Details for: SCARB2

Gene ID: 950

Symbol: SCARB2

Ensembl ID: ENSG00000138760

Description: scavenger receptor class B member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.03
    Marker Score: 21117.5
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.25
    Marker Score: 17470
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.02
    Marker Score: 7234
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.69
    Marker Score: 20269
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.48
    Marker Score: 8332
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.34
    Marker Score: 1364
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.34
    Marker Score: 5324
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.32
    Marker Score: 20367
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.31
    Marker Score: 3110.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.31
    Marker Score: 9624
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.3
    Marker Score: 2451
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.26
    Marker Score: 1180
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.24
    Marker Score: 5152
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.19
    Marker Score: 3232
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.18
    Marker Score: 1233
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.06
    Marker Score: 20724
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.02
    Marker Score: 4115
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.01
    Marker Score: 838
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.96
    Marker Score: 11897
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.9
    Marker Score: 64289.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.89
    Marker Score: 536
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.89
    Marker Score: 1612.5
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.89
    Marker Score: 1051
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.89
    Marker Score: 4760
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.88
    Marker Score: 5129
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.88
    Marker Score: 1181
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.88
    Marker Score: 1976
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.86
    Marker Score: 1864
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.85
    Marker Score: 4856
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.85
    Marker Score: 1035
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.83
    Marker Score: 1378
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.82
    Marker Score: 1710
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.81
    Marker Score: 623
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.8
    Marker Score: 3194
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.8
    Marker Score: 750
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.79
    Marker Score: 1129
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.79
    Marker Score: 721
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.78
    Marker Score: 1015
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.75
    Marker Score: 425
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.73
    Marker Score: 399
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.72
    Marker Score: 7201
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.71
    Marker Score: 426
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.7
    Marker Score: 1961
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.7
    Marker Score: 2341
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.7
    Marker Score: 426
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.68
    Marker Score: 871
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.67
    Marker Score: 1835
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.66
    Marker Score: 1774
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.66
    Marker Score: 2335
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.65
    Marker Score: 6729.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.65
    Marker Score: 1712
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.64
    Marker Score: 1814.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.64
    Marker Score: 1982
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.63
    Marker Score: 487
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.63
    Marker Score: 1758
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.63
    Marker Score: 24316
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.63
    Marker Score: 1962
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.63
    Marker Score: 366
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.62
    Marker Score: 61580
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.62
    Marker Score: 756
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.62
    Marker Score: 41430.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.61
    Marker Score: 25898
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.61
    Marker Score: 2663
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.61
    Marker Score: 16576
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.59
    Marker Score: 54236
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.59
    Marker Score: 1917
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.59
    Marker Score: 5887
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.58
    Marker Score: 6123
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.56
    Marker Score: 737
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.55
    Marker Score: 14703
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.54
    Marker Score: 574
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.54
    Marker Score: 94584
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.53
    Marker Score: 4819
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.53
    Marker Score: 642
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.52
    Marker Score: 1431
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.52
    Marker Score: 1959
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.52
    Marker Score: 341
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.51
    Marker Score: 1697
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.51
    Marker Score: 55589.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.5
    Marker Score: 1005
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.5
    Marker Score: 1856
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.5
    Marker Score: 776
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.48
    Marker Score: 1833
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.48
    Marker Score: 1505
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.48
    Marker Score: 12739
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.48
    Marker Score: 31613
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.48
    Marker Score: 878
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.48
    Marker Score: 3120
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.47
    Marker Score: 363
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.47
    Marker Score: 3935
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.47
    Marker Score: 11240
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.47
    Marker Score: 998
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.46
    Marker Score: 13768
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.45
    Marker Score: 3535.5
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.44
    Marker Score: 1741
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.44
    Marker Score: 1000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.44
    Marker Score: 28567
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.43
    Marker Score: 5520
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.43
    Marker Score: 975
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.43
    Marker Score: 412

