CD36 | ENSG00000135218 | NCBI 948

Details for: CD36

Gene ID: 948

Symbol: CD36

Ensembl ID: ENSG00000135218

Description: CD36 molecule (CD36 blood group)

Associated with

Adaptive immune system
(R-HSA-1280218)
Adipogenesis
(R-HSA-9843745)
Antigen processing-cross presentation
(R-HSA-1236975)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Cross-presentation of particulate exogenous antigens (phagosomes)
(R-HSA-1236973)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases associated with the tlr signaling cascade
(R-HSA-5602358)
Diseases of immune system
(R-HSA-5260271)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Er-phagosome pathway
(R-HSA-1236974)
Free fatty acids regulate insulin secretion
(R-HSA-400451)
Gene expression (transcription)
(R-HSA-74160)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Integration of energy metabolism
(R-HSA-163685)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Intracellular metabolism of fatty acids regulates insulin secretion
(R-HSA-434313)
Irak4 deficiency (tlr2/4)
(R-HSA-5603041)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
Myd88 deficiency (tlr2/4)
(R-HSA-5602498)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Neutrophil degranulation
(R-HSA-6798695)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of insulin secretion
(R-HSA-422356)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Regulation of tlr by endogenous ligand
(R-HSA-5686938)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Scavenging by class b receptors
(R-HSA-3000471)
Signaling by interleukins
(R-HSA-449147)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Vesicle-mediated transport
(R-HSA-5653656)
Amyloid-beta binding
(GO:0001540)
Blood coagulation
(GO:0007596)
Cargo receptor activity
(GO:0038024)
Cell adhesion
(GO:0007155)
Cell surface receptor signaling pathway
(GO:0007166)
Cgmp-mediated signaling
(GO:0019934)
Fatty acid metabolic process
(GO:0006631)
Fatty acid transport
(GO:0015908)
High-density lipoprotein particle binding
(GO:0008035)
Lipid binding
(GO:0008289)
Lipid metabolic process
(GO:0006629)
Lipid storage
(GO:0019915)
Lipoprotein particle binding
(GO:0071813)
Lipoteichoic acid immune receptor activity
(GO:0070892)
Long-chain fatty acid import across plasma membrane
(GO:0015911)
Long-chain fatty acid transmembrane transporter activity
(GO:0005324)
Long-chain fatty acid transport
(GO:0015909)
Low-density lipoprotein particle binding
(GO:0030169)
Low-density lipoprotein particle receptor activity
(GO:0005041)
Mapk cascade
(GO:0000165)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Oleate transmembrane transporter activity
(GO:1901480)
Oxidised low-density lipoprotein particle receptor activity
(GO:0150025)
Phagocytosis, engulfment
(GO:0006911)
Phagocytosis, recognition
(GO:0006910)
Positive regulation of blood coagulation
(GO:0030194)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of cholesterol storage
(GO:0010886)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of macrophage derived foam cell differentiation
(GO:0010744)
Production of molecular mediator involved in inflammatory response
(GO:0002532)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Receptor-mediated endocytosis
(GO:0006898)
Scavenger receptor activity
(GO:0005044)
Short-chain fatty acid transmembrane transporter activity
(GO:0015636)
Short-chain fatty acid transport
(GO:0015912)
Thrombospondin receptor activity
(GO:0070053)
Toll-like receptor binding
(GO:0035325)
Transforming growth factor beta binding
(GO:0050431)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 89.6534
Cell Significance Index: -22.7400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 57.3282
Cell Significance Index: -23.2900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 56.2207
Cell Significance Index: -23.1600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 51.6179
Cell Significance Index: -24.3700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 50.8568
Cell Significance Index: -26.1600
Cell Name: basophilic erythroblast (CL0000549)
Fold Change: 40.2937
Cell Significance Index: 18.3500
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 24.4045
Cell Significance Index: -23.3000
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 13.3694
Cell Significance Index: -29.2600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 10.5194
Cell Significance Index: -12.9700
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 10.3556
Cell Significance Index: 130.4000
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 9.2508
Cell Significance Index: 133.0500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 7.0863
Cell Significance Index: 543.8000
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 6.2259
Cell Significance Index: 110.0200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.7665
Cell Significance Index: -22.7600
Cell Name: type I muscle cell (CL0002211)
Fold Change: 5.0419
Cell Significance Index: 123.0200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.2975
Cell Significance Index: 79.4300
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 3.0462
Cell Significance Index: 37.6800
Cell Name: preadipocyte (CL0002334)
Fold Change: 2.7381
Cell Significance Index: 53.4400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.0262
Cell Significance Index: 91.8400
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.6549
Cell Significance Index: 13.0700
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 1.4679
Cell Significance Index: 6.3900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.3525
Cell Significance Index: 70.4500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2548
Cell Significance Index: 249.0200
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.9155
Cell Significance Index: 9.2400
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.8015
Cell Significance Index: 12.4000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7525
Cell Significance Index: 679.4700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6808
Cell Significance Index: 67.3500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.5804
Cell Significance Index: 18.5900
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.5127
Cell Significance Index: 7.5700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3763
Cell Significance Index: 61.2100
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.3516
Cell Significance Index: 2.5500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3364
Cell Significance Index: 36.5900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3100
Cell Significance Index: 14.5700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2680
Cell Significance Index: 16.0900
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.2679
Cell Significance Index: 2.1700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.2233
Cell Significance Index: 139.4600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2140
Cell Significance Index: 40.7300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2063
Cell Significance Index: 14.2700
Cell Name: peg cell (CL4033014)
Fold Change: 0.1407
Cell Significance Index: 3.2500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1170
Cell Significance Index: 7.8700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0986
Cell Significance Index: 2.8400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0855
Cell Significance Index: 30.6600
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.0564
Cell Significance Index: 0.2700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0519
Cell Significance Index: 39.2700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0272
Cell Significance Index: 0.6800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0060
Cell Significance Index: 1.2000
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0046
Cell Significance Index: 0.0700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0020
