Details for: IGDCC3

Gene ID: 9543

Symbol: IGDCC3

Ensembl ID: ENSG00000174498

Description: immunoglobulin superfamily DCC subclass member 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.49
    Marker Score: 3,002
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.76
    Marker Score: 926
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.65
    Marker Score: 5,537
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 1.64
    Marker Score: 589
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.61
    Marker Score: 6,326
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.35
    Marker Score: 5,004
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.25
    Marker Score: 1,030
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.18
    Marker Score: 2,010
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.09
    Marker Score: 1,909
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.05
    Marker Score: 440
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.03
    Marker Score: 13,598
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,809
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,034
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.98
    Marker Score: 1,851
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.98
    Marker Score: 328
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.96
    Marker Score: 2,442
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,348
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.93
    Marker Score: 449
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.88
    Marker Score: 54,261
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.86
    Marker Score: 32,625
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.86
    Marker Score: 4,487
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 13,010
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.82
    Marker Score: 12,263
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.81
    Marker Score: 447
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 614
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.8
    Marker Score: 450
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.78
    Marker Score: 452
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.78
    Marker Score: 16,590
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.78
    Marker Score: 5,958
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.78
    Marker Score: 830
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.76
    Marker Score: 605
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7
    Marker Score: 2,712
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.69
    Marker Score: 2,794
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.68
    Marker Score: 255
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.65
    Marker Score: 380
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.64
    Marker Score: 21,598
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.64
    Marker Score: 554
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.63
    Marker Score: 1,282
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.62
    Marker Score: 2,390
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.62
    Marker Score: 291
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.62
    Marker Score: 281
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.61
    Marker Score: 871
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.6
    Marker Score: 569
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.59
    Marker Score: 188
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.58
    Marker Score: 550
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 378
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 447
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.56
    Marker Score: 161
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.56
    Marker Score: 163
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.54
    Marker Score: 186
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.53
    Marker Score: 459
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.53
    Marker Score: 4,976
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.53
    Marker Score: 236
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.51
    Marker Score: 559
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 293
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.45
    Marker Score: 4,697
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.45
    Marker Score: 218
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.45
    Marker Score: 506
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.45
    Marker Score: 280
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.44
    Marker Score: 297
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.43
    Marker Score: 1,016
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.43
    Marker Score: 3,220
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.42
    Marker Score: 474
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.42
    Marker Score: 1,763
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.42
    Marker Score: 970
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.41
    Marker Score: 2,199
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4
    Marker Score: 228
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.4
    Marker Score: 213
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.39
    Marker Score: 608
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.38
    Marker Score: 470
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.37
    Marker Score: 1,559
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.36
    Marker Score: 237
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.36
    Marker Score: 143
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.35
    Marker Score: 373
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.35
    Marker Score: 727
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.35
    Marker Score: 716
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.34
    Marker Score: 363
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.33
    Marker Score: 334
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.33
    Marker Score: 126
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 156
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.32
    Marker Score: 227
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.31
    Marker Score: 6,135
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.29
    Marker Score: 91
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.28
    Marker Score: 1,844
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.27
    Marker Score: 1,137
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.27
    Marker Score: 1,258
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.27
    Marker Score: 337
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.27
    Marker Score: 377
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.25
    Marker Score: 93
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 152