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * SCARB2 is a type of scavenger receptor that is involved in the clathrin-mediated endocytosis pathway. * It is a transmembrane protein that is expressed in a variety of cell types. * It is significantly expressed in neurons, stellate neurons, oligodendrocytes, granule cells, neuronal brush cells, luminal cells of the prostate epithelium, acinar cells of the salivary gland, lung endothelial cells, and anterior lens cells. **Pathways and functions:** * SCARB2 is involved in the clathrin-mediated endocytosis pathway, a process by which cells take in extracellular materials through a process called phagocytosis. * It is a key component of the clathrin-mediated endocytosis pathway, which is responsible for the internalization of a variety of extracellular materials, including proteins, lipids, and carbohydrates. * It is also involved in the recognition and internalization of clathrin-coated particles. **Clinical significance:** SCARB2 is a potential therapeutic target for a variety of diseases, including neurodegenerative disorders such as Alzheimer's disease and amyotrophic lateral sclerosis. SCARB2 is a key component of the clathrin-mediated endocytosis pathway, which is involved in the internalization of a variety of extracellular materials. Dysregulation of the clathrin-mediated endocytosis pathway has been linked to a number of diseases, including neurodegenerative disorders. Therefore, targeting SCARB2 could be a potential therapeutic strategy for these diseases.

Genular Protein ID: 3789113216

Symbol: SCRB2_HUMAN

Name: Lysosome membrane protein 2

UniProtKB Accession Codes:

Q14108 B4DKD8 E7EM68 Q53Y63

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 EMDB 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 32 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 9 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1374238

Title: Isolation and sequencing of a cDNA clone encoding the 85 kDa human lysosomal sialoglycoprotein (hLGP85) in human metastatic pancreas islet tumor cells.

PubMed ID: 1374238

DOI: 10.1016/0006-291x(92)90632-u

PubMed ID: 7539776

Title: The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution.

PubMed ID: 7539776

DOI: 10.1016/0888-7543(95)80114-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7509809

Title: The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes.

PubMed ID: 7509809

DOI: 10.1016/s0021-9258(17)37418-5

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 18022370

Title: LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase.

PubMed ID: 18022370

DOI: 10.1016/j.cell.2007.10.018

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 18308289

Title: Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis.

PubMed ID: 18308289

DOI: 10.1016/j.ajhg.2007.12.019

PubMed ID: 18424452

Title: A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome.

PubMed ID: 18424452

DOI: 10.1093/hmg/ddn124

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19543282

Title: Scavenger receptor B2 is a cellular receptor for enterovirus 71.

PubMed ID: 19543282

DOI: 10.1038/nm.1992

PubMed ID: 21670406

Title: Mutation of SCARB2 in a patient with progressive myoclonus epilepsy and demyelinating peripheral neuropathy.

PubMed ID: 21670406

DOI: 10.1001/archneurol.2011.120

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21796727

Title: A mutation in SCARB2 is a modifier in Gaucher disease.

PubMed ID: 21796727

DOI: 10.1002/humu.21566

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30531980

Title: Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.

PubMed ID: 30531980

DOI: 10.1038/s41564-018-0319-z

PubMed ID: 24162852

Title: Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36.

PubMed ID: 24162852

DOI: 10.1038/nature12684

PubMed ID: 19454373

Title: Biochemical and molecular findings in a patient with myoclonic epilepsy due to a mistarget of the beta-glucosidase enzyme.

PubMed ID: 19454373

DOI: 10.1016/j.ymgme.2009.04.011

Sequence Information:

  • Length: 478
  • Mass: 54290
  • Checksum: FDCF27F3BA337B2C
  • Sequence:
    • MGRCCFYTAG TLSLLLLVTS VTLLVARVFQ KAVDQSIEKK IVLRNGTEAF DSWEKPPLPV 
YTQFYFFNVT NPEEILRGET PRVEEVGPYT YRELRNKANI QFGDNGTTIS AVSNKAYVFE 
RDQSVGDPKI DLIRTLNIPV LTVIEWSQVH FLREIIEAML KAYQQKLFVT HTVDELLWGY 
KDEILSLIHV FRPDISPYFG LFYEKNGTND GDYVFLTGED SYLNFTKIVE WNGKTSLDWW 
ITDKCNMING TDGDSFHPLI TKDEVLYVFP SDFCRSVYIT FSDYESVQGL PAFRYKVPAE 
ILANTSDNAG FCIPEGNCLG SGVLNVSICK NGAPIIMSFP HFYQADERFV SAIEGMHPNQ 
EDHETFVDIN PLTGIILKAA KRFQINIYVK KLDDFVETGD IRTMVFPVMY LNESVHIDKE 
TASRLKSMIN TTLIITNIPY IIMALGVFFG LVFTWLACKG QGSMDEGTAD ERAPLIRT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.