SCARB1 | ENSG00000073060 | NCBI 949

Details for: SCARB1

Gene ID: 949

Symbol: SCARB1

Ensembl ID: ENSG00000073060

Description: scavenger receptor class B member 1

Associated with

Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Hdl clearance
(R-HSA-8964011)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein clearance
(R-HSA-8964043)
Scavenging by class b receptors
(R-HSA-3000471)
Transport of small molecules
(R-HSA-382551)
Vesicle-mediated transport
(R-HSA-5653656)
1-phosphatidylinositol binding
(GO:0005545)
Adhesion of symbiont to host
(GO:0044406)
Amyloid-beta binding
(GO:0001540)
Apolipoprotein a-i binding
(GO:0034186)
Apolipoprotein binding
(GO:0034185)
Blood vessel endothelial cell migration
(GO:0043534)
Carotenoid transport
(GO:0046867)
Caveola
(GO:0005901)
Cell surface
(GO:0009986)
Cholesterol catabolic process
(GO:0006707)
Cholesterol efflux
(GO:0033344)
Cholesterol homeostasis
(GO:0042632)
Cholesterol import
(GO:0070508)
Cytoplasm
(GO:0005737)
Detection of lipopolysaccharide
(GO:0032497)
Endocytic vesicle membrane
(GO:0030666)
Endothelial cell proliferation
(GO:0001935)
Extracellular exosome
(GO:0070062)
High-density lipoprotein particle binding
(GO:0008035)
High-density lipoprotein particle clearance
(GO:0034384)
High-density lipoprotein particle receptor activity
(GO:0070506)
High-density lipoprotein particle remodeling
(GO:0034375)
Intestinal lipid absorption
(GO:0098856)
Intracellular membrane-bounded organelle
(GO:0043231)
Lipid binding
(GO:0008289)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Lipopolysaccharide binding
(GO:0001530)
Lipopolysaccharide immune receptor activity
(GO:0001875)
Lipopolysaccharide transport
(GO:0015920)
Low-density lipoprotein particle binding
(GO:0030169)
Low-density lipoprotein particle clearance
(GO:0034383)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Phosphatidylserine binding
(GO:0001786)
Phospholipid transport
(GO:0015914)
Plasma lipoprotein particle clearance
(GO:0034381)
Plasma membrane
(GO:0005886)
Positive regulation of cholesterol storage
(GO:0010886)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of nitric-oxide synthase activity
(GO:0051000)
Positive regulation of triglyceride biosynthetic process
(GO:0010867)
Protein binding
(GO:0005515)
Recognition of apoptotic cell
(GO:0043654)
Regulation of phagocytosis
(GO:0050764)
Regulation of phosphatidylcholine catabolic process
(GO:0010899)
Reverse cholesterol transport
(GO:0043691)
Scavenger receptor activity
(GO:0005044)
Symbiont entry into host cell
(GO:0046718)
Triglyceride homeostasis
(GO:0070328)
Virus receptor activity
(GO:0001618)
Vitamin transmembrane transport
(GO:0035461)
Wound healing
(GO:0042060)

Other Information

Proteins

Scavenger receptor class B member 1

Genular Protein ID: 1100366454

Symbol: SCRB1_HUMAN

Name: Scavenger receptor class B member 1

UniProtKB Accession Codes:

Q8WTV0 F8W8N0 Q14016 Q52LZ5 Q6KFX4

Database IDs:

Citations:

PubMed ID: 7689561

Title: Identification, primary structure and distribution of CLA-1, a novel member of the CD36/LIMPII gene family.

PubMed ID: 7689561

DOI: 10.1016/s0021-9258(17)46716-0

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9254074

Title: Alternative forms of the scavenger receptor BI (SR-BI).

PubMed ID: 9254074

PubMed ID: 9614139

Title: SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells.

PubMed ID: 9614139

DOI: 10.1074/jbc.273.24.15241

PubMed ID: 12356718

Title: The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus.

