Details for: MACROH2A1
Gene ID: 9555
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MACROH2A1
Ensembl ID: ENSG00000113648
Description: macroH2A.1 histone
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 107.47rCSI 86.9%PRS 9.61
-
CSI 106.23rCSI 70.6%PRS 11.6
-
CSI 91.21rCSI 80.1%PRS 10.93
-
CSI 90.95rCSI 75.32%PRS 9.74
-
CSI 89.36rCSI 77.37%PRS 10.84
-
CSI 88.92rCSI 81.64%PRS 11.15
-
CSI 86.8rCSI 78.39%PRS 8.6
-
CSI 84.76rCSI 65.3%PRS 8.8
-
CSI 78.63rCSI 90.01%PRS 20.06
-
CSI 74.13rCSI 73.98%PRS 8.34
-
CSI 68.28rCSI 91.25%PRS 18.58
-
CSI 66.08rCSI 82.93%PRS 12.42
-
CSI 54.62rCSI 45.6%PRS 29.59
-
CSI 53.75rCSI 62.07%PRS 8.63
-
CSI 52.98rCSI 55.37%PRS 10.27
-
CSI 50.7rCSI 46.78%PRS 9.87
-
CSI 47.31rCSI 81.06%PRS 13.04
-
CSI 45.62rCSI 65.79%PRS 13.56
-
CSI 45.26rCSI 43.57%PRS 10.04
-
CSI 44.43rCSI 39.08%PRS 7.04
-
CSI 43.24rCSI 32.49%PRS 10.06
-
CSI 42.75rCSI 43.98%PRS 15.82
-
CSI 42.37rCSI 63.93%PRS 9.59
-
CSI 40.92rCSI 49.42%PRS 11.44
-
CSI 38.19rCSI 52.04%PRS 8.69
-
CSI 37.7rCSI 62.1%PRS 11.39
-
CSI 37.16rCSI 36.55%PRS 10.57
-
CSI 34.87rCSI 30.54%PRS 12.99
-
CSI 34.63rCSI 50.17%PRS 14.35
-
CSI 34.34rCSI 50.91%PRS 66.05
-
CSI 33.64rCSI 27.89%PRS 9.21
-
CSI 33.31rCSI 29.56%PRS 9.73
-
CSI 32.41rCSI 40.74%PRS 14.87
-
CSI 32.33rCSI 77.8%PRS 15.48
-
CSI 31.12rCSI 47.44%PRS 9.11
-
CSI 30.76rCSI 37.45%PRS 12.25
-
CSI 28.49rCSI 67.74%PRS 14.61
-
CSI 28.12rCSI 38.45%PRS 16.31
-
CSI 28.06rCSI 80.11%PRS 17.03
-
CSI 27.99rCSI 29.74%PRS 17.33
-
CSI 27.76rCSI 42.46%PRS 15.79
-
CSI 26.04rCSI 27.28%PRS 10.37
-
CSI 25.99rCSI 100%PRS 16.03
-
CSI 25.9rCSI 18.08%PRS 10.25
-
CSI 24.81rCSI 20.79%PRS 11.64
-
CSI 24.79rCSI 46.81%PRS 12.07
-
CSI 23.54rCSI 29%PRS 31.85
-
CSI 22.71rCSI 36.4%PRS 30.82
-
CSI 22.04rCSI 23.62%PRS 8.95
-
CSI 21.8rCSI 30.28%PRS 10.04
-
CSI 21.49rCSI 29.36%PRS 10.74
-
CSI 21.29rCSI 34.34%PRS 15.56
-
CSI 21.03rCSI 32.5%PRS 9.11
-
CSI 20.35rCSI 16.08%PRS 6.7
-
CSI 20.26rCSI 68.49%PRS 16.56
-
CSI 20.12rCSI 24.15%PRS 9.61
-
CSI 20.09rCSI 36.32%PRS 26.82
-
CSI 19.75rCSI 22.84%PRS 7.12
-
CSI 19.21rCSI 20.12%PRS 9.04
-
CSI 19.08rCSI 27.5%PRS 15.68
-
CSI 18.92rCSI 40.27%PRS 15.72
-
CSI 18.9rCSI 24.76%PRS 13.61
