Details for: ENTPD3

Gene ID: 956

Symbol: ENTPD3

Ensembl ID: ENSG00000168032

Description: ectonucleoside triphosphate diphosphohydrolase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.1471
    Cell Significance Index: -13.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 31.5596
    Cell Significance Index: -14.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.6405
    Cell Significance Index: 293.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.0313
    Cell Significance Index: 134.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.5632
    Cell Significance Index: 97.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.3442
    Cell Significance Index: 840.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.8154
    Cell Significance Index: 39.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9852
    Cell Significance Index: 31.5600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.9508
    Cell Significance Index: 12.3300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8988
    Cell Significance Index: 7.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7234
    Cell Significance Index: 33.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6487
    Cell Significance Index: 18.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5620
    Cell Significance Index: 112.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3608
    Cell Significance Index: 35.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3096
    Cell Significance Index: 279.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2861
    Cell Significance Index: 2.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2695
    Cell Significance Index: 186.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2518
    Cell Significance Index: 15.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2408
    Cell Significance Index: 131.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1869
    Cell Significance Index: 4.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1831
    Cell Significance Index: 29.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1741
    Cell Significance Index: 4.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1451
    Cell Significance Index: 4.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1424
    Cell Significance Index: 15.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1130
    Cell Significance Index: 20.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0963
    Cell Significance Index: 16.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0708
    Cell Significance Index: 13.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0461
    Cell Significance Index: 2.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0428
    Cell Significance Index: 5.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0426
    Cell Significance Index: 78.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0379
    Cell Significance Index: 51.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0314
    Cell Significance Index: 48.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0166
    Cell Significance Index: 3.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0150
    Cell Significance Index: 28.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0038
    Cell Significance Index: 0.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0037
    Cell Significance Index: 0.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0001
    Cell Significance Index: 0.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0031
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0038
    Cell Significance Index: -2.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0041
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0051
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0056
    Cell Significance Index: -4.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0057
    Cell Significance Index: -0.6600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0061
    Cell Significance Index: -0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0084
    Cell Significance Index: -5.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0102
    Cell Significance Index: -7.7400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0115
    Cell Significance Index: -0.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0123
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0197
    Cell Significance Index: -4.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0204
    Cell Significance Index: -14.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0208
    Cell Significance Index: -3.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0219
    Cell Significance Index: -9.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0250
    Cell Significance Index: -0.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0255
    Cell Significance Index: -1.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0292
    Cell Significance Index: -0.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0296
    Cell Significance Index: -0.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0333
    Cell Significance Index: -1.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0424
    Cell Significance Index: -12.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0424
    Cell Significance Index: -0.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0455
    Cell Significance Index: -1.1700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0475
    Cell Significance Index: -0.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0480
    Cell Significance Index: -6.1500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0611
    Cell Significance Index: -0.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0797
    Cell Significance Index: -10.9400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0850
    Cell Significance Index: -1.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1014
    Cell Significance Index: -5.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1026
    Cell Significance Index: -1.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1113
    Cell Significance Index: -12.7000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1173
    Cell Significance Index: -1.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1177
    Cell Significance Index: -15.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1283
    Cell Significance Index: -1.7500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1335
    Cell Significance Index: -2.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1351
    Cell Significance Index: -14.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1476
    Cell Significance Index: -15.0800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1519
    Cell Significance Index: -3.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1612
    Cell Significance Index: -11.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1655
    Cell Significance Index: -11.1300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1656
    Cell Significance Index: -1.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1838
    Cell Significance Index: -3.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1854
    Cell Significance Index: -13.8200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1928
    Cell Significance Index: -4.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1971
    Cell Significance Index: -12.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1988
    Cell Significance Index: -10.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2309
    Cell Significance Index: -3.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2326
    Cell Significance Index: -10.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2345
    Cell Significance Index: -7.4700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2464
    Cell Significance Index: -4.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2465
    Cell Significance Index: -8.0700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2482
    Cell Significance Index: -10.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2552
    Cell Significance Index: -8.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2997
    Cell Significance Index: -11.0000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.3118
    Cell Significance Index: -2.0700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3132
    Cell Significance Index: -6.2500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3189
    Cell Significance Index: -4.5400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3339
    Cell Significance Index: -3.1700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3740
    Cell Significance Index: -4.7200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3766
    Cell Significance Index: -2.4600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3841
    Cell Significance Index: -12.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3856
    Cell Significance Index: -7.5300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4266
    Cell Significance Index: -5.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Enzymatic activity**: ENTPD3 is a diphosphohydrolase, meaning it catalyzes the hydrolysis of high-energy phosphate bonds. 2. **Nucleotide regulation**: The protein regulates the concentration and activity of extracellular nucleotides, which are involved in various cellular processes, including signaling, metabolism, and immune responses. 3. **Tissue specificity**: ENTPD3 is primarily expressed in the nervous system, particularly in retinal bipolar neurons, GABAergic cortical interneurons, and other neural cells. 4. **Cellular localization**: The protein is localized to the plasma membrane, where it can interact with extracellular nucleotides. **Pathways and Functions** 1. **Nucleotide metabolism**: ENTPD3 is involved in the catabolism of extracellular nucleotides, such as ATP, UTP, and UDP, into their corresponding nucleosides and phosphates. 2. **Signaling regulation**: The protein regulates the concentration and activity of extracellular nucleotides, which are involved in various signaling pathways, including those involved in neural communication and immune responses. 3. **Immune regulation**: ENTPD3 may play a role in regulating immune responses by modulating the concentration and activity of extracellular nucleotides. 4. **Neurotransmitter regulation**: The protein may also regulate the concentration and activity of neurotransmitters, such as GABA, which is involved in inhibitory neurotransmission. **Clinical Significance** 1. **Neurological disorders**: Alterations in ENTPD3 expression or function may contribute to various neurological disorders, including neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Immune system dysregulation**: Dysregulation of ENTPD3 expression or function may also contribute to immune system dysregulation, leading to autoimmune diseases or immune-related disorders. 3. **Cancer**: ENTPD3 has been implicated in cancer development and progression, particularly in tumors with high levels of extracellular nucleotides. 4. **Neurodevelopmental disorders**: ENTPD3 may also play a role in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, ENTPD3 is a gene that encodes a protein involved in the regulation of extracellular nucleotides in the nervous system. The protein's primary function is to hydrolyze extracellular nucleotides, regulating their concentration and activity. Alterations in ENTPD3 expression or function may contribute to various neurological disorders, immune system dysregulation, and cancer development. Further research is needed to fully understand the role of ENTPD3 in human health and disease.

