Details for: SCARB1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 147.1919
Cell Significance Index: -22.9000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 84.2127
Cell Significance Index: -21.3600 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 55.0555
Cell Significance Index: -22.6800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 49.5745
Cell Significance Index: -20.1400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 21.1052
Cell Significance Index: -20.1500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 20.6466
Cell Significance Index: 553.2300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 18.6219
Cell Significance Index: -22.9600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.0636
Cell Significance Index: -22.0300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.8590
Cell Significance Index: -23.1200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 3.1778
Cell Significance Index: 140.5600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 3.1434
Cell Significance Index: 52.9500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.8626
Cell Significance Index: 108.4000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.3921
Cell Significance Index: 474.7200 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.3386
Cell Significance Index: 23.6600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.2201
Cell Significance Index: 244.7500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.8374
Cell Significance Index: 22.0200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.7284
Cell Significance Index: 19.4500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.7203
Cell Significance Index: 84.9500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6814
Cell Significance Index: 244.4000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6680
Cell Significance Index: 19.2500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.6485
Cell Significance Index: 43.6100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.6265
Cell Significance Index: 964.5000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5523
Cell Significance Index: 33.1600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5046
Cell Significance Index: 348.9900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4616
Cell Significance Index: 50.2100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.4320
Cell Significance Index: 2.6100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4213
Cell Significance Index: 68.5300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4105
Cell Significance Index: 21.3800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.3945
Cell Significance Index: 727.5400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.3564
Cell Significance Index: 8.9100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3454
Cell Significance Index: 24.4300 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.3420
Cell Significance Index: 4.2300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3351
Cell Significance Index: 7.2600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.3250
Cell Significance Index: 9.2800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2816
Cell Significance Index: 19.4800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2462
Cell Significance Index: 11.4800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2360
Cell Significance Index: 444.3800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2347
Cell Significance Index: 10.6400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.2242
Cell Significance Index: 304.9100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1489
Cell Significance Index: 28.3300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1341
Cell Significance Index: 13.2700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.0935
Cell Significance Index: 1.3800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0922
Cell Significance Index: 40.7700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0846
Cell Significance Index: 11.6100 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0606
Cell Significance Index: 7.8300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0561
Cell Significance Index: 30.6200 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0481
Cell Significance Index: 6.1600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0347
Cell Significance Index: 1.6300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0336
Cell Significance Index: 1.1800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0309
Cell Significance Index: 2.3700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0308
Cell Significance Index: 19.5300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0305
Cell Significance Index: 5.4900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0245
Cell Significance Index: 22.1200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0142
Cell Significance Index: 6.4700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0138
Cell Significance Index: -2.0100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0189
Cell Significance Index: -1.1600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0247
Cell Significance Index: -18.6700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0279
Cell Significance Index: -20.6700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0299
Cell Significance Index: -21.9000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0422
Cell Significance Index: -23.7900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0426
Cell Significance Index: -2.7500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0431
Cell Significance Index: -26.9200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0582
Cell Significance Index: -3.0600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0583
Cell Significance Index: -7.1700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0621
Cell Significance Index: -6.3400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0676
Cell Significance Index: -19.4600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0730
Cell Significance Index: -12.4700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0733
Cell Significance Index: -3.8100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0751
Cell Significance Index: -8.7500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1107
Cell Significance Index: -6.2100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1228
Cell Significance Index: -7.5300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1309
Cell Significance Index: -27.5600 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1348
Cell Significance Index: -1.9300 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1383
Cell Significance Index: -1.9400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1551
Cell Significance Index: -4.1500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1758
Cell Significance Index: -18.3000 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1821
Cell Significance Index: -1.8900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1974
Cell Significance Index: -22.6100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2020
Cell Significance Index: -12.7300 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.2186
Cell Significance Index: -2.8000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2274
Cell Significance Index: -16.9500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2305
Cell Significance Index: -3.9500 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.2649
Cell Significance Index: -4.0300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2797
Cell Significance Index: -22.1500 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2855
Cell Significance Index: -6.0600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3178
Cell Significance Index: -10.1200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3198
Cell Significance Index: -10.4700 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3323
Cell Significance Index: -7.9700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3417
Cell Significance Index: -10.9500 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.3529
Cell Significance Index: -5.9400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3599
Cell Significance Index: -12.5100 - Cell Name: Mueller cell (CL0000636)
Fold Change: -0.3724
Cell Significance Index: -2.8700 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3763
Cell Significance Index: -7.4400 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.3913
Cell Significance Index: -8.4600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3954
Cell Significance Index: -8.4200 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.4035
Cell Significance Index: -8.1000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4257
Cell Significance Index: -7.1300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.4462
Cell Significance Index: -11.1300 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.4539
Cell Significance Index: -6.8400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4543
Cell Significance Index: -15.9200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1100366454
Symbol: SCRB1_HUMAN
Name: Scavenger receptor class B member 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7689561
Title: Identification, primary structure and distribution of CLA-1, a novel member of the CD36/LIMPII gene family.