-
CSI 18.51rCSI 40.41%PRS 19.76
-
CSI 18.44rCSI 41.18%PRS 11.03
-
CSI 18.2rCSI 58.4%PRS 14.38
-
CSI 17.27rCSI 16.32%PRS 10.15
-
CSI 17.01rCSI 78.56%PRS 20.69
-
CSI 16.93rCSI 36%PRS 17.65
-
CSI 16.79rCSI 45.25%PRS 12.56
-
CSI 16.46rCSI 20.51%PRS 13.93
-
CSI 16.09rCSI 45.1%PRS 15.09
-
CSI 15.86rCSI 24.37%PRS 13.92
-
CSI 15.78rCSI 28.71%PRS 40.24
-
CSI 15.58rCSI 39.05%PRS 30.03
-
CSI 15.54rCSI 19.93%PRS 11.22
-
CSI 15.05rCSI 15.25%PRS 53
-
CSI 13.9rCSI 17.29%PRS 10.33
-
CSI 13.82rCSI 20.22%PRS 10.29
-
CSI 13.76rCSI 10.27%PRS 16.4
-
CSI 13.75rCSI 20.99%PRS 17.02
-
CSI 13.74rCSI 54.69%PRS 17.12
-
CSI 13.65rCSI 33.18%PRS 5.6
-
CSI 13.49rCSI 55.55%PRS 36.6
-
CSI 12.93rCSI 10.88%PRS 15.94
-
CSI 12.56rCSI 47.04%PRS 8.29
-
CSI 12.47rCSI 44.25%PRS 15.96
-
CSI 12.26rCSI 36.2%PRS 12.13
-
CSI 12.13rCSI 68.26%PRS 30.9
-
CSI 12.07rCSI 17.82%PRS 15.32
-
CSI 12.07rCSI 21.52%PRS 16.56
-
CSI 12.06rCSI 26.56%PRS 14.88
-
CSI 11.94rCSI 12.46%PRS 9.98
-
CSI 11.82rCSI 22.17%PRS 19.24
-
CSI 11.64rCSI 62.13%PRS 35.8
-
CSI 11.64rCSI 26.13%PRS 21.17
-
CSI 11.56rCSI 50.76%PRS 18.21
-
CSI 11.5rCSI 69.55%PRS 21.98
-
CSI 11.15rCSI 16.49%PRS 11.15
-
CSI 10.56rCSI 23.25%PRS 10.71
-
CSI 10.46rCSI 15%PRS 13.34
-
CSI -12.8rCSI -22.5%PRS 12.9%
-
CSI -11.3rCSI -22.4%PRS 26.6%
-
CSI -8.2rCSI -14.4%PRS 7.2%
-
CSI -7.5rCSI -21.4%PRS 14.1%
-
CSI -5.7rCSI -7.8%PRS 14.9%
-
CSI -4.8rCSI -4.4%PRS 14.9%
-
CSI -4.7rCSI -7.5%PRS 6.4%
-
CSI -4.2rCSI -3.3%PRS 14.0%
-
CSI -4.2rCSI -11.8%PRS 12.0%
-
CSI -3.5rCSI -21.6%PRS 7.8%
-
CSI -3.1rCSI -7.5%PRS 12.0%
-
CSI -2.8rCSI -13.2%PRS 6.3%
-
CSI -2.4rCSI -4.8%PRS 7.2%
-
CSI -2.3rCSI -7.5%PRS 7.1%
-
CSI -1.3rCSI -3.2%PRS 5.3%
-
CSI -1.2rCSI -0.8%PRS 13.2%
-
CSI -1.0rCSI -17.7%PRS 40.3%
-
CSI -1.0rCSI -1.3%PRS 6.1%
-
CSI -0.9rCSI -2.1%PRS 15.6%
-
CSI -0.7rCSI -3.8%PRS 3.7%
-
CSI -0.5rCSI -1.5%PRS 6.7%
-
CSI -0.4rCSI -0.4%PRS 5.7%
-
CSI -0.2rCSI -2.5%PRS 31.3%
-
CSI -0.1rCSI -0.4%PRS 25.8%
-
CSI 0.1rCSI 2.2%PRS 51.6%
-
CSI 0.1rCSI 0.3%PRS 10.0%
-
CSI 0.1rCSI 3.9%PRS 72.5%
-
CSI 0.2rCSI 0.5%PRS 7.5%
-
CSI 0.2rCSI 0.6%PRS 9.5%
-
CSI 0.2rCSI 1.6%PRS 19.1%
-
CSI 0.3rCSI 0.7%PRS 11.6%
-
CSI 0.3rCSI 0.5%PRS 5.7%
