Details for: SCARB2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 506.5729
Cell Significance Index: -78.8000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 305.4682
Cell Significance Index: -77.4800 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 210.1238
Cell Significance Index: -86.5600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 177.0885
Cell Significance Index: -83.6100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 159.1603
Cell Significance Index: -64.6600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 147.3215
Cell Significance Index: -75.7800 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 125.1300
Cell Significance Index: -83.9700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 67.6727
Cell Significance Index: -64.6100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 64.8442
Cell Significance Index: -79.9500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 29.2363
Cell Significance Index: -78.3200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 20.3241
Cell Significance Index: -80.2000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 16.2616
Cell Significance Index: -35.5900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.6150
Cell Significance Index: 136.2100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.2954
Cell Significance Index: 107.0200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.1306
Cell Significance Index: 19.6200 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.7928
Cell Significance Index: 229.8300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.7548
Cell Significance Index: 98.4700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.6559
Cell Significance Index: 332.1700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.6546
Cell Significance Index: 85.9500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.5021
Cell Significance Index: 270.7800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.4408
Cell Significance Index: 234.3300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.3092
Cell Significance Index: 35.6400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.2623
Cell Significance Index: 155.2200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1274
Cell Significance Index: 223.7400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.0934
Cell Significance Index: 75.6200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.0211
Cell Significance Index: 366.2400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.9967
Cell Significance Index: 136.8700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8333
Cell Significance Index: 37.7700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7395
Cell Significance Index: 21.3100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7101
Cell Significance Index: 77.2400 - Cell Name: peg cell (CL4033014)
Fold Change: 0.6770
Cell Significance Index: 15.6400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.5318
Cell Significance Index: 33.5200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5018
Cell Significance Index: 85.6800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4994
Cell Significance Index: 272.7300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4618
Cell Significance Index: 319.4100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4570
Cell Significance Index: 45.2100 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.4538
Cell Significance Index: 5.4100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4401
Cell Significance Index: 32.8000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4385
Cell Significance Index: 193.8800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3875
Cell Significance Index: 23.8200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2609
Cell Significance Index: 13.7000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.2142
Cell Significance Index: 395.1000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1955
Cell Significance Index: 368.1900 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1510
Cell Significance Index: 3.9700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1030
Cell Significance Index: 92.9800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0952
Cell Significance Index: 146.4900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0037
Cell Significance Index: 0.1000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0039
Cell Significance Index: -2.4500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0058
Cell Significance Index: -4.3000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0140
Cell Significance Index: -8.7700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0173
Cell Significance Index: -23.5800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0219
Cell Significance Index: -4.1700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0296
Cell Significance Index: -2.2700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0388
Cell Significance Index: -28.4700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0408
Cell Significance Index: -30.9100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0519
Cell Significance Index: -23.5600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0539
Cell Significance Index: -6.1600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0556
Cell Significance Index: -3.7400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0677
Cell Significance Index: -6.9200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0946
Cell Significance Index: -53.3400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1510
Cell Significance Index: -31.8100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2004
Cell Significance Index: -25.8900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2111
Cell Significance Index: -5.9000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2146
Cell Significance Index: -7.5400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2246
Cell Significance Index: -64.6200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2407
Cell Significance Index: -11.3200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2536
Cell Significance Index: -5.4000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3226
Cell Significance Index: -46.8900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3275
Cell Significance Index: -37.5200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3461
Cell Significance Index: -40.3400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3724
Cell Significance Index: -26.3400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3956
Cell Significance Index: -11.3400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4012
Cell Significance Index: -6.7200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4015
Cell Significance Index: -25.9000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4505
Cell Significance Index: -7.7200 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.5523
Cell Significance Index: -10.7800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.6220
Cell Significance Index: -73.3500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6382
Cell Significance Index: -66.4500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.6688
Cell Significance Index: -14.4900 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.6781
Cell Significance Index: -12.5300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.6788
Cell Significance Index: -11.4400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.6934
Cell Significance Index: -9.4600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8778
Cell Significance Index: -69.5200 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.9364
Cell Significance Index: -9.6900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.0177
Cell Significance Index: -32.6000 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -1.0398
Cell Significance Index: -25.3700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.0657
Cell Significance Index: -47.1400 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -1.1157
Cell Significance Index: -8.6000 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.1710
Cell Significance Index: -25.6400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.1723
Cell Significance Index: -28.1200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.3090
Cell Significance Index: -27.4000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.3336
Cell Significance Index: -50.5000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.3551
Cell Significance Index: -47.0900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.3630
Cell Significance Index: -83.5700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.5154
Cell Significance Index: -40.6100 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.5644
Cell Significance Index: -23.0900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.6048
Cell Significance Index: -51.1100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.6288
Cell Significance Index: -57.0600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.6704
Cell Significance Index: -54.6900 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -1.7169
Cell Significance Index: -24.4400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3789113216
Symbol: SCRB2_HUMAN
Name: Lysosome membrane protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1374238
Title: Isolation and sequencing of a cDNA clone encoding the 85 kDa human lysosomal sialoglycoprotein (hLGP85) in human metastatic pancreas islet tumor cells.
