Details for: ENTPD3

Gene ID: 956

Symbol: ENTPD3

Ensembl ID: ENSG00000168032

Description: ectonucleoside triphosphate diphosphohydrolase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.66
    Marker Score: 30976.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.22
    Marker Score: 33210
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.18
    Marker Score: 1505
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.11
    Marker Score: 80127
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.05
    Marker Score: 7924
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.83
    Marker Score: 67444
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.82
    Marker Score: 13925
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.57
    Marker Score: 6515
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.53
    Marker Score: 14352
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168704
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.32
    Marker Score: 694
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.29
    Marker Score: 1897
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.27
    Marker Score: 530
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 850
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.23
    Marker Score: 24476
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.23
    Marker Score: 891
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.22
    Marker Score: 4949
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 484
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.16
    Marker Score: 1788
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4804
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.13
    Marker Score: 381
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.05
    Marker Score: 1446
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1
    Marker Score: 273
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5326
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.86
    Marker Score: 505
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.83
    Marker Score: 8570
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 619
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.78
    Marker Score: 6698
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.78
    Marker Score: 47765
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.73
    Marker Score: 232
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.71
    Marker Score: 1613
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.65
    Marker Score: 1238
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.65
    Marker Score: 6139
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.64
    Marker Score: 862
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.63
    Marker Score: 4725
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.61
    Marker Score: 1505.5
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.6
    Marker Score: 424
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.59
    Marker Score: 584
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.58
    Marker Score: 19447
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.57
    Marker Score: 303.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.55
    Marker Score: 366
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.54
    Marker Score: 217
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.54
    Marker Score: 227
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.54
    Marker Score: 613
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.53
    Marker Score: 2214
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.5
    Marker Score: 609
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.47
    Marker Score: 7431
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.47
    Marker Score: 528
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.46
    Marker Score: 2783
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.45
    Marker Score: 15490
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.43
    Marker Score: 122
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.42
    Marker Score: 441
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.42
    Marker Score: 209
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 181
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.41
    Marker Score: 234
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.41
    Marker Score: 271
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.39
    Marker Score: 798
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.39
    Marker Score: 79
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.39
    Marker Score: 497
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.38
    Marker Score: 362
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.37
    Marker Score: 266
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.37
    Marker Score: 789
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.36
    Marker Score: 401
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.36
    Marker Score: 599
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.35
    Marker Score: 1457
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.35
    Marker Score: 121
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.33
    Marker Score: 156
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.33
    Marker Score: 325
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.32
    Marker Score: 176
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.32
    Marker Score: 718
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3
    Marker Score: 301
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.3
    Marker Score: 137
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.29
    Marker Score: 85
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.29
    Marker Score: 138
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.28
    Marker Score: 170
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.28
    Marker Score: 148
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.27
    Marker Score: 438

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Other Information

**Key characteristics:** - ENTP3 is a transmembrane protein with a molecular weight of approximately 140 kDa. - It is a member of the Ectonucleoside triphosphate diphosphohydrolase (ETP) family of enzymes. - ETPs are involved in a variety of cellular processes, including cell migration, differentiation, and apoptosis. **Pathways and functions:** - ENTP3 is involved in the regulation of ectonucleoside triphosphate (ETP) levels in the plasma membrane. - ETPs are produced by retinal bipolar neurons and are thought to play a role in the regulation of retinal development and function. - They are also involved in the regulation of synaptic plasticity in the central nervous system. **Clinical significance:** - Mutations in ENTP3 have been linked to a number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. - Studies of ENTP3 knockout mice have shown that they have a number of neuroprotective effects, including reducing inflammation, promoting neurogenesis, and protecting against apoptosis. - Therefore, ENTP3 is a promising target for the treatment of neurodegenerative diseases.

Genular Protein ID: 1057328402

Symbol: ENTP3_HUMAN

Name: Ectonucleoside triphosphate diphosphohydrolase 3

UniProtKB Accession Codes:

O75355 B2R8D0 G5E9N0 O60495 Q8N6K2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 8 ChEMBL 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9676430

Title: The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster.

PubMed ID: 9676430

DOI: 10.1006/geno.1998.5317

PubMed ID: 9675246

Title: Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases.

PubMed ID: 9675246

DOI: 10.1016/s0167-4838(98)00063-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10231536

Title: Mutagenesis of two conserved tryptophan residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto-NTPase.

PubMed ID: 10231536

DOI: 10.1021/bi990171k

PubMed ID: 11300774

Title: Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions.

PubMed ID: 11300774

DOI: 10.1021/bi002711f

PubMed ID: 15966724

Title: Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling.

PubMed ID: 15966724

DOI: 10.1021/bi047487z

Sequence Information:

  • Length: 529
  • Mass: 59105
  • Checksum: 5043CF0202978B88
  • Sequence:
    • MFTVLTRQPC EQAGLKALYR TPTIIALVVL LVSIVVLVSI TVIQIHKQEV LPPGLKYGIV 
LDAGSSRTTV YVYQWPAEKE NNTGVVSQTF KCSVKGSGIS SYGNNPQDVP RAFEECMQKV 
KGQVPSHLHG STPIHLGATA GMRLLRLQNE TAANEVLESI QSYFKSQPFD FRGAQIISGQ 
EEGVYGWITA NYLMGNFLEK NLWHMWVHPH GVETTGALDL GGASTQISFV AGEKMDLNTS 
DIMQVSLYGY VYTLYTHSFQ CYGRNEAEKK FLAMLLQNSP TKNHLTNPCY PRDYSISFTM 
GHVFDSLCTV DQRPESYNPN DVITFEGTGD PSLCKEKVAS IFDFKACHDQ ETCSFDGVYQ 
PKIKGPFVAF AGFYYTASAL NLSGSFSLDT FNSSTWNFCS QNWSQLPLLL PKFDEVYARS 
YCFSANYIYH LFVNGYKFTE ETWPQIHFEK EVGNSSIAWS LGYMLSLTNQ IPAESPLIRL 
PIEPPVFVGT LAFFTAAALL CLAFLAYLCS ATRRKRHSEH AFDHAVDSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.