Details for: MAGED1

Gene ID: 9500

Symbol: MAGED1

Ensembl ID: ENSG00000179222

Description: MAGE family member D1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 5.39
    Marker Score: 71,664
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.4
    Marker Score: 3,038
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.84
    Marker Score: 1,898
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.65
    Marker Score: 17,206
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.43
    Marker Score: 8,649
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.4
    Marker Score: 14,228
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.22
    Marker Score: 8,728
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.21
    Marker Score: 2,348
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.14
    Marker Score: 42,628
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.14
    Marker Score: 28,266
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.13
    Marker Score: 8,839
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.12
    Marker Score: 2,286
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.11
    Marker Score: 77,954
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.11
    Marker Score: 9,767
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.11
    Marker Score: 21,221
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.08
    Marker Score: 78,929
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.04
    Marker Score: 45,548
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.95
    Marker Score: 1,038
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.95
    Marker Score: 29,165
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.94
    Marker Score: 7,493
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.92
    Marker Score: 5,216
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.91
    Marker Score: 14,663
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.89
    Marker Score: 1,039
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.86
    Marker Score: 2,503
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.85
    Marker Score: 747
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.84
    Marker Score: 3,832
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.81
    Marker Score: 17,045
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.79
    Marker Score: 3,939
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.79
    Marker Score: 109,801
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.76
    Marker Score: 498
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.76
    Marker Score: 7,348
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.74
    Marker Score: 1,164
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.74
    Marker Score: 845
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.72
    Marker Score: 579
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.7
    Marker Score: 14,579
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.7
    Marker Score: 16,112
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.68
    Marker Score: 1,487
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.63
    Marker Score: 2,239
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.62
    Marker Score: 3,695
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.62
    Marker Score: 18,247
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.6
    Marker Score: 1,690
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.57
    Marker Score: 1,905
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.54
    Marker Score: 32,956
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.53
    Marker Score: 2,355
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.52
    Marker Score: 836
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.5
    Marker Score: 6,490
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.5
    Marker Score: 483
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.48
    Marker Score: 1,741
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,328
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.46
    Marker Score: 688
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.45
    Marker Score: 1,464
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.43
    Marker Score: 1,647
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.43
    Marker Score: 335
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.42
    Marker Score: 1,514
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.39
    Marker Score: 966
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.39
    Marker Score: 3,727
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.39
    Marker Score: 5,139
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.37
    Marker Score: 812
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.36
    Marker Score: 1,280
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.35
    Marker Score: 1,042
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.34
    Marker Score: 754
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.34
    Marker Score: 561
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.34
    Marker Score: 2,570
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.34
    Marker Score: 755
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.33
    Marker Score: 834
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.32
    Marker Score: 387
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.32
    Marker Score: 298
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.32
    Marker Score: 45,790
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.32
    Marker Score: 880
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.31
    Marker Score: 415
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.3
    Marker Score: 756
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.3
    Marker Score: 1,616
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.28
    Marker Score: 596
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.28
    Marker Score: 672
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.27
    Marker Score: 2,985
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.26
    Marker Score: 363
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.25
    Marker Score: 1,379
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.24
    Marker Score: 2,037
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.24
    Marker Score: 6,522
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.24
    Marker Score: 1,336
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.24
    Marker Score: 610
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.21
    Marker Score: 1,269
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.18
    Marker Score: 1,127
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.18
    Marker Score: 1,192
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.17
    Marker Score: 451
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.17
    Marker Score: 442
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.17
    Marker Score: 2,660
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.16
    Marker Score: 297
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.16
    Marker Score: 606
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.15
    Marker Score: 4,720
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.15
    Marker Score: 8,573
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.14
    Marker Score: 2,322
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.13
    Marker Score: 363
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.12
    Marker Score: 2,925
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.11
    Marker Score: 416
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.11
    Marker Score: 583
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.1
    Marker Score: 382
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.08
    Marker Score: 342
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.08
    Marker Score: 2,937
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.07
    Marker Score: 731

