Details for: SCARB1

Gene ID: 949

Symbol: SCARB1

Ensembl ID: ENSG00000073060

Description: scavenger receptor class B member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 13.13
    Marker Score: 233128
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.14
    Marker Score: 3799
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.86
    Marker Score: 3843
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.57
    Marker Score: 1534
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.35
    Marker Score: 3306
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.27
    Marker Score: 7443
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.2
    Marker Score: 1285
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.13
    Marker Score: 705
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.1
    Marker Score: 2421
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.95
    Marker Score: 1137
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.93
    Marker Score: 3933
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.92
    Marker Score: 1440
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.61
    Marker Score: 6751
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.52
    Marker Score: 14273
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.51
    Marker Score: 22533
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.5
    Marker Score: 29867
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.44
    Marker Score: 12339
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.43
    Marker Score: 13550
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.39
    Marker Score: 52726
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.39
    Marker Score: 8926
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.39
    Marker Score: 5984
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.35
    Marker Score: 82917
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.34
    Marker Score: 456
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.32
    Marker Score: 7108
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20435
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.29
    Marker Score: 9868
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.28
    Marker Score: 1974
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.27
    Marker Score: 4893
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.26
    Marker Score: 46523
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.22
    Marker Score: 12605
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.21
    Marker Score: 2854
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.16
    Marker Score: 641
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.15
    Marker Score: 1243
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.11
    Marker Score: 11131.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.07
    Marker Score: 533
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.06
    Marker Score: 340
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.01
    Marker Score: 3000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71769
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47994
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.99
    Marker Score: 1671.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.98
    Marker Score: 242
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.96
    Marker Score: 574
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.95
    Marker Score: 20322
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.95
    Marker Score: 3943
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 446
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1509
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.93
    Marker Score: 3773
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.91
    Marker Score: 5418
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.9
    Marker Score: 362
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.9
    Marker Score: 1507
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.89
    Marker Score: 425
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5039
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.86
    Marker Score: 584
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.82
    Marker Score: 2333
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.81
    Marker Score: 1608
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.79
    Marker Score: 246
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.78
    Marker Score: 1087
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.76
    Marker Score: 4967
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 579
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.75
    Marker Score: 1803
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3133
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.74
    Marker Score: 280
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.74
    Marker Score: 363
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.73
    Marker Score: 861.5
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.72
    Marker Score: 229
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.72
    Marker Score: 716
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.71
    Marker Score: 316
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.71
    Marker Score: 2215
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 632
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.68
    Marker Score: 1501
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.68
    Marker Score: 818
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.66
    Marker Score: 532
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.66
    Marker Score: 1146
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.65
    Marker Score: 698
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.64
    Marker Score: 421
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.63
    Marker Score: 906
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.62
    Marker Score: 533
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.61
    Marker Score: 219
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.6
    Marker Score: 1620
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.59
    Marker Score: 403
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.59
    Marker Score: 1072
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.59
    Marker Score: 237
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.57
    Marker Score: 214
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.56
    Marker Score: 4940
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.56
    Marker Score: 177
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.56
    Marker Score: 525
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.55
    Marker Score: 1264
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.55
    Marker Score: 162
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.54
    Marker Score: 2515
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.54
    Marker Score: 130

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Other Information

**Key characteristics:** * SCARB1 is a type I scavenger receptor, which are characterized by the presence of a single extracellular domain that is responsible for ligand binding. * It is expressed in high levels in epithelial cells, where it is involved in the clearance of damaged or abnormal proteins. * It is also expressed in immune cells, where it is involved in the uptake of ligands by cells and the regulation of inflammation. * It is a highly conserved protein, with a sequence that is similar to SRs from other species. **Pathways and functions:** * SCARB1 is involved in a variety of cellular processes, including the clearance of damaged or abnormal proteins, the uptake of ligands by cells, and the regulation of inflammation. * It is involved in the clearance of damaged proteins by binding to unfolded or misfolded proteins and then delivering them to the lysosome for degradation. * It is also involved in the uptake of ligands by cells by binding to ligands and then delivering them to the cytoplasm. * It is involved in the regulation of inflammation by binding to inflammatory mediators and triggering the release of cytokines and chemokines. * It is also involved in the assembly and remodeling of plasma lipoproteins, and its expression is regulated by hormones such as growth hormone and insulin. **Clinical significance:** SCARB1 is a potential therapeutic target for a variety of diseases, including cancer, cardiovascular disease, and inflammation. Studies have shown that SCARB1 inhibitors can inhibit the uptake of ligands by cells, which can lead to the accumulation of damaged or abnormal proteins and the development of diseases such as cancer and cardiovascular disease.

