Details for: CD37

Gene ID: 951

Symbol: CD37

Ensembl ID: ENSG00000104894

Description: CD37 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 150.5671
    Cell Significance Index: -23.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 102.8413
    Cell Significance Index: -41.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 86.3944
    Cell Significance Index: -44.4400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 69.4523
    Cell Significance Index: -32.7900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 48.8956
    Cell Significance Index: -32.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.6618
    Cell Significance Index: -44.5500
  • Cell Name: centroblast (CL0009112)
    Fold Change: 45.8796
    Cell Significance Index: 107.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.1815
    Cell Significance Index: -23.6500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 12.5593
    Cell Significance Index: 33.6500
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 12.1199
    Cell Significance Index: 54.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.0012
    Cell Significance Index: -19.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.9599
    Cell Significance Index: -27.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 7.1478
    Cell Significance Index: 132.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.9619
    Cell Significance Index: 821.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7359
    Cell Significance Index: -26.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.4325
    Cell Significance Index: 159.5500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.7527
    Cell Significance Index: 14.4900
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.6062
    Cell Significance Index: 15.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.5031
    Cell Significance Index: 161.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0231
    Cell Significance Index: 43.8300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.7410
    Cell Significance Index: 11.5500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.6542
    Cell Significance Index: 10.5600
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.4206
    Cell Significance Index: 4.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.3679
    Cell Significance Index: 36.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9746
    Cell Significance Index: 96.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9235
    Cell Significance Index: 833.8600
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.8931
    Cell Significance Index: 4.4700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.5282
    Cell Significance Index: 2.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4563
    Cell Significance Index: 74.2200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.4358
    Cell Significance Index: 4.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2395
    Cell Significance Index: 26.0600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.2127
    Cell Significance Index: 1.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1998
    Cell Significance Index: 138.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1312
    Cell Significance Index: 26.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1067
    Cell Significance Index: 20.3000
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.0745
    Cell Significance Index: 0.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0683
    Cell Significance Index: 4.7300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0308
    Cell Significance Index: 0.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0122
    Cell Significance Index: 0.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0049
    Cell Significance Index: 8.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0033
    Cell Significance Index: 0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0003
    Cell Significance Index: 0.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0020
    Cell Significance Index: -2.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0089
    Cell Significance Index: -16.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0128
    Cell Significance Index: -9.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0193
    Cell Significance Index: -12.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0236
    Cell Significance Index: -13.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0284
    Cell Significance Index: -21.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0314
    Cell Significance Index: -17.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0368
    Cell Significance Index: -7.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0380
    Cell Significance Index: -6.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0402
    Cell Significance Index: -1.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0482
    Cell Significance Index: -1.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0501
    Cell Significance Index: -1.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0564
    Cell Significance Index: -24.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0601
    Cell Significance Index: -6.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0623
    Cell Significance Index: -45.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0661
    Cell Significance Index: -23.7200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0673
    Cell Significance Index: -1.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0694
    Cell Significance Index: -44.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0823
    Cell Significance Index: -23.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0834
    Cell Significance Index: -37.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1236
    Cell Significance Index: -24.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1535
    Cell Significance Index: -21.0800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1665
    Cell Significance Index: -6.8200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1972
    Cell Significance Index: -3.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2047
    Cell Significance Index: -36.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2165
    Cell Significance Index: -25.2300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2219
    Cell Significance Index: -9.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2411
    Cell Significance Index: -30.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2435
    Cell Significance Index: -27.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2442
    Cell Significance Index: -25.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2525
    Cell Significance Index: -15.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2756
    Cell Significance Index: -40.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2761
    Cell Significance Index: -31.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2842
    Cell Significance Index: -36.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2904
    Cell Significance Index: -13.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2946
    Cell Significance Index: -36.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3406
    Cell Significance Index: -26.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3798
    Cell Significance Index: -26.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4220
    Cell Significance Index: -6.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4676
    Cell Significance Index: -29.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4726
    Cell Significance Index: -31.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4903
    Cell Significance Index: -36.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5017
    Cell Significance Index: -28.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5342
    Cell Significance Index: -28.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5400
    Cell Significance Index: -28.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5514
    Cell Significance Index: -33.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5872
    Cell Significance Index: -36.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6091
    Cell Significance Index: -28.4000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6328
    Cell Significance Index: -5.1600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.6564
    Cell Significance Index: -6.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6604
    Cell Significance Index: -29.2100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6669
    Cell Significance Index: -13.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7212
    Cell Significance Index: -15.3600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.7353
    Cell Significance Index: -5.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7428
    Cell Significance Index: -26.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7661
    Cell Significance Index: -29.0100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.7717
    Cell Significance Index: -8.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CD37 is a transmembrane glycoprotein, also known as Leukocyte antigen CD37 (LCT), which is primarily expressed on the surface of B cells, T cells, and monocytes. The gene is highly conserved across species, with a high degree of sequence similarity between human and mouse orthologs. CD37's structure consists of a single transmembrane domain and a cytoplasmic tail, which is involved in the regulation of its activity. The gene's expression is tightly regulated, with CD37 being downregulated upon activation or differentiation of immune cells. **Pathways and Functions:** CD37's involvement in various signaling pathways underscores its multifaceted role in immunological processes. The gene is associated with the following pathways: 1. **Extracellular Exosome**: CD37 is involved in the regulation of exosome-mediated immune responses, influencing the exchange of molecules between immune cells and the extracellular environment. 2. **Immunological Synapse**: CD37 plays a crucial role in the formation and maintenance of the immunological synapse, the site of T cell-B cell interaction during antigen presentation. 3. **Membrane**: CD37 is embedded in the plasma membrane, where it interacts with other membrane-bound proteins to regulate cell signaling and adhesion. 4. **Protein Binding**: CD37 interacts with various proteins, including CD38, CD62L, and CD45, to modulate immune responses and cell-cell interactions. **Functions:** CD37's functions are diverse and far-reaching, including: 1. **Regulation of Immune Responses**: CD37 modulates the intensity and duration of immune responses by influencing the activation and differentiation of immune cells. 2. **Maintenance of Immune Homeostasis**: CD37 helps maintain immune homeostasis by regulating the balance between immune activation and suppression. 3. **Cell Signaling**: CD37 is involved in the regulation of cell signaling pathways, including the activation of protein kinase C and the production of cytokines. 4. **Antigen Presentation**: CD37 plays a role in the presentation of antigens to T cells, influencing the recognition and targeting of pathogens. **Clinical Significance:** CD37's involvement in various immune-related disorders highlights its clinical significance. Dysregulation of CD37 has been implicated in: 1. **Autoimmune Diseases**: CD37's dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where immune cell activation and dysregulation contribute to disease pathogenesis. 2. **Cancer**: CD37's role in cancer immunity has been explored, with studies suggesting its potential as a target for immunotherapy. 3. **Infectious Diseases**: CD37's involvement in the regulation of immune responses to pathogens underscores its potential as a therapeutic target for infectious disease treatment. In conclusion, CD37 is a complex gene involved in various immunological processes, including regulation of immune responses, maintenance of immune homeostasis, and cell signaling. Its dysregulation has been implicated in various immune-related disorders, highlighting its clinical significance and potential as a therapeutic target. Further research into the mechanisms and functions of CD37 will provide valuable insights into the intricate balance of the immune system and the development of novel immunotherapies.

