Details for: SCARB1

Gene ID: 949

Symbol: SCARB1

Ensembl ID: ENSG00000073060

Description: scavenger receptor class B member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 147.1919
    Cell Significance Index: -22.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 84.2127
    Cell Significance Index: -21.3600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 55.0555
    Cell Significance Index: -22.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.5745
    Cell Significance Index: -20.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.1052
    Cell Significance Index: -20.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 20.6466
    Cell Significance Index: 553.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.6219
    Cell Significance Index: -22.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.0636
    Cell Significance Index: -22.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8590
    Cell Significance Index: -23.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.1778
    Cell Significance Index: 140.5600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.1434
    Cell Significance Index: 52.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.8626
    Cell Significance Index: 108.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3921
    Cell Significance Index: 474.7200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.3386
    Cell Significance Index: 23.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2201
    Cell Significance Index: 244.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8374
    Cell Significance Index: 22.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7284
    Cell Significance Index: 19.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7203
    Cell Significance Index: 84.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6814
    Cell Significance Index: 244.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6680
    Cell Significance Index: 19.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6485
    Cell Significance Index: 43.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.6265
    Cell Significance Index: 964.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5523
    Cell Significance Index: 33.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5046
    Cell Significance Index: 348.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4616
    Cell Significance Index: 50.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.4320
    Cell Significance Index: 2.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4213
    Cell Significance Index: 68.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4105
    Cell Significance Index: 21.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3945
    Cell Significance Index: 727.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3564
    Cell Significance Index: 8.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3454
    Cell Significance Index: 24.4300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.3420
    Cell Significance Index: 4.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3351
    Cell Significance Index: 7.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3250
    Cell Significance Index: 9.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2816
    Cell Significance Index: 19.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2462
    Cell Significance Index: 11.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2360
    Cell Significance Index: 444.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2347
    Cell Significance Index: 10.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2242
    Cell Significance Index: 304.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1489
    Cell Significance Index: 28.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1341
    Cell Significance Index: 13.2700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0935
    Cell Significance Index: 1.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0922
    Cell Significance Index: 40.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0846
    Cell Significance Index: 11.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0606
    Cell Significance Index: 7.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0561
    Cell Significance Index: 30.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0481
    Cell Significance Index: 6.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0347
    Cell Significance Index: 1.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0336
    Cell Significance Index: 1.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0309
    Cell Significance Index: 2.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0308
    Cell Significance Index: 19.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0305
    Cell Significance Index: 5.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0245
    Cell Significance Index: 22.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0142
    Cell Significance Index: 6.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0138
    Cell Significance Index: -2.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0189
    Cell Significance Index: -1.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0247
    Cell Significance Index: -18.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0279
    Cell Significance Index: -20.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0299
    Cell Significance Index: -21.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0422
    Cell Significance Index: -23.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0426
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0431
    Cell Significance Index: -26.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0582
    Cell Significance Index: -3.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0583
    Cell Significance Index: -7.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0621
    Cell Significance Index: -6.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0676
    Cell Significance Index: -19.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0730
    Cell Significance Index: -12.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0733
    Cell Significance Index: -3.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0751
    Cell Significance Index: -8.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1107
    Cell Significance Index: -6.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1228
    Cell Significance Index: -7.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1309
    Cell Significance Index: -27.5600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1348
    Cell Significance Index: -1.9300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1383
    Cell Significance Index: -1.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1551
    Cell Significance Index: -4.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1758
    Cell Significance Index: -18.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1821
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1974
    Cell Significance Index: -22.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2020
    Cell Significance Index: -12.7300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2186
    Cell Significance Index: -2.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2274
    Cell Significance Index: -16.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2305
    Cell Significance Index: -3.9500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2649
    Cell Significance Index: -4.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2797
    Cell Significance Index: -22.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2855
    Cell Significance Index: -6.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3178
    Cell Significance Index: -10.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3198
    Cell Significance Index: -10.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3323
    Cell Significance Index: -7.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3417
    Cell Significance Index: -10.9500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3529
    Cell Significance Index: -5.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3599
    Cell Significance Index: -12.5100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3724
    Cell Significance Index: -2.8700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3763
    Cell Significance Index: -7.4400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3913
    Cell Significance Index: -8.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3954
    Cell Significance Index: -8.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4035
    Cell Significance Index: -8.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4257
    Cell Significance Index: -7.1300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4462
    Cell Significance Index: -11.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4539
    Cell Significance Index: -6.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4543
    Cell Significance Index: -15.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Lipid-binding receptor**: SCARB1 is a class B scavenger receptor that recognizes and binds to various lipids, including cholesterol, lipopolysaccharides, and triglycerides. 2. **Endocytic pathway**: SCARB1 facilitates the uptake of ligands by endocytic vesicles, leading to their internalization and degradation. 3. **Modulation of lipid metabolism**: SCARB1 influences lipid homeostasis by regulating the clearance of lipoproteins and the transport of lipids across cell membranes. 4. **Immune response**: SCARB1 is involved in the recognition and uptake of apoptotic cells, and modulates the immune response by regulating phagocytosis and the production of nitric oxide. 5. **Cell migration**: SCARB1 promotes endothelial cell migration and proliferation, which is essential for wound healing and angiogenesis. **Pathways and Functions** 1. **Cholesterol homeostasis**: SCARB1 regulates the clearance of high-density lipoprotein (HDL) particles, which is essential for maintaining cholesterol balance in the body. 2. **Reverse cholesterol transport**: SCARB1 facilitates the transfer of cholesterol from peripheral tissues to the liver for excretion, which is critical for reducing cardiovascular risk. 3. **Immune response**: SCARB1 recognizes and binds to lipopolysaccharides, which triggers an immune response and modulates the production of cytokines and chemokines. 4. **Endothelial cell migration**: SCARB1 promotes endothelial cell migration and proliferation, which is essential for angiogenesis and wound healing. 5. **Triglyceride homeostasis**: SCARB1 regulates the clearance of triglycerides from peripheral tissues, which is critical for maintaining energy homeostasis. **Clinical Significance** Dysregulation of SCARB1 has been implicated in various diseases, including: 1. **Atherosclerosis**: SCARB1 plays a critical role in the development of atherosclerosis by regulating the clearance of lipoproteins and cholesterol from peripheral tissues. 2. **Cardiovascular disease**: SCARB1 is involved in the regulation of blood pressure and cardiovascular risk, making it a potential target for therapeutic interventions. 3. **Diabetes**: SCARB1 regulates glucose homeostasis and insulin sensitivity, making it a potential target for the treatment of diabetes. 4. **Inflammatory diseases**: SCARB1 is involved in the regulation of the immune response, making it a potential target for the treatment of inflammatory diseases. In conclusion, SCARB1 is a multifunctional receptor that plays a critical role in lipid metabolism, immune response, and cell migration. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic interventions. Further research is needed to fully understand the mechanisms by which SCARB1 regulates these processes and to develop effective therapeutic strategies to modulate its activity.