Cell Significance Index: -3.8000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0030
Cell Significance Index: -2.2300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0077
Cell Significance Index: -14.2500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0082
Cell Significance Index: -11.1800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0088
Cell Significance Index: -13.5300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0102
Cell Significance Index: -7.0800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0120
Cell Significance Index: -0.4200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0141
Cell Significance Index: -2.5500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0261
Cell Significance Index: -14.7000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0282
Cell Significance Index: -17.9300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0286
Cell Significance Index: -0.6200
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0288
Cell Significance Index: -3.6900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0337
Cell Significance Index: -24.6900
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0393
Cell Significance Index: -0.3300
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0398
Cell Significance Index: -21.7400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0429
Cell Significance Index: -19.4500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0465
Cell Significance Index: -20.5800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0631
Cell Significance Index: -18.1500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0707
Cell Significance Index: -12.0700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0758
Cell Significance Index: -15.9700
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0811
Cell Significance Index: -0.4900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0980
Cell Significance Index: -14.2400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0980
Cell Significance Index: -10.0200
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -0.1168
Cell Significance Index: -1.6000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1181
Cell Significance Index: -16.2200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1460
Cell Significance Index: -17.9500
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1668
Cell Significance Index: -21.5500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1794
Cell Significance Index: -20.4800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1896
Cell Significance Index: -22.1000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1923
Cell Significance Index: -11.7900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1930
Cell Significance Index: -4.9600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1955
Cell Significance Index: -5.2200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1987
Cell Significance Index: -22.7600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2040
Cell Significance Index: -12.5400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2045
Cell Significance Index: -5.4800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2117
Cell Significance Index: -22.0500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2226
Cell Significance Index: -26.2500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2329
Cell Significance Index: -16.4700
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2361
Cell Significance Index: -1.9300
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.2390
Cell Significance Index: -3.0700
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2716
Cell Significance Index: -3.8900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2916
Cell Significance Index: -21.7400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3047
Cell Significance Index: -8.1500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3148
Cell Significance Index: -24.9300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3254
Cell Significance Index: -18.2600
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.3457
Cell Significance Index: -5.9300
Cell Name: mural cell (CL0008034)
Fold Change: -0.3573
Cell Significance Index: -4.3500
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3788
Cell Significance Index: -9.4500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3883
Cell Significance Index: -8.2700
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4020
Cell Significance Index: -25.9400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4202
Cell Significance Index: -21.8300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4234
Cell Significance Index: -22.2300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4743
Cell Significance Index: -20.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Transmembrane glycoprotein**: CD36 is a transmembrane protein with a large extracellular domain and a small intracellular domain. 2. **Scavenger receptor**: CD36 belongs to the scavenger receptor family and is involved in the uptake of various ligands, including fatty acids, cholesterol, and lipoproteins. 3. **Lipid-binding protein**: CD36 has a high affinity for long-chain fatty acids and plays a crucial role in fatty acid uptake and metabolism. 4. **Immune system involvement**: CD36 is expressed on cells of the immune system, including monocytes, macrophages, and dendritic cells, and is involved in the regulation of immune responses. 5. **Cell signaling**: CD36 can interact with various signaling molecules, including G-proteins, and is involved in the regulation of cell signaling pathways. **Pathways and Functions** 1. **Lipid metabolism**: CD36 plays a crucial role in the uptake and metabolism of fatty acids, which is essential for energy production, lipid storage, and insulin secretion. 2. **Immune system regulation**: CD36 is involved in the regulation of immune responses, including the activation of macrophages and the production of cytokines. 3. **Cell signaling**: CD36 interacts with various signaling molecules and is involved in the regulation of cell signaling pathways, including the MAPK cascade and the PI3K/AKT pathway. 4. **Gene regulation**: CD36 can regulate gene expression by interacting with transcription factors and influencing the expression of genes involved in lipid metabolism and immune responses. 5. **Blood coagulation**: CD36 is involved in the regulation of blood coagulation, including the activation of platelets and the regulation of thrombin formation. **Clinical Significance** 1. **Atherosclerosis**: CD36 has been implicated in the development of atherosclerosis, a condition characterized by the buildup of fatty deposits in the arteries. 2. **Diabetes**: CD36 is involved in the regulation of insulin secretion and glucose metabolism, making it a potential target for the treatment of diabetes. 3. **Inflammatory disorders**: CD36 is involved in the regulation of immune responses and has been implicated in the development of inflammatory disorders, including rheumatoid arthritis and multiple sclerosis. 4. **Cancer**: CD36 is involved in the regulation of cell signaling pathways and has been implicated in the development and progression of various types of cancer. 5. **Cardiovascular disease**: CD36 is involved in the regulation of blood coagulation and has been implicated in the development of cardiovascular disease, including myocardial infarction and stroke. In conclusion, CD36 is a multifunctional protein that plays a crucial role in various physiological and pathological processes. Its involvement in lipid metabolism, immune system regulation, cell signaling, and gene regulation makes it an important target for the treatment of various diseases, including atherosclerosis, diabetes, and inflammatory disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 605099939

