Details for: SLC25A27

Gene ID: 9481

Symbol: SLC25A27

Ensembl ID: ENSG00000153291

Description: solute carrier family 25 member 27

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.54
    Marker Score: 5,577
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.46
    Marker Score: 1,968
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.25
    Marker Score: 3,029
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.07
    Marker Score: 8,662
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.04
    Marker Score: 596
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.03
    Marker Score: 2,454
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.92
    Marker Score: 1,117
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.78
    Marker Score: 16,934
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.78
    Marker Score: 7,381
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.76
    Marker Score: 736
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.75
    Marker Score: 18,050
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.74
    Marker Score: 64,370
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.71
    Marker Score: 14,730
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.66
    Marker Score: 62,949
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.62
    Marker Score: 99,804
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.61
    Marker Score: 6,240
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.57
    Marker Score: 14,736
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.55
    Marker Score: 30,911
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.55
    Marker Score: 908
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.54
    Marker Score: 32,831
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.47
    Marker Score: 465
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.45
    Marker Score: 2,239
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.42
    Marker Score: 483
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.39
    Marker Score: 1,722
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.38
    Marker Score: 376
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.37
    Marker Score: 1,582
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.36
    Marker Score: 10,423
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.35
    Marker Score: 20,163
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.28
    Marker Score: 4,558
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.28
    Marker Score: 2,460
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.2
    Marker Score: 26,799
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.14
    Marker Score: 2,737
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.13
    Marker Score: 4,600
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.12
    Marker Score: 623
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.09
    Marker Score: 347
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.09
    Marker Score: 690
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.07
    Marker Score: 825
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.02
    Marker Score: 538
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.01
    Marker Score: 1,771
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.01
    Marker Score: 565
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1
    Marker Score: 677
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,797
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,023
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.97
    Marker Score: 580
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.96
    Marker Score: 6,188
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.95
    Marker Score: 4,377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,234
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.91
    Marker Score: 3,934
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.88
    Marker Score: 2,879
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.84
    Marker Score: 1,049
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.84
    Marker Score: 472
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.84
    Marker Score: 901
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.83
    Marker Score: 918
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 616
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.79
    Marker Score: 4,259
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3,245
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.77
    Marker Score: 245
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,253
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.75
    Marker Score: 646
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11,598
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 662
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.69
    Marker Score: 661
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.67
    Marker Score: 1,832
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.66
    Marker Score: 435
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.66
    Marker Score: 6,631
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.66
    Marker Score: 239
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.65
    Marker Score: 1,849
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.64
    Marker Score: 204
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.62
    Marker Score: 428
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.62
    Marker Score: 464
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6
    Marker Score: 20,392
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.6
    Marker Score: 1,715
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.59
    Marker Score: 217
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.58
    Marker Score: 1,174
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.57
    Marker Score: 215
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.57
    Marker Score: 811
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 371
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.56
    Marker Score: 142
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.56
    Marker Score: 226
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.55
    Marker Score: 297
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.55
    Marker Score: 1,285
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.55
    Marker Score: 110
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.54
    Marker Score: 8,685
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.54
    Marker Score: 475
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.53
    Marker Score: 456
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.53
    Marker Score: 616
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.52
    Marker Score: 878
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.52
    Marker Score: 303
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.52
    Marker Score: 134

