Details for: SCARB2

Gene ID: 950

Symbol: SCARB2

Ensembl ID: ENSG00000138760

Description: scavenger receptor class B member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 506.5729
    Cell Significance Index: -78.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 305.4682
    Cell Significance Index: -77.4800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 210.1238
    Cell Significance Index: -86.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 177.0885
    Cell Significance Index: -83.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 159.1603
    Cell Significance Index: -64.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 147.3215
    Cell Significance Index: -75.7800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 125.1300
    Cell Significance Index: -83.9700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 67.6727
    Cell Significance Index: -64.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 64.8442
    Cell Significance Index: -79.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.2363
    Cell Significance Index: -78.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.3241
    Cell Significance Index: -80.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.2616
    Cell Significance Index: -35.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.6150
    Cell Significance Index: 136.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2954
    Cell Significance Index: 107.0200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.1306
    Cell Significance Index: 19.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.7928
    Cell Significance Index: 229.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.7548
    Cell Significance Index: 98.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6559
    Cell Significance Index: 332.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6546
    Cell Significance Index: 85.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5021
    Cell Significance Index: 270.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4408
    Cell Significance Index: 234.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3092
    Cell Significance Index: 35.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2623
    Cell Significance Index: 155.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1274
    Cell Significance Index: 223.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0934
    Cell Significance Index: 75.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0211
    Cell Significance Index: 366.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9967
    Cell Significance Index: 136.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8333
    Cell Significance Index: 37.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7395
    Cell Significance Index: 21.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7101
    Cell Significance Index: 77.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6770
    Cell Significance Index: 15.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5318
    Cell Significance Index: 33.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5018
    Cell Significance Index: 85.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4994
    Cell Significance Index: 272.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4618
    Cell Significance Index: 319.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4570
    Cell Significance Index: 45.2100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4538
    Cell Significance Index: 5.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4401
    Cell Significance Index: 32.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4385
    Cell Significance Index: 193.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3875
    Cell Significance Index: 23.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2609
    Cell Significance Index: 13.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2142
    Cell Significance Index: 395.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1955
    Cell Significance Index: 368.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1510
    Cell Significance Index: 3.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1030
    Cell Significance Index: 92.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0952
    Cell Significance Index: 146.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0037
    Cell Significance Index: 0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0039
    Cell Significance Index: -2.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0140
    Cell Significance Index: -8.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0173
    Cell Significance Index: -23.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0219
    Cell Significance Index: -4.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0296
    Cell Significance Index: -2.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0388
    Cell Significance Index: -28.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0408
    Cell Significance Index: -30.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0519
    Cell Significance Index: -23.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0539
    Cell Significance Index: -6.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0556
    Cell Significance Index: -3.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0677
    Cell Significance Index: -6.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0946
    Cell Significance Index: -53.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1510
    Cell Significance Index: -31.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2004
    Cell Significance Index: -25.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2111
    Cell Significance Index: -5.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2146
    Cell Significance Index: -7.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2246
    Cell Significance Index: -64.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2407
    Cell Significance Index: -11.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2536
    Cell Significance Index: -5.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3226
    Cell Significance Index: -46.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3275
    Cell Significance Index: -37.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3461
    Cell Significance Index: -40.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3724
    Cell Significance Index: -26.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3956
    Cell Significance Index: -11.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4012
    Cell Significance Index: -6.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4015
    Cell Significance Index: -25.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4505
    Cell Significance Index: -7.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5523
    Cell Significance Index: -10.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.6220
    Cell Significance Index: -73.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6382
    Cell Significance Index: -66.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6688
    Cell Significance Index: -14.4900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6781
    Cell Significance Index: -12.5300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6788
    Cell Significance Index: -11.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6934
    Cell Significance Index: -9.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8778
    Cell Significance Index: -69.5200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.9364
    Cell Significance Index: -9.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0177
    Cell Significance Index: -32.6000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.0398
    Cell Significance Index: -25.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0657
    Cell Significance Index: -47.1400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.1157
    Cell Significance Index: -8.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.1710
    Cell Significance Index: -25.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.1723
    Cell Significance Index: -28.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.3090
    Cell Significance Index: -27.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.3336
    Cell Significance Index: -50.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3551
    Cell Significance Index: -47.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3630
    Cell Significance Index: -83.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.5154
    Cell Significance Index: -40.6100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.5644
    Cell Significance Index: -23.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.6048
    Cell Significance Index: -51.1100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.6288
    Cell Significance Index: -57.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.6704
    Cell Significance Index: -54.6900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.7169
    Cell Significance Index: -24.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SCARB2 is a member of the scavenger receptor family, which is characterized by their ability to bind to various ligands, including lipids, proteins, and carbohydrates. The SCARB2 protein is a transmembrane receptor that spans the plasma membrane, with an extracellular domain that interacts with ligands and an intracellular domain that regulates signaling pathways. SCARB2 is primarily expressed in neurons, glial cells, and epithelial cells, suggesting its involvement in cellular processes such as lipid metabolism, endocytosis, and cellular signaling. **Pathways and Functions:** SCARB2 is involved in several cellular pathways, including: 1. **Aminophospholipid transport:** SCARB2 has been shown to transport aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, across the plasma membrane. 2. **Cargo recognition for clathrin-mediated endocytosis:** SCARB2 interacts with clathrin, a protein that coats and internalizes cargo into endosomes. 3. **Cholesterol binding:** SCARB2 has been shown to bind to cholesterol, which is involved in lipid metabolism and cellular signaling. 4. **Protein binding:** SCARB2 interacts with various proteins, including enzymes, receptors, and signaling molecules, to regulate cellular processes. 5. **Regulation of carbohydrate catabolic process:** SCARB2 has been implicated in the regulation of carbohydrate catabolic processes, including glycolysis and gluconeogenesis. **Clinical Significance:** SCARB2 has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** SCARB2 has been shown to play a role in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where lipid metabolism and endocytosis are dysregulated. 2. **Cancer:** SCARB2 has been implicated in cancer, where it is involved in lipid metabolism and endocytosis, contributing to tumor growth and metastasis. 3. **Metabolic disorders:** SCARB2 has been shown to play a role in metabolic disorders, such as obesity and diabetes, where lipid metabolism is dysregulated. In conclusion, SCARB2 is a multifunctional protein that plays a critical role in various cellular processes, including lipid metabolism, endocytosis, and regulation of cellular signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying SCARB2 function and its role in human disease. **Recommendations:** 1. **Further research:** Further research is needed to elucidate the mechanisms underlying SCARB2 function and its role in human disease. 2. **Therapeutic targeting:** SCARB2 may serve as a therapeutic target for diseases characterized by dysregulation of lipid metabolism and endocytosis, such as neurodegenerative disorders and cancer. 3. **Diagnostic biomarkers:** SCARB2 may serve as a diagnostic biomarker for diseases characterized by dysregulation of lipid metabolism and endocytosis, such as metabolic disorders.