PubMed ID: 12356718

DOI: 10.1093/emboj/cdf529

PubMed ID: 12016218

Title: Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular Sertoli cells.

PubMed ID: 12016218

DOI: 10.1074/jbc.m202879200

PubMed ID: 12913001

Title: Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor.

PubMed ID: 12913001

DOI: 10.1074/jbc.m305289200

PubMed ID: 16020694

Title: Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection.

PubMed ID: 16020694

DOI: 10.1126/science.1116006

PubMed ID: 18000990

Title: Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81.

PubMed ID: 18000990

DOI: 10.1002/hep.21994

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20686565

Title: Biological, clinical and population relevance of 95 loci for blood lipids.

PubMed ID: 20686565

DOI: 10.1038/nature09270

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33244168

Title: HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry.

PubMed ID: 33244168

DOI: 10.1038/s42255-020-00324-0

PubMed ID: 26965621

Title: Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.

PubMed ID: 26965621

DOI: 10.1126/science.aad3517

PubMed ID: 12519372

Title: Polymorphisms at the SRBI locus are associated with lipoprotein levels in subjects with heterozygous familial hypercholesterolemia.

PubMed ID: 12519372

DOI: 10.1034/j.1399-0004.2003.630108.x

PubMed ID: 12966036

Title: Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors.

PubMed ID: 12966036

DOI: 10.1093/hmg/ddg314

PubMed ID: 21226579

Title: Genetic variant of the scavenger receptor BI in humans.

PubMed ID: 21226579

DOI: 10.1056/nejmoa0907687

Sequence Information:

Length: 552
Mass: 60878
Checksum: 06B0BD771FEA284F
Sequence:

MGCSAKARWA AGALGVAGLL CAVLGAVMIV MVPSLIKQQV LKNVRIDPSS LSFNMWKEIP 
IPFYLSVYFF DVMNPSEILK GEKPQVRERG PYVYREFRHK SNITFNNNDT VSFLEYRTFQ 
FQPSKSHGSE SDYIVMPNIL VLGAAVMMEN KPMTLKLIMT LAFTTLGERA FMNRTVGEIM 
WGYKDPLVNL INKYFPGMFP FKDKFGLFAE LNNSDSGLFT VFTGVQNISR IHLVDKWNGL 
SKVDFWHSDQ CNMINGTSGQ MWPPFMTPES SLEFYSPEAC RSMKLMYKES GVFEGIPTYR 
FVAPKTLFAN GSIYPPNEGF CPCLESGIQN VSTCRFSAPL FLSHPHFLNA DPVLAEAVTG 
LHPNQEAHSL FLDIHPVTGI PMNCSVKLQL SLYMKSVAGI GQTGKIEPVV LPLLWFAESG 
AMEGETLHTF YTQLVLMPKV MHYAQYVLLA LGCVLLLVPV ICQIRSQVGA GQRAARADSH 
SLACWGKGAS DRTLWPTAAW SPPPAAVLRL CRSGSGHCWG LRSTLASFAC RVATTLPVLE 
GLGPSLGGGT GS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SCARB1

Associated with

Other Information

Identification, primary structure and distribution of CLA-1, a novel member of the CD36/LIMPII gene family. PubMed ID: 7689561

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Alternative forms of the scavenger receptor BI (SR-BI). PubMed ID: 9254074

SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells. PubMed ID: 9614139

The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus. PubMed ID: 12356718

Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular Sertoli cells. PubMed ID: 12016218

Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor. PubMed ID: 12913001

Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. PubMed ID: 16020694

Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81. PubMed ID: 18000990

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Biological, clinical and population relevance of 95 loci for blood lipids. PubMed ID: 20686565

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry. PubMed ID: 33244168

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. PubMed ID: 26965621

Polymorphisms at the SRBI locus are associated with lipoprotein levels in subjects with heterozygous familial hypercholesterolemia. PubMed ID: 12519372

Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors. PubMed ID: 12966036

Genetic variant of the scavenger receptor BI in humans. PubMed ID: 21226579