Genular Protein ID: 1100366454

Symbol: SCRB1_HUMAN

Name: Scavenger receptor class B member 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7689561

Title: Identification, primary structure and distribution of CLA-1, a novel member of the CD36/LIMPII gene family.

PubMed ID: 7689561

DOI: 10.1016/s0021-9258(17)46716-0

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9254074

Title: Alternative forms of the scavenger receptor BI (SR-BI).

PubMed ID: 9254074

PubMed ID: 9614139

Title: SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells.

PubMed ID: 9614139

DOI: 10.1074/jbc.273.24.15241

PubMed ID: 12356718

Title: The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus.

PubMed ID: 12356718

DOI: 10.1093/emboj/cdf529

PubMed ID: 12016218

Title: Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular Sertoli cells.

PubMed ID: 12016218

DOI: 10.1074/jbc.m202879200

PubMed ID: 12913001

Title: Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor.

PubMed ID: 12913001

DOI: 10.1074/jbc.m305289200

PubMed ID: 16020694

Title: Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection.

PubMed ID: 16020694

DOI: 10.1126/science.1116006

PubMed ID: 18000990

Title: Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81.

PubMed ID: 18000990

DOI: 10.1002/hep.21994

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20686565

Title: Biological, clinical and population relevance of 95 loci for blood lipids.

PubMed ID: 20686565

DOI: 10.1038/nature09270

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33244168

Title: HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry.

PubMed ID: 33244168

DOI: 10.1038/s42255-020-00324-0

PubMed ID: 26965621

Title: Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.

PubMed ID: 26965621

DOI: 10.1126/science.aad3517

PubMed ID: 12519372

Title: Polymorphisms at the SRBI locus are associated with lipoprotein levels in subjects with heterozygous familial hypercholesterolemia.

PubMed ID: 12519372

DOI: 10.1034/j.1399-0004.2003.630108.x

PubMed ID: 12966036

Title: Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors.

PubMed ID: 12966036

DOI: 10.1093/hmg/ddg314

PubMed ID: 21226579

Title: Genetic variant of the scavenger receptor BI in humans.

PubMed ID: 21226579

DOI: 10.1056/nejmoa0907687

Sequence Information:

  • Length: 552
  • Mass: 60878
  • Checksum: 06B0BD771FEA284F
  • Sequence:
  • MGCSAKARWA AGALGVAGLL CAVLGAVMIV MVPSLIKQQV LKNVRIDPSS LSFNMWKEIP 
    IPFYLSVYFF DVMNPSEILK GEKPQVRERG PYVYREFRHK SNITFNNNDT VSFLEYRTFQ 
    FQPSKSHGSE SDYIVMPNIL VLGAAVMMEN KPMTLKLIMT LAFTTLGERA FMNRTVGEIM 
    WGYKDPLVNL INKYFPGMFP FKDKFGLFAE LNNSDSGLFT VFTGVQNISR IHLVDKWNGL 
    SKVDFWHSDQ CNMINGTSGQ MWPPFMTPES SLEFYSPEAC RSMKLMYKES GVFEGIPTYR 
    FVAPKTLFAN GSIYPPNEGF CPCLESGIQN VSTCRFSAPL FLSHPHFLNA DPVLAEAVTG 
    LHPNQEAHSL FLDIHPVTGI PMNCSVKLQL SLYMKSVAGI GQTGKIEPVV LPLLWFAESG 
    AMEGETLHTF YTQLVLMPKV MHYAQYVLLA LGCVLLLVPV ICQIRSQVGA GQRAARADSH 
    SLACWGKGAS DRTLWPTAAW SPPPAAVLRL CRSGSGHCWG LRSTLASFAC RVATTLPVLE 
    GLGPSLGGGT GS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.