PubMed ID: 1374238
PubMed ID: 7539776
Title: The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution.
PubMed ID: 7539776
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7509809
Title: The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes.
PubMed ID: 7509809
PubMed ID: 11840567
Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.
PubMed ID: 11840567
DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 18022370
Title: LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase.
PubMed ID: 18022370
PubMed ID: 17897319
Title: Integral and associated lysosomal membrane proteins.
PubMed ID: 17897319
PubMed ID: 18308289
Title: Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis.
PubMed ID: 18308289
PubMed ID: 18424452
Title: A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome.
PubMed ID: 18424452
DOI: 10.1093/hmg/ddn124
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19543282
Title: Scavenger receptor B2 is a cellular receptor for enterovirus 71.
PubMed ID: 19543282
DOI: 10.1038/nm.1992
PubMed ID: 21670406
Title: Mutation of SCARB2 in a patient with progressive myoclonus epilepsy and demyelinating peripheral neuropathy.
PubMed ID: 21670406
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21796727
Title: A mutation in SCARB2 is a modifier in Gaucher disease.
PubMed ID: 21796727
DOI: 10.1002/humu.21566
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30531980
Title: Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.
PubMed ID: 30531980
PubMed ID: 24162852
Title: Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36.
PubMed ID: 24162852
DOI: 10.1038/nature12684
PubMed ID: 19454373
Title: Biochemical and molecular findings in a patient with myoclonic epilepsy due to a mistarget of the beta-glucosidase enzyme.
PubMed ID: 19454373
Sequence Information:
- Length: 478
- Mass: 54290
- Checksum: FDCF27F3BA337B2C
- Sequence:
MGRCCFYTAG TLSLLLLVTS VTLLVARVFQ KAVDQSIEKK IVLRNGTEAF DSWEKPPLPV YTQFYFFNVT NPEEILRGET PRVEEVGPYT YRELRNKANI QFGDNGTTIS AVSNKAYVFE RDQSVGDPKI DLIRTLNIPV LTVIEWSQVH FLREIIEAML KAYQQKLFVT HTVDELLWGY KDEILSLIHV FRPDISPYFG LFYEKNGTND GDYVFLTGED SYLNFTKIVE WNGKTSLDWW ITDKCNMING TDGDSFHPLI TKDEVLYVFP SDFCRSVYIT FSDYESVQGL PAFRYKVPAE ILANTSDNAG FCIPEGNCLG SGVLNVSICK NGAPIIMSFP HFYQADERFV SAIEGMHPNQ EDHETFVDIN PLTGIILKAA KRFQINIYVK KLDDFVETGD IRTMVFPVMY LNESVHIDKE TASRLKSMIN TTLIITNIPY IIMALGVFFG LVFTWLACKG QGSMDEGTAD ERAPLIRT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.