Details for: PAGE4

Gene ID: 9506

Symbol: PAGE4

Ensembl ID: ENSG00000101951

Description: PAGE family member 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,061
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.68
    Marker Score: 8,267
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.75
    Marker Score: 6,833
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.57
    Marker Score: 3,044
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.31
    Marker Score: 2,958
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.36
    Marker Score: 9,275
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.11
    Marker Score: 1,163
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.87
    Marker Score: 1,287
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.71
    Marker Score: 713
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.49
    Marker Score: 1,947
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.44
    Marker Score: 1,186
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 875
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.32
    Marker Score: 1,713
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 801
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.04
    Marker Score: 11,659
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,809
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,036
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,346
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.94
    Marker Score: 233
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.93
    Marker Score: 233
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,274
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 506
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 183
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.66
    Marker Score: 736
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 512
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.63
    Marker Score: 1,200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.62
    Marker Score: 375
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.55
    Marker Score: 551
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.51
    Marker Score: 1,029
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 481
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.47
    Marker Score: 240
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.46
    Marker Score: 434
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.45
    Marker Score: 7,114
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 251
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.44
    Marker Score: 299
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 378
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.35
    Marker Score: 91
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 206
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.34
    Marker Score: 198
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.29
    Marker Score: 168
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.29
    Marker Score: 171
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.28
    Marker Score: 1,705
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.27
    Marker Score: 115
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.27
    Marker Score: 119
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.23
    Marker Score: 121
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.22
    Marker Score: 945
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.2
    Marker Score: 51
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.19
    Marker Score: 333
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.19
    Marker Score: 129
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.19
    Marker Score: 89
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.18
    Marker Score: 103
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.18
    Marker Score: 176
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.16
    Marker Score: 231
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.16
    Marker Score: 267
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.15
    Marker Score: 380
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.15
    Marker Score: 128
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.15
    Marker Score: 42
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.14
    Marker Score: 42
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.14
    Marker Score: 163
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.14
    Marker Score: 260
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.14
    Marker Score: 38
  • Cell Name: fibrocyte (CL0000135)
    Fold Change: 0.14
    Marker Score: 42
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.13
    Marker Score: 83
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.12
    Marker Score: 198
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.12
    Marker Score: 56
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.11
    Marker Score: 295
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 42
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: 0.11
    Marker Score: 38
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.11
    Marker Score: 42
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.1
    Marker Score: 127
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.1
    Marker Score: 44
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.09
    Marker Score: 189
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.09
    Marker Score: 113
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.08
    Marker Score: 39
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 75
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.08
    Marker Score: 247
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.08
    Marker Score: 29

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The PAGE4 gene is characterized by its involvement in multiple cellular pathways, including: 1. **Negative regulation of apoptotic process**: PAGE4 has been shown to inhibit apoptosis, suggesting its role as a pro-survival gene. 2. **Negative regulation of reactive oxygen species biosynthetic process**: PAGE4 may also regulate ROS production, which is a key factor in cellular stress responses. 3. **Regulation of stress-activated MAPK cascade**: PAGE4 is involved in modulating the MAPK cascade, a signaling pathway that responds to various cellular stresses. 4. **Transcriptional activity**: PAGE4 has been shown to regulate DNA-templated transcription, suggesting its role as a transcriptional coactivator. **Pathways and Functions:** The PAGE4 gene is involved in several key pathways, including: 1. **Intracellular signal transduction**: PAGE4 regulates the MAPK cascade, a signaling pathway that responds to various cellular stresses. 2. **Mitochondrial function**: PAGE4 may also regulate mitochondrial function, which is critical for energy metabolism and cellular stress responses. 3. **Nuclear function**: PAGE4 regulates DNA-templated transcription, suggesting its role as a transcriptional coactivator. 4. **Cytoplasmic function**: PAGE4 is involved in regulating ROS production and modulating the MAPK cascade. **Clinical Significance:** The PAGE4 gene has significant implications for various diseases, including: 1. **Neurological disorders**: Alterations in PAGE4 expression have been observed in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: PAGE4 may play a role in regulating cancer cell survival and proliferation. 3. **Autoimmune diseases**: PAGE4 may also be involved in regulating immune responses and modulating the MAPK cascade. 4. **Reproductive disorders**: PAGE4 expression is observed in cells of the reproductive system, suggesting its role in regulating fertility and reproductive health. In conclusion, the PAGE4 gene is a critical regulator of cellular stress responses and transcriptional activity. Its involvement in multiple cellular pathways, including the MAPK cascade, DNA-templated transcription, and ROS production, highlights its significance in various diseases. Further research is needed to fully elucidate the role of PAGE4 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2447917505

Symbol: PAGE4_HUMAN

Name: P antigen family member 4

UniProtKB Accession Codes:

O60829 B2R529 D3DX68 Q6IBI1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 9 Ensembl 2 GO 11 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9724777

Title: PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus.

PubMed ID: 9724777

DOI: 10.1073/pnas.95.18.10757

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12489849

Title: PAGE4 is a cytoplasmic protein that is expressed in normal prostate and in prostate cancers.

PubMed ID: 12489849

PubMed ID: 21357425

Title: The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein.

PubMed ID: 21357425

DOI: 10.1074/jbc.m110.210765

PubMed ID: 25374899

Title: Prostate-associated gene 4 (PAGE4) protects cells against stress by elevating p21 and suppressing reactive oxygen species production.

PubMed ID: 25374899

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24559171

Title: Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway.

PubMed ID: 24559171

DOI: 10.1021/bi500013w

PubMed ID: 24263171

Title: The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation.

PubMed ID: 24263171

DOI: 10.1016/j.bbadis.2013.11.014

PubMed ID: 26242913

Title: Phosphorylation-induced conformational ensemble switching in an intrinsically disordered cancer/testis antigen.

PubMed ID: 26242913

DOI: 10.1074/jbc.m115.658583

PubMed ID: 27270343

Title: Prostate-associated gene 4 (PAGE4), an intrinsically disordered cancer/testis antigen, is a novel therapeutic target for prostate cancer.

PubMed ID: 27270343

DOI: 10.4103/1008-682x.181818

PubMed ID: 28289210

Title: Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity.

PubMed ID: 28289210

DOI: 10.1073/pnas.1700082114

PubMed ID: 30658679

Title: PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway.

PubMed ID: 30658679

DOI: 10.1186/s13046-019-1032-3

Sequence Information:

  • Length: 102
  • Mass: 11153
  • Checksum: CE5D07AFBF73301B
  • Sequence:
    • MSARVRSRSR GRGDGQEAPD VVAFVAPGES QQEEPPTDNQ DIEPGQEREG TPPIEERKVE 
GDCQEMDLEK TRSERGDGSD VKEKTPPNPK HAKTKEAGDG QP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.