Symbol: CD36_HUMAN

Name: Platelet glycoprotein 4

UniProtKB Accession Codes:

P16671 D9IX66 D9IX67 D9IX68 D9IX69 Q13966 Q16093 Q8TCV7 Q9BPZ8 Q9BQC2 Q9BZM8 Q9BZN3 Q9BZN4 Q9BZN5

Database IDs:

Citations:

PubMed ID: 2473841

Title: CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes.

PubMed ID: 2473841

DOI: 10.1016/0092-8674(89)90406-6

PubMed ID: 7693552

Title: Characterization of two alternatively spliced 5'-untranslated exons of the human CD36 gene in different cell types.

PubMed ID: 7693552

DOI: 10.1016/0378-1119(93)90639-k

PubMed ID: 7505064

Title: Cloning of the cDNA encoding human platelet CD36: comparison to PCR amplified fragments of monocyte, endothelial and HEL cells.

PubMed ID: 7505064

PubMed ID: 7518447

Title: Structural organization of the gene for human CD36 glycoprotein.

PubMed ID: 7518447

DOI: 10.1016/s0021-9258(17)32263-9

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2468669

Title: Isolation and characterization of platelet glycoprotein IV (CD36).

PubMed ID: 2468669

DOI: 10.1016/s0021-9258(18)83272-0

PubMed ID: 11668637

Title: Variability of the CD36 gene in West Africa.

PubMed ID: 11668637

DOI: 10.1002/humu.1215

PubMed ID: 7503937

Title: Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2.

PubMed ID: 7503937

DOI: 10.1006/geno.1993.1401

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 1371676

Title: Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding.

PubMed ID: 1371676

DOI: 10.1016/0006-291x(92)91860-s

PubMed ID: 8798390

Title: CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails.

PubMed ID: 8798390

DOI: 10.1074/jbc.271.37.22315

PubMed ID: 10613822

Title: Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1.

PubMed ID: 10613822

DOI: 10.1038/71517

PubMed ID: 16880211

Title: Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.

PubMed ID: 16880211

DOI: 10.1074/jbc.m602794200

PubMed ID: 18353783

Title: Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake.

PubMed ID: 18353783

DOI: 10.1074/jbc.m800008200

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 19864601

Title: CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria.

PubMed ID: 19864601

DOI: 10.4049/jimmunol.0901374

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19471024

Title: CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior.

PubMed ID: 19471024

DOI: 10.1126/scisignal.272re3

PubMed ID: 20037584

Title: CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

PubMed ID: 20037584

DOI: 10.1038/ni.1836

PubMed ID: 21610069

Title: Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis.

