Details for: MRPL33

Gene ID: 9553

Symbol: MRPL33

Ensembl ID: ENSG00000243147

Description: mitochondrial ribosomal protein L33

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 3.72
    Marker Score: 2,539
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.47
    Marker Score: 8,749
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.23
    Marker Score: 8,648
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.06
    Marker Score: 1,632
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.92
    Marker Score: 4,848
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.86
    Marker Score: 14,043
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.81
    Marker Score: 3,970
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.79
    Marker Score: 2,183
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.76
    Marker Score: 4,247
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.7
    Marker Score: 5,077
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.62
    Marker Score: 90,815
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.62
    Marker Score: 1,860
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.59
    Marker Score: 16,914
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.51
    Marker Score: 1,572
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.5
    Marker Score: 4,025
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.46
    Marker Score: 2,610
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.42
    Marker Score: 3,148
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.41
    Marker Score: 2,519
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.41
    Marker Score: 2,818
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.41
    Marker Score: 4,815
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.4
    Marker Score: 2,437
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.39
    Marker Score: 12,543
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.38
    Marker Score: 5,853
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.36
    Marker Score: 3,756
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.32
    Marker Score: 5,454
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.31
    Marker Score: 2,468
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.31
    Marker Score: 5,755
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.3
    Marker Score: 6,356
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.25
    Marker Score: 9,691
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.23
    Marker Score: 7,932
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.22
    Marker Score: 2,680
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.21
    Marker Score: 762
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 2.2
    Marker Score: 1,003
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 2.19
    Marker Score: 1,130
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.17
    Marker Score: 1,936
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.17
    Marker Score: 843
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.16
    Marker Score: 4,506
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.15
    Marker Score: 2,053
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.13
    Marker Score: 1,422
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.13
    Marker Score: 28,057
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.1
    Marker Score: 674
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.1
    Marker Score: 7,774
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.09
    Marker Score: 1,078
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.09
    Marker Score: 2,206
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.08
    Marker Score: 1,368
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.08
    Marker Score: 4,222
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.07
    Marker Score: 18,019
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.06
    Marker Score: 7,941
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.06
    Marker Score: 4,691
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.05
    Marker Score: 1,373
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.05
    Marker Score: 490
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.05
    Marker Score: 675
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.04
    Marker Score: 646
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.02
    Marker Score: 12,267
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.02
    Marker Score: 1,902
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.01
    Marker Score: 743
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.01
    Marker Score: 1,261
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.01
    Marker Score: 2,423
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2
    Marker Score: 709
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.99
    Marker Score: 795
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.99
    Marker Score: 22,417
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.99
    Marker Score: 1,782
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.99
    Marker Score: 2,924
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.98
    Marker Score: 110,512
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.97
    Marker Score: 20,009
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.96
    Marker Score: 4,455
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.94
    Marker Score: 1,828
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.94
    Marker Score: 1,004
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.94
    Marker Score: 548
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.93
    Marker Score: 916
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.93
    Marker Score: 800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.92
    Marker Score: 12,241
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.91
    Marker Score: 2,461
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.91
    Marker Score: 5,436
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.9
    Marker Score: 18,807
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.89
    Marker Score: 852
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.89
    Marker Score: 1,101
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.89
    Marker Score: 2,020
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.89
    Marker Score: 3,585
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.88
    Marker Score: 2,026
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.87
    Marker Score: 755
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.87
    Marker Score: 4,447
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.87
    Marker Score: 3,070
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.87
    Marker Score: 887
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.86
    Marker Score: 4,553
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.86
    Marker Score: 437
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.85
    Marker Score: 2,688
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.84
    Marker Score: 3,122
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.84
    Marker Score: 2,037
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.84
    Marker Score: 687
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.84
    Marker Score: 7,232
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.83
    Marker Score: 413
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.83
    Marker Score: 62,346
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.82
    Marker Score: 46,709
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.82
    Marker Score: 1,961
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.8
    Marker Score: 895
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.79
    Marker Score: 1,544
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.79
    Marker Score: 2,099
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.79
    Marker Score: 442
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.79
    Marker Score: 1,879

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern**: MRPL33 is widely expressed in various tissues and cell types, including hepatocytes, kidney cells, and epithelial cells of the mammary gland. 2. **Function**: MRPL33 is a mitochondrial ribosomal protein that participates in the translation of mitochondrial mRNAs into polypeptides, which are essential for energy production and cellular function. 3. **Subcellular Localization**: MRPL33 is localized to the mitochondrial large ribosomal subunit, where it plays a critical role in the translation of mitochondrial mRNAs. 4. **Protein Structure**: The MRPL33 protein consists of a 39S ribosomal protein L33 subunit, which is essential for the proper functioning of the mitochondrial ribosome. **Pathways and Functions:** 1. **Mitochondrial Translation**: MRPL33 is involved in the translation of mitochondrial mRNAs into polypeptides, which are essential for energy production and cellular function. 2. **Mitochondrial Translation Elongation**: MRPL33 participates in the elongation phase of mitochondrial translation, where it helps to assemble the polypeptide chain. 3. **Mitochondrial Translation Initiation**: MRPL33 is involved in the initiation phase of mitochondrial translation, where it helps to recruit the ribosome to the mRNA. 4. **Mitochondrial Translation Termination**: MRPL33 participates in the termination phase of mitochondrial translation, where it helps to release the completed polypeptide from the ribosome. **Clinical Significance:** Dysregulation or mutation of MRPL33 has been implicated in various diseases, including: 1. **Mitochondrial Myopathies**: Mutations in MRPL33 have been associated with mitochondrial myopathies, which are characterized by muscle weakness and fatigue. 2. **Neurodegenerative Diseases**: MRPL33 mutations have been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: MRPL33 dysregulation has been observed in various types of cancer, including breast cancer and lung cancer. 4. **Metabolic Disorders**: MRPL33 mutations have been associated with metabolic disorders, such as diabetes and metabolic syndrome. In conclusion, MRPL33 is a critical component of the mitochondrial ribosome, playing a vital role in the translation of mitochondrial mRNAs into polypeptides essential for energy production and cellular function. Its dysregulation or mutation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis. Further research is needed to fully understand the role of MRPL33 in human disease and to develop therapeutic strategies to target this gene in various disease states.

Genular Protein ID: 3730619969

Symbol: RM33_HUMAN

Name: 39S ribosomal protein L33, mitochondrial

UniProtKB Accession Codes:

O75394 Q53RZ6 Q5FVE3 Q96Q50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 55 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 64 PDBsum 58 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9653160

Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.

PubMed ID: 9653160

DOI: 10.1073/pnas.95.14.8175

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11543634

Title: The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

PubMed ID: 11543634

DOI: 10.1006/geno.2001.6622

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

Sequence Information:

  • Length: 65
  • Mass: 7619
  • Checksum: F32C16A238A5D08A
  • Sequence:
    • MFLSAVFFAK SKSKNILVRM VSEAGTGFCF NTKRNRLREK LTLLHYDPVV KQRVLFVEKK 
KIRSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.