Gene ENTPD2 - ENSG00000054179 | NCBI Gene ID: 954

Details for: ENTPD2

Gene ID: 954

Symbol: ENTPD2

Ensembl ID: ENSG00000054179

Description: ectonucleoside triphosphate diphosphohydrolase 2

Associated with

Metabolism
(R-HSA-1430728)
Metabolism of nucleotides
(R-HSA-15869)
Nucleotide catabolism
(R-HSA-8956319)
Phosphate bond hydrolysis by ntpdase proteins
(R-HSA-8850843)
Atp binding
(GO:0005524)
Basement membrane
(GO:0005604)
Endoplasmic reticulum membrane
(GO:0005789)
Extracellular exosome
(GO:0070062)
Gdp phosphatase activity
(GO:0004382)
G protein-coupled receptor signaling pathway
(GO:0007186)
Nucleoside diphosphate catabolic process
(GO:0009134)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Protein binding
(GO:0005515)
Purine ribonucleoside diphosphate catabolic process
(GO:0009181)
Ribonucleoside triphosphate phosphatase activity
(GO:0017111)
Udp phosphatase activity
(GO:0045134)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.55
Marker Score: 3214
Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 169426
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 867
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 793
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71820
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48045
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 506
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 460
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.92
Marker Score: 2165
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2737
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5206
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5286
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.82
Marker Score: 542
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 304
Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 687
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.75
Marker Score: 1418
Cell Name: mast cell (CL0000097)
Fold Change: 0.72
Marker Score: 420
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2859.5
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.67
Marker Score: 14351
Cell Name: PP cell (CL0000696)
Fold Change: 0.61
Marker Score: 137
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.61
Marker Score: 401
Cell Name: astrocyte (CL0000127)
Fold Change: 0.6
Marker Score: 517
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.58
Marker Score: 889
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.57
Marker Score: 363
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 147
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 440
Cell Name: neural cell (CL0002319)
Fold Change: 0.53
Marker Score: 257
Cell Name: enterocyte (CL0000584)
Fold Change: 0.5
Marker Score: 2413
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 473
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.47
Marker Score: 195
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.44
Marker Score: 441
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.44
Marker Score: 1392
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.42
Marker Score: 144
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4
Marker Score: 400
Cell Name: male germ cell (CL0000015)
Fold Change: 0.39
Marker Score: 112
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.38
Marker Score: 1873
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 370
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.37
Marker Score: 833
Cell Name: stem cell (CL0000034)
Fold Change: 0.36
Marker Score: 862
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.35
Marker Score: 1188
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.33
Marker Score: 123
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.32
Marker Score: 104
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.32
Marker Score: 326
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.31
Marker Score: 90
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.31
Marker Score: 4778
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.3
Marker Score: 105
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.29
Marker Score: 1047
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.28
Marker Score: 224
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.28
Marker Score: 133
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.28
Marker Score: 271
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.28
Marker Score: 1796
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.27
Marker Score: 102
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.26
Marker Score: 135
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.26
Marker Score: 81
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.25
Marker Score: 1601
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.24
Marker Score: 142
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.23
Marker Score: 102
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.23
Marker Score: 463
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.22
Marker Score: 55
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.22
Marker Score: 132
Cell Name: stromal cell (CL0000499)
Fold Change: 0.22
Marker Score: 255
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.22
Marker Score: 208
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.22
Marker Score: 116
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.21
Marker Score: 121
Cell Name: precursor cell (CL0011115)
Fold Change: 0.21
Marker Score: 51
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.21
Marker Score: 91
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.21
Marker Score: 65
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.2
Marker Score: 125
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.2
Marker Score: 82
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.2
Marker Score: 206
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2
Marker Score: 67
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.2
Marker Score: 532
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.19
Marker Score: 50
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.19
Marker Score: 115
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.19
Marker Score: 259
Cell Name: pericyte (CL0000669)
Fold Change: 0.18
Marker Score: 106
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.18
Marker Score: 57
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.18
Marker Score: 62
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.18
Marker Score: 189
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.18
Marker Score: 62
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.17
Marker Score: 55
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.17
Marker Score: 281
Cell Name: fibroblast (CL0000057)
Fold Change: 0.16
Marker Score: 157
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.16
Marker Score: 65
Cell Name: chondrocyte (CL0000138)
Fold Change: 0.16
Marker Score: 70
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.16
Marker Score: 438
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.15
Marker Score: 30
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 0.15
Marker Score: 44
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.15
Marker Score: 34
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.15
Marker Score: 265
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.15
Marker Score: 60
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.15
Marker Score: 30
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.15
Marker Score: 38