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAGED1 exhibits a wide range of cellular expression, with notable presence in cardiac muscle cells, extravillous trophoblasts, and skeletal muscle satellite cells. Its expression is also observed in other cell types, including interstitial cells of the ovary, regular atrial cardiac myocytes, Sertoli cells, and placental villous trophoblasts. This diverse expression pattern suggests that MAGED1 may play a role in various cellular processes, including cell death, transcriptional regulation, and circadian rhythm control. **Pathways and Functions:** MAGED1 is involved in multiple signaling pathways, including apoptosis, caspase activation, and cell death signaling. Its role in apoptosis is mediated through the P75 NTR receptor, which signals through JNK pathways to induce programmed cell death. Additionally, MAGED1 is involved in the regulation of circadian rhythms, with npas4 regulating the expression of target genes, including MAGED1. MAGED1 also exhibits transcriptional regulation activity, coactivating with npas4 to promote the transcription of target genes. Furthermore, MAGED1 is implicated in the regulation of epithelial cell proliferation, negative regulation of protein localization to the nucleus, and negative regulation of transcription by RNA polymerase II. Its role in DNA-templated transcription and branching involved in ureteric bud morphogenesis suggests that MAGED1 may play a crucial role in the development and morphogenesis of various tissues. **Clinical Significance:** The clinical significance of MAGED1 remains unclear, but its involvement in various cellular processes suggests that it may play a role in the development and progression of diseases. For example, its expression in cardiac muscle cells and extravillous trophoblasts may be relevant to cardiovascular and reproductive disorders. Additionally, MAGED1's role in apoptosis and cell death signaling may make it a potential target for cancer therapy. Furthermore, the regulation of circadian rhythms by MAGED1 may have implications for the development of novel therapeutic strategies for disorders of sleep and circadian rhythm regulation. Further research is needed to fully elucidate the clinical significance of MAGED1 and to explore its potential as a therapeutic target. In conclusion, MAGED1 is a gene of diverse cellular expression and regulation, with a complex role in various cellular processes. Further research is needed to fully elucidate its functions and clinical significance, but its involvement in apoptosis, transcriptional regulation, and circadian rhythm control suggests that it may play a crucial role in the development and progression of various diseases.

Genular Protein ID: 1164389701

Symbol: MAGD1_HUMAN

Name: Melanoma-associated antigen D1

UniProtKB Accession Codes:

Q9Y5V3 Q5VSH6 Q8IZ84 Q8WY92 Q9H352 Q9HBT4 Q9UF36

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 4 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 7 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10985348

Title: NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor dependent apoptosis.

PubMed ID: 10985348

DOI: 10.1016/s0896-6273(00)00036-2

PubMed ID: 15094062

Title: hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation.

PubMed ID: 15094062

DOI: 10.1016/s0014-5793(04)00353-9

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10409427

Title: Identification of a new, unorthodox member of the MAGE gene family.

PubMed ID: 10409427

DOI: 10.1006/geno.1999.5870

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11280991

Title: A new melanoma antigen-encoding gene subfamily in human chromosome X.

PubMed ID: 11280991

PubMed ID: 11087672

Title: Identification of the translational initiation codon in human MAGED1.

PubMed ID: 11087672

DOI: 10.1006/geno.2000.6356

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 20864041

Title: MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.

PubMed ID: 20864041

DOI: 10.1016/j.molcel.2010.08.029

Sequence Information:

  • Length: 778
  • Mass: 86161
  • Checksum: D818690052D166CE
  • Sequence:
    • MAQKMDCGAG LLGFQAEASV EDSALLMQTL MEAIQISEAP PTNQATAAAS PQSSQPPTAN 
EMADIQVSAA AARPKSAFKV QNATTKGPNG VYDFSQAHNA KDVPNTQPKA AFKSQNATPK 
GPNAAYDFSQ AATTGELAAN KSEMAFKAQN ATTKVGPNAT YNFSQSLNAN DLANSRPKTP 
FKAWNDTTKA PTADTQTQNV NQAKMATSQA DIETDPGISE PDGATAQTSA DGSQAQNLES 
RTIIRGKRTR KINNLNVEEN SSGDQRRAPL AAGTWRSAPV PVTTQNPPGA PPNVLWQTPL 
AWQNPSGWQN QTARQTPPAR QSPPARQTPP AWQNPVAWQN PVIWPNPVIW QNPVIWPNPI 
VWPGPVVWPN PLAWQNPPGW QTPPGWQTPP GWQGPPDWQG PPDWPLPPDW PLPPDWPLPT 
DWPLPPDWIP ADWPIPPDWQ NLRPSPNLRP SPNSRASQNP GAAQPRDVAL LQERANKLVK 
YLMLKDYTKV PIKRSEMLRD IIREYTDVYP EIIERACFVL EKKFGIQLKE IDKEEHLYIL 
ISTPESLAGI LGTTKDTPKL GLLLVILGVI FMNGNRASEA VLWEALRKMG LRPGVRHPLL 
GDLRKLLTYE FVKQKYLDYR RVPNSNPPEY EFLWGLRSYH ETSKMKVLRF IAEVQKRDPR 
DWTAQFMEAA DEALDALDAA AAEAEARAEA RTRMGIGDEA VSGPWSWDDI EFELLTWDEE 
GDFGDPWSRI PFTFWARYHQ NARSRFPQTF AGPIIGPGGT ASANFAANFG AIGFFWVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.