Details for: ENTPD6

Gene ID: 955

Symbol: ENTPD6

Ensembl ID: ENSG00000197586

Description: ectonucleoside triphosphate diphosphohydrolase 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.35
    Marker Score: 12846
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.31
    Marker Score: 5133
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19892
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.24
    Marker Score: 10642
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.23
    Marker Score: 3855
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.22
    Marker Score: 1890
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2
    Marker Score: 73508
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.18
    Marker Score: 4198.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.18
    Marker Score: 12157
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.16
    Marker Score: 4492
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.14
    Marker Score: 4647.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.14
    Marker Score: 1224
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.14
    Marker Score: 5451
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.1
    Marker Score: 2317
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.09
    Marker Score: 2211
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.05
    Marker Score: 2401
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.04
    Marker Score: 39445
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1
    Marker Score: 9428
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71733
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47957
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.99
    Marker Score: 7588.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.99
    Marker Score: 36502
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.99
    Marker Score: 2343
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.98
    Marker Score: 657
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.97
    Marker Score: 4028.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.97
    Marker Score: 19228
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.97
    Marker Score: 14448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5270
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.91
    Marker Score: 909
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2713
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.89
    Marker Score: 856
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.89
    Marker Score: 5658
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.88
    Marker Score: 968
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.86
    Marker Score: 272
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.83
    Marker Score: 865
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.83
    Marker Score: 18470
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.82
    Marker Score: 4033
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.8
    Marker Score: 4831
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8
    Marker Score: 1616
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.79
    Marker Score: 1786
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.78
    Marker Score: 457
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.77
    Marker Score: 2065
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 586
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.76
    Marker Score: 375
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.74
    Marker Score: 280
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.74
    Marker Score: 678.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.74
    Marker Score: 345
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.73
    Marker Score: 293
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.72
    Marker Score: 1065
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 288.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.72
    Marker Score: 255
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2963
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.69
    Marker Score: 4119.5
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.69
    Marker Score: 612
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.68
    Marker Score: 2349
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.68
    Marker Score: 14520
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.67
    Marker Score: 683
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 611
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.67
    Marker Score: 6698
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.66
    Marker Score: 529
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.66
    Marker Score: 211
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.64
    Marker Score: 303
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.63
    Marker Score: 157
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.63
    Marker Score: 671
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.63
    Marker Score: 793
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.63
    Marker Score: 220
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.63
    Marker Score: 1486
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.63
    Marker Score: 347
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.63
    Marker Score: 969
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.62
    Marker Score: 434
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.59
    Marker Score: 981
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.58
    Marker Score: 621
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.57
    Marker Score: 138
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.56
    Marker Score: 339
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.56
    Marker Score: 1414
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.56
    Marker Score: 160
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.55
    Marker Score: 385
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.55
    Marker Score: 338
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.55
    Marker Score: 709
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.54
    Marker Score: 472
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.54
    Marker Score: 1462.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 428
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.53
    Marker Score: 612
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.53
    Marker Score: 197
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.53
    Marker Score: 849
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.53
    Marker Score: 745
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.52
    Marker Score: 240
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.52
    Marker Score: 150
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.51
    Marker Score: 340
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.51
    Marker Score: 222

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Other Information

## Summary ENTPD6 is a protein involved in the regulation of cell signaling and metabolism. It is expressed in a variety of cell types, including neurons, epithelial cells, and cardiac myocytes. ENTP6 is a key regulator of the cGMP/cAMP signaling pathway, which is involved in a variety of cellular processes, including cell growth, differentiation, and apoptosis. ## Key characteristics * ENTP6 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a member of the Ectonucleoside triphosphate diphosphohydrolase (EctonTPase) family of proteins. * ENTP6 is expressed in high levels in the brain, particularly in neurons and glial cells. * It is also expressed in other tissues, including the heart, liver, and kidney. ## Pathways and functions * ENTP6 is a key regulator of the cGMP/cAMP signaling pathway. * The cGMP/cAMP pathway is involved in a variety of cellular processes, including cell growth, differentiation, and apoptosis. * ENTP6 is thought to regulate the cGMP/cAMP pathway by inhibiting the activity of the enzyme protein GMP-dependent protein kinase (Gdk). * This inhibition prevents the activation of Gdk and the downstream signaling pathways that are involved in cell growth and differentiation. * In the absence of cGMP, ENTP6 is thought to be fully activated and to promote the activation of Gdk and the downstream signaling pathways. ## Clinical significance * Mutations in ENTP6 have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. * These mutations can lead to changes in the activity of the cGMP/cAMP signaling pathway, which can disrupt cellular processes and lead to neurological symptoms. * Therefore, ENTP6 is a promising target for the treatment of neurological disorders that are characterized by cGMP/cAMP signaling pathway dysfunction.

Genular Protein ID: 2002118271

Symbol: ENTP6_HUMAN

Name: Ectonucleoside triphosphate diphosphohydrolase 6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9676430

Title: The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster.

PubMed ID: 9676430

DOI: 10.1006/geno.1998.5317

PubMed ID: 14529283

Title: Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function.

PubMed ID: 14529283

DOI: 10.1021/bi035137r

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11041856

Title: CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart.

PubMed ID: 11041856

DOI: 10.1021/bi000959z

PubMed ID: 10948193

Title: Expression and characterization of soluble and membrane-bound human nucleoside triphosphate diphosphohydrolase 6 (CD39L2).