PubMed ID: 21610069

DOI: 10.1074/jbc.m111.233551

PubMed ID: 21395585

Title: Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells.

PubMed ID: 21395585

DOI: 10.1111/j.1471-4159.2011.07245.x

PubMed ID: 22240721

Title: Common variants in the CD36 gene are associated with oral fat perception, fat preferences, and obesity in African Americans.

PubMed ID: 22240721

DOI: 10.1038/oby.2011.374

PubMed ID: 25822988

Title: The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women.

PubMed ID: 25822988

DOI: 10.1017/s0007114515000343

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32958780

Title: CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis.

PubMed ID: 32958780

DOI: 10.1038/s41467-020-18565-8

PubMed ID: 37461827

Title: ARF6 plays a general role in targeting palmitoylated proteins from golgi to the plasma membrane.

PubMed ID: 37461827

DOI: 10.1242/jcs.261319

PubMed ID: 7533783

Title: Molecular basis of CD36 deficiency. Evidence that a 478C-->T substitution (proline90-->serine) in CD36 cDNA accounts for CD36 deficiency.

PubMed ID: 7533783

DOI: 10.1172/jci117749

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 10890433

Title: Malaria susceptibility and CD36 mutation.

PubMed ID: 10890433

DOI: 10.1038/35016636

PubMed ID: 11950861

Title: Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency.

PubMed ID: 11950861

DOI: 10.1136/jmg.39.4.286

PubMed ID: 12506336

Title: CD36 polymorphism is associated with protection from cerebral malaria.

PubMed ID: 12506336

DOI: 10.1086/346091

PubMed ID: 15282206

Title: A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians.

PubMed ID: 15282206

DOI: 10.1093/hmg/ddh233

PubMed ID: 18753675

Title: Chylomicron remnants are increased in the postprandial state in CD36 deficiency.

PubMed ID: 18753675

DOI: 10.1194/jlr.p700032-jlr200

PubMed ID: 27667267

Title: The structural basis for CD36 binding by the malaria parasite.

PubMed ID: 27667267

DOI: 10.1038/ncomms12837

Sequence Information:

Length: 472
Mass: 53053
Checksum: 543E748259A094FA
Sequence:

MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DLLIQKTIKK QVVLEEGTIA FKNWVKTGTE 
VYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK ENVTQDAEDN TVSFLQPNGA 
IFEPSLSVGT EADNFTVLNL AVAAASHIYQ NQFVQMILNS LINKSKSSMF QVRTLRELLW 
GYRDPFLSLV PYPVTTTVGL FYPYNNTADG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE 
SHCDMINGTD AASFPPFVEK SQVLQFFSSD ICRSIYAVFE SDVNLKGIPV YRFVLPSKAF 
ASPVENPDNY CFCTEKIISK NCTSYGVLDI SKCKEGRPVY ISLPHFLYAS PDVSEPIDGL 
NPNEEEHRTY LDIEPITGFT LQFAKRLQVN LLVKPSEKIQ VLKNLKRNYI VPILWLNETG 
TIGDEKANMF RSQVTGKINL LGLIEMILLS VGVVMFVAFM ISYCACRSKT IK

Genular Protein ID: 2027290459

Symbol: E9PLT1_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PLT1

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

Length: 396
Mass: 44733
Checksum: 00CF85D70FACB3AF
Sequence:

MMNSSNIQVK QRGPYTYRVR FLAKENVTQD AEDNTVSFLQ PNGAIFEPSL SVGTEADNFT 
VLNLAVAAAS HIYQNQFVQM ILNSLINKSK SSMFQVRTLR ELLWGYRDPF LSLVPYPVTT 
TVGLFYPYNN TADGVYKVFN GKDNISKVAI IDTYKGKRNL SYWESHCDMI NGTDAASFPP 
FVEKSQVLQF FSSDICRSIY AVFESDVNLK GIPVYRFVLP SKAFASPVEN PDNYCFCTEK 
IISKNCTSYG VLDISKCKEG RPVYISLPHF LYASPDVSEP IDGLNPNEEE HRTYLDIEPI 
TGFTLQFAKR LQVNLLVKPS EKIQVLKNLK RNYIVPILWL NETGTIGDEK ANMFRSQVTG 
KINLLGLIEM ILLSVGVVMF VAFMISYCAC RSKTIK

Genular Protein ID: 3278563106

Symbol: B7Z6C3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z6C3

Database IDs:

Sequence Information:

