Gene ACY1 - ENSG00000243989 | NCBI Gene ID: 95

Details for: ACY1

Gene ID: 95

Symbol: ACY1

Ensembl ID: ENSG00000243989

Description: aminoacylase 1

Associated with

Aflatoxin activation and detoxification
(R-HSA-5423646)
Biological oxidations
(R-HSA-211859)
Defective acy1 causes encephalopathy
(R-HSA-5579007)
Disease
(R-HSA-1643685)
Diseases of metabolism
(R-HSA-5668914)
Drug adme
(R-HSA-9748784)
Metabolic disorders of biological oxidation enzymes
(R-HSA-5579029)
Metabolism
(R-HSA-1430728)
Paracetamol adme
(R-HSA-9753281)
Amino acid metabolic process
(GO:0006520)
Aminoacylase activity
(GO:0004046)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Protein binding
(GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.25
Marker Score: 441
Cell Name: germ cell (CL0000586)
Fold Change: 1.22
Marker Score: 2129
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.19
Marker Score: 2800
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.12
Marker Score: 760
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.1
Marker Score: 1692
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.08
Marker Score: 867
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71810
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48034
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 500
Cell Name: goblet cell (CL0000160)
Fold Change: 0.97
Marker Score: 6438
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 454
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5291
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2734
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 320
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.89
Marker Score: 3149
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5280
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.87
Marker Score: 1090
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.83
Marker Score: 266
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 390
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.75
Marker Score: 1417
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 566
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.72
Marker Score: 211
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.72
Marker Score: 539
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.71
Marker Score: 285.5
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.71
Marker Score: 11077
Cell Name: brush cell (CL0002204)
Fold Change: 0.71
Marker Score: 646
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.67
Marker Score: 5015.5
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.66
Marker Score: 2754
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.64
Marker Score: 2010
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.63
Marker Score: 1274
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.61
Marker Score: 336
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.6
Marker Score: 550
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.59
Marker Score: 204
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.57
Marker Score: 177
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: enterocyte (CL0000584)
Fold Change: 0.55
Marker Score: 2650
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.54
Marker Score: 665
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.53
Marker Score: 384
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.51
Marker Score: 735
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5
Marker Score: 319
Cell Name: Unknown (CL0002371)
Fold Change: 0.48
Marker Score: 507
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.47
Marker Score: 166
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.44
Marker Score: 143
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.44
Marker Score: 265
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.43
Marker Score: 287
Cell Name: osteoclast (CL0000092)
Fold Change: 0.43
Marker Score: 216
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.42
Marker Score: 222
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.42
Marker Score: 194
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.41
Marker Score: 288
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.41
Marker Score: 108
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.4
Marker Score: 652
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.39
Marker Score: 171
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.39
Marker Score: 2556
Cell Name: hepatoblast (CL0005026)
Fold Change: 0.39
Marker Score: 1285
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.37
Marker Score: 175.5
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.36
Marker Score: 2317
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.36
Marker Score: 216
Cell Name: Unknown (CL0000548)
Fold Change: 0.34
Marker Score: 246
Cell Name: stem cell (CL0000034)
Fold Change: 0.32
Marker Score: 769
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.32
Marker Score: 344
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.31
Marker Score: 131
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.31
Marker Score: 88
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.31
Marker Score: 208
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.3
Marker Score: 79
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.29
Marker Score: 6223
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.29
Marker Score: 256
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.29
Marker Score: 132
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.29
Marker Score: 181
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.28
Marker Score: 172
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.27
Marker Score: 112
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.27
Marker Score: 136
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.27
Marker Score: 211
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.27
Marker Score: 133
Cell Name: erythroblast (CL0000765)
Fold Change: 0.27
Marker Score: 170
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.27
Marker Score: 678
Cell Name: centrocyte (CL0009111)
Fold Change: 0.27
Marker Score: 64
Cell Name: kidney cell (CL1000497)
Fold Change: 0.27
Marker Score: 177
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.26
Marker Score: 100
Cell Name: astrocyte (CL0000127)
Fold Change: 0.25
Marker Score: 215
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.25
Marker Score: 258
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.25
Marker Score: 1209
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.25
Marker Score: 250.5
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.24
Marker Score: 426
Cell Name: precursor cell (CL0011115)
Fold Change: 0.24
Marker Score: 59
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.24
Marker Score: 1572
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.24
Marker Score: 3179
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.24
Marker Score: 106
Cell Name: osteoblast (CL0000062)
Fold Change: 0.24
Marker Score: 127
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.24
Marker Score: 196
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.23
Marker Score: 144
Cell Name: plasmablast (CL0000980)
Fold Change: 0.23
Marker Score: 311
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.23
Marker Score: 626
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.23
Marker Score: 390
Cell Name: mast cell (CL0000097)
Fold Change: 0.23
Marker Score: 132
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.22
Marker Score: 134
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64