Genular Protein ID: 1057328402

Symbol: ENTP3_HUMAN

Name: Ectonucleoside triphosphate diphosphohydrolase 3

UniProtKB Accession Codes:

O75355 B2R8D0 G5E9N0 O60495 Q8N6K2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 8 ChEMBL 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9676430

Title: The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster.

PubMed ID: 9676430

DOI: 10.1006/geno.1998.5317

PubMed ID: 9675246

Title: Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases.

PubMed ID: 9675246

DOI: 10.1016/s0167-4838(98)00063-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10231536

Title: Mutagenesis of two conserved tryptophan residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto-NTPase.

PubMed ID: 10231536

DOI: 10.1021/bi990171k

PubMed ID: 11300774

Title: Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions.

PubMed ID: 11300774

DOI: 10.1021/bi002711f

PubMed ID: 15966724

Title: Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling.

PubMed ID: 15966724

DOI: 10.1021/bi047487z

Sequence Information:

  • Length: 529
  • Mass: 59105
  • Checksum: 5043CF0202978B88
  • Sequence:
    • MFTVLTRQPC EQAGLKALYR TPTIIALVVL LVSIVVLVSI TVIQIHKQEV LPPGLKYGIV 
LDAGSSRTTV YVYQWPAEKE NNTGVVSQTF KCSVKGSGIS SYGNNPQDVP RAFEECMQKV 
KGQVPSHLHG STPIHLGATA GMRLLRLQNE TAANEVLESI QSYFKSQPFD FRGAQIISGQ 
EEGVYGWITA NYLMGNFLEK NLWHMWVHPH GVETTGALDL GGASTQISFV AGEKMDLNTS 
DIMQVSLYGY VYTLYTHSFQ CYGRNEAEKK FLAMLLQNSP TKNHLTNPCY PRDYSISFTM 
GHVFDSLCTV DQRPESYNPN DVITFEGTGD PSLCKEKVAS IFDFKACHDQ ETCSFDGVYQ 
PKIKGPFVAF AGFYYTASAL NLSGSFSLDT FNSSTWNFCS QNWSQLPLLL PKFDEVYARS 
YCFSANYIYH LFVNGYKFTE ETWPQIHFEK EVGNSSIAWS LGYMLSLTNQ IPAESPLIRL 
PIEPPVFVGT LAFFTAAALL CLAFLAYLCS ATRRKRHSEH AFDHAVDSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.