Length: 396
Mass: 44747
Checksum: 022B1511BE68E73E
Sequence:

MMNSSNIQVK QRGPYTYRVR FLAKENVTQD AEDNTVSFLQ PNGAIFEPSL SVGTEADNFT 
VLNLAVAAAS HIYQKQFVQM ILNSLINKSK SSMFQVRTLR ELLWGYRDPF LSLVPYPVTT 
TVGLFYPYNN TADGVYKVFN GKDNISKVAI IDTYKGKRNL SYWESHCDMI NGTDAASFPP 
FVEKSQVLQF FSSDICRSIY AVFESDVNLK GIPVYRFVLP SKAFASPVEN PDNYCFCTEK 
IISKNCTSYG VLDISKCKEG RPVYISLPHF LYASPDVSEP IDGLNPNEEE HRTYLDIEPI 
TGFTLQFAKR LQVNLLVKPS EKIQVLKNLK RNYIVPILWL NETGTIGDEK ANMFRSQVTG 
KINLLGLIEM ILLSVGVVMF VAFMISYCAC RSKTIK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD36

Associated with

Cells (max top 100)

Other Information

CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. PubMed ID: 2473841

Characterization of two alternatively spliced 5'-untranslated exons of the human CD36 gene in different cell types. PubMed ID: 7693552

Cloning of the cDNA encoding human platelet CD36: comparison to PCR amplified fragments of monocyte, endothelial and HEL cells. PubMed ID: 7505064

Structural organization of the gene for human CD36 glycoprotein. PubMed ID: 7518447

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and characterization of platelet glycoprotein IV (CD36). PubMed ID: 2468669

Variability of the CD36 gene in West Africa. PubMed ID: 11668637

Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2. PubMed ID: 7503937

Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. PubMed ID: 15242332

Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding. PubMed ID: 1371676

CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails. PubMed ID: 8798390

Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. PubMed ID: 10613822

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. PubMed ID: 16880211

Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake. PubMed ID: 18353783

Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. PubMed ID: 16263699

Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. PubMed ID: 18780401

CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria. PubMed ID: 19864601

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior. PubMed ID: 19471024

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. PubMed ID: 20037584

Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis. PubMed ID: 21610069

Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells. PubMed ID: 21395585

Common variants in the CD36 gene are associated with oral fat perception, fat preferences, and obesity in African Americans. PubMed ID: 22240721

The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women. PubMed ID: 25822988

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis. PubMed ID: 32958780

ARF6 plays a general role in targeting palmitoylated proteins from golgi to the plasma membrane. PubMed ID: 37461827

Molecular basis of CD36 deficiency. Evidence that a 478C--&gt;T substitution (proline90--&gt;serine) in CD36 cDNA accounts for CD36 deficiency. PubMed ID: 7533783

Characterization of single-nucleotide polymorphisms in coding regions of human genes. PubMed ID: 10391209

Malaria susceptibility and CD36 mutation. PubMed ID: 10890433

Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency. PubMed ID: 11950861

CD36 polymorphism is associated with protection from cerebral malaria. PubMed ID: 12506336

A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. PubMed ID: 15282206

Chylomicron remnants are increased in the postprandial state in CD36 deficiency. PubMed ID: 18753675

The structural basis for CD36 binding by the malaria parasite. PubMed ID: 27667267

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The DNA sequence of human chromosome 7. PubMed ID: 12853948

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Database document:

PubMed ID: 2473841

PubMed ID: 7693552

PubMed ID: 7505064

PubMed ID: 7518447

PubMed ID: 12853948

PubMed ID: 15489334

PubMed ID: 2468669

PubMed ID: 11668637

PubMed ID: 7503937

PubMed ID: 15242332

PubMed ID: 1371676

PubMed ID: 8798390

PubMed ID: 10613822

PubMed ID: 16880211

PubMed ID: 18353783

PubMed ID: 16263699

PubMed ID: 18780401

PubMed ID: 19864601

PubMed ID: 19159218

PubMed ID: 19471024

PubMed ID: 20037584

PubMed ID: 21610069

PubMed ID: 21395585

PubMed ID: 22240721

PubMed ID: 25822988

PubMed ID: 25944712

PubMed ID: 32958780

PubMed ID: 37461827

PubMed ID: 7533783

PubMed ID: 10391209

PubMed ID: 10890433

PubMed ID: 11950861

PubMed ID: 12506336

PubMed ID: 15282206

PubMed ID: 18753675

PubMed ID: 27667267

PubMed ID: 11237011

PubMed ID: 12853948

PubMed ID: 15496913

PubMed ID: 25944712