BAG3 | ENSG00000151929 | NCBI 9531

Details for: BAG3

Gene ID: 9531

Symbol: BAG3

Ensembl ID: ENSG00000151929

Description: BAG cochaperone 3

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Adenyl-nucleotide exchange factor activity
(GO:0000774)
Aggresome
(GO:0016235)
Aggresome assembly
(GO:0070842)
Autophagosome assembly
(GO:0000045)
Cadherin binding
(GO:0045296)
Cellular response to heat
(GO:0034605)
Cellular response to mechanical stimulus
(GO:0071260)
Cellular response to unfolded protein
(GO:0034620)
Chaperone-mediated autophagy
(GO:0061684)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dynein intermediate chain binding
(GO:0045505)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Membrane
(GO:0016020)
Muscle cell cellular homeostasis
(GO:0046716)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of striated muscle cell apoptotic process
(GO:0010664)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of aggrephagy
(GO:1905337)
Positive regulation of protein export from nucleus
(GO:0046827)
Positive regulation of protein import into nucleus
(GO:0042307)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein carrier chaperone
(GO:0140597)
Protein folding
(GO:0006457)
Protein folding chaperone complex
(GO:0101031)
Protein stabilization
(GO:0050821)
Protein transport along microtubule
(GO:0098840)
Stress fiber
(GO:0001725)
Striated muscle cell apoptotic process
(GO:0010658)
Z disc
(GO:0030018)

Other Information

Proteins

BAG family molecular chaperone regulator 3

Genular Protein ID: 3742340647

Symbol: BAG3_HUMAN

Name: BAG family molecular chaperone regulator 3

UniProtKB Accession Codes:

O95817 A8K5L8 Q3B763 Q9NT20 Q9P120

Database IDs:

Citations:

PubMed ID: 9873016

Title: An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.

PubMed ID: 9873016

DOI: 10.1074/jbc.274.2.781

PubMed ID: 10597216

Title: Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.

PubMed ID: 10597216

DOI: 10.1038/sj.onc.1203043

PubMed ID: 10980614

Title: CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70.

PubMed ID: 10980614

DOI: 10.1038/sj.onc.1203797

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22366786

Title: Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy.

PubMed ID: 22366786

DOI: 10.1038/ng.1103

PubMed ID: 23434281

Title: Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.

PubMed ID: 23434281

DOI: 10.1016/j.cub.2013.01.064

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24318877

Title: Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.

PubMed ID: 24318877

DOI: 10.1074/jbc.m113.521997

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 26159920

Title: BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress.

PubMed ID: 26159920

DOI: 10.1016/j.bbrc.2015.07.006

PubMed ID: 27474739

Title: Non-canonical interactions between heat shock cognate protein 70 (Hsc70) and Bcl2-associated anthanogene (BAG) co-chaperones are important for client release.

PubMed ID: 27474739

DOI: 10.1074/jbc.m116.742502

PubMed ID: 28144995

Title: Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations.

PubMed ID: 28144995

DOI: 10.1002/humu.23189

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 19085932

Title: Mutation in BAG3 causes severe dominant childhood muscular dystrophy.

PubMed ID: 19085932

DOI: 10.1002/ana.21553

PubMed ID: 21353195

Title: Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy.

PubMed ID: 21353195

DOI: 10.1016/j.ajhg.2011.01.016

PubMed ID: 21361913

Title: BAG3-related myofibrillar myopathy in a Chinese family.

PubMed ID: 21361913

DOI: 10.1111/j.1399-0004.2011.01659.x

PubMed ID: 21459883

Title: A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy.

PubMed ID: 21459883

DOI: 10.1093/eurheartj/ehr105

PubMed ID: 21898660

Title: Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes.

PubMed ID: 21898660

DOI: 10.1002/humu.21603

Sequence Information:

Length: 575
Mass: 61595
Checksum: A6328A44F37A406A
Sequence:

MSAATHSPMM QVASGNGDRD PLPPGWEIKI DPQTGWPFFV DHNSRTTTWN DPRVPSEGPK 
ETPSSANGPS REGSRLPPAR EGHPVYPQLR PGYIPIPVLH EGAENRQVHP FHVYPQPGMQ 
RFRTEAAAAA PQRSQSPLRG MPETTQPDKQ CGQVAAAAAA QPPASHGPER SQSPAASDCS 
SSSSSASLPS SGRSSLGSHQ LPRGYISIPV IHEQNVTRPA AQPSFHQAQK THYPAQQGEY 
QTHQPVYHKI QGDDWEPRPL RAASPFRSSV QGASSREGSP ARSSTPLHSP SPIRVHTVVD 
RPQQPMTHRE TAPVSQPENK PESKPGPVGP ELPPGHIPIQ VIRKEVDSKP VSQKPPPPSE 
KVEVKVPPAP VPCPPPSPGP SAVPSSPKSV ATEERAAPST APAEATPPKP GEAEAPPKHP 
GVLKVEAILE KVQGLEQAVD NFEGKKTDKK YLMIEEYLTK ELLALDSVDP EGRADVRQAR 
RDGVRKVQTI LEKLEQKAID VPGQVQVYEL QPSNLEADQP LQAIMEMGAV AADKGKKNAG 
NAEDPHTETQ QPEATAAATS NPSSMTDTPG NPAAP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BAG3

Associated with

Other Information

An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. PubMed ID: 9873016

Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. PubMed ID: 10597216

CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70. PubMed ID: 10980614

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy. PubMed ID: 22366786

Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. PubMed ID: 23434281

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. PubMed ID: 24318877

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress. PubMed ID: 26159920

Non-canonical interactions between heat shock cognate protein 70 (Hsc70) and Bcl2-associated anthanogene (BAG) co-chaperones are important for client release. PubMed ID: 27474739

Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations. PubMed ID: 28144995

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Mutation in BAG3 causes severe dominant childhood muscular dystrophy. PubMed ID: 19085932

Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy. PubMed ID: 21353195

BAG3-related myofibrillar myopathy in a Chinese family. PubMed ID: 21361913

A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. PubMed ID: 21459883

Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes. PubMed ID: 21898660