CD36 | ENSG00000135218 | NCBI 948

Details for: CD36

Gene ID: 948

Symbol: CD36

Ensembl ID: ENSG00000135218

Description: CD36 molecule (CD36 blood group)

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Cross-presentation of particulate exogenous antigens (phagosomes)
(R-HSA-1236973)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases associated with the tlr signaling cascade
(R-HSA-5602358)
Diseases of immune system
(R-HSA-5260271)
Er-phagosome pathway
(R-HSA-1236974)
Free fatty acids regulate insulin secretion
(R-HSA-400451)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Integration of energy metabolism
(R-HSA-163685)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Intracellular metabolism of fatty acids regulates insulin secretion
(R-HSA-434313)
Irak4 deficiency (tlr2/4)
(R-HSA-5603041)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Myd88 deficiency (tlr2/4)
(R-HSA-5602498)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Neutrophil degranulation
(R-HSA-6798695)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of insulin secretion
(R-HSA-422356)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Regulation of tlr by endogenous ligand
(R-HSA-5686938)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Scavenging by class b receptors
(R-HSA-3000471)
Signaling by interleukins
(R-HSA-449147)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Vesicle-mediated transport
(R-HSA-5653656)
Amyloid-beta binding
(GO:0001540)
Blood coagulation
(GO:0007596)
Cell adhesion
(GO:0007155)
Cell surface receptor signaling pathway
(GO:0007166)
Cgmp-mediated signaling
(GO:0019934)
Cholesterol transport
(GO:0030301)
Fatty acid binding
(GO:0005504)
Fatty acid metabolic process
(GO:0006631)
High-density lipoprotein particle binding
(GO:0008035)
Intestinal cholesterol absorption
(GO:0030299)
Lipid binding
(GO:0008289)
Lipid metabolic process
(GO:0006629)
Lipid storage
(GO:0019915)
Lipoprotein particle binding
(GO:0071813)
Lipoteichoic acid immune receptor activity
(GO:0070892)
Long-chain fatty acid import across plasma membrane
(GO:0015911)
Long-chain fatty acid transport
(GO:0015909)
Long-chain fatty acid transporter activity
(GO:0005324)
Low-density lipoprotein particle binding
(GO:0030169)
Low-density lipoprotein particle receptor activity
(GO:0005041)
Mapk cascade
(GO:0000165)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nitric oxide mediated signal transduction
(GO:0007263)
Oleate transmembrane transporter activity
(GO:1901480)
Oxidised low-density lipoprotein particle receptor activity
(GO:0150025)
Phagocytosis, engulfment
(GO:0006911)
Phagocytosis, recognition
(GO:0006910)
Positive regulation of blood coagulation
(GO:0030194)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of cholesterol storage
(GO:0010886)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of macrophage derived foam cell differentiation
(GO:0010744)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Production of molecular mediator involved in inflammatory response
(GO:0002532)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Receptor-mediated endocytosis
(GO:0006898)
Receptor internalization
(GO:0031623)
Regulation of lipopolysaccharide-mediated signaling pathway
(GO:0031664)
Response to lipid
(GO:0033993)
Scavenger receptor activity
(GO:0005044)
Short-chain fatty acid transmembrane transporter activity
(GO:0015636)
Short-chain fatty acid transport
(GO:0015912)
Thrombospondin receptor activity
(GO:0070053)
Toll-like receptor binding
(GO:0035325)
Transforming growth factor beta binding
(GO:0050431)

Other Information

Proteins

Genular Protein ID: 605099939

Symbol: CD36_HUMAN

Name: Platelet glycoprotein 4

UniProtKB Accession Codes:

P16671 D9IX66 D9IX67 D9IX68 D9IX69 Q13966 Q16093 Q8TCV7 Q9BPZ8 Q9BQC2 Q9BZM8 Q9BZN3 Q9BZN4 Q9BZN5

Database IDs:

Citations:

PubMed ID: 2473841

Title: CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes.

PubMed ID: 2473841

DOI: 10.1016/0092-8674(89)90406-6

PubMed ID: 7693552

Title: Characterization of two alternatively spliced 5'-untranslated exons of the human CD36 gene in different cell types.

PubMed ID: 7693552

DOI: 10.1016/0378-1119(93)90639-k

PubMed ID: 7505064

Title: Cloning of the cDNA encoding human platelet CD36: comparison to PCR amplified fragments of monocyte, endothelial and HEL cells.

PubMed ID: 7505064

PubMed ID: 7518447

Title: Structural organization of the gene for human CD36 glycoprotein.

PubMed ID: 7518447

DOI: 10.1016/s0021-9258(17)32263-9

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2468669

Title: Isolation and characterization of platelet glycoprotein IV (CD36).

PubMed ID: 2468669

DOI: 10.1016/s0021-9258(18)83272-0

PubMed ID: 11668637

Title: Variability of the CD36 gene in West Africa.

PubMed ID: 11668637

DOI: 10.1002/humu.1215

PubMed ID: 7503937

Title: Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2.