PubMed ID: 7689561
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9254074
Title: Alternative forms of the scavenger receptor BI (SR-BI).
PubMed ID: 9254074
PubMed ID: 9614139
Title: SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells.
PubMed ID: 9614139
PubMed ID: 12356718
Title: The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus.
PubMed ID: 12356718
DOI: 10.1093/emboj/cdf529
PubMed ID: 12016218
Title: Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular Sertoli cells.
PubMed ID: 12016218
PubMed ID: 12913001
Title: Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor.
PubMed ID: 12913001
PubMed ID: 16020694
Title: Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection.
PubMed ID: 16020694
PubMed ID: 18000990
Title: Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81.
PubMed ID: 18000990
DOI: 10.1002/hep.21994
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 20686565
Title: Biological, clinical and population relevance of 95 loci for blood lipids.
PubMed ID: 20686565
DOI: 10.1038/nature09270
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 33244168
Title: HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry.
PubMed ID: 33244168
PubMed ID: 26965621
Title: Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.
PubMed ID: 26965621
PubMed ID: 12519372
Title: Polymorphisms at the SRBI locus are associated with lipoprotein levels in subjects with heterozygous familial hypercholesterolemia.
PubMed ID: 12519372
PubMed ID: 12966036
Title: Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors.
PubMed ID: 12966036
DOI: 10.1093/hmg/ddg314
PubMed ID: 21226579
Title: Genetic variant of the scavenger receptor BI in humans.
PubMed ID: 21226579
Sequence Information:
- Length: 552
- Mass: 60878
- Checksum: 06B0BD771FEA284F
- Sequence:
MGCSAKARWA AGALGVAGLL CAVLGAVMIV MVPSLIKQQV LKNVRIDPSS LSFNMWKEIP IPFYLSVYFF DVMNPSEILK GEKPQVRERG PYVYREFRHK SNITFNNNDT VSFLEYRTFQ FQPSKSHGSE SDYIVMPNIL VLGAAVMMEN KPMTLKLIMT LAFTTLGERA FMNRTVGEIM WGYKDPLVNL INKYFPGMFP FKDKFGLFAE LNNSDSGLFT VFTGVQNISR IHLVDKWNGL SKVDFWHSDQ CNMINGTSGQ MWPPFMTPES SLEFYSPEAC RSMKLMYKES GVFEGIPTYR FVAPKTLFAN GSIYPPNEGF CPCLESGIQN VSTCRFSAPL FLSHPHFLNA DPVLAEAVTG LHPNQEAHSL FLDIHPVTGI PMNCSVKLQL SLYMKSVAGI GQTGKIEPVV LPLLWFAESG AMEGETLHTF YTQLVLMPKV MHYAQYVLLA LGCVLLLVPV ICQIRSQVGA GQRAARADSH SLACWGKGAS DRTLWPTAAW SPPPAAVLRL CRSGSGHCWG LRSTLASFAC RVATTLPVLE GLGPSLGGGT GS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.