SCARB2 | ENSG00000138760 | NCBI 950

Details for: SCARB2

Gene ID: 950

Symbol: SCARB2

Ensembl ID: ENSG00000138760

Description: scavenger receptor class B member 2

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Membrane trafficking
(R-HSA-199991)
Vesicle-mediated transport
(R-HSA-5653656)
Aminophospholipid transport
(GO:0015917)
Cargo receptor activity
(GO:0038024)
Cholesterol binding
(GO:0015485)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Cytoplasm
(GO:0005737)
Endocytic vesicle membrane
(GO:0030666)
Endoplasmic reticulum membrane
(GO:0005789)
Endosome membrane
(GO:0010008)
Endosome to plasma membrane protein transport
(GO:0099638)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Golgi membrane
(GO:0000139)
Late endosome membrane
(GO:0031902)
Lysosomal lumen
(GO:0043202)
Lysosomal membrane
(GO:0005765)
Membrane
(GO:0016020)
Phosphatidylcholine binding
(GO:0031210)
Phosphatidylserine binding
(GO:0001786)
Plasma membrane
(GO:0005886)
Positive regulation of neuron projection development
(GO:0010976)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein targeting to lysosome
(GO:0006622)
Receptor-mediated endocytosis
(GO:0006898)
Regulation of carbohydrate catabolic process
(GO:0043470)
Regulation of endosome organization
(GO:1904978)
Regulation of glucosylceramidase activity
(GO:1905123)
Regulation of glucosylceramide catabolic process
(GO:2000752)
Regulation of lysosome organization
(GO:1905671)
Scavenger receptor activity
(GO:0005044)
Sensory perception of sound
(GO:0007605)
Symbiont entry into host cell
(GO:0046718)
Transmembrane signaling receptor activity
(GO:0004888)
Virus receptor activity
(GO:0001618)

Other Information

Proteins

Lysosome membrane protein 2

Genular Protein ID: 3789113216

Symbol: SCRB2_HUMAN

Name: Lysosome membrane protein 2

UniProtKB Accession Codes:

Q14108 B4DKD8 E7EM68 Q53Y63

Database IDs:

Citations:

PubMed ID: 1374238

Title: Isolation and sequencing of a cDNA clone encoding the 85 kDa human lysosomal sialoglycoprotein (hLGP85) in human metastatic pancreas islet tumor cells.

PubMed ID: 1374238

DOI: 10.1016/0006-291x(92)90632-u

PubMed ID: 7539776

Title: The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution.

PubMed ID: 7539776

DOI: 10.1016/0888-7543(95)80114-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7509809

Title: The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes.

PubMed ID: 7509809

DOI: 10.1016/s0021-9258(17)37418-5

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 18022370

Title: LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase.

PubMed ID: 18022370

DOI: 10.1016/j.cell.2007.10.018

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 18308289

Title: Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis.

PubMed ID: 18308289

DOI: 10.1016/j.ajhg.2007.12.019

PubMed ID: 18424452

Title: A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome.

PubMed ID: 18424452

DOI: 10.1093/hmg/ddn124

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19543282

Title: Scavenger receptor B2 is a cellular receptor for enterovirus 71.

PubMed ID: 19543282

DOI: 10.1038/nm.1992

PubMed ID: 21670406

Title: Mutation of SCARB2 in a patient with progressive myoclonus epilepsy and demyelinating peripheral neuropathy.

PubMed ID: 21670406

DOI: 10.1001/archneurol.2011.120

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21796727

Title: A mutation in SCARB2 is a modifier in Gaucher disease.

PubMed ID: 21796727

DOI: 10.1002/humu.21566

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30531980

Title: Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.

PubMed ID: 30531980

DOI: 10.1038/s41564-018-0319-z

PubMed ID: 24162852

Title: Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36.

PubMed ID: 24162852

DOI: 10.1038/nature12684

PubMed ID: 19454373

Title: Biochemical and molecular findings in a patient with myoclonic epilepsy due to a mistarget of the beta-glucosidase enzyme.

PubMed ID: 19454373

DOI: 10.1016/j.ymgme.2009.04.011

Sequence Information:

Length: 478
Mass: 54290
Checksum: FDCF27F3BA337B2C
Sequence:

MGRCCFYTAG TLSLLLLVTS VTLLVARVFQ KAVDQSIEKK IVLRNGTEAF DSWEKPPLPV 
YTQFYFFNVT NPEEILRGET PRVEEVGPYT YRELRNKANI QFGDNGTTIS AVSNKAYVFE 
RDQSVGDPKI DLIRTLNIPV LTVIEWSQVH FLREIIEAML KAYQQKLFVT HTVDELLWGY 
KDEILSLIHV FRPDISPYFG LFYEKNGTND GDYVFLTGED SYLNFTKIVE WNGKTSLDWW 
ITDKCNMING TDGDSFHPLI TKDEVLYVFP SDFCRSVYIT FSDYESVQGL PAFRYKVPAE 
ILANTSDNAG FCIPEGNCLG SGVLNVSICK NGAPIIMSFP HFYQADERFV SAIEGMHPNQ 
EDHETFVDIN PLTGIILKAA KRFQINIYVK KLDDFVETGD IRTMVFPVMY LNESVHIDKE 
TASRLKSMIN TTLIITNIPY IIMALGVFFG LVFTWLACKG QGSMDEGTAD ERAPLIRT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SCARB2

Associated with

Other Information

Isolation and sequencing of a cDNA clone encoding the 85 kDa human lysosomal sialoglycoprotein (hLGP85) in human metastatic pancreas islet tumor cells. PubMed ID: 1374238

The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution. PubMed ID: 7539776

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes. PubMed ID: 7509809

Cluster analysis of an extensive human breast cancer cell line protein expression map database. PubMed ID: 11840567

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. PubMed ID: 12754519

LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase. PubMed ID: 18022370

Integral and associated lysosomal membrane proteins. PubMed ID: 17897319

Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis. PubMed ID: 18308289

A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome. PubMed ID: 18424452

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Scavenger receptor B2 is a cellular receptor for enterovirus 71. PubMed ID: 19543282

Mutation of SCARB2 in a patient with progressive myoclonus epilepsy and demyelinating peripheral neuropathy. PubMed ID: 21670406

Initial characterization of the human central proteome. PubMed ID: 21269460

A mutation in SCARB2 is a modifier in Gaucher disease. PubMed ID: 21796727

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2. PubMed ID: 30531980

Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. PubMed ID: 24162852

Biochemical and molecular findings in a patient with myoclonic epilepsy due to a mistarget of the beta-glucosidase enzyme. PubMed ID: 19454373