Details for: CD37

Gene ID: 951

Symbol: CD37

Ensembl ID: ENSG00000104894

Description: CD37 molecule

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.9
    Marker Score: 12358.5
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.95
    Marker Score: 3962
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4.26
    Marker Score: 4194
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.19
    Marker Score: 41485
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.16
    Marker Score: 2529
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.12
    Marker Score: 12994
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.09
    Marker Score: 216288
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.97
    Marker Score: 46171
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.81
    Marker Score: 213272
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.75
    Marker Score: 3629
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.75
    Marker Score: 16079
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.45
    Marker Score: 1701
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.45
    Marker Score: 6715.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.42
    Marker Score: 9594
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.36
    Marker Score: 3001
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.32
    Marker Score: 2794
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.28
    Marker Score: 9565
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.25
    Marker Score: 3839.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 3.24
    Marker Score: 1953
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.24
    Marker Score: 9615
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.23
    Marker Score: 4753
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.2
    Marker Score: 1878
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 3.16
    Marker Score: 5514
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 3.13
    Marker Score: 1107
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.12
    Marker Score: 8610
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.11
    Marker Score: 2923.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.09
    Marker Score: 1541
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.08
    Marker Score: 2881
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.04
    Marker Score: 4193
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.98
    Marker Score: 1416
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.95
    Marker Score: 5786
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.91
    Marker Score: 7034
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.9
    Marker Score: 7229.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.87
    Marker Score: 1241
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.86
    Marker Score: 2072
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.84
    Marker Score: 2530
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.82
    Marker Score: 4845
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.8
    Marker Score: 1804
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.75
    Marker Score: 2015
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.71
    Marker Score: 2047
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.69
    Marker Score: 874
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.68
    Marker Score: 936
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.67
    Marker Score: 1373
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.66
    Marker Score: 17037
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.65
    Marker Score: 1554
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.63
    Marker Score: 1133
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.62
    Marker Score: 3713
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 2.62
    Marker Score: 1279
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.59
    Marker Score: 66381.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.58
    Marker Score: 2953
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.55
    Marker Score: 2758
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.54
    Marker Score: 1402
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.54
    Marker Score: 1459
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.52
    Marker Score: 1980.5
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.51
    Marker Score: 1895
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.51
    Marker Score: 826
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.51
    Marker Score: 1818
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.5
    Marker Score: 1654
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 2.49
    Marker Score: 2756
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.49
    Marker Score: 3004
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.47
    Marker Score: 1520
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.44
    Marker Score: 1761.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.43
    Marker Score: 9950
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.43
    Marker Score: 753
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.37
    Marker Score: 600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.36
    Marker Score: 593
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 2.34
    Marker Score: 2538
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.34
    Marker Score: 711
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 2.34
    Marker Score: 620
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.33
    Marker Score: 2588.5
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.3
    Marker Score: 546
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 2.28
    Marker Score: 525
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.28
    Marker Score: 793
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 2.26
    Marker Score: 792
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.26
    Marker Score: 1012.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.22
    Marker Score: 3960
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 2.19
    Marker Score: 702
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.13
    Marker Score: 5786
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.13
    Marker Score: 1766
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.06
    Marker Score: 4634
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.01
    Marker Score: 5196.5
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 2
    Marker Score: 511
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.93
    Marker Score: 788
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.92
    Marker Score: 7956.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9
    Marker Score: 19231
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.89
    Marker Score: 1042
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.88
    Marker Score: 808
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.86
    Marker Score: 11285
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.85
    Marker Score: 972
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.79
    Marker Score: 1306
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.76
    Marker Score: 2341
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.74
    Marker Score: 382
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.72
    Marker Score: 1305
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.71
    Marker Score: 1625
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.67
    Marker Score: 2723
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.66
    Marker Score: 1693
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.6
    Marker Score: 1104.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.6
    Marker Score: 1091
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.6
    Marker Score: 493
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.59
    Marker Score: 1729

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Other Information

**Key characteristics** * CD37 is a glycoprotein with a molecular weight of approximately 40-50 kDa. * It is expressed on the surface of professional antigen-presenting cells, such as B cells and macrophages. * CD37 is also expressed on activated T cells, natural killer (NK) cells, and activated dendritic cells. * It is a homophilic interaction between CD37 on a cell and CD37 on another cell. **Pathways and functions** * CD37 is involved in the regulation of B cell activation and differentiation. * It is expressed on B cells that are in the early stages of differentiation and are receiving signals from T cells. * CD37 signaling can inhibit B cell activation, differentiation, and cytokine production. * It is also expressed on mature B cells that are in the plasma membrane. * CD37 signaling can promote B cell activation and survival. **Clinical significance** CD37 is a promising target for cancer immunotherapy. Antibodies against CD37 have been shown to be effective in blocking B cell activation and inhibiting tumor growth in mouse models of cancer. Clinical trials of CD37 inhibitors are currently underway in humans with several types of cancer.

Genular Protein ID: 1954038182

Symbol: CD37_HUMAN

Name: Leukocyte antigen CD37

UniProtKB Accession Codes:

P11049 B4DVC1 Q3KPF9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2466944

Title: The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen.

PubMed ID: 2466944

DOI: 10.1084/jem.169.4.1497

PubMed ID: 2388030

Title:

PubMed ID: 2388030

DOI: 10.1084/jem.172.3.1007

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21930792

Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.

PubMed ID: 21930792

DOI: 10.1128/mcb.05817-11

Sequence Information:

  • Length: 281
  • Mass: 31703
  • Checksum: 4342C5FB4479FDC8
  • Sequence:
    • MSAQESCLSL IKYFLFVFNL FFFVLGSLIF CFGIWILIDK TSFVSFVGLA FVPLQIWSKV 
LAISGIFTMG IALLGCVGAL KELRCLLGLY FGMLLLLFAT QITLGILIST QRAQLERSLR 
DVVEKTIQKY GTNPEETAAE ESWDYVQFQL RCCGWHYPQD WFQVLILRGN GSEAHRVPCS 
CYNLSATNDS TILDKVILPQ LSRLGHLARS RHSADICAVP AESHIYREGC AQGLQKWLHN 
NLISIVGICL GVGLLELGFM TLSIFLCRNL DHVYNRLARY R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.