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SLC25A27 is a mitochondrial inner membrane protein that belongs to the solute carrier family 25. It is a homodimeric protein composed of two identical subunits, each with a transmembrane domain. UCP4 is a mitochondrial uncoupling protein that disrupts the proton gradient across the mitochondrial inner membrane, leading to the dissipation of ATP and the production of heat. **Pathways and Functions:** UCP4 is involved in several cellular pathways, including: 1. **Mitochondrial inner membrane potential regulation:** UCP4 regulates the mitochondrial inner membrane potential by disrupting the proton gradient, leading to the dissipation of ATP and the production of heat. 2. **Calcium ion concentration regulation:** UCP4 regulates mitochondrial calcium ion concentration by modulating the activity of the calcium uniporter. 3. **Energy metabolism:** UCP4 regulates energy metabolism by disrupting the proton gradient, leading to the dissipation of ATP and the production of heat. 4. **Proton buffering:** UCP4 regulates proton buffering by modulating the activity of the proton pump. 5. **Fatty acid cycling:** UCP4 regulates fatty acid cycling by modulating the activity of the fatty acid synthase. **Clinical Significance:** Dysregulation of UCP4 has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** UCP4 has been implicated in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Metabolic disorders:** UCP4 has been implicated in the pathogenesis of metabolic disorders, such as diabetes and obesity. 3. **Cardiovascular diseases:** UCP4 has been implicated in the pathogenesis of cardiovascular diseases, such as atherosclerosis and hypertension. 4. **Cancer:** UCP4 has been implicated in the pathogenesis of cancer, including the regulation of cell growth, proliferation, and apoptosis. **Significantly Expressed Cells:** UCP4 is significantly expressed in various cell types, including: 1. **Ciliary muscle cells:** UCP4 is expressed in ciliary muscle cells, which are involved in the regulation of lens shape and focus. 2. **Pulmonary interstitial fibroblasts:** UCP4 is expressed in pulmonary interstitial fibroblasts, which are involved in the regulation of lung tissue repair. 3. **Anterior lens cells:** UCP4 is expressed in anterior lens cells, which are involved in the regulation of lens shape and focus. 4. **Pigmented epithelial cells:** UCP4 is expressed in pigmented epithelial cells, which are involved in the regulation of eye color and iris pigmentation. 5. **Corneal endothelial cells:** UCP4 is expressed in corneal endothelial cells, which are involved in the regulation of corneal hydration and transparency. In conclusion, SLC25A27 encodes for the mitochondrial uncoupling protein 4 (UCP4), which plays a crucial role in regulating mitochondrial inner membrane potential, calcium ion concentration, and energy metabolism. Its dysregulation has been implicated in various diseases, including neurodegenerative disorders, metabolic disorders, and cardiovascular diseases. Further research is needed to fully understand the function and clinical significance of UCP4.

Genular Protein ID: 2959388602

Symbol: UCP4_HUMAN

Name: Mitochondrial uncoupling protein 4

UniProtKB Accession Codes:

O95847 F5GWR4 Q5VTS9 Q8N518

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 3 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10025957

Title: UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells.

PubMed ID: 10025957

DOI: 10.1016/s0014-5793(98)01713-x

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22524567

Title: Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4, and UCP5.

PubMed ID: 22524567

DOI: 10.1021/bi3003378

PubMed ID: 26182433

Title: A biophysical study on molecular physiology of the uncoupling proteins of the central nervous system.

PubMed ID: 26182433

DOI: 10.1042/bsr20150130

Sequence Information:

  • Length: 323
  • Mass: 36064
  • Checksum: 4C54A56BB10333ED
  • Sequence:
    • MSVPEEEERL LPLTQRWPRA SKFLLSGCAA TVAELATFPL DLTKTRLQMQ GEAALARLGD 
GARESAPYRG MVRTALGIIE EEGFLKLWQG VTPAIYRHVV YSGGRMVTYE HLREVVFGKS 
EDEHYPLWKS VIGGMMAGVI GQFLANPTDL VKVQMQMEGK RKLEGKPLRF RGVHHAFAKI 
LAEGGIRGLW AGWVPNIQRA ALVNMGDLTT YDTVKHYLVL NTPLEDNIMT HGLSSLCSGL 
VASILGTPAD VIKSRIMNQP RDKQGRGLLY KSSTDCLIQA VQGEGFMSLY KGFLPSWLRM 
TPWSMVFWLT YEKIREMSGV SPF

Genular Protein ID: 2313225948

Symbol: B4DHR4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DHR4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 300
  • Mass: 33290
  • Checksum: 3E6A069081100B27
  • Sequence:
    • MSVPEEEERL LPLTQRWPRA SKFLLSGCAA TVAELATFPL DLTKTRLQMQ GEAALARLGD 
GARESAPYRG MVRTALGIIE EEGFLKLWQG VTPAIYRHVV YSGGRMVTYE HLREVVFGKS 
EDEHYPLWKS VIGGMMAGVI GQFLANPTDL VKVQMQMEGK RKLEGKPLRF RGVHHAFAKI 
LAEGGIRGLW AGWVPNIQRA ALVNMGDLTT YDTVKHYLVL NTPLEDNIMT HGLSSLCSGL 
VASILGTPAD VIKSRIMNQP RDKQGRGLLY KSSTDCLIQA VQGEGFMSLY KGFLPSWLRM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.