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**Key characteristics:** * ENTP2 is a transmembrane protein that is localized to the plasma membrane. * It is a member of the ecto-5' nuclease family of phosphatases. * ENTP2 is expressed in high levels in cells that are involved in the innate immune response, including dendritic cells, macrophages, and neutrophils. * It is also expressed in cells that are involved in tissue repair and regeneration. **Pathways and functions:** * ENTP2 is involved in a variety of immune pathways, including the regulation of inflammation, the activation of dendritic cells, and the regulation of cell migration. * It is a key regulator of the innate immune response, and its expression and activity are important for the development and maintenance of immune tolerance. * ENTP2 is also involved in the regulation of cell migration, and its expression and activity are important for the development and maintenance of tissue repair and regeneration. **Clinical significance:** * Mutations in ENTP2 have been linked to a number of human diseases, including inflammatory bowel disease, cancer, and autoimmune disorders. * ENTP2 is a potential target for the treatment of inflammatory diseases. * Inhibition of ENTP2 has been shown to be effective in reducing inflammation and promoting tissue repair. **Additional information:** * ENTP2 is a highly conserved protein, with a similar protein found in other vertebrates. * It is a ubiquitin-dependent protein, which means that it is targeted for degradation by the proteasome. * ENTP2 is a highly regulated protein, and its expression and activity are tightly controlled by a variety of factors, including cytokines, hormones, and metabolites.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ectonucleoside triphosphate diphosphohydrolase 2

Genular Protein ID: 2671766504

Symbol: ENTP2_HUMAN

Name: Ectonucleoside triphosphate diphosphohydrolase 2

UniProtKB Accession Codes:

Q9Y5L3 O15464 Q5SPY6 Q5SPY7

Database IDs:

Citations:

PubMed ID: 9271669

Title: Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes.

PubMed ID: 9271669

DOI: 10.1007/s003359900534

PubMed ID: 10510450

Title: Functional expression of a cDNA encoding a human ecto-ATPase.

PubMed ID: 10510450

DOI: 10.1038/sj.bjp.0702805

PubMed ID: 16101300

Title: Either the carboxyl- or the amino-terminal region of the human ecto-ATPase (E-NTPDase 2) confers detergent and temperature sensitivity to the chicken ecto-ATP-diphosphohydrolase (E-NTPDase 8).

PubMed ID: 16101300

DOI: 10.1021/bi050019k

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12888562

Title: Requirement of Cys399 for processing of the human ecto-ATPase (NTPDase2) and its implications for determination of the activities of splice variants of the enzyme.

PubMed ID: 12888562

DOI: 10.1074/jbc.m307854200

Sequence Information:

Length: 495
Mass: 53665
Checksum: 3BDBA114A679B422
Sequence:

MAGKVRSLLP PLLLAAAGLA GLLLLCVPTR DVREPPALKY GIVLDAGSSH TSMFIYKWPA 
DKENDTGIVG QHSSCDVPGG GISSYADNPS GASQSLVGCL EQALQDVPKE RHAGTPLYLG 
ATAGMRLLNL TNPEASTSVL MAVTHTLTQY PFDFRGARIL SGQEEGVFGW VTANYLLENF 
IKYGWVGRWF RPRKGTLGAM DLGGASTQIT FETTSPAEDR ASEVQLHLYG QHYRVYTHSF 
LCYGRDQVLQ RLLASALQTH GFHPCWPRGF STQVLLGDVY QSPCTMAQRP QNFNSSARVS 
LSGSSDPHLC RDLVSGLFSF SSCPFSRCSF NGVFQPPVAG NFVAFSAFFY TVDFLRTSMG 
LPVATLQQLE AAAVNVCNQT WAQLQARVPG QRARLADYCA GAMFVQQLLS RGYGFDERAF 
GGVIFQKKAA DTAVGWALGY MLNLTNLIPA DPPGLRKGTD FSSWVVLLLL FASALLAALV 
LLLRQVHSAK LPSTI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ENTPD2

Associated with

Cells (max top 100)

Other Information

Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes. PubMed ID: 9271669

Functional expression of a cDNA encoding a human ecto-ATPase. PubMed ID: 10510450

Either the carboxyl- or the amino-terminal region of the human ecto-ATPase (E-NTPDase 2) confers detergent and temperature sensitivity to the chicken ecto-ATP-diphosphohydrolase (E-NTPDase 8). PubMed ID: 16101300

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334