Genular Protein ID: 1954038182

Symbol: CD37_HUMAN

Name: Leukocyte antigen CD37

UniProtKB Accession Codes:

P11049 B4DVC1 Q3KPF9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2466944

Title: The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen.

PubMed ID: 2466944

DOI: 10.1084/jem.169.4.1497

PubMed ID: 2388030

Title:

PubMed ID: 2388030

DOI: 10.1084/jem.172.3.1007

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17182550

Title: Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production.

PubMed ID: 17182550

DOI: 10.4049/jimmunol.178.1.154

PubMed ID: 21930792

Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.

PubMed ID: 21930792

DOI: 10.1128/mcb.05817-11

PubMed ID: 22624718

Title: Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals.

PubMed ID: 22624718

DOI: 10.1016/j.ccr.2012.03.040

PubMed ID: 26784544

Title: Tetraspanin CD37 protects against the development of B cell lymphoma.

PubMed ID: 26784544

DOI: 10.1172/jci81041

Sequence Information:

  • Length: 281
  • Mass: 31703
  • Checksum: 4342C5FB4479FDC8
  • Sequence:
    • MSAQESCLSL IKYFLFVFNL FFFVLGSLIF CFGIWILIDK TSFVSFVGLA FVPLQIWSKV 
LAISGIFTMG IALLGCVGAL KELRCLLGLY FGMLLLLFAT QITLGILIST QRAQLERSLR 
DVVEKTIQKY GTNPEETAAE ESWDYVQFQL RCCGWHYPQD WFQVLILRGN GSEAHRVPCS 
CYNLSATNDS TILDKVILPQ LSRLGHLARS RHSADICAVP AESHIYREGC AQGLQKWLHN 
NLISIVGICL GVGLLELGFM TLSIFLCRNL DHVYNRLARY R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.