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**Key characteristics** * The ACY1 gene is located on chromosome 19. * It is a protein of 1,062 amino acids. * ACY1 is expressed in a variety of cell types, including immune cells. * It is a key enzyme in the detoxification of aflatoxins. **Pathways and functions** * ACY1 is involved in the detoxification of aflatoxins produced by fungi. * Aflatoxins are produced when fungi metabolize dietary compounds, such as those found in peanuts, corn, and cotton. * ACY1 is responsible for the acylation of aflatoxins, which converts them into more water-soluble compounds that can be excreted from the body. * The detoxification of aflatoxins is essential for preventing their toxic effects on cells. **Clinical significance** * Mutations in the ACY1 gene have been linked to a number of human diseases, including liver damage, cancer, and neurodegenerative disorders. * In some cases, mutations in ACY1 can cause aflatoxin poisoning. * Acylase inhibitors are being investigated as potential treatments for aflatoxin-induced liver damage. **Additional information** * ACY1 is a member of the cytochrome P450 (CYP) family of enzymes, which are responsible for the metabolism of a wide range of chemicals. * Acylase inhibitors can inhibit the activity of CYP enzymes, which can lead to the accumulation of aflatoxins in the body. * Clinical trials of ACY1 inhibitors are currently underway to evaluate their potential for preventing or treating aflatoxin-induced diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Aminoacylase-1

Genular Protein ID: 3071519865

Symbol: ACY1_HUMAN

Name: Aminoacylase-1

UniProtKB Accession Codes:

Q03154 C9J6I6 C9J9D8 C9JWD4

Database IDs:

Citations:

PubMed ID: 8357837

Title: The nucleotide sequence of human aminoacylase-1.

PubMed ID: 8357837

DOI: 10.1016/0167-4781(93)90116-u

PubMed ID: 8394326

Title: Human aminoacylase-1. Cloning, sequence, and expression analysis of a chromosome 3p21 gene inactivated in small cell lung cancer.

PubMed ID: 8394326

DOI: 10.1016/s0021-9258(19)85294-8

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12933810

Title: Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family.

PubMed ID: 12933810

DOI: 10.1074/jbc.m304233200

PubMed ID: 16274666

Title: Aminoacylase I deficiency: a novel inborn error of metabolism.

PubMed ID: 16274666

DOI: 10.1016/j.bbrc.2005.10.126

PubMed ID: 16465618

Title: Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism.

PubMed ID: 16465618

DOI: 10.1086/500563

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17562838

Title: Neurological findings in aminoacylase 1 deficiency.

PubMed ID: 17562838

DOI: 10.1212/01.wnl.0000264933.56204.e8

PubMed ID: 21414403

Title: The molecular basis of aminoacylase 1 deficiency.

PubMed ID: 21414403

DOI: 10.1016/j.bbadis.2011.03.005

Sequence Information:

Length: 408
Mass: 45885
Checksum: 293350CD7759826C
Sequence:

MTSKGPEEEH PSVTLFRQYL RIRTVQPKPD YGAAVAFFEE TARQLGLGCQ KVEVAPGYVV 
TVLTWPGTNP TLSSILLNSH TDVVPVFKEH WSHDPFEAFK DSEGYIYARG AQDMKCVSIQ 
YLEAVRRLKV EGHRFPRTIH MTFVPDEEVG GHQGMELFVQ RPEFHALRAG FALDEGIANP 
TDAFTVFYSE RSPWWVRVTS TGRPGHASRF MEDTAAEKLH KVVNSILAFR EKEWQRLQSN 
PHLKEGSVTS VNLTKLEGGV AYNVIPATMS ASFDFRVAPD VDFKAFEEQL QSWCQAAGEG 
VTLEFAQKWM HPQVTPTDDS NPWWAAFSRV CKDMNLTLEP EIMPAATDNR YIRAVGVPAL 
GFSPMNRTPV LLHDHDERLH EAVFLRGVDI YTRLLPALAS VPALPSDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ACY1

Associated with

Cells (max top 100)

Other Information

The nucleotide sequence of human aminoacylase-1. PubMed ID: 8357837

Human aminoacylase-1. Cloning, sequence, and expression analysis of a chromosome 3p21 gene inactivated in small cell lung cancer. PubMed ID: 8394326

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family. PubMed ID: 12933810

Aminoacylase I deficiency: a novel inborn error of metabolism. PubMed ID: 16274666

Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism. PubMed ID: 16465618

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Neurological findings in aminoacylase 1 deficiency. PubMed ID: 17562838

The molecular basis of aminoacylase 1 deficiency. PubMed ID: 21414403