nuclear localization sequences. 4. **Sensory perception and processing**: CABP1 plays a crucial role in sensory perception, particularly in the cochlea, where it regulates the activity of inner hair cells and sensory processing of sound. **Clinical Significance:** Dysregulation of CABP1 has been implicated in various neurological and sensory disorders, including: 1. **Neurodegenerative diseases**: CABP1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where dysregulation of calcium-dependent signaling and protein binding is a hallmark of disease progression. 2. **Sensory disorders**: CABP1 plays a crucial role in sensory perception, particularly in the cochlea, where dysregulation of CABP1 has been implicated in hearing loss and tinnitus. 3. **Neurodevelopmental disorders**: CABP1 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder, where dysregulation of calcium-dependent signaling and protein binding is a hallmark of disease pathogenesis. In conclusion, CABP1 is a crucial regulator of various cellular processes, including calcium-dependent signaling, protein binding, and localization. Its dysregulation has been implicated in various neurological and sensory disorders, highlighting the importance of CABP1 in maintaining cellular homeostasis and regulating the activity of numerous proteins involved in neuronal function and sensory perception.

Genular Protein ID: 1525407328

Symbol: CABP1_HUMAN

Name: Calcium-binding protein 1

UniProtKB Accession Codes:

Q9NZU7 O95663 Q8N6H5 Q9NZU8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 22 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 7 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9920909

Title: Calbrain, a novel two EF-hand calcium-binding protein that suppresses Ca2+/calmodulin-dependent protein kinase II activity in the brain.

PubMed ID: 9920909

DOI: 10.1074/jbc.274.6.3610

PubMed ID: 10625670

Title: Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin.

PubMed ID: 10625670

DOI: 10.1074/jbc.275.2.1247

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9694893

Title: Caldendrin, a novel neuronal calcium-binding protein confined to the somato-dendritic compartment.

PubMed ID: 9694893

DOI: 10.1074/jbc.273.33.21324

PubMed ID: 12032348

Title: Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.

PubMed ID: 12032348

DOI: 10.1073/pnas.102006299

PubMed ID: 11865310

Title: Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1.

PubMed ID: 11865310

DOI: 10.1038/nn805

PubMed ID: 14685260

Title: Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.

PubMed ID: 14685260

DOI: 10.1038/sj.emboj.7600037

PubMed ID: 14570872

Title: Calcium-binding protein 1 is an inhibitor of agonist-evoked, inositol 1,4,5-trisphosphate-mediated calcium signaling.

PubMed ID: 14570872

DOI: 10.1074/jbc.m309617200

PubMed ID: 15095872

Title: Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins.

PubMed ID: 15095872

DOI: 10.1016/j.jmb.2003.12.054

PubMed ID: 15140941

Title: Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels.

PubMed ID: 15140941

DOI: 10.1523/jneurosci.5523-03.2004

PubMed ID: 15980432

Title: Molecular mechanism for divergent regulation of Cav1.2 Ca2+ channels by calmodulin and Ca2+-binding protein-1.

PubMed ID: 15980432

DOI: 10.1074/jbc.m504167200

PubMed ID: 15895247

Title: Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes.

PubMed ID: 15895247

DOI: 10.1007/s00424-005-1419-1

PubMed ID: 16147998

Title: Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron-specific regulator of calcium channels.

PubMed ID: 16147998

DOI: 10.1074/jbc.m508541200

PubMed ID: 19008222

Title: Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1.

PubMed ID: 19008222

DOI: 10.1074/jbc.m806513200

Sequence Information:

  • Length: 370
  • Mass: 39838
  • Checksum: 3444721152E01AA7
  • Sequence:
    • MGGGDGAAFK RPGDGARLQR VLGLGSRREP RSLPAGGPAP RRTAPPPPGH ASAGPAAMSS 
HIAKSESKTS LLKAAAAAAS GGSRAPRHGP ARDPGLPSRR LPGSCPATPQ SSGDPSSRRP 
LCRPAPREEG ARGSQRVLPQ AHCRPREALP AAASRPSPSS PLPPARGRDG EERGLSPALG 
LRGSLRARGR GDSVPAAASE ADPFLHRLRP MLSSAFGQDR SLRPEEIEEL REAFREFDKD 
KDGYINCRDL GNCMRTMGYM PTEMELIELS QQINMNLGGH VDFDDFVELM GPKLLAETAD 
MIGVKELRDA FREFDTNGDG EISTSELREA MRKLLGHQVG HRDIEEIIRD VDLNGDGRVD 
FEEFVRMMSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.