PubMed ID: 7503937

DOI: 10.1006/geno.1993.1401

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 1371676

Title: Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding.

PubMed ID: 1371676

DOI: 10.1016/0006-291x(92)91860-s

PubMed ID: 8798390

Title: CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails.

PubMed ID: 8798390

DOI: 10.1074/jbc.271.37.22315

PubMed ID: 10613822

Title: Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1.

PubMed ID: 10613822

DOI: 10.1038/71517

PubMed ID: 16880211

Title: Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.

PubMed ID: 16880211

DOI: 10.1074/jbc.m602794200

PubMed ID: 18353783

Title: Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake.

PubMed ID: 18353783

DOI: 10.1074/jbc.m800008200

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 19864601

Title: CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria.

PubMed ID: 19864601

DOI: 10.4049/jimmunol.0901374

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19471024

Title: CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior.

PubMed ID: 19471024

DOI: 10.1126/scisignal.272re3

PubMed ID: 20037584

Title: CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

PubMed ID: 20037584

DOI: 10.1038/ni.1836

PubMed ID: 21610069

Title: Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis.

PubMed ID: 21610069

DOI: 10.1074/jbc.m111.233551

PubMed ID: 21395585

Title: Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells.

PubMed ID: 21395585

DOI: 10.1111/j.1471-4159.2011.07245.x

PubMed ID: 22240721

Title: Common variants in the CD36 gene are associated with oral fat perception, fat preferences, and obesity in African Americans.

PubMed ID: 22240721

DOI: 10.1038/oby.2011.374

PubMed ID: 25822988

Title: The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women.

PubMed ID: 25822988

DOI: 10.1017/s0007114515000343

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32958780

Title: CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis.

PubMed ID: 32958780

DOI: 10.1038/s41467-020-18565-8

PubMed ID: 37461827

Title: ARF6 plays a general role in targeting palmitoylated proteins from golgi to the plasma membrane.

PubMed ID: 37461827

DOI: 10.1242/jcs.261319

PubMed ID: 7533783

Title: Molecular basis of CD36 deficiency. Evidence that a 478C-->T substitution (proline90-->serine) in CD36 cDNA accounts for CD36 deficiency.

PubMed ID: 7533783

DOI: 10.1172/jci117749

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 10890433

Title: Malaria susceptibility and CD36 mutation.

PubMed ID: 10890433

DOI: 10.1038/35016636

PubMed ID: 11950861

Title: Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency.

PubMed ID: 11950861

DOI: 10.1136/jmg.39.4.286

PubMed ID: 12506336

Title: CD36 polymorphism is associated with protection from cerebral malaria.

PubMed ID: 12506336

DOI: 10.1086/346091

PubMed ID: 15282206

Title: A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians.

PubMed ID: 15282206

DOI: 10.1093/hmg/ddh233

PubMed ID: 18753675

Title: Chylomicron remnants are increased in the postprandial state in CD36 deficiency.

PubMed ID: 18753675

DOI: 10.1194/jlr.p700032-jlr200

PubMed ID: 27667267

Title: The structural basis for CD36 binding by the malaria parasite.

PubMed ID: 27667267

DOI: 10.1038/ncomms12837

Sequence Information:

Length: 472
Mass: 53053
Checksum: 543E748259A094FA
Sequence:

MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DLLIQKTIKK QVVLEEGTIA FKNWVKTGTE 
VYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK ENVTQDAEDN TVSFLQPNGA 
IFEPSLSVGT EADNFTVLNL AVAAASHIYQ NQFVQMILNS LINKSKSSMF QVRTLRELLW 
GYRDPFLSLV PYPVTTTVGL FYPYNNTADG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE 
SHCDMINGTD AASFPPFVEK SQVLQFFSSD ICRSIYAVFE SDVNLKGIPV YRFVLPSKAF 
ASPVENPDNY CFCTEKIISK NCTSYGVLDI SKCKEGRPVY ISLPHFLYAS PDVSEPIDGL 
NPNEEEHRTY LDIEPITGFT LQFAKRLQVN LLVKPSEKIQ VLKNLKRNYI VPILWLNETG 
TIGDEKANMF RSQVTGKINL LGLIEMILLS VGVVMFVAFM ISYCACRSKT IK

Genular Protein ID: 3278563106

Symbol: B7Z6C3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z6C3

Database IDs:

Sequence Information:

Length: 396
Mass: 44747
Checksum: 022B1511BE68E73E
Sequence:

MMNSSNIQVK QRGPYTYRVR FLAKENVTQD AEDNTVSFLQ PNGAIFEPSL SVGTEADNFT 
VLNLAVAAAS HIYQKQFVQM ILNSLINKSK SSMFQVRTLR ELLWGYRDPF LSLVPYPVTT 
TVGLFYPYNN TADGVYKVFN GKDNISKVAI IDTYKGKRNL SYWESHCDMI NGTDAASFPP 
FVEKSQVLQF FSSDICRSIY AVFESDVNLK GIPVYRFVLP SKAFASPVEN PDNYCFCTEK 
IISKNCTSYG VLDISKCKEG RPVYISLPHF LYASPDVSEP IDGLNPNEEE HRTYLDIEPI 
TGFTLQFAKR LQVNLLVKPS EKIQVLKNLK RNYIVPILWL NETGTIGDEK ANMFRSQVTG 
KINLLGLIEM ILLSVGVVMF VAFMISYCAC RSKTIK