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGDCC3 is a member of the immunoglobulin superfamily, a group of proteins known for their involvement in cell-cell adhesion and recognition. The gene is specifically classified as a DCC subclass member, suggesting its unique characteristics and functions. IGDCC3 is expressed in various cell types, including mesangial cells, hematopoietic stem cells, neuronal brush cells, and syncytiotrophoblast cells. Its expression patterns suggest a wide range of cellular functions, from immune response modulation to cellular adhesion and migration. **Pathways and Functions:** IGDCC3 is involved in several biological pathways, including cell-cell adhesion, neuromuscular process controlling balance, and plasma membrane function. Cell-cell adhesion is a critical process that maintains tissue integrity and regulates immune responses. IGDCC3's involvement in this pathway suggests its role in modulating immune cell interactions and tissue organization. The neuromuscular process controlling balance is also of interest, as IGDCC3's expression in neuronal brush cells and cortical thymic epithelial cells may contribute to the development and maintenance of balance and motor control. In addition to its role in cell-cell adhesion, IGDCC3 may also function as a plasma membrane protein. Its localization to the plasma membrane suggests its involvement in signaling and cellular processes such as migration, differentiation, and survival. Furthermore, IGDCC3's expression in hematopoietic stem cells and granulocyte monocyte progenitor cells may indicate its role in regulating hematopoiesis and immune cell development. **Clinical Significance:** The clinical significance of IGDCC3 is an area of ongoing research. As a gene involved in cell-cell adhesion and immune response modulation, IGDCC3 may play a role in various diseases, including autoimmune disorders, inflammatory conditions, and neurological disorders. For instance, alterations in IGDCC3 expression or function may contribute to the development of autoimmune diseases, such as multiple sclerosis or rheumatoid arthritis. Moreover, IGDCC3's expression in syncytiotrophoblast cells suggests its potential role in placental development and function. Abnormalities in IGDCC3 expression or function may contribute to placental dysfunction, leading to complications such as preeclampsia or preterm birth. In conclusion, IGDCC3 is a gene of emerging significance in immunology and beyond. Its diverse expression patterns, involvement in cell-cell adhesion, neuromuscular balance, and plasma membrane function, and its potential role in various diseases make it an area of active research. Further studies are needed to fully elucidate the functions of IGDCC3 and its clinical significance.

Genular Protein ID: 3438138286

Symbol: IGDC3_HUMAN

Name: Immunoglobulin superfamily DCC subclass member 3

UniProtKB Accession Codes:

Q8IVU1 O95215

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9922388

Title: Genomic structure and chromosomal localization of the mouse gene Punc.

PubMed ID: 9922388

DOI: 10.1007/s003359900953

Sequence Information:

  • Length: 814
  • Mass: 86724
  • Checksum: 7081B88569F77C68
  • Sequence:
    • MAVQRAASPR RPPAPLWPRL LLPLLLLLLP APSEGLGHSA ELAFAVEPSD DVAVPGQPIV 
LDCRVEGTPP VRITWRKNGV ELPESTHSTL LANGSLMIRH FRLEPGGSPS DEGDYECVAQ 
NRFGLVVSRK ARIQAATMSD FHVHPQATVG EEGGVARFQC QIHGLPKPLI TWEKNRVPID 
TDNERYTLLP KGVLQITGLR AEDGGIFHCV ASNIASIRIS HGARLTVSGS GSGAYKEPAI 
LVGPENLTLT VHQTAVLECV ATGNPRPIVS WSRLDGRPIG VEGIQVLGTG NLIISDVTVQ 
HSGVYVCAAN RPGTRVRRTA QGRLVVQAPA EFVQHPQSIS RPAGTTAMFT CQAQGEPPPH 
VTWLKNGQVL GPGGHVRLKN NNSTLTISGI GPEDEAIYQC VAENSAGSSQ ASARLTVLWA 
EGLPGPPRNV RAVSVSSTEV RVSWSEPLAN TKEIIGYVLH IRKAADPPEL EYQEAVSKST 
FQHLVSDLEP STAYSFYIKA YTPRGASSAS VPTLASTLGE APAPPPLSVR VLGSSSLQLL 
WEPWPRLAQH EGGFKLFYRP ASKTSFTGPI LLPGTVSSYN LSQLDPTAVY EVKLLAYNQH 
GDGNATVRFV SLRGASERTA LSPPCDCRKE EAANQTSTTG IVIGIHIGVT CIIFCVLFLL 
FGQRGRVLLC KDVENQLSPP QGPRSQRDPG ILALNGARRG QRGQLGRDEK RVDMKELEQL 
FPPASAAGQP DPRPTQDPAA PAPCEETQLS VLPLQGCGLM EGKTTEAKTT EATAPCAGLA 
AAPPPPDGGP GLLSEGQASR PAAARVTQPA HSEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.