Details for: CD38

Gene ID: 952

Symbol: CD38

Ensembl ID: ENSG00000004468

Description: CD38 molecule

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 2.68
    Marker Score: 739
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.5
    Marker Score: 2951
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 2.37
    Marker Score: 7589
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.19
    Marker Score: 1752
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.14
    Marker Score: 5829
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.14
    Marker Score: 1056
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 2.06
    Marker Score: 540
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.89
    Marker Score: 5610
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.88
    Marker Score: 2668
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.87
    Marker Score: 477
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.73
    Marker Score: 4775.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.68
    Marker Score: 17022
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.64
    Marker Score: 1418
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.62
    Marker Score: 1384
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.54
    Marker Score: 495
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.53
    Marker Score: 532
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168622
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.36
    Marker Score: 826
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.26
    Marker Score: 2199
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.23
    Marker Score: 1368
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.23
    Marker Score: 831
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.21
    Marker Score: 1270
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.2
    Marker Score: 589
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.18
    Marker Score: 10278
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.16
    Marker Score: 506
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4770.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.13
    Marker Score: 823.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.1
    Marker Score: 3765
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.07
    Marker Score: 2028
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.02
    Marker Score: 1944
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.01
    Marker Score: 1346
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71766.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47989
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.95
    Marker Score: 219
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 392
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 446.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.94
    Marker Score: 541
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.92
    Marker Score: 202.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5214
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 361
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.89
    Marker Score: 652
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.88
    Marker Score: 885
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.88
    Marker Score: 2570
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.87
    Marker Score: 18657
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5268
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.86
    Marker Score: 9964
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.85
    Marker Score: 566
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.84
    Marker Score: 941
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.84
    Marker Score: 468
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.84
    Marker Score: 1701
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.83
    Marker Score: 274
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.81
    Marker Score: 5267
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.8
    Marker Score: 576.5
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.78
    Marker Score: 422
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.77
    Marker Score: 175
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 590
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1237
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.76
    Marker Score: 384
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 691
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.75
    Marker Score: 178
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.75
    Marker Score: 187
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.74
    Marker Score: 542
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.74
    Marker Score: 4425
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.71
    Marker Score: 11112.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.71
    Marker Score: 425
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 447
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.7
    Marker Score: 337.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.69
    Marker Score: 328
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.68
    Marker Score: 462
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.68
    Marker Score: 879
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.66
    Marker Score: 174
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.65
    Marker Score: 340
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.64
    Marker Score: 6357
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.63
    Marker Score: 366
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.61
    Marker Score: 265
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.61
    Marker Score: 9835
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.61
    Marker Score: 145
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.6
    Marker Score: 168
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.6
    Marker Score: 570
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.59
    Marker Score: 145
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.58
    Marker Score: 201
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.58
    Marker Score: 241
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.57
    Marker Score: 273.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.57
    Marker Score: 468
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.57
    Marker Score: 654
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.57
    Marker Score: 149
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.56
    Marker Score: 181
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.55
    Marker Score: 194
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.54
    Marker Score: 358
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.54
    Marker Score: 341
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 136

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Other Information

**Key characteristics:** - CD38 is a glycoprotein with a molecular weight of approximately 120 kDa. - It is a member of the immunoglobulin superfamily. - It is expressed in high levels on the surface of activated T cells and some other immune cells. - It is also expressed on some normal cells, such as endothelial cells and fibroblasts. **Pathways and functions:** - CD38 is a key regulator of cell adhesion and migration. It is expressed on the surface of activated T cells and some other immune cells, and it plays a role in the adhesion of these cells to extracellular matrix proteins. - It is also expressed on some normal cells, such as endothelial cells and fibroblasts, and it plays a role in their migration. - CD38 is involved in the regulation of cell growth, survival, and differentiation. - It is also involved in the regulation of the immune response. - CD38 is a key regulator of the activation of B cells. It is expressed on the surface of early pro-B cells and is required for the activation of B cells. - It is also expressed on the surface of plasmablasts, which are a type of B cell that is responsible for the production of antibodies. - CD38 is a key regulator of the activation of T cells. It is expressed on the surface of CD8-alpha-alpha-positive T cells and is required for the activation of these cells. **Clinical significance:** - Mutations in the CD38 gene have been linked to several human diseases, including cancer and autoimmune disorders. - CD38 is a potential target for cancer immunotherapy. - Blockade of CD38 signaling has been shown to inhibit cancer growth in preclinical models.

Genular Protein ID: 2579884226

Symbol: CD38_HUMAN

Name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

UniProtKB Accession Codes:

P28907 O00121 O00122 Q96HY4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 3 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 2 EMBL 5 EMDB 1 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 56 PDBsum 50 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 Rhea 11 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2319135

Title: Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation.

PubMed ID: 2319135

DOI: 10.4049/jimmunol.144.7.2811

PubMed ID: 9074508

Title: Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing.

PubMed ID: 9074508

DOI: 10.1016/s0378-1119(96)00723-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1471258

Title: Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38.

PubMed ID: 1471258

DOI: 10.1016/0968-0004(92)90337-9

PubMed ID: 8253715

Title: Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP.

PubMed ID: 8253715

DOI: 10.1016/s0021-9258(19)74275-6

PubMed ID: 7961800

Title: Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38.

PubMed ID: 7961800

DOI: 10.1016/s0021-9258(19)61940-x

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 16690024

Title: NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases.

PubMed ID: 16690024

DOI: 10.1016/j.bbrc.2006.04.096

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16154090

Title: Crystal structure of human CD38 extracellular domain.

PubMed ID: 16154090

DOI: 10.1016/j.str.2005.05.012

PubMed ID: 9754820

Title: A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro.

PubMed ID: 9754820

DOI: 10.1007/s001250051026

Sequence Information:

  • Length: 300
  • Mass: 34328
  • Checksum: 47BBE38C3DE3E6AA
  • Sequence:
    • MANCEFSPVS GDKPCCRLSR RAQLCLGVSI LVLILVVVLA VVVPRWRQQW SGPGTTKRFP 
ETVLARCVKY TEIHPEMRHV DCQSVWDAFK GAFISKHPCN ITEEDYQPLM KLGTQTVPCN 
KILLWSRIKD LAHQFTQVQR DMFTLEDTLL GYLADDLTWC GEFNTSKINY QSCPDWRKDC 
SNNPVSVFWK TVSRRFAEAA CDVVHVMLNG SRSKIFDKNS TFGSVEVHNL QPEKVQTLEA 
WVIHGGREDS RDLCQDPTIK ELESIISKRN IQFSCKNIYR PDKFLQCVKN PEDSSCTSEI

Genular Protein ID: 896845194

Symbol: B4E006_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E006

Database IDs:

ARBA 19 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 DNASU 1 EC 1 EMBL 2 GO 4 GenomeRNAi 1 InterPro 1 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 160
  • Mass: 17929
  • Checksum: E95F0F14F0DCAA1F
  • Sequence:
    • MANCEFSPVS GDKPCCRLSR IAQLCLGVSI LVLILVVVLA VVVPRWRQQW SGPGTTKRFP 
ETVLARCVKY TEIHPEMRHV DCQSVWDAFK GAFISKHPCN ITEEDYQPLM KLGTQTVPCN 
KKSTINLAQT GERTAATTLF QYSGKRFPAG LQKLPVMWSM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.