LITAF | ENSG00000189067 | NCBI 9516

Details for: LITAF

Gene ID: 9516

Symbol: LITAF

Ensembl ID: ENSG00000189067

Description: lipopolysaccharide induced TNF factor

Associated with

Cellular response to lipopolysaccharide
(GO:0071222)
Cytoplasmic side of early endosome membrane
(GO:0098559)
Cytoplasmic side of late endosome membrane
(GO:0098560)
Cytoplasmic side of lysosomal membrane
(GO:0098574)
Cytoplasmic side of plasma membrane
(GO:0009898)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Identical protein binding
(GO:0042802)
Intracellular membrane-bounded organelle
(GO:0043231)
Lysosomal membrane
(GO:0005765)
Negative regulation of non-canonical nf-kappab signal transduction
(GO:1901223)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of cytokine production
(GO:0001817)
Regulation of macrophage cytokine production
(GO:0010935)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Ww domain binding
(GO:0050699)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

LITAF_HUMAN

Genular Protein ID: 998405093

Symbol: LITAF_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99732 D3DUG1 G5E9K0 Q05DW0 Q9C0L6

Database IDs:

Citations:

PubMed ID: 9305847

Title: A model for p53-induced apoptosis.

PubMed ID: 9305847

DOI: 10.1038/38525

PubMed ID: 10200294

Title: A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment.

PubMed ID: 10200294

DOI: 10.1073/pnas.96.8.4518

PubMed ID: 11274176

Title: Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1.

PubMed ID: 11274176

DOI: 10.1074/jbc.m011660200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15064722

Title: WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins.

PubMed ID: 15064722

DOI: 10.1038/sj.onc.1207680

PubMed ID: 16118794

Title: SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease.

PubMed ID: 16118794

DOI: 10.1002/jnr.20628

PubMed ID: 15793005

Title: LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines.

PubMed ID: 15793005

DOI: 10.1073/pnas.0501159102

PubMed ID: 16954198

Title: LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways.

PubMed ID: 16954198

DOI: 10.1073/pnas.0605988103

PubMed ID: 21896645

Title: Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways.

PubMed ID: 21896645

DOI: 10.1242/jcs.087114

PubMed ID: 23166352

Title: Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking.

PubMed ID: 23166352

DOI: 10.1083/jcb.201204137

PubMed ID: 27927196

Title: The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C.

PubMed ID: 27927196

DOI: 10.1186/s12915-016-0332-8

PubMed ID: 27582497

Title: The Charcot Marie Tooth disease protein LITAF is a zinc-binding monotopic membrane protein.

PubMed ID: 27582497

DOI: 10.1042/bcj20160657

PubMed ID: 12525712

Title: Mutation of a putative protein degradation gene LITAF/SIMPLE in Charcot-Marie-Tooth disease 1C.

PubMed ID: 12525712

DOI: 10.1212/wnl.60.1.22

PubMed ID: 15197774

Title: PIG7/LITAF gene mutation and overexpression of its gene product in extramammary Paget's disease.

PubMed ID: 15197774

DOI: 10.1002/ijc.20251

PubMed ID: 15786462

Title: Early onset neuropathy in a compound form of Charcot-Marie-Tooth disease.

PubMed ID: 15786462

DOI: 10.1002/ana.20434

PubMed ID: 15776429

Title: SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation.

PubMed ID: 15776429

DOI: 10.1002/humu.20153

PubMed ID: 24604904

Title: Application of whole exome sequencing in undiagnosed inherited polyneuropathies.

PubMed ID: 24604904

DOI: 10.1136/jnnp-2013-306740

Sequence Information:

Length: 161
Mass: 17107
Checksum: 08D15BF1FDCA16F0
Sequence:

MSVPGPYQAA TGPSSAPSAP PSYEETVAVN SYYPTPPAPM PGPTTGLVTG PDGKGMNPPS 
YYTQPAPIPN NNPITVQTVY VQHPITFLDR PIQMCCPSCN KMIVSQLSYN AGALTWLSCG 
SLCLLGCIAG CCFIPFCVDA LQDVDHYCPN CRALLGTYKR L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: LITAF

Associated with

Other Information

A model for p53-induced apoptosis. PubMed ID: 9305847

A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment. PubMed ID: 10200294

Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1. PubMed ID: 11274176

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. PubMed ID: 15064722

SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease. PubMed ID: 16118794

LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines. PubMed ID: 15793005

LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways. PubMed ID: 16954198

Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways. PubMed ID: 21896645

Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking. PubMed ID: 23166352

The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C. PubMed ID: 27927196

The Charcot Marie Tooth disease protein LITAF is a zinc-binding monotopic membrane protein. PubMed ID: 27582497

Mutation of a putative protein degradation gene LITAF/SIMPLE in Charcot-Marie-Tooth disease 1C. PubMed ID: 12525712

PIG7/LITAF gene mutation and overexpression of its gene product in extramammary Paget's disease. PubMed ID: 15197774

Early onset neuropathy in a compound form of Charcot-Marie-Tooth disease. PubMed ID: 15786462

SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation. PubMed ID: 15776429

Application of whole exome sequencing in undiagnosed inherited polyneuropathies. PubMed ID: 24604904