-
CSI 0.3rCSI 1.7%PRS 18.0%
-
CSI 0.4rCSI 0.3%PRS 17.8%
-
CSI 0.4rCSI 3.2%PRS 51.9%
-
CSI 0.4rCSI 6.6%PRS 39.3%
-
CSI 0.4rCSI 1.4%PRS 39.8%
-
CSI 0.4rCSI 1.1%PRS 16.2%
-
CSI 0.4rCSI 1.0%PRS 14.7%
-
CSI 0.4rCSI 0.6%PRS 10.1%
-
CSI 0.4rCSI 10.6%PRS 34.4%
-
CSI 0.5rCSI 14.6%PRS 81.3%
-
CSI 0.5rCSI 11.3%PRS 16.9%
-
CSI 0.5rCSI 1.8%PRS 4.8%
-
CSI 0.6rCSI 7.2%PRS 40.5%
-
CSI 0.6rCSI 0.7%PRS 16.8%
-
CSI 0.6rCSI 15.6%PRS 32.3%
-
CSI 0.7rCSI 2.2%PRS 39.5%
-
CSI 0.7rCSI 3.5%PRS 17.6%
-
CSI 0.7rCSI 1.9%PRS 7.9%
-
CSI 0.7rCSI 1.7%PRS 9.0%
-
CSI 0.7rCSI 1.6%PRS 6.0%
-
CSI 0.7rCSI 1.8%PRS 9.1%
-
CSI 0.7rCSI 3.2%PRS 40.2%
-
CSI 0.7rCSI 0.6%PRS 10.3%
-
CSI 0.8rCSI 4.7%PRS 13.3%
-
CSI 0.8rCSI 1.3%PRS 10.6%
-
CSI 0.8rCSI 1.2%PRS 20.4%
-
CSI 0.9rCSI 1.0%PRS 16.9%
-
CSI 0.9rCSI 3.8%PRS 7.3%
-
CSI 0.9rCSI 1.4%PRS 9.7%
-
CSI 0.9rCSI 2.9%PRS 11.9%
-
CSI 0.9rCSI 17.9%PRS 7.8%
-
CSI 0.9rCSI 1.2%PRS 5.3%
-
CSI 1.0rCSI 3.8%PRS 14.5%
-
CSI 1.0rCSI 1.9%PRS 7.2%
-
CSI 1.0rCSI 1.9%PRS 27.0%
-
CSI 1.0rCSI 7.9%PRS 21.7%
-
CSI 1.1rCSI 6.3%PRS 16.5%
-
CSI 1.1rCSI 3.6%PRS 28.6%
-
CSI 1.1rCSI 3.4%PRS 16.3%
-
CSI 1.1rCSI 0.9%PRS 15.8%
-
CSI 1.2rCSI 16.3%PRS 6.8%
-
CSI 1.2rCSI 10.6%PRS 31.5%
-
CSI 1.2rCSI 2.3%PRS 10.4%
-
CSI 1.2rCSI 23.8%PRS 8.7%
-
CSI 1.2rCSI 2.0%PRS 12.6%
-
CSI 1.3rCSI 6.3%PRS 12.7%
-
CSI 1.4rCSI 2.7%PRS 30.0%
-
CSI 1.4rCSI 6.9%PRS 11.3%
-
CSI 1.5rCSI 2.1%PRS 7.8%
-
CSI 1.5rCSI 4.2%PRS 14.0%
-
CSI 1.5rCSI 2.2%PRS 9.1%
-
CSI 1.6rCSI 4.2%PRS 8.1%
-
CSI 1.6rCSI 1.1%PRS 13.9%
-
CSI 1.6rCSI 11.6%PRS 26.8%
-
CSI 1.7rCSI 4.8%PRS 21.8%
-
CSI 1.7rCSI 3.2%PRS 23.2%
-
CSI 1.7rCSI 2.8%PRS 7.6%
-
CSI 1.8rCSI 6.5%PRS 16.7%
-
CSI 1.9rCSI 4.5%PRS 23.8%
-
CSI 1.9rCSI 4.7%PRS 18.0%
-
CSI 2.0rCSI 8.6%PRS 9.6%
-
CSI 2.0rCSI 1.9%PRS 20.5%
-
CSI 2.0rCSI 3.7%PRS 21.3%
-
CSI 2.0rCSI 5.2%PRS 16.3%
-
CSI 2.1rCSI 3.3%PRS 8.4%
-
CSI 2.1rCSI 5.5%PRS 19.1%
-
CSI 2.1rCSI 4.3%PRS 9.7%
-
CSI 2.1rCSI 8.1%PRS 20.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1969928789
Symbol: H2AY_HUMAN
Name: Core histone macro-H2A.1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9714746
Title: Isolation of cDNA clones encoding human histone macroH2A1 subtypes.
