Details for: GDF15
Associated with
Other Information
Genular Protein ID: 3794796598
Symbol: GDF15_HUMAN
Name: NSAID-activated gene 1 protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9375789
Title: PLAB, a novel placental bone morphogenetic protein.
PubMed ID: 9375789
PubMed ID: 9348093
Title: Human cDNA encoding a novel TGF-beta superfamily protein highly expressed in placenta.
PubMed ID: 9348093
PubMed ID: 9326641
Title: MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily.
PubMed ID: 9326641
PubMed ID: 9593718
Title: Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family.
PubMed ID: 9593718
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9426002
Title: Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta.
PubMed ID: 9426002
PubMed ID: 11259636
Title: Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities.
PubMed ID: 11259636
DOI: 10.1124/mol.59.4.901
PubMed ID: 23468844
Title: TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator.
PubMed ID: 23468844
PubMed ID: 28572090
Title: GDF15 is a heart-derived hormone that regulates body growth.
PubMed ID: 28572090
PubMed ID: 28846097
Title: GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.
PubMed ID: 28846097
DOI: 10.1038/nm.4392
PubMed ID: 28846099
Title: GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
PubMed ID: 28846099
DOI: 10.1038/nm.4394
PubMed ID: 28846098
Title: The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.
PubMed ID: 28846098
DOI: 10.1038/nm.4393
PubMed ID: 28953886
Title: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
PubMed ID: 28953886
DOI: 10.1038/nature24042
PubMed ID: 29144449
Title: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
PubMed ID: 29144449
DOI: 10.1038/nature24481
PubMed ID: 29046435
Title: Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.
PubMed ID: 29046435
Sequence Information:
- Length: 308
- Mass: 34140
- Checksum: 2FF3959021B95238
- Sequence:
MPGQELRTVN GSQMLLVLLV LSWLPHGGAL SLAEASRASF PGPSELHSED SRFRELRKRY EDLLTRLRAN QSWEDSNTDL VPAPAVRILT PEVRLGSGGH LHLRISRAAL PEGLPEASRL HRALFRLSPT ASRSWDVTRP LRRQLSLARP QAPALHLRLS PPPSQSDQLL AESSSARPQL ELHLRPQAAR GRRRARARNG DHCPLGPGRC CRLHTVRASL EDLGWADWVL SPREVQVTMC IGACPSQFRA ANMHAQIKTS LHRLKPDTVP APCCVPASYN PMVLIQKTDT GVSLQTYDDL LAKDCHCI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.