FXR2 | ENSG00000129245 | NCBI 9513

Details for: FXR2

Gene ID: 9513

Symbol: FXR2

Ensembl ID: ENSG00000129245

Description: FMR1 autosomal homolog 2

Associated with

Animal organ development
(GO:0048513)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Dentate gyrus development
(GO:0021542)
Identical protein binding
(GO:0042802)
Membrane
(GO:0016020)
Mrna 3'-utr binding
(GO:0003730)
Mrna destabilization
(GO:0061157)
Mrna transport
(GO:0051028)
Neuron projection
(GO:0043005)
Nucleus
(GO:0005634)
Positive regulation of long-term neuronal synaptic plasticity
(GO:0048170)
Positive regulation of translation
(GO:0045727)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of mrna stability
(GO:0043488)
Regulation of translation at presynapse, modulating synaptic transmission
(GO:0099577)
Rna binding
(GO:0003723)
Translation regulator activity
(GO:0045182)

Other Information

Proteins

FXR2_HUMAN

Genular Protein ID: 370985789

Symbol: FXR2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P51116 B2R9M2 D3DTQ1 Q86V09 Q8WUM2

Database IDs:

Citations:

PubMed ID: 7489725

Title: The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.

PubMed ID: 7489725

DOI: 10.1002/j.1460-2075.1995.tb00220.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9437788

Title: The rat androgen-binding protein (ABP/SHBG) gene contains triplet repeats similar to unstable triplets: evidence that the ABP/SHBG and the fragile X-related 2 genes overlap.

PubMed ID: 9437788

DOI: 10.1016/s0039-128x(97)00087-1

PubMed ID: 8668200

Title: Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them.

PubMed ID: 8668200

DOI: 10.1128/mcb.16.7.3825

PubMed ID: 9259278

Title: Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.

PubMed ID: 9259278

DOI: 10.1093/hmg/6.8.1315

PubMed ID: 11157796

Title: Evidence that fragile X mental retardation protein is a negative regulator of translation.

PubMed ID: 11157796

DOI: 10.1093/hmg/10.4.329

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18664458

Title: Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP.

PubMed ID: 18664458

DOI: 10.1093/hmg/ddn219

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21771594

Title: Evidence for the association of the human regulatory protein Ki-1/57 with the translational machinery.

PubMed ID: 21771594

DOI: 10.1016/j.febslet.2011.07.010

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27509095

Title: New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes.

PubMed ID: 27509095

DOI: 10.1371/journal.ppat.1005810

PubMed ID: 21072162

Title: Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.

PubMed ID: 21072162

DOI: 10.1371/journal.pone.0013559

Sequence Information:

Length: 673
Mass: 74223
Checksum: B8A498C3F634D41F
Sequence:

MGGLASGGDV EPGLPVEVRG SNGAFYKGFV KDVHEDSVTI FFENNWQSER QIPFGDVRLP 
PPADYNKEIT EGDEVEVYSR ANEQEPCGWW LARVRMMKGD FYVIEYAACD ATYNEIVTLE 
RLRPVNPNPL ATKGSFFKVT MAVPEDLREA CSNENVHKEF KKALGANCIF LNITNSELFI 
LSTTEAPVKR ASLLGDMHFR SLRTKLLLMS RNEEATKHLE TSKQLAAAFQ EEFTVREDLM 
GLAIGTHGAN IQQARKVPGV TAIELGEETC TFRIYGETPE ACRQARSYLE FSEDSVQVPR 
NLVGKVIGKN GKVIQEIVDK SGVVRVRVEG DNDKKNPREE GMVPFIFVGT RENISNAQAL 
LEYHLSYLQE VEQLRLERLQ IDEQLRQIGL GFRPPGSGRG SGGSDKAGYS TDESSSSSLH 
ATRTYGGSYG GRGRGRRTGG PAYGPSSDVS TASETESEKR EEPNRAGPGD RDPPTRGEES 
RRRPTGGRGR GPPPAPRPTS RYNSSSISSV LKDPDSNPYS LLDTSEPEPP VDSEPGEPPP 
ASARRRRSRR RRTDEDRTVM DGGLESDGPN MTENGLEDES RPQRRNRSRR RRNRGNRTDG 
SISGDRQPVT VADYISRAES QSRQRPPLER TKPSEDSLSG QKGDSVSKLP KGPSENGELS 
APLELGSMVN GVS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FXR2

Associated with

Other Information

The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. PubMed ID: 7489725

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The rat androgen-binding protein (ABP/SHBG) gene contains triplet repeats similar to unstable triplets: evidence that the ABP/SHBG and the fragile X-related 2 genes overlap. PubMed ID: 9437788

Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them. PubMed ID: 8668200

Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis. PubMed ID: 9259278

Evidence that fragile X mental retardation protein is a negative regulator of translation. PubMed ID: 11157796

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. PubMed ID: 15144186

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP. PubMed ID: 18664458

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Evidence for the association of the human regulatory protein Ki-1/57 with the translational machinery. PubMed ID: 21771594

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes. PubMed ID: 27509095

Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2. PubMed ID: 21072162