VPS4B | ENSG00000119541 | NCBI 9525

Details for: VPS4B

Gene ID: 9525

Symbol: VPS4B

Ensembl ID: ENSG00000119541

Description: vacuolar protein sorting 4 homolog B

Associated with

Budding and maturation of hiv virion
(R-HSA-162588)
Disease
(R-HSA-1643685)
Endosomal sorting complex required for transport (escrt)
(R-HSA-917729)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
Membrane trafficking
(R-HSA-199991)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Angiogenesis
(GO:0001525)
Atpase complex
(GO:1904949)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Autophagosome maturation
(GO:0097352)
Autophagy
(GO:0006914)
Canonical wnt signaling pathway
(GO:0060070)
Centrosome
(GO:0005813)
Cholesterol transport
(GO:0030301)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endosomal transport
(GO:0016197)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Endosome to lysosome transport via multivesicular body sorting pathway
(GO:0032510)
Escrt iii complex disassembly
(GO:1904903)
Establishment of blood-brain barrier
(GO:0060856)
Extracellular exosome
(GO:0070062)
Flemming body
(GO:0090543)
Identical protein binding
(GO:0042802)
Late endosomal microautophagy
(GO:0061738)
Late endosome membrane
(GO:0031902)
Late endosome to lysosome transport via multivesicular body sorting pathway
(GO:0061764)
Macroautophagy
(GO:0016236)
Membrane fission
(GO:0090148)
Midbody
(GO:0030496)
Midbody abscission
(GO:0061952)
Mitotic metaphase chromosome alignment
(GO:0007080)
Multivesicular body assembly
(GO:0036258)
Multivesicular body sorting pathway
(GO:0071985)
Negative regulation of exosomal secretion
(GO:1903542)
Nuclear membrane reassembly
(GO:0031468)
Nuclear pore
(GO:0005643)
Nucleus
(GO:0005634)
Nucleus organization
(GO:0006997)
Plasma membrane
(GO:0005886)
Plasma membrane repair
(GO:0001778)
Positive regulation of centriole elongation
(GO:1903724)
Positive regulation of exosomal secretion
(GO:1903543)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Potassium ion transport
(GO:0006813)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein depolymerization
(GO:0051261)
Protein homodimerization activity
(GO:0042803)
Protein transport
(GO:0015031)
Regulation of centrosome duplication
(GO:0010824)
Regulation of mitotic spindle assembly
(GO:1901673)
Response to lipid
(GO:0033993)
Spindle pole
(GO:0000922)
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
(GO:0043162)
Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
(GO:0090611)
Vacuole organization
(GO:0007033)
Viral budding from plasma membrane
(GO:0046761)
Viral budding via host escrt complex
(GO:0039702)

Other Information

Proteins

Cell migration-inducing gene 1 protein

Genular Protein ID: 1266318558

Symbol: VPS4B_HUMAN

Name: Cell migration-inducing gene 1 protein

UniProtKB Accession Codes:

O75351 Q69HW4 Q9GZS7

Database IDs:

Citations:

PubMed ID: 11563910

Title: Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking.

PubMed ID: 11563910

DOI: 10.1006/jmbi.2001.4917

PubMed ID: 12594041

Title: Comparative sequence and expression analyses of four mammalian VPS4 genes.

PubMed ID: 12594041

DOI: 10.1016/s0378-1119(02)01205-2

PubMed ID: 9653160

Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.

PubMed ID: 9653160

DOI: 10.1073/pnas.95.14.8175

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11559748

Title: CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins.

PubMed ID: 11559748

DOI: 10.1242/jcs.114.13.2395

PubMed ID: 14505570

Title: The protein network of HIV budding.

PubMed ID: 14505570

DOI: 10.1016/s0092-8674(03)00714-1

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18606141

Title: Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding.

PubMed ID: 18606141

DOI: 10.1016/j.devcel.2008.05.014

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18385515

Title: Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly.

PubMed ID: 18385515

DOI: 10.1091/mbc.e07-12-1263

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 18687924

Title: Helical structures of ESCRT-III are disassembled by VPS4.

PubMed ID: 18687924

DOI: 10.1126/science.1161070

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19129479

Title: Biochemical analyses of human IST1 and its function in cytokinesis.

PubMed ID: 19129479

DOI: 10.1091/mbc.e08-05-0475

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22660413

Title: Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.

PubMed ID: 22660413

DOI: 10.1038/ncb2502

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16018968

Title: Structural characterization of the MIT domain from human Vps4b.

PubMed ID: 16018968

DOI: 10.1016/j.bbrc.2005.06.110

PubMed ID: 16193069

Title: Structural and mechanistic studies of VPS4 proteins.

PubMed ID: 16193069

DOI: 10.1038/sj.emboj.7600818

PubMed ID: 17928862

Title: ESCRT-III recognition by VPS4 ATPases.

PubMed ID: 17928862

DOI: 10.1038/nature06172

Sequence Information:

Length: 444
Mass: 49302
Checksum: 9D565E4B20AF73FB
Sequence:

MSSTSPNLQK AIDLASKAAQ EDKAGNYEEA LQLYQHAVQY FLHVVKYEAQ GDKAKQSIRA 
KCTEYLDRAE KLKEYLKNKE KKAQKPVKEG QPSPADEKGN DSDGEGESDD PEKKKLQNQL 
QGAIVIERPN VKWSDVAGLE GAKEALKEAV ILPIKFPHLF TGKRTPWRGI LLFGPPGTGK 
SYLAKAVATE ANNSTFFSIS SSDLVSKWLG ESEKLVKNLF QLARENKPSI IFIDEIDSLC 
GSRSENESEA ARRIKTEFLV QMQGVGVDND GILVLGATNI PWVLDSAIRR RFEKRIYIPL 
PEPHARAAMF KLHLGTTQNS LTEADFRELG RKTDGYSGAD ISIIVRDALM QPVRKVQSAT 
HFKKVRGPSR ADPNHLVDDL LTPCSPGDPG AIEMTWMDVP GDKLLEPVVS MSDMLRSLSN 
TKPTVNEHDL LKLKKFTEDF GQEG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: VPS4B

Associated with

Other Information

Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking. PubMed ID: 11563910

Comparative sequence and expression analyses of four mammalian VPS4 genes. PubMed ID: 12594041

Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. PubMed ID: 9653160

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. PubMed ID: 11559748

The protein network of HIV budding. PubMed ID: 14505570

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. PubMed ID: 18606141

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly. PubMed ID: 18385515

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. PubMed ID: 18318008

Helical structures of ESCRT-III are disassembled by VPS4. PubMed ID: 18687924

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Biochemical analyses of human IST1 and its function in cytokinesis. PubMed ID: 19129479

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. PubMed ID: 22660413

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structural characterization of the MIT domain from human Vps4b. PubMed ID: 16018968

Structural and mechanistic studies of VPS4 proteins. PubMed ID: 16193069

ESCRT-III recognition by VPS4 ATPases. PubMed ID: 17928862