PubMed ID: 9714746
PubMed ID: 9653160
Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.
PubMed ID: 9653160
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12800201
Title: Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.
PubMed ID: 12800201
DOI: 10.1002/ijc.11208
PubMed ID: 9634239
Title: Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals.
PubMed ID: 9634239
DOI: 10.1038/31275
PubMed ID: 12718888
Title: The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling.
PubMed ID: 12718888
PubMed ID: 16129414
Title: Histone variant macroH2A1.2 is mono-ubiquitinated at its histone domain.
PubMed ID: 16129414
PubMed ID: 15621527
Title: Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA.
PubMed ID: 15621527
PubMed ID: 15902274
Title: The macro domain is an ADP-ribose binding module.
PubMed ID: 15902274
PubMed ID: 15897469
Title: Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase.
PubMed ID: 15897469
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16428466
Title: Mechanism of polymerase II transcription repression by the histone variant macroH2A.
PubMed ID: 16428466
PubMed ID: 16210244
Title: Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry.
PubMed ID: 16210244
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21211722
Title: DNA repair factor APLF is a histone chaperone.
PubMed ID: 21211722
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23022728
Title: Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness.
PubMed ID: 23022728
DOI: 10.1038/nsmb.2390
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23474714
Title: Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.
PubMed ID: 23474714
DOI: 10.1038/nsmb.2521
PubMed ID: 29905837
Title: DNA repair factor APLF acts as a H2A-H2B histone chaperone through binding its DNA interaction surface.
PubMed ID: 29905837
DOI: 10.1093/nar/gky507
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 16107708
Title: Structural characterization of the histone variant macroH2A.
PubMed ID: 16107708
PubMed ID: 15965484
Title: Splicing regulates NAD metabolite binding to histone macroH2A.
PubMed ID: 15965484
DOI: 10.1038/nsmb956
PubMed ID: 19818708
Title: Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
PubMed ID: 19818708
Sequence Information:
- Length: 369
- Mass: 39184
- Checksum: D21A4CE6C7AA3BB1
- Sequence:
MSSRGGKKKS TKTSRSAKAG VIFPVGRMLR YIKKGHPKYR IGVGAPVYMA AVLEYLTAEI LELAGNAARD NKKGRVTPRH ILLAVANDEE LNQLLKGVTI ASGGVLPNIH PELLAKKRGS KGKLEAIITP PPAKKAKSPS QKKPVSKKAG GKKGARKSKK KQGEVSKAAS ADSTTEGTPA DGFTVLSTKS LFLGQKLQVV QADIASIDSD AVVHPTNTDF YIGGEVGNTL EKKGGKEFVE AVLELRKKNG PLEVAGAAVS AGHGLPAKFV IHCNSPVWGA DKCEELLEKT VKNCLALADD KKLKSIAFPS IGSGRNGFPK QTAAQLILKA ISSYFVSTMS SSIKTVYFVL FDSESIGIYV QEMAKLDAN
Genular Protein ID: 4176396830
Symbol: A0A994J4J7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
Sequence Information:
- Length: 199
- Mass: 21045
- Checksum: 09179AC79704AB54
- Sequence:
MSSRGGKKKS TKTSRSAKAG VIFPVGRMLR YIKKGHPKYR IGVGAPVYMA AVLEYLTAEI LELAGNAARD NKKGRVTPRH ILLAVANDEE LNQLLKGVTI ASGGVLPNIH PELLAKKRGS KGKLEAIITP PPAKKAKSPS QKKPVSKKAG GKKGARKSKK KQGEVSKAAS ADSTTEGTPA DGFTVLSTKS LFLGQKPPQ