Details for: ENTPD2

Gene ID: 954

Symbol: ENTPD2

Ensembl ID: ENSG00000054179

Description: ectonucleoside triphosphate diphosphohydrolase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.0650
    Cell Significance Index: -7.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.3783
    Cell Significance Index: -9.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6476
    Cell Significance Index: 74.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1613
    Cell Significance Index: 25.1600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9744
    Cell Significance Index: 14.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9406
    Cell Significance Index: 27.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8623
    Cell Significance Index: 778.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7286
    Cell Significance Index: 43.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6927
    Cell Significance Index: 75.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6851
    Cell Significance Index: 48.4500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.6577
    Cell Significance Index: 5.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6455
    Cell Significance Index: 75.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5957
    Cell Significance Index: 96.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5497
    Cell Significance Index: 54.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3867
    Cell Significance Index: 26.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3006
    Cell Significance Index: 132.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2950
    Cell Significance Index: 56.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2681
    Cell Significance Index: 5.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2388
    Cell Significance Index: 7.6500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.2182
    Cell Significance Index: 3.1000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1863
    Cell Significance Index: 0.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1732
    Cell Significance Index: 22.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1649
    Cell Significance Index: 3.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1150
    Cell Significance Index: 4.0400
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.1071
    Cell Significance Index: 1.1900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0957
    Cell Significance Index: 0.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0628
    Cell Significance Index: 2.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0572
    Cell Significance Index: 1.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0390
    Cell Significance Index: 2.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0383
    Cell Significance Index: 4.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0338
    Cell Significance Index: 18.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0239
    Cell Significance Index: 2.7400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0199
    Cell Significance Index: 0.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0165
    Cell Significance Index: 0.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0064
    Cell Significance Index: 4.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0005
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0012
    Cell Significance Index: -0.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0016
    Cell Significance Index: -0.9300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0041
    Cell Significance Index: -2.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0074
    Cell Significance Index: -13.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0085
    Cell Significance Index: -13.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0088
    Cell Significance Index: -1.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0106
    Cell Significance Index: -14.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0112
    Cell Significance Index: -8.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0120
    Cell Significance Index: -9.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0127
    Cell Significance Index: -2.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0129
    Cell Significance Index: -8.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0130
    Cell Significance Index: -4.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0134
    Cell Significance Index: -0.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0145
    Cell Significance Index: -2.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0225
    Cell Significance Index: -10.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0235
    Cell Significance Index: -4.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0238
    Cell Significance Index: -6.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0282
    Cell Significance Index: -5.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0315
    Cell Significance Index: -0.4300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0364
    Cell Significance Index: -1.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0417
    Cell Significance Index: -5.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0438
    Cell Significance Index: -1.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0444
    Cell Significance Index: -3.3100
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.0485
    Cell Significance Index: -0.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0516
    Cell Significance Index: -7.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0537
    Cell Significance Index: -2.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0544
    Cell Significance Index: -6.6900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0584
    Cell Significance Index: -1.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0584
    Cell Significance Index: -3.5800
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.0618
    Cell Significance Index: -0.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0656
    Cell Significance Index: -3.4100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0674
    Cell Significance Index: -1.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0687
    Cell Significance Index: -1.8700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0808
    Cell Significance Index: -1.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0824
    Cell Significance Index: -8.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1058
    Cell Significance Index: -8.3800
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1155
    Cell Significance Index: -1.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1196
    Cell Significance Index: -14.1100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1218
    Cell Significance Index: -1.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1244
    Cell Significance Index: -6.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1247
    Cell Significance Index: -9.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1269
    Cell Significance Index: -8.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1495
    Cell Significance Index: -9.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1505
    Cell Significance Index: -3.1500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1505
    Cell Significance Index: -1.0200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1536
    Cell Significance Index: -3.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1584
    Cell Significance Index: -1.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1597
    Cell Significance Index: -1.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1650
    Cell Significance Index: -7.3000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1658
    Cell Significance Index: -2.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1768
    Cell Significance Index: -9.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1815
    Cell Significance Index: -9.5300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1897
    Cell Significance Index: -2.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1901
    Cell Significance Index: -6.6600
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: -0.1959
    Cell Significance Index: -0.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1962
    Cell Significance Index: -5.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2015
    Cell Significance Index: -7.6300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2053
    Cell Significance Index: -2.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2137
    Cell Significance Index: -3.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2303
    Cell Significance Index: -7.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2315
    Cell Significance Index: -5.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2343
    Cell Significance Index: -8.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ENTPD2 is a membrane-bound protein with a high degree of sequence similarity to other ENT family members. Its primary function is to hydrolyze nucleoside triphosphates (NTPs) and diphosphonucleotides (NDPs) into their corresponding nucleoside monophosphates (NMPs) and diphosphonucleotides (NDPs). This process is essential for maintaining nucleotide homeostasis and regulating various cellular signaling pathways. **Pathways and Functions:** ENTPD2 is involved in multiple cellular processes, including: 1. **Nucleotide Metabolism:** ENTPD2 regulates the breakdown of NTPs and NDPs, which is crucial for maintaining nucleotide homeostasis and preventing excessive accumulation of these molecules. 2. **Cell Signaling:** ENTPD2 modulates various signaling pathways, including the G-protein coupled receptor (GPCR) pathway, which is involved in regulating cell growth, differentiation, and survival. 3. **Endoplasmic Reticulum (ER) Membrane:** ENTPD2 is also present on the ER membrane, where it regulates the degradation of misfolded proteins and lipid metabolism. 4. **Extracellular Exosome:** ENTPD2 is secreted into the extracellular environment, where it can influence cellular communication and immune responses. **Significantly Expressed Cells:** ENTPD2 is expressed in various cell types, including: 1. **Kidney Proximal Convoluted Tubule Epithelial Cells:** ENTPD2 plays a crucial role in maintaining renal function and regulating electrolyte balance. 2. **Mural Cells:** ENTPD2 is involved in the regulation of vascular tone and blood pressure. 3. **Granulocyte Monocyte Progenitor Cells:** ENTPD2 regulates the development and function of immune cells. 4. **Cerebral Cortex GABAergic Interneurons:** ENTPD2 modulates neurotransmitter release and synaptic transmission in the brain. **Clinical Significance:** Dysregulation of ENTPD2 has been implicated in various diseases, including: 1. **Renal Disease:** ENTPD2 deficiency has been linked to kidney dysfunction and electrolyte imbalance. 2. **Vascular Disease:** ENTPD2 dysregulation has been associated with hypertension and cardiovascular disease. 3. **Neurological Disorders:** ENTPD2 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Cancer:** ENTPD2 dysregulation has been linked to cancer progression and metastasis. In conclusion, ENTPD2 is a multifaceted gene with a wide range of cellular expressions and functions. Further research is needed to fully understand the role of ENTPD2 in maintaining cellular homeostasis and regulating various signaling pathways.

