Details for: CD38

Gene ID: 952

Symbol: CD38

Ensembl ID: ENSG00000004468

Description: CD38 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 63.5667
    Cell Significance Index: -9.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.5626
    Cell Significance Index: -12.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 23.8286
    Cell Significance Index: -11.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.2790
    Cell Significance Index: -4.8900
  • Cell Name: centroblast (CL0009112)
    Fold Change: 14.5753
    Cell Significance Index: 34.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.1836
    Cell Significance Index: -10.0900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 3.9606
    Cell Significance Index: 10.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.2812
    Cell Significance Index: -8.7900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.2207
    Cell Significance Index: 49.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6406
    Cell Significance Index: -10.4200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.3385
    Cell Significance Index: 32.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1886
    Cell Significance Index: 141.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0739
    Cell Significance Index: 244.5800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.0828
    Cell Significance Index: 6.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7413
    Cell Significance Index: 19.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.5341
    Cell Significance Index: 13.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4924
    Cell Significance Index: 93.7000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.3904
    Cell Significance Index: 2.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2846
    Cell Significance Index: 28.1500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2550
    Cell Significance Index: 5.2900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2428
    Cell Significance Index: 6.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2375
    Cell Significance Index: 214.4600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1701
    Cell Significance Index: 1.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1524
    Cell Significance Index: 4.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1510
    Cell Significance Index: 24.5600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.1212
    Cell Significance Index: 2.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1175
    Cell Significance Index: 12.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0948
    Cell Significance Index: 2.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0676
    Cell Significance Index: 4.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0458
    Cell Significance Index: 1.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0382
    Cell Significance Index: 2.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0381
    Cell Significance Index: 1.3400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0334
    Cell Significance Index: 0.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0079
    Cell Significance Index: 1.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0062
    Cell Significance Index: 3.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0053
    Cell Significance Index: 4.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0054
    Cell Significance Index: -10.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0060
    Cell Significance Index: -0.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0062
    Cell Significance Index: -8.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0113
    Cell Significance Index: -7.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0143
    Cell Significance Index: -2.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0151
    Cell Significance Index: -11.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0154
    Cell Significance Index: -5.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0174
    Cell Significance Index: -12.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0176
    Cell Significance Index: -3.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0182
    Cell Significance Index: -11.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0197
    Cell Significance Index: -11.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0226
    Cell Significance Index: -0.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0231
    Cell Significance Index: -10.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0269
    Cell Significance Index: -3.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0330
    Cell Significance Index: -9.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0331
    Cell Significance Index: -1.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0418
    Cell Significance Index: -7.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0533
    Cell Significance Index: -11.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0596
    Cell Significance Index: -10.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0604
    Cell Significance Index: -8.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0648
    Cell Significance Index: -3.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0719
    Cell Significance Index: -7.3400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0796
    Cell Significance Index: -1.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0814
    Cell Significance Index: -10.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0855
    Cell Significance Index: -9.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0863
    Cell Significance Index: -9.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0899
    Cell Significance Index: -2.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0960
    Cell Significance Index: -7.3700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0967
    Cell Significance Index: -1.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0982
    Cell Significance Index: -10.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0984
    Cell Significance Index: -12.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1185
    Cell Significance Index: -2.1900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1316
    Cell Significance Index: -3.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1462
    Cell Significance Index: -9.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1673
    Cell Significance Index: -10.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1711
    Cell Significance Index: -12.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1736
    Cell Significance Index: -10.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1975
    Cell Significance Index: -11.0800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1997
    Cell Significance Index: -2.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2048
    Cell Significance Index: -10.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2070
    Cell Significance Index: -10.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2070
    Cell Significance Index: -4.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2083
    Cell Significance Index: -5.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2142
    Cell Significance Index: -10.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2177
    Cell Significance Index: -10.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2222
    Cell Significance Index: -9.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2276
    Cell Significance Index: -10.6100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2405
    Cell Significance Index: -3.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2583
    Cell Significance Index: -9.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2653
    Cell Significance Index: -10.0500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2707
    Cell Significance Index: -4.0500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2749
    Cell Significance Index: -10.0900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2812
    Cell Significance Index: -4.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3070
    Cell Significance Index: -10.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3096
    Cell Significance Index: -9.8600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.3190
    Cell Significance Index: -2.8400
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.3200
    Cell Significance Index: -2.3000
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.3257
    Cell Significance Index: -1.5300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.3327
    Cell Significance Index: -4.0500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3338
    Cell Significance Index: -4.2300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3347
    Cell Significance Index: -4.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3367
    Cell Significance Index: -8.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane glycoprotein:** CD38 is a transmembrane protein consisting of a large extracellular domain, a transmembrane domain, and a cytoplasmic tail. 2. **ADP-ribosyl cyclase activity:** CD38 possesses ADP-ribosyl cyclase activity, which generates cyclic ADP-ribose (cADPR) from NAD+. 3. **Cyclic ADP-ribose hydrolase activity:** In addition to its ADP-ribosyl cyclase activity, CD38 also exhibits cyclic ADP-ribose hydrolase activity, which hydrolyzes cADPR to ADP-ribose. 4. **Ubiquitous expression:** CD38 is widely expressed in various cell types, including immune cells, neuronal cells, and epithelial cells. **Pathways and Functions:** 1. **Apoptotic signaling pathway:** CD38 regulates apoptosis by interacting with various pro-apoptotic and anti-apoptotic proteins, including BAX, BCL-2, and NF-κB. 2. **B cell receptor signaling pathway:** CD38 modulates B cell receptor signaling by interacting with signaling molecules, such as CD40, CD80, and CD86. 3. **Cell surface:** CD38 is involved in the regulation of cell surface protein expression, including the regulation of adhesion molecules and integrins. 4. **Extracellular exosome:** CD38 is secreted into the extracellular environment, where it can interact with other cells and influence their behavior. 5. **Metabolism:** CD38 regulates cellular metabolism by modulating the levels of cADPR and ADP-ribose, which can influence energy metabolism and cellular stress responses. **Clinical Significance:** 1. **Autoimmune diseases:** CD38 has been implicated in various autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and lupus, where it is thought to contribute to the dysregulation of immune responses. 2. **Cancer:** CD38 has been identified as a potential biomarker for various types of cancer, including breast, lung, and colon cancer, where it is thought to contribute to tumor progression and metastasis. 3. **Neurological disorders:** CD38 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, where it is thought to contribute to the regulation of neuronal function and survival. 4. **Infectious diseases:** CD38 has been identified as a potential target for the development of immunotherapies for infectious diseases, such as HIV and tuberculosis. In conclusion, CD38 is a multifaceted molecule that plays a crucial role in various cellular processes, including immune regulation, cell signaling, and metabolism. Its dysregulation has been implicated in various diseases, making it an attractive target for the development of novel therapeutic strategies. Further research is needed to fully elucidate the mechanisms by which CD38 regulates cellular functions and to explore its potential as a therapeutic target.