PubMed ID: 10948193

DOI: 10.1074/jbc.m004723200

Sequence Information:

  • Length: 484
  • Mass: 53246
  • Checksum: 3CBA96040BC196CB
  • Sequence:
  • MKKGIRYETS RKTSYIFQQP QHGPWQTRMR KISNHGSLRV AKVAYPLGLC VGVFIYVAYI 
    KWHRATATQA FFSITRAAPG ARWGQQAHSP LGTAADGHEV FYGIMFDAGS TGTRVHVFQF 
    TRPPRETPTL THETFKALKP GLSAYADDVE KSAQGIRELL DVAKQDIPFD FWKATPLVLK 
    ATAGLRLLPG EKAQKLLQKV KKVFKASPFL VGDDCVSIMN GTDEGVSAWI TINFLTGSLK 
    TPGGSSVGML DLGGGSTQIA FLPRVEGTLQ ASPPGYLTAL RMFNRTYKLY SYSYLGLGLM 
    SARLAILGGV EGQPAKDGKE LVSPCLSPSF KGEWEHAEVT YRVSGQKAAA SLHELCAARV 
    SEVLQNRVHR TEEVKHVDFY AFSYYYDLAA GVGLIDAEKG GSLVVGDFEI AAKYVCRTLE 
    TQPQSSPFSC MDLTYVSLLL QEFGFPRSKV LKLTRKIDNV ETSWALGAIF HYIDSLNRQK 
    SPAS

Genular Protein ID: 918610127

Symbol: B4DDM7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 453
  • Mass: 49065
  • Checksum: E216B86D15747536
  • Sequence:
  • MPQHGPWQTR MRKISNHGSL RVAKVAYPLG LCVGVFIYVA YIKWHRATAT QAFFSITRAA 
    PGARWGQQAH SPLGTAADGH EVFYGIMFDA GSTGTRVHVF QFTRPPRETP TLTHETFKAL 
    KPGLSAYADD VEKSAQGIRE LLDVAKQDIP FDFWKATPLV LKATAGLRLL PGEKAQKLLQ 
    KVKEVFKASP FLVGDDCVSI MNGTDEGVSA WITINFLTGS LKTPGGSSVG MLDLGGGSTQ 
    IAFLPRVEGT LQASPPGYLT ALRMFNRTYK LYSYSYLGLG LMSARLAILG GVEGQPAKDG 
    KELVSPCLSP SFKGEWEHAE VTYRVSGQKA AASLHELCAA RVSEVLQNRV HRTEEVKHVD 
    FYAFSYYYDL AAGVGLIDAE KGGSLVVGDF EIAAKYGGSH LEREGTCLIP SVSDPGDTAA 
    EQPLLMHGPH LRQPATPGVR LSQEQSAEAH SEN

Genular Protein ID: 812805852

Symbol: B4DHS2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 232
  • Mass: 25255
  • Checksum: 7B521389160E4D21
  • Sequence:
  • MNGTDEGVSA WITINFLTGS LKTPGGSSVG MLDLGGGSTQ IAFLPRVEGT LQASPPGYLT 
    ALRMFNRTYK LYSYSYLGLG LMSARLAILG GVEGQPAASL HELCAARVSE VLQNRVHRTE 
    EVKHVDFYAF SYYYDLAAGV GLIDAEKGGS LVVGDFEIAA KYVCRTLETQ PQSSPFSCMD 
    LTYVSLLLQE FGFPRSKVLK LTRKIDNVET SWALGAIFHY IDSLNRQKSP AS

Genular Protein ID: 1568304190

Symbol: B4E1D1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 466
  • Mass: 51032
  • Checksum: E865A23A422625E0
  • Sequence:
  • MPQHGPWQTR MRKISNHGSL RVAKVAYPLG LCVGVFIYVA YIKWHRATAT QAFFSITRAA 
    PGARWGQQAH SPLGTAADGH EVFYGIMFDA GSTGTRVHVF QFTRPPRETP TLTHETFKAL 
    KPGLSAYADD VEKSAQGIRE LLDVAKQDIP FDFWKATPLV LKATAGLRLL PGEKAQKLLQ 
    KVKEVFKASP FLVGDDCVSI MNGTDEGVSA WITINFLTGS LKTPGGSSVG MLDLGGGSTQ 
    IAFLPRVEGT LQASPPGYLT ALRMFNRTYK LYSYSYLGLG LMSARLAILG GVEGQPAKDG 
    KELVSPCLSP SFKGEWEHAE VTYRVSGQKA AASLHELCAA RVSEVLQNRV HRTEEVKHVD 
    FYAFSYYYDL AAGVGLIDAE KGGSLVVGDF EIAAKYVCRT LETQPQSSPF SCMDLTYVSL 
    LLQEFGFPRS KVLKLTRKID NVETSWALGA IFHYIDSLNR QKSPAS

Genular Protein ID: 1673984339

Symbol: B4DU64_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 266
  • Mass: 28997
  • Checksum: 404E67F205EEA93F
  • Sequence:
  • MNGTDEGVSA WITINFLTGS LKTPGGSSVG MLDLGGGSTQ IAFLPRVEGT LQASPPGYLT 
    ALRRFNRTYK LYSYSYLGLG LMSARLAILG GVEGQPAKDG KELVSPCLSP SFKGEWEHAE 
    VTYRVSGQKA AASLHELCAA RVSEVLQNRV HRTEEVKHVD FYAFSYYYDL AAGVGLIDAE 
    KGGSLVVGDF EIAAKYVCRT LETQPQSSPF SCMDLTYVSL LLQEFGFPRS KVLKLTRKID 
    NVETSWALGA IFHYIDSLNR QKSPAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.