POLR1C | ENSG00000171453 | NCBI 9533

Details for: POLR1C

Gene ID: 9533

Symbol: POLR1C

Ensembl ID: ENSG00000171453

Description: RNA polymerase I and III subunit C

Associated with

B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Epigenetic regulation of gene expression
(R-HSA-212165)
Gene expression (transcription)
(R-HSA-74160)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Rna polymerase iii abortive and retractive initiation
(R-HSA-749476)
Rna polymerase iii chain elongation
(R-HSA-73780)
Rna polymerase iii transcription
(R-HSA-74158)
Rna polymerase iii transcription initiation
(R-HSA-76046)
Rna polymerase iii transcription initiation from type 1 promoter
(R-HSA-76061)
Rna polymerase iii transcription initiation from type 2 promoter
(R-HSA-76066)
Rna polymerase iii transcription initiation from type 3 promoter
(R-HSA-76071)
Rna polymerase iii transcription termination
(R-HSA-73980)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Rna polymerase i transcription termination
(R-HSA-73863)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-directed 5'-3' rna polymerase activity
(GO:0003899)
Dna binding
(GO:0003677)
Fibrillar center
(GO:0001650)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Rna polymerase i activity
(GO:0001054)
Rna polymerase i complex
(GO:0005736)
Rna polymerase iii activity
(GO:0001056)
Rna polymerase iii complex
(GO:0005666)
Transcription by rna polymerase i
(GO:0006360)
Transcription by rna polymerase iii
(GO:0006383)

Other Information

Proteins

DNA-directed RNA polymerases I and III subunit RPAC1

Genular Protein ID: 1308567985

Symbol: RPAC1_HUMAN

Name: DNA-directed RNA polymerases I and III subunit RPAC1

UniProtKB Accession Codes:

O15160 O75395 Q5JTE3

Database IDs:

Citations:

PubMed ID: 9540830

Title: Cloning and characterization of the human RNA polymerase I subunit hRPA40.

PubMed ID: 9540830

DOI: 10.1016/s0167-4781(97)00206-6

PubMed ID: 9653160

Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.

PubMed ID: 9653160

DOI: 10.1073/pnas.95.14.8175

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12391170

Title: Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.

PubMed ID: 12391170

DOI: 10.1128/mcb.22.22.8044-8055.2002

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20413673

Title: Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells.

PubMed ID: 20413673

DOI: 10.1101/gr.101337.109

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26151409

Title: Recessive mutations in POLR1C cause a leukodystrophy by impairing biogenesis of RNA polymerase III.

PubMed ID: 26151409

DOI: 10.1038/ncomms8623

PubMed ID: 33335104

Title: Structure of human RNA polymerase III.

PubMed ID: 33335104

DOI: 10.1038/s41467-020-20262-5

PubMed ID: 33674783

Title: Structure of human RNA polymerase III elongation complex.

PubMed ID: 33674783

DOI: 10.1038/s41422-021-00472-2

PubMed ID: 34675218

Title: Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.

PubMed ID: 34675218

DOI: 10.1038/s41467-021-26402-9

PubMed ID: 33558764

Title: Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.

PubMed ID: 33558764

DOI: 10.1038/s41594-020-00555-5

PubMed ID: 33558766

Title: Structural insights into transcriptional regulation of human RNA polymerase III.

PubMed ID: 33558766

DOI: 10.1038/s41594-021-00557-x

PubMed ID: 21131976

Title: Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome.

PubMed ID: 21131976

DOI: 10.1038/ng.724

Sequence Information:

Length: 346
Mass: 39250
Checksum: B7D558BC8F33D92E
Sequence:

MAASQAVEEM RSRVVLGEFG VRNVHTTDFP GNYSGYDDAW DQDRFEKNFR VDVVHMDENS 
LEFDMVGIDA AIANAFRRIL LAEVPTMAVE KVLVYNNTSI VQDEILAHRL GLIPIHADPR 
LFEYRNQGDE EGTEIDTLQF RLQVRCTRNP HAAKDSSDPN ELYVNHKVYT RHMTWIPLGN 
QADLFPEGTI RPVHDDILIA QLRPGQEIDL LMHCVKGIGK DHAKFSPVAT ASYRLLPDIT 
LLEPVEGEAA EELSRCFSPG VIEVQEVQGK KVARVANPRL DTFSREIFRN EKLKKVVRLA 
RVRDHYIFSV ESTGVLPPDV LVSEAIKVLM GKCRRFLDEL DAVQMD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: POLR1C

Associated with

Other Information

Cloning and characterization of the human RNA polymerase I subunit hRPA40. PubMed ID: 9540830

Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. PubMed ID: 9653160

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. PubMed ID: 12391170

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells. PubMed ID: 20413673

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Recessive mutations in POLR1C cause a leukodystrophy by impairing biogenesis of RNA polymerase III. PubMed ID: 26151409

Structure of human RNA polymerase III. PubMed ID: 33335104

Structure of human RNA polymerase III elongation complex. PubMed ID: 33674783

Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine. PubMed ID: 34675218

Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. PubMed ID: 33558764

Structural insights into transcriptional regulation of human RNA polymerase III. PubMed ID: 33558766

Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome. PubMed ID: 21131976