BAG5 | ENSG00000166170 | NCBI 9529

Details for: BAG5

Gene ID: 9529

Symbol: BAG5

Ensembl ID: ENSG00000166170

Description: BAG cochaperone 5

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Adenyl-nucleotide exchange factor activity
(GO:0000774)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Golgi organization
(GO:0007030)
Inclusion body
(GO:0016234)
Junctional membrane complex
(GO:0030314)
Membrane
(GO:0016020)
Mitochondrion
(GO:0005739)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
(GO:1902176)
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032435)
Negative regulation of protein refolding
(GO:0061084)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of ubiquitin-protein transferase activity
(GO:0051444)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein folding
(GO:0006457)
Protein kinase binding
(GO:0019901)
Protein stabilization
(GO:0050821)
Regulation of inclusion body assembly
(GO:0090083)
Regulation of ubiquitin-protein transferase activity
(GO:0051438)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

BAG family molecular chaperone regulator 5

Genular Protein ID: 2999744703

Symbol: BAG5_HUMAN

Name: BAG family molecular chaperone regulator 5

UniProtKB Accession Codes:

Q9UL15 O94950 Q86W59

Database IDs:

Citations:

PubMed ID: 9873016

Title: An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.

PubMed ID: 9873016

DOI: 10.1074/jbc.274.2.781

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24270810

Title: High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.

PubMed ID: 24270810

DOI: 10.1038/nature12748

PubMed ID: 20223214

Title: The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange.

PubMed ID: 20223214

DOI: 10.1016/j.str.2010.01.004

PubMed ID: 35044787

Title: Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation.

PubMed ID: 35044787

DOI: 10.1126/scitranslmed.abf3274

Sequence Information:

Length: 447
Mass: 51200
Checksum: 0D3F7EA6B612C1F5
Sequence:

MDMGNQHPSI SRLQEIQKEV KSVEQQVIGF SGLSDDKNYK KLERILTKQL FEIDSVDTEG 
KGDIQQARKR AAQETERLLK ELEQNANHPH RIEIQNIFEE AQSLVREKIV PFYNGGNCVT 
DEFEEGIQDI ILRLTHVKTG GKISLRKARY HTLTKICAVQ EIIEDCMKKQ PSLPLSEDAH 
PSVAKINFVM CEVNKARGVL IALLMGVNNN ETCRHLSCVL SGLIADLDAL DVCGRTEIRN 
YRREVVEDIN KLLKYLDLEE EADTTKAFDL RQNHSILKIE KVLKRMREIK NELLQAQNPS 
ELYLSSKTEL QGLIGQLDEV SLEKNPCIRE ARRRAVIEVQ TLITYIDLKE ALEKRKLFAC 
EEHPSHKAVW NVLGNLSEIQ GEVLSFDGNR TDKNYIRLEE LLTKQLLALD AVDPQGEEKC 
KAARKQAVRL AQNILSYLDL KSDEWEY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BAG5

Associated with

Other Information

An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. PubMed ID: 9873016

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10048485

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial characterization of the human central proteome. PubMed ID: 21269460

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. PubMed ID: 24270810

The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange. PubMed ID: 20223214

Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation. PubMed ID: 35044787