Details for: ENTPD1

Gene ID: 953

Symbol: ENTPD1

Ensembl ID: ENSG00000138185

Description: ectonucleoside triphosphate diphosphohydrolase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 117.8435
    Cell Significance Index: -18.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.5034
    Cell Significance Index: -18.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.4392
    Cell Significance Index: -18.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 38.8458
    Cell Significance Index: -18.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.3565
    Cell Significance Index: -19.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.8180
    Cell Significance Index: -18.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.6122
    Cell Significance Index: -16.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.3786
    Cell Significance Index: -16.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6350
    Cell Significance Index: -18.2900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.4688
    Cell Significance Index: 69.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.8300
    Cell Significance Index: -10.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.7825
    Cell Significance Index: 31.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.5510
    Cell Significance Index: 156.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3552
    Cell Significance Index: 70.5900
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.1941
    Cell Significance Index: 7.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9927
    Cell Significance Index: 26.6000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8396
    Cell Significance Index: 7.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7666
    Cell Significance Index: 145.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6195
    Cell Significance Index: 11.4500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5736
    Cell Significance Index: 8.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5724
    Cell Significance Index: 56.6300
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.4934
    Cell Significance Index: 5.1100
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.4440
    Cell Significance Index: 2.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4316
    Cell Significance Index: 389.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2952
    Cell Significance Index: 48.0100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2892
    Cell Significance Index: 5.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2496
    Cell Significance Index: 49.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1913
    Cell Significance Index: 20.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0960
    Cell Significance Index: 2.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0876
    Cell Significance Index: 54.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0824
    Cell Significance Index: 16.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0812
    Cell Significance Index: 152.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0604
    Cell Significance Index: 21.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0597
    Cell Significance Index: 27.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0561
    Cell Significance Index: 5.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0265
    Cell Significance Index: 14.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0252
    Cell Significance Index: 1.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0237
    Cell Significance Index: 32.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0170
    Cell Significance Index: 10.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0100
    Cell Significance Index: 15.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0092
    Cell Significance Index: 0.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0037
    Cell Significance Index: 6.7600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0043
    Cell Significance Index: -0.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0076
    Cell Significance Index: -0.9000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0100
    Cell Significance Index: -0.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0110
    Cell Significance Index: -1.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0120
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0150
    Cell Significance Index: -11.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0170
    Cell Significance Index: -0.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0182
    Cell Significance Index: -2.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0199
    Cell Significance Index: -11.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0229
    Cell Significance Index: -17.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0256
    Cell Significance Index: -5.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0257
    Cell Significance Index: -18.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0428
    Cell Significance Index: -18.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0485
    Cell Significance Index: -1.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0517
    Cell Significance Index: -14.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0575
    Cell Significance Index: -10.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0675
    Cell Significance Index: -6.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0746
    Cell Significance Index: -12.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0792
    Cell Significance Index: -10.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0980
    Cell Significance Index: -11.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1006
    Cell Significance Index: -12.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1078
    Cell Significance Index: -12.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1165
    Cell Significance Index: -5.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1318
    Cell Significance Index: -3.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1373
    Cell Significance Index: -10.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1405
    Cell Significance Index: -4.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1420
    Cell Significance Index: -18.3500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1496
    Cell Significance Index: -2.5700
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1580
    Cell Significance Index: -1.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1794
    Cell Significance Index: -5.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1879
    Cell Significance Index: -21.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2029
    Cell Significance Index: -12.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2092
    Cell Significance Index: -4.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2128
    Cell Significance Index: -6.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2235
    Cell Significance Index: -15.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2372
    Cell Significance Index: -13.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2415
    Cell Significance Index: -19.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2458
    Cell Significance Index: -15.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2491
    Cell Significance Index: -11.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2494
    Cell Significance Index: -18.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2545
    Cell Significance Index: -16.4200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2863
    Cell Significance Index: -12.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2892
    Cell Significance Index: -20.4500
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.3147
    Cell Significance Index: -3.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3201
    Cell Significance Index: -14.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3645
    Cell Significance Index: -6.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3690
    Cell Significance Index: -19.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3711
    Cell Significance Index: -19.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3729
    Cell Significance Index: -14.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3867
    Cell Significance Index: -18.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4093
    Cell Significance Index: -14.3400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4117
    Cell Significance Index: -8.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4565
    Cell Significance Index: -10.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4637
    Cell Significance Index: -15.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4788
    Cell Significance Index: -15.2500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5083
    Cell Significance Index: -8.7100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5195
    Cell Significance Index: -7.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ENTPD1 is a membrane-bound enzyme that belongs to the ectonucleoside triphosphate diphosphohydrolase family. It is characterized by its ability to hydrolyze nucleoside triphosphate (NTP) and diphosphate (NDP) molecules, generating nucleoside monophosphate (NMP) and pyrophosphate (PPi) products. ENTPD1 is highly expressed in immune cells, such as macrophages, lymphocytes, and microglia, where it regulates purinergic signaling and modulates inflammatory responses. **Pathways and Functions:** ENTPD1 plays a crucial role in various signaling pathways, including: 1. **Purinergic signaling**: ENTPD1 regulates the breakdown of NTP and NDP molecules, influencing purinergic signaling pathways that modulate immune responses, inflammation, and cell survival. 2. **Inflammatory responses**: ENTPD1 modulates the production of pro-inflammatory cytokines and chemokines, influencing the recruitment of immune cells to sites of inflammation. 3. **Immune cell function**: ENTPD1 regulates the activity of immune cells, including macrophages, lymphocytes, and microglia, influencing their proliferation, differentiation, and survival. 4. **Cell adhesion and migration**: ENTPD1 modulates the expression of adhesion molecules and integrins, influencing the migration and invasion of immune cells. **Clinical Significance:** ENTPD1 has been implicated in various immune-related disorders, including: 1. **Leishmaniasis**: ENTPD1 has been shown to play a critical role in the regulation of purinergic signaling pathways in Leishmania-infected cells, influencing the progression of the disease. 2. **Inflammatory diseases**: ENTPD1 has been implicated in the pathogenesis of inflammatory diseases, such as atherosclerosis, arthritis, and multiple sclerosis. 3. **Cancer**: ENTPD1 has been shown to regulate the activity of immune cells in the tumor microenvironment, influencing cancer progression and metastasis. 4. **Neurological disorders**: ENTPD1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In conclusion, ENTPD1 is a critical regulator of purinergic signaling pathways, immune cell function, and inflammatory responses. Its dysregulation has been implicated in various immune-related disorders, highlighting the need for further research into the role of ENTPD1 in human disease.