Genular Protein ID: 2671766504

Symbol: ENTP2_HUMAN

Name: Ectonucleoside triphosphate diphosphohydrolase 2

UniProtKB Accession Codes:

Q9Y5L3 O15464 Q5SPY6 Q5SPY7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 2 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SABIO-RK 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9271669

Title: Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes.

PubMed ID: 9271669

DOI: 10.1007/s003359900534

PubMed ID: 10510450

Title: Functional expression of a cDNA encoding a human ecto-ATPase.

PubMed ID: 10510450

DOI: 10.1038/sj.bjp.0702805

PubMed ID: 16101300

Title: Either the carboxyl- or the amino-terminal region of the human ecto-ATPase (E-NTPDase 2) confers detergent and temperature sensitivity to the chicken ecto-ATP-diphosphohydrolase (E-NTPDase 8).

PubMed ID: 16101300

DOI: 10.1021/bi050019k

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12888562

Title: Requirement of Cys399 for processing of the human ecto-ATPase (NTPDase2) and its implications for determination of the activities of splice variants of the enzyme.

PubMed ID: 12888562

DOI: 10.1074/jbc.m307854200

Sequence Information:

  • Length: 495
  • Mass: 53665
  • Checksum: 3BDBA114A679B422
  • Sequence:
    • MAGKVRSLLP PLLLAAAGLA GLLLLCVPTR DVREPPALKY GIVLDAGSSH TSMFIYKWPA 
DKENDTGIVG QHSSCDVPGG GISSYADNPS GASQSLVGCL EQALQDVPKE RHAGTPLYLG 
ATAGMRLLNL TNPEASTSVL MAVTHTLTQY PFDFRGARIL SGQEEGVFGW VTANYLLENF 
IKYGWVGRWF RPRKGTLGAM DLGGASTQIT FETTSPAEDR ASEVQLHLYG QHYRVYTHSF 
LCYGRDQVLQ RLLASALQTH GFHPCWPRGF STQVLLGDVY QSPCTMAQRP QNFNSSARVS 
LSGSSDPHLC RDLVSGLFSF SSCPFSRCSF NGVFQPPVAG NFVAFSAFFY TVDFLRTSMG 
LPVATLQQLE AAAVNVCNQT WAQLQARVPG QRARLADYCA GAMFVQQLLS RGYGFDERAF 
GGVIFQKKAA DTAVGWALGY MLNLTNLIPA DPPGLRKGTD FSSWVVLLLL FASALLAALV 
LLLRQVHSAK LPSTI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.