Details for: RAB3D

Gene ID: 9545

Symbol: RAB3D

Ensembl ID: ENSG00000105514

Description: RAB3D, member RAS oncogene family

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.49
    Marker Score: 3,147
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,704
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.22
    Marker Score: 68,198
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.22
    Marker Score: 510
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.15
    Marker Score: 2,617
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.09
    Marker Score: 9,374
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.07
    Marker Score: 2,658
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.02
    Marker Score: 817
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1
    Marker Score: 1,545
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,769
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,993
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.99
    Marker Score: 1,874
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.97
    Marker Score: 651
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.94
    Marker Score: 392
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.93
    Marker Score: 268
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1,504
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,724
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.89
    Marker Score: 6,962
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.89
    Marker Score: 5,684
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.87
    Marker Score: 281
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,267
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,954
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.85
    Marker Score: 8,103
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13,191
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.83
    Marker Score: 1,881
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.83
    Marker Score: 1,947
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.8
    Marker Score: 294
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.8
    Marker Score: 5,988
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.8
    Marker Score: 783
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.79
    Marker Score: 198
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.79
    Marker Score: 507
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 310
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.76
    Marker Score: 239
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.76
    Marker Score: 443
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.75
    Marker Score: 206
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.73
    Marker Score: 1,485
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.72
    Marker Score: 44,464
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.72
    Marker Score: 288
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.72
    Marker Score: 354
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.71
    Marker Score: 6,113
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.7
    Marker Score: 674
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 632
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.69
    Marker Score: 6,514
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.69
    Marker Score: 484
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.69
    Marker Score: 573
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.67
    Marker Score: 348
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2,821
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.65
    Marker Score: 1,179
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.65
    Marker Score: 1,038
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.65
    Marker Score: 4,208
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.64
    Marker Score: 257
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.63
    Marker Score: 302
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.62
    Marker Score: 393
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.62
    Marker Score: 900
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.62
    Marker Score: 718
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.61
    Marker Score: 194
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.61
    Marker Score: 575
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6
    Marker Score: 363
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6
    Marker Score: 3,630
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.6
    Marker Score: 674
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.6
    Marker Score: 280
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6
    Marker Score: 631
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6
    Marker Score: 20,656
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 381
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.59
    Marker Score: 867
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.58
    Marker Score: 1,121
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.57
    Marker Score: 213
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.56
    Marker Score: 382
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.55
    Marker Score: 6,409
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.55
    Marker Score: 631
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 434
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.53
    Marker Score: 5,465
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.53
    Marker Score: 368
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.53
    Marker Score: 839
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.52
    Marker Score: 587
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.52
    Marker Score: 557
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.51
    Marker Score: 2,133
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.5
    Marker Score: 513
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.5
    Marker Score: 216
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.5
    Marker Score: 866
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.49
    Marker Score: 107
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.49
    Marker Score: 252
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.48
    Marker Score: 153
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.48
    Marker Score: 531
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.48
    Marker Score: 617
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.48
    Marker Score: 496
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.47
    Marker Score: 2,488
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.47
    Marker Score: 478
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.47
    Marker Score: 6,999
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 123
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.46
    Marker Score: 3,557
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.45
    Marker Score: 117

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RAB3D is a small GTPase, approximately 20 kDa in size, which is rich in proline and glutamine residues. It belongs to the RAS superfamily, which is characterized by its guanine nucleotide-binding (GTP-binding) activity. RAB3D is predominantly localized to the plasma membrane, where it regulates the fusion of vesicles with the plasma membrane. Its GTP-binding activity allows it to interact with various proteins, including SNARE proteins, which are essential for vesicle docking and fusion. **Pathways and Functions:** RAB3D is involved in several critical pathways, including: 1. **Regulated Secretory Pathway:** RAB3D regulates the release of proteins and molecules from secretory vesicles, which is essential for various cellular processes, such as immune response, cell signaling, and neurotransmission. 2. **Immune Response:** RAB3D is expressed in immune cells, including classical monocytes and neutrophils, where it plays a crucial role in regulating the secretion of antimicrobial peptides and cytokines. 3. **Neurotransmission:** RAB3D is expressed in neurons, particularly in the cerebral cortex, where it regulates the release of neurotransmitters, such as GABA. 4. **Protein Binding and Localization:** RAB3D interacts with various proteins, including SNARE proteins, which are essential for vesicle docking and fusion. **Clinical Significance:** Dysregulation of RAB3D has been implicated in various diseases, including: 1. **Immune System Disorders:** RAB3D deficiency has been linked to impaired immune response and increased susceptibility to infections. 2. **Neurological Disorders:** RAB3D mutations have been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** RAB3D is overexpressed in certain types of cancer, including pancreatic cancer, where it promotes tumor growth and metastasis. 4. **Infectious Diseases:** RAB3D has been shown to regulate the secretion of antimicrobial peptides, which is essential for fighting off infections. In conclusion, RAB3D is a complex protein that plays a critical role in regulating various cellular processes, including protein secretion, immune response, and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and its clinical significance. **References:** 1. [Insert references to relevant studies on RAB3D] Note: As an expert immunologist, it is essential to provide evidence-based information and references to support the discussion on RAB3D. The references provided above are hypothetical and should be replaced with actual studies and publications on RAB3D.

Genular Protein ID: 2002073087

Symbol: RAB3D_HUMAN

Name: Ras-related protein Rab-3D

UniProtKB Accession Codes:

O95716

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10023084

Title: Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation.

PubMed ID: 10023084

DOI: 10.1016/s0167-4781(98)00279-6

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

Sequence Information:

  • Length: 219
  • Mass: 24267
  • Checksum: 714754826C405EA7
  • Sequence:
    • MASAGDTQAG PRDAADQNFD YMFKLLLIGN SSVGKTSFLF RYADDSFTPA FVSTVGIDFK 
VKTVYRHDKR IKLQIWDTAG QERYRTITTA YYRGAMGFLL MYDIANQESF AAVQDWATQI 
KTYSWDNAQV ILVGNKCDLE DERVVPAEDG RRLADDLGFE FFEASAKENI NVKQVFERLV 
DVICEKMNES LEPSSSSGSN GKGPAVGDAP APQPSSCSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.