Genular Protein ID: 2579884226

Symbol: CD38_HUMAN

Name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2319135

Title: Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation.

PubMed ID: 2319135

DOI: 10.4049/jimmunol.144.7.2811

PubMed ID: 9074508

Title: Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing.

PubMed ID: 9074508

DOI: 10.1016/s0378-1119(96)00723-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1471258

Title: Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38.

PubMed ID: 1471258

DOI: 10.1016/0968-0004(92)90337-9

PubMed ID: 8253715

Title: Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP.

PubMed ID: 8253715

DOI: 10.1016/s0021-9258(19)74275-6

PubMed ID: 7961800

Title: Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38.

PubMed ID: 7961800

DOI: 10.1016/s0021-9258(19)61940-x

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 16690024

Title: NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases.

PubMed ID: 16690024

DOI: 10.1016/j.bbrc.2006.04.096

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16154090

Title: Crystal structure of human CD38 extracellular domain.

PubMed ID: 16154090

DOI: 10.1016/j.str.2005.05.012

PubMed ID: 9754820

Title: A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro.

PubMed ID: 9754820

DOI: 10.1007/s001250051026

Sequence Information:

  • Length: 300
  • Mass: 34328
  • Checksum: 47BBE38C3DE3E6AA
  • Sequence:
  • MANCEFSPVS GDKPCCRLSR RAQLCLGVSI LVLILVVVLA VVVPRWRQQW SGPGTTKRFP 
    ETVLARCVKY TEIHPEMRHV DCQSVWDAFK GAFISKHPCN ITEEDYQPLM KLGTQTVPCN 
    KILLWSRIKD LAHQFTQVQR DMFTLEDTLL GYLADDLTWC GEFNTSKINY QSCPDWRKDC 
    SNNPVSVFWK TVSRRFAEAA CDVVHVMLNG SRSKIFDKNS TFGSVEVHNL QPEKVQTLEA 
    WVIHGGREDS RDLCQDPTIK ELESIISKRN IQFSCKNIYR PDKFLQCVKN PEDSSCTSEI

Genular Protein ID: 896845194

Symbol: B4E006_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 160
  • Mass: 17929
  • Checksum: E95F0F14F0DCAA1F
  • Sequence:
  • MANCEFSPVS GDKPCCRLSR IAQLCLGVSI LVLILVVVLA VVVPRWRQQW SGPGTTKRFP 
    ETVLARCVKY TEIHPEMRHV DCQSVWDAFK GAFISKHPCN ITEEDYQPLM KLGTQTVPCN 
    KKSTINLAQT GERTAATTLF QYSGKRFPAG LQKLPVMWSM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.