Genular Protein ID: 1100366454

Symbol: SCRB1_HUMAN

Name: Scavenger receptor class B member 1

UniProtKB Accession Codes:

Q8WTV0 F8W8N0 Q14016 Q52LZ5 Q6KFX4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 9 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 49 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7689561

Title: Identification, primary structure and distribution of CLA-1, a novel member of the CD36/LIMPII gene family.

PubMed ID: 7689561

DOI: 10.1016/s0021-9258(17)46716-0

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9254074

Title: Alternative forms of the scavenger receptor BI (SR-BI).

PubMed ID: 9254074

PubMed ID: 9614139

Title: SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells.

PubMed ID: 9614139

DOI: 10.1074/jbc.273.24.15241

PubMed ID: 12356718

Title: The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus.

PubMed ID: 12356718

DOI: 10.1093/emboj/cdf529

PubMed ID: 12016218

Title: Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular Sertoli cells.

PubMed ID: 12016218

DOI: 10.1074/jbc.m202879200

PubMed ID: 12913001

Title: Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor.

PubMed ID: 12913001

DOI: 10.1074/jbc.m305289200

PubMed ID: 16020694

Title: Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection.

PubMed ID: 16020694

DOI: 10.1126/science.1116006

PubMed ID: 18000990

Title: Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81.

PubMed ID: 18000990

DOI: 10.1002/hep.21994

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20686565

Title: Biological, clinical and population relevance of 95 loci for blood lipids.

PubMed ID: 20686565

DOI: 10.1038/nature09270

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33244168

Title: HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry.

PubMed ID: 33244168

DOI: 10.1038/s42255-020-00324-0

PubMed ID: 26965621

Title: Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.

PubMed ID: 26965621

DOI: 10.1126/science.aad3517

PubMed ID: 12519372

Title: Polymorphisms at the SRBI locus are associated with lipoprotein levels in subjects with heterozygous familial hypercholesterolemia.

PubMed ID: 12519372

DOI: 10.1034/j.1399-0004.2003.630108.x

PubMed ID: 12966036

Title: Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors.

PubMed ID: 12966036

DOI: 10.1093/hmg/ddg314

PubMed ID: 21226579

Title: Genetic variant of the scavenger receptor BI in humans.

PubMed ID: 21226579

DOI: 10.1056/nejmoa0907687

Sequence Information:

  • Length: 552
  • Mass: 60878
  • Checksum: 06B0BD771FEA284F
  • Sequence:
    • MGCSAKARWA AGALGVAGLL CAVLGAVMIV MVPSLIKQQV LKNVRIDPSS LSFNMWKEIP 
IPFYLSVYFF DVMNPSEILK GEKPQVRERG PYVYREFRHK SNITFNNNDT VSFLEYRTFQ 
FQPSKSHGSE SDYIVMPNIL VLGAAVMMEN KPMTLKLIMT LAFTTLGERA FMNRTVGEIM 
WGYKDPLVNL INKYFPGMFP FKDKFGLFAE LNNSDSGLFT VFTGVQNISR IHLVDKWNGL 
SKVDFWHSDQ CNMINGTSGQ MWPPFMTPES SLEFYSPEAC RSMKLMYKES GVFEGIPTYR 
FVAPKTLFAN GSIYPPNEGF CPCLESGIQN VSTCRFSAPL FLSHPHFLNA DPVLAEAVTG 
LHPNQEAHSL FLDIHPVTGI PMNCSVKLQL SLYMKSVAGI GQTGKIEPVV LPLLWFAESG 
AMEGETLHTF YTQLVLMPKV MHYAQYVLLA LGCVLLLVPV ICQIRSQVGA GQRAARADSH 
SLACWGKGAS DRTLWPTAAW SPPPAAVLRL CRSGSGHCWG LRSTLASFAC RVATTLPVLE 
GLGPSLGGGT GS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.