MINPP1 | ENSG00000107789 | NCBI 9562

Details for: MINPP1

Gene ID: 9562

Symbol: MINPP1

Ensembl ID: ENSG00000107789

Description: multiple inositol-polyphosphate phosphatase 1

Associated with

Inositol phosphate metabolism
(R-HSA-1483249)
Metabolism
(R-HSA-1430728)
Synthesis of ips in the er lumen
(R-HSA-1855231)
3-phytase activity
(GO:0016158)
4-phytase activity
(GO:0008707)
Acid phosphatase activity
(GO:0003993)
Bisphosphoglycerate 3-phosphatase activity
(GO:0034417)
Bone mineralization
(GO:0030282)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
(GO:0030351)
Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
(GO:0051717)
Inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
(GO:0030352)
Inositol-hexakisphosphate phosphatase activity
(GO:0004446)
Inositol bisphosphate phosphatase activity
(GO:0016312)
Inositol hexakisphosphate 2-phosphatase activity
(GO:0052826)
Inositol pentakisphosphate phosphatase activity
(GO:0052827)
Inositol phosphate metabolic process
(GO:0043647)
Inositol phosphate phosphatase activity
(GO:0052745)
Inositol trisphosphate phosphatase activity
(GO:0046030)
Intracellular monoatomic cation homeostasis
(GO:0030003)
Ossification
(GO:0001503)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)

Other Information

Proteins

MINP1_HUMAN

Genular Protein ID: 2870580108

Symbol: MINP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UNW1 F5H683 O95172 O95286 Q59EJ2 Q9UGA3

Database IDs:

Citations:

PubMed ID: 9923613

Title: The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification.

PubMed ID: 9923613

DOI: 10.1016/s0014-5793(98)01636-6

PubMed ID: 10087200

Title: Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19.

PubMed ID: 10087200

DOI: 10.1006/geno.1998.5736

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16759730

Title: Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's 'phosphate crisis'.

PubMed ID: 16759730

DOI: 10.1016/j.jbiotec.2006.04.028

PubMed ID: 18413611

Title: Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt.

PubMed ID: 18413611

DOI: 10.1073/pnas.0710980105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 36589890

Title: Stable Isotopomers of myo-Inositol Uncover a Complex MINPP1-Dependent Inositol Phosphate Network.

PubMed ID: 36589890

DOI: 10.1021/acscentsci.2c01032

PubMed ID: 11297621

Title: Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas.

PubMed ID: 11297621

DOI: 10.1210/jcem.86.4.7419

PubMed ID: 33257696

Title: MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia.

PubMed ID: 33257696

DOI: 10.1038/s41467-020-19919-y

PubMed ID: 33168985

Title: Pontocerebellar hypoplasia due to bi-allelic variants in MINPP1.

PubMed ID: 33168985

DOI: 10.1038/s41431-020-00749-x

Sequence Information:

Length: 487
Mass: 55051
Checksum: 89B8F347885B320A
Sequence:

MLRAPGCLLR TSVAPAAALA AALLSSLARC SLLEPRDPVA SSLSPYFGTK TRYEDVNPVL 
LSGPEAPWRD PELLEGTCTP VQLVALIRHG TRYPTVKQIR KLRQLHGLLQ ARGSRDGGAS 
STGSRDLGAA LADWPLWYAD WMDGQLVEKG RQDMRQLALR LASLFPALFS RENYGRLRLI 
TSSKHRCMDS SAAFLQGLWQ HYHPGLPPPD VADMEFGPPT VNDKLMRFFD HCEKFLTEVE 
KNATALYHVE AFKTGPEMQN ILKKVAATLQ VPVNDLNADL IQVAFFTCSF DLAIKGVKSP 
WCDVFDIDDA KVLEYLNDLK QYWKRGYGYT INSRSSCTLF QDIFQHLDKA VEQKQRSQPI 
SSPVILQFGH AETLLPLLSL MGYFKDKEPL TAYNYKKQMH RKFRSGLIVP YASNLIFVLY 
HCENAKTPKE QFRVQMLLNE KVLPLAYSQE TVSFYEDLKN HYKDILQSCQ TSEECELARA 
NSTSDEL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MINPP1

Associated with

Other Information

The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification. PubMed ID: 9923613

Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. PubMed ID: 10087200

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's 'phosphate crisis'. PubMed ID: 16759730

Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt. PubMed ID: 18413611

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Stable Isotopomers of myo-Inositol Uncover a Complex MINPP1-Dependent Inositol Phosphate Network. PubMed ID: 36589890

Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas. PubMed ID: 11297621

MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. PubMed ID: 33257696

Pontocerebellar hypoplasia due to bi-allelic variants in MINPP1. PubMed ID: 33168985