Genular Protein ID: 2027290459

Symbol: E9PLT1_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PLT1

Database IDs:

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

Length: 396
Mass: 44733
Checksum: 00CF85D70FACB3AF
Sequence:

MMNSSNIQVK QRGPYTYRVR FLAKENVTQD AEDNTVSFLQ PNGAIFEPSL SVGTEADNFT 
VLNLAVAAAS HIYQNQFVQM ILNSLINKSK SSMFQVRTLR ELLWGYRDPF LSLVPYPVTT 
TVGLFYPYNN TADGVYKVFN GKDNISKVAI IDTYKGKRNL SYWESHCDMI NGTDAASFPP 
FVEKSQVLQF FSSDICRSIY AVFESDVNLK GIPVYRFVLP SKAFASPVEN PDNYCFCTEK 
IISKNCTSYG VLDISKCKEG RPVYISLPHF LYASPDVSEP IDGLNPNEEE HRTYLDIEPI 
TGFTLQFAKR LQVNLLVKPS EKIQVLKNLK RNYIVPILWL NETGTIGDEK ANMFRSQVTG 
KINLLGLIEM ILLSVGVVMF VAFMISYCAC RSKTIK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD36

Associated with

Other Information

CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. PubMed ID: 2473841

Characterization of two alternatively spliced 5'-untranslated exons of the human CD36 gene in different cell types. PubMed ID: 7693552

Cloning of the cDNA encoding human platelet CD36: comparison to PCR amplified fragments of monocyte, endothelial and HEL cells. PubMed ID: 7505064

Structural organization of the gene for human CD36 glycoprotein. PubMed ID: 7518447

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and characterization of platelet glycoprotein IV (CD36). PubMed ID: 2468669

Variability of the CD36 gene in West Africa. PubMed ID: 11668637

Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2. PubMed ID: 7503937

Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. PubMed ID: 15242332

Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding. PubMed ID: 1371676

CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails. PubMed ID: 8798390

Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. PubMed ID: 10613822

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. PubMed ID: 16880211

Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake. PubMed ID: 18353783

Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. PubMed ID: 16263699

Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. PubMed ID: 18780401

CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria. PubMed ID: 19864601

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior. PubMed ID: 19471024

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. PubMed ID: 20037584

Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis. PubMed ID: 21610069

Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells. PubMed ID: 21395585

Common variants in the CD36 gene are associated with oral fat perception, fat preferences, and obesity in African Americans. PubMed ID: 22240721

The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women. PubMed ID: 25822988

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis. PubMed ID: 32958780

ARF6 plays a general role in targeting palmitoylated proteins from golgi to the plasma membrane. PubMed ID: 37461827

Molecular basis of CD36 deficiency. Evidence that a 478C--&gt;T substitution (proline90--&gt;serine) in CD36 cDNA accounts for CD36 deficiency. PubMed ID: 7533783

Characterization of single-nucleotide polymorphisms in coding regions of human genes. PubMed ID: 10391209

Malaria susceptibility and CD36 mutation. PubMed ID: 10890433

Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency. PubMed ID: 11950861

CD36 polymorphism is associated with protection from cerebral malaria. PubMed ID: 12506336

A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. PubMed ID: 15282206

Chylomicron remnants are increased in the postprandial state in CD36 deficiency. PubMed ID: 18753675

The structural basis for CD36 binding by the malaria parasite. PubMed ID: 27667267

The DNA sequence of human chromosome 7. PubMed ID: 12853948

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Database document:

PubMed ID: 2473841

PubMed ID: 7693552

PubMed ID: 7505064

PubMed ID: 7518447

PubMed ID: 12853948

PubMed ID: 15489334

PubMed ID: 2468669

PubMed ID: 11668637

PubMed ID: 7503937

PubMed ID: 15242332

PubMed ID: 1371676

PubMed ID: 8798390

PubMed ID: 10613822

PubMed ID: 16880211

PubMed ID: 18353783

PubMed ID: 16263699

PubMed ID: 18780401

PubMed ID: 19864601

PubMed ID: 19159218

PubMed ID: 19471024

PubMed ID: 20037584

PubMed ID: 21610069

PubMed ID: 21395585

PubMed ID: 22240721

PubMed ID: 25822988

PubMed ID: 25944712

PubMed ID: 32958780

PubMed ID: 37461827

PubMed ID: 7533783

PubMed ID: 10391209

PubMed ID: 10890433

PubMed ID: 11950861

PubMed ID: 12506336

PubMed ID: 15282206

PubMed ID: 18753675

PubMed ID: 27667267

PubMed ID: 12853948

PubMed ID: 25944712