Details for: ATP5MJ

Gene ID: 9556

Symbol: ATP5MJ

Ensembl ID: ENSG00000156411

Description: ATP synthase membrane subunit j

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 7.74
    Marker Score: 8,382
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 6.95
    Marker Score: 6,803
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 6.5
    Marker Score: 4,348
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.17
    Marker Score: 10,915
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 4.99
    Marker Score: 2,577
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.78
    Marker Score: 63,608
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 4.43
    Marker Score: 18,405
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.2
    Marker Score: 3,172
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.14
    Marker Score: 2,921
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 4.03
    Marker Score: 1,674
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.82
    Marker Score: 1,121
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 3.82
    Marker Score: 2,317
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.8
    Marker Score: 2,028
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.78
    Marker Score: 2,109
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.73
    Marker Score: 5,744
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.72
    Marker Score: 2,911
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.67
    Marker Score: 3,271
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.58
    Marker Score: 200,133
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.58
    Marker Score: 3,731
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 3.56
    Marker Score: 1,627
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.51
    Marker Score: 4,238
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.5
    Marker Score: 46,207
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.43
    Marker Score: 1,893
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.38
    Marker Score: 9,054
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.27
    Marker Score: 3,088
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.23
    Marker Score: 15,500
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.23
    Marker Score: 37,541
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.22
    Marker Score: 1,450
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.21
    Marker Score: 5,319
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.21
    Marker Score: 4,176
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.2
    Marker Score: 1,947
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.2
    Marker Score: 110,804
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.19
    Marker Score: 3,194
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.19
    Marker Score: 11,334
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.16
    Marker Score: 24,668
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.16
    Marker Score: 5,022
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.15
    Marker Score: 2,811
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.14
    Marker Score: 1,035
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.13
    Marker Score: 8,652
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.08
    Marker Score: 7,513
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.06
    Marker Score: 6,227
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.03
    Marker Score: 1,210
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.03
    Marker Score: 19,333
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.02
    Marker Score: 6,847
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.01
    Marker Score: 1,039
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.99
    Marker Score: 19,499
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.99
    Marker Score: 8,521
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.94
    Marker Score: 9,231
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.92
    Marker Score: 5,494
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.9
    Marker Score: 4,021
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.9
    Marker Score: 2,282
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.89
    Marker Score: 1,540
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.88
    Marker Score: 7,275
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.88
    Marker Score: 25,025
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.85
    Marker Score: 2,965
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.84
    Marker Score: 4,565
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.83
    Marker Score: 6,444
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.82
    Marker Score: 1,603
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.8
    Marker Score: 2,687
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.79
    Marker Score: 24,068
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.78
    Marker Score: 14,611
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.76
    Marker Score: 659
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.71
    Marker Score: 17,604
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.7
    Marker Score: 2,741
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.69
    Marker Score: 10,387
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.69
    Marker Score: 5,624
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.69
    Marker Score: 10,994
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.69
    Marker Score: 5,233
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 2.68
    Marker Score: 1,166
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.67
    Marker Score: 2,828
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.67
    Marker Score: 11,499
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.66
    Marker Score: 68,205
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.66
    Marker Score: 850
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.64
    Marker Score: 3,017
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.63
    Marker Score: 3,727
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.62
    Marker Score: 842
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.61
    Marker Score: 1,873
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.61
    Marker Score: 1,351
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.61
    Marker Score: 5,210
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.6
    Marker Score: 1,233
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.59
    Marker Score: 976
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.59
    Marker Score: 1,624
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.58
    Marker Score: 3,655
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.58
    Marker Score: 34,646
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.58
    Marker Score: 2,894
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.57
    Marker Score: 3,957
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.57
    Marker Score: 6,389
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.55
    Marker Score: 2,728
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.55
    Marker Score: 6,006
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.55
    Marker Score: 1,813
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.55
    Marker Score: 1,677
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 2.55
    Marker Score: 1,738
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.54
    Marker Score: 28,603
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.53
    Marker Score: 2,705
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.53
    Marker Score: 2,257
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.53
    Marker Score: 7,492
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.52
    Marker Score: 2,147
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.52
    Marker Score: 4,277
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.51
    Marker Score: 1,416
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 2.5
    Marker Score: 657

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ATP5MJ is a membrane subunit of the mitochondrial ATP synthase complex, which is responsible for producing ATP through the process of chemiosmosis. This complex is composed of multiple subunits, including ATP5MJ, which is encoded by the ENSG00000156411 gene. The ATP5MJ subunit is characterized by its ability to bind to the mitochondrial inner membrane and facilitate the transfer of protons across the membrane, generating a proton gradient that drives ATP synthesis. **Pathways and Functions:** ATP5MJ is integral to the following cellular pathways: 1. **Mitochondrial proton-transporting atp synthase complex:** ATP5MJ plays a crucial role in the assembly and functioning of this complex, which is responsible for generating the PMF that drives ATP synthesis. 2. **Biological_process:** ATP5MJ is involved in various biological processes, including energy metabolism, cell growth, and differentiation. 3. **Molecular_function:** ATP5MJ is a proton channel that facilitates the transfer of protons across the mitochondrial inner membrane, generating the PMF that drives ATP synthesis. The functions of ATP5MJ include: 1. **Energy production:** ATP5MJ plays a critical role in generating ATP through the process of chemiosmosis, which is essential for maintaining cellular homeostasis and function. 2. **Cell signaling:** ATP5MJ may also be involved in cell signaling pathways, including those related to immune response and inflammation. 3. **Antigen presentation:** ATP5MJ has been shown to be expressed in professional antigen-presenting cells, suggesting a potential role in immune response and antigen presentation. **Clinical Significance:** Dysregulation of ATP5MJ has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** ATP5MJ has been shown to be involved in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Inflammatory disorders:** ATP5MJ has been implicated in inflammatory disorders, including atherosclerosis and inflammatory bowel disease. 3. **Cancer:** ATP5MJ has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma. In conclusion, ATP5MJ is a critical component of the mitochondrial ATP synthase complex, playing a pivotal role in energy production, cell signaling, and immune response. Further research is needed to fully elucidate the mechanisms by which ATP5MJ regulates cellular function and to explore its potential as a therapeutic target in immune-related disorders.

Genular Protein ID: 253405126

Symbol: ATP68_HUMAN

Name: N/A

UniProtKB Accession Codes:

P56378 B2R588 G3V5Q3 Q86TT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 1 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 8 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9653160

Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.

PubMed ID: 9653160

DOI: 10.1073/pnas.95.14.8175

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 24330338

Title: Population of ATP synthase molecules in mitochondria is limited by available 6.8-kDa proteolipid protein (MLQ).

PubMed ID: 24330338

DOI: 10.1111/gtc.12121

Sequence Information:

  • Length: 58
  • Mass: 6662
  • Checksum: 1B8A63046C0383F6
  • Sequence:
    • MLQSIIKNIW IPMKPYYTKV YQEIWIGMGL MGFIVYKIRA ADKRSKALKA SAPAPGHH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.