Genular Protein ID: 469578330

Symbol: ENTP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P49961 A9Z1X8 B4DWB9 B4E1X1 B7Z599 G3XAF6 Q5T561 Q5T562 Q86VV3 Q9UQQ9 Q9Y3Q9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CPTAC 1 CPTC 1 CTD 1 ChEBI 92 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 15 Ensembl 4 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 2 RefSeq 12 Rhea 36 SABIO-RK 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7930580

Title: The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization.

PubMed ID: 7930580

PubMed ID: 8955160

Title: Identification and characterization of CD39/vascular ATP diphosphohydrolase.

PubMed ID: 8955160

DOI: 10.1074/jbc.271.51.33116

PubMed ID: 10405171

Title: The cDNA cloning of human placental ecto-ATP diphosphohydrolases I and II.

PubMed ID: 10405171

DOI: 10.1016/s0014-5793(99)00751-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8529670

Title: Purification and properties of human placental ATP diphosphohydrolase.

PubMed ID: 8529670

DOI: 10.1111/j.1432-1033.1995.066_c.x

PubMed ID: 9846014

Title: Placental ecto-ATP diphosphohydrolase: its structural feature distinct from CD39, localization and inhibition on shear-induced platelet aggregation.

PubMed ID: 9846014

DOI: 10.1016/s0925-5710(98)00080-2

PubMed ID: 8996251

Title: Loss of ATP diphosphohydrolase activity with endothelial cell activation.

PubMed ID: 8996251

DOI: 10.1084/jem.185.1.153

PubMed ID: 8626624

Title: CD39 is an ecto-(Ca2+,Mg2+)-apyrase.

PubMed ID: 8626624

DOI: 10.1074/jbc.271.17.10391

PubMed ID: 10636909

Title: Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae.

PubMed ID: 10636909

DOI: 10.1074/jbc.275.3.2057

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24482476

Title: Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.

PubMed ID: 24482476

DOI: 10.1126/science.1247363

Sequence Information:

  • Length: 510
  • Mass: 57965
  • Checksum: BAD87D2499649159
  • Sequence:
    • MEDTKESNVK TFCSKNILAI LGFSSIIAVI ALLAVGLTQN KALPENVKYG IVLDAGSSHT 
SLYIYKWPAE KENDTGVVHQ VEECRVKGPG ISKFVQKVNE IGIYLTDCME RAREVIPRSQ 
HQETPVYLGA TAGMRLLRME SEELADRVLD VVERSLSNYP FDFQGARIIT GQEEGAYGWI 
TINYLLGKFS QKTRWFSIVP YETNNQETFG ALDLGGASTQ VTFVPQNQTI ESPDNALQFR 
LYGKDYNVYT HSFLCYGKDQ ALWQKLAKDI QVASNEILRD PCFHPGYKKV VNVSDLYKTP 
CTKRFEMTLP FQQFEIQGIG NYQQCHQSIL ELFNTSYCPY SQCAFNGIFL PPLQGDFGAF 
SAFYFVMKFL NLTSEKVSQE KVTEMMKKFC AQPWEEIKTS YAGVKEKYLS EYCFSGTYIL 
SLLLQGYHFT ADSWEHIHFI GKIQGSDAGW TLGYMLNLTN MIPAEQPLST PLSHSTYVFL 
MVLFSLVLFT VAIIGLLIFH KPSYFWKDMV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.