Genular Protein ID: 3789113216

Symbol: SCRB2_HUMAN

Name: Lysosome membrane protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1374238

Title: Isolation and sequencing of a cDNA clone encoding the 85 kDa human lysosomal sialoglycoprotein (hLGP85) in human metastatic pancreas islet tumor cells.

PubMed ID: 1374238

DOI: 10.1016/0006-291x(92)90632-u

PubMed ID: 7539776

Title: The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution.

PubMed ID: 7539776

DOI: 10.1016/0888-7543(95)80114-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7509809

Title: The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes.

PubMed ID: 7509809

DOI: 10.1016/s0021-9258(17)37418-5

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 18022370

Title: LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase.

PubMed ID: 18022370

DOI: 10.1016/j.cell.2007.10.018

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 18308289

Title: Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis.

PubMed ID: 18308289

DOI: 10.1016/j.ajhg.2007.12.019

PubMed ID: 18424452

Title: A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome.

PubMed ID: 18424452

DOI: 10.1093/hmg/ddn124

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19543282

Title: Scavenger receptor B2 is a cellular receptor for enterovirus 71.

PubMed ID: 19543282

DOI: 10.1038/nm.1992

PubMed ID: 21670406

Title: Mutation of SCARB2 in a patient with progressive myoclonus epilepsy and demyelinating peripheral neuropathy.

PubMed ID: 21670406

DOI: 10.1001/archneurol.2011.120

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21796727

Title: A mutation in SCARB2 is a modifier in Gaucher disease.

PubMed ID: 21796727

DOI: 10.1002/humu.21566

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30531980

Title: Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.

PubMed ID: 30531980

DOI: 10.1038/s41564-018-0319-z

PubMed ID: 24162852

Title: Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36.

PubMed ID: 24162852

DOI: 10.1038/nature12684

PubMed ID: 19454373

Title: Biochemical and molecular findings in a patient with myoclonic epilepsy due to a mistarget of the beta-glucosidase enzyme.

PubMed ID: 19454373

DOI: 10.1016/j.ymgme.2009.04.011

Sequence Information:

  • Length: 478
  • Mass: 54290
  • Checksum: FDCF27F3BA337B2C
  • Sequence:
  • MGRCCFYTAG TLSLLLLVTS VTLLVARVFQ KAVDQSIEKK IVLRNGTEAF DSWEKPPLPV 
    YTQFYFFNVT NPEEILRGET PRVEEVGPYT YRELRNKANI QFGDNGTTIS AVSNKAYVFE 
    RDQSVGDPKI DLIRTLNIPV LTVIEWSQVH FLREIIEAML KAYQQKLFVT HTVDELLWGY 
    KDEILSLIHV FRPDISPYFG LFYEKNGTND GDYVFLTGED SYLNFTKIVE WNGKTSLDWW 
    ITDKCNMING TDGDSFHPLI TKDEVLYVFP SDFCRSVYIT FSDYESVQGL PAFRYKVPAE 
    ILANTSDNAG FCIPEGNCLG SGVLNVSICK NGAPIIMSFP HFYQADERFV SAIEGMHPNQ 
    EDHETFVDIN PLTGIILKAA KRFQINIYVK KLDDFVETGD IRTMVFPVMY LNESVHIDKE 
    TASRLKSMIN TTLIITNIPY IIMALGVFFG LVFTWLACKG QGSMDEGTAD ERAPLIRT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.