PTGES | ENSG00000148344 | NCBI 9536

Details for: PTGES

Gene ID: 9536

Symbol: PTGES

Ensembl ID: ENSG00000148344

Description: prostaglandin E synthase

Associated with

Arachidonic acid metabolism
(R-HSA-2142753)
Fatty acid metabolism
(R-HSA-8978868)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Synthesis of prostaglandins (pg) and thromboxanes (tx)
(R-HSA-2162123)
Cell population proliferation
(GO:0008283)
Cellular oxidant detoxification
(GO:0098869)
Endoplasmic reticulum membrane
(GO:0005789)
Glutathione binding
(GO:0043295)
Glutathione peroxidase activity
(GO:0004602)
Glutathione transferase activity
(GO:0004364)
Membrane
(GO:0016020)
Negative regulation of cell population proliferation
(GO:0008285)
Nuclear envelope lumen
(GO:0005641)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of prostaglandin secretion
(GO:0032308)
Prostaglandin-d synthase activity
(GO:0004667)
Prostaglandin-e synthase activity
(GO:0050220)
Prostaglandin biosynthetic process
(GO:0001516)
Prostaglandin metabolic process
(GO:0006693)
Protein binding
(GO:0005515)
Regulation of fever generation
(GO:0031620)
Regulation of inflammatory response
(GO:0050727)
Sensory perception of pain
(GO:0019233)
Signal transduction
(GO:0007165)

Other Information

Proteins

Prostaglandin E synthase

Genular Protein ID: 4231975511

Symbol: PTGES_HUMAN

Name: Prostaglandin E synthase

UniProtKB Accession Codes:

O14684 O14900 Q5SZC0

Database IDs:

Citations:

PubMed ID: 9305847

Title: A model for p53-induced apoptosis.

PubMed ID: 9305847

DOI: 10.1038/38525

PubMed ID: 10377395

Title: Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target.

PubMed ID: 10377395

DOI: 10.1073/pnas.96.13.7220

PubMed ID: 10760517

Title: Human glutathione dependent prostaglandin E synthase: gene structure and regulation.

PubMed ID: 10760517

DOI: 10.1016/s0014-5793(00)01367-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10869354

Title: Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2.

PubMed ID: 10869354

DOI: 10.1074/jbc.m003505200

PubMed ID: 12244105

Title: Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides.

PubMed ID: 12244105

DOI: 10.1074/jbc.m206788200

PubMed ID: 12460774

Title: Purification and characterization of recombinant microsomal prostaglandin E synthase-1.

PubMed ID: 12460774

DOI: 10.1016/s1046-5928(02)00566-1

PubMed ID: 16439136

Title: Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis.

PubMed ID: 16439136

DOI: 10.1016/j.bmc.2006.01.010

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 12672824

Title: Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination.

PubMed ID: 12672824

DOI: 10.1074/jbc.m303227200

PubMed ID: 27684486

Title: Arg126 and Asp49 Are Essential for the Catalytic Function of Microsomal Prostaglandin E2 Synthase 1 and Ser127 Is Not.

PubMed ID: 27684486

DOI: 10.1371/journal.pone.0163600

PubMed ID: 26755582

Title: A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase.

PubMed ID: 26755582

DOI: 10.1073/pnas.1522891113

PubMed ID: 18682561

Title: Structural basis for induced formation of the inflammatory mediator prostaglandin E2.

PubMed ID: 18682561

DOI: 10.1073/pnas.0802894105

PubMed ID: 23431194

Title: Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily.

PubMed ID: 23431194

DOI: 10.1073/pnas.1218504110

Sequence Information:

Length: 152
Mass: 17102
Checksum: BF9B9ED81CA67A3D
Sequence:

MPAHSLVMSS PALPAFLLCS TLLVIKMYVV AIITGQVRLR KKAFANPEDA LRHGGPQYCR 
SDPDVERCLR AHRNDMETIY PFLFLGFVYS FLGPNPFVAW MHFLVFLVGR VAHTVAYLGK 
LRAPIRSVTY TLAQLPCASM ALQILWEAAR HL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PTGES

Associated with

Other Information

A model for p53-induced apoptosis. PubMed ID: 9305847

Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. PubMed ID: 10377395

Human glutathione dependent prostaglandin E synthase: gene structure and regulation. PubMed ID: 10760517

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2. PubMed ID: 10869354

Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. PubMed ID: 12244105

Purification and characterization of recombinant microsomal prostaglandin E synthase-1. PubMed ID: 12460774

Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis. PubMed ID: 16439136

Initial characterization of the human central proteome. PubMed ID: 21269460

Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. PubMed ID: 12672824

Arg126 and Asp49 Are Essential for the Catalytic Function of Microsomal Prostaglandin E2 Synthase 1 and Ser127 Is Not. PubMed ID: 27684486

A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase. PubMed ID: 26755582

Structural basis for induced formation of the inflammatory mediator prostaglandin E2. PubMed ID: 18682561

Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily. PubMed ID: 23431194