Details for: ENTPD5

Gene ID: 957

Symbol: ENTPD5

Ensembl ID: ENSG00000187097

Description: ectonucleoside triphosphate diphosphohydrolase 5 (inactive)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 87.1129
    Cell Significance Index: -13.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.2564
    Cell Significance Index: -15.0300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 24.9768
    Cell Significance Index: -16.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.1497
    Cell Significance Index: -14.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.2265
    Cell Significance Index: -16.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9812
    Cell Significance Index: -15.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.1893
    Cell Significance Index: 220.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.6512
    Cell Significance Index: 137.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.5397
    Cell Significance Index: 115.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.4611
    Cell Significance Index: 53.3200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.9158
    Cell Significance Index: 11.8200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.8818
    Cell Significance Index: 31.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6331
    Cell Significance Index: 1474.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4290
    Cell Significance Index: 155.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2927
    Cell Significance Index: 256.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2090
    Cell Significance Index: 34.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0905
    Cell Significance Index: 16.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9768
    Cell Significance Index: 176.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8090
    Cell Significance Index: 7.4500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8035
    Cell Significance Index: 13.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5252
    Cell Significance Index: 18.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4376
    Cell Significance Index: 11.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4198
    Cell Significance Index: 120.8000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.4145
    Cell Significance Index: 4.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3852
    Cell Significance Index: 17.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3750
    Cell Significance Index: 46.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3459
    Cell Significance Index: 239.2200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.3166
    Cell Significance Index: 5.0800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.3045
    Cell Significance Index: 3.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2940
    Cell Significance Index: 7.3500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2891
    Cell Significance Index: 6.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2719
    Cell Significance Index: 54.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2672
    Cell Significance Index: 5.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2550
    Cell Significance Index: 41.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2170
    Cell Significance Index: 31.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1928
    Cell Significance Index: 2.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1847
    Cell Significance Index: 11.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1687
    Cell Significance Index: 4.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1651
    Cell Significance Index: 16.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1645
    Cell Significance Index: 12.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1634
    Cell Significance Index: 89.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1589
    Cell Significance Index: 57.0000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1255
    Cell Significance Index: 2.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1249
    Cell Significance Index: 4.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1035
    Cell Significance Index: 19.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0923
    Cell Significance Index: 6.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0755
    Cell Significance Index: 33.3900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0713
    Cell Significance Index: 1.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0712
    Cell Significance Index: 9.7800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0678
    Cell Significance Index: 1.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0312
    Cell Significance Index: 1.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0185
    Cell Significance Index: 34.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0168
    Cell Significance Index: 2.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0156
    Cell Significance Index: 23.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0155
    Cell Significance Index: 9.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0135
    Cell Significance Index: 24.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0127
    Cell Significance Index: 0.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0065
    Cell Significance Index: 8.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0048
    Cell Significance Index: -3.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0125
    Cell Significance Index: -0.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0137
    Cell Significance Index: -10.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0156
    Cell Significance Index: -7.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0166
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0211
    Cell Significance Index: -15.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0277
    Cell Significance Index: -15.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0317
    Cell Significance Index: -19.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0463
    Cell Significance Index: -5.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0474
    Cell Significance Index: -1.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0476
    Cell Significance Index: -4.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0498
    Cell Significance Index: -1.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0594
    Cell Significance Index: -7.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0628
    Cell Significance Index: -7.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0729
    Cell Significance Index: -8.3600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0812
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0851
    Cell Significance Index: -17.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0858
    Cell Significance Index: -1.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0885
    Cell Significance Index: -4.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1108
    Cell Significance Index: -6.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1183
    Cell Significance Index: -2.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1217
    Cell Significance Index: -8.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1365
    Cell Significance Index: -14.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1392
    Cell Significance Index: -3.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1620
    Cell Significance Index: -10.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1708
    Cell Significance Index: -13.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1960
    Cell Significance Index: -8.6700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1982
    Cell Significance Index: -1.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2027
    Cell Significance Index: -10.6400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2433
    Cell Significance Index: -1.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2500
    Cell Significance Index: -9.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2536
    Cell Significance Index: -2.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2710
    Cell Significance Index: -16.6600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2753
    Cell Significance Index: -2.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2898
    Cell Significance Index: -4.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3194
    Cell Significance Index: -7.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3218
    Cell Significance Index: -5.3900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3342
    Cell Significance Index: -4.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3358
    Cell Significance Index: -11.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3392
    Cell Significance Index: -7.1000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3421
    Cell Significance Index: -5.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3426
    Cell Significance Index: -9.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ENTPD5 is a non-functional member of the ENTPD family, which consists of enzymes that catalyze the hydrolysis of nucleoside triphosphates to nucleoside diphosphates. The ENTPD5 gene is located on chromosome 1q23.3 and is highly expressed in various tissues, including those involved in immune responses. Notably, its expression in immune cells, such as macrophages and T cells, suggests a potential role in regulating purinergic signaling pathways. **Pathways and Functions:** ENTPD5 is involved in several signaling pathways, including: 1. **Purinergic signaling:** ENTPD5 regulates the levels of extracellular ATP, which is a key player in purinergic signaling. By controlling ATP hydrolysis, ENTPD5 modulates the intensity and duration of purinergic responses. 2. **Cell recruitment and inflammatory response:** ENTPD5 has been implicated in the recruitment of immune cells to sites of inflammation. Its expression in immune cells and its involvement in purinergic signaling pathways suggest a role in regulating the inflammatory response. 3. **Metabolism of nucleotides:** ENTPD5 is involved in the catabolism of nucleoside triphosphates, which is essential for maintaining nucleotide homeostasis in cells. 4. **Leishmania infection:** ENTPD5 has been identified as a significant expressed gene in Leishmania-infected cells, suggesting a potential role in the regulation of purinergic signaling during parasitic infections. **Clinical Significance:** The identification of ENTPD5 as a non-functional member of the ENTPD family with significant expression in immune cells and involvement in disease pathways has significant implications for our understanding of immune regulation and disease mechanisms. Further studies are needed to elucidate the functional role of ENTPD5 in immune responses and to explore its potential as a therapeutic target for various diseases, including inflammatory disorders and parasitic infections. In conclusion, ENTPD5 is a fascinating gene that highlights the complexity of immune regulation and the importance of purinergic signaling pathways in various disease processes. Further research is necessary to fully understand the functional role of ENTPD5 and its potential applications in human health and disease.

Genular Protein ID: 199272517

Symbol: ENTP5_HUMAN

Name: CD39 antigen-like 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9676430

Title: The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster.

PubMed ID: 9676430

DOI: 10.1006/geno.1998.5317

PubMed ID: 10708485

Title: The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells.

PubMed ID: 10708485

DOI: 10.1002/(sici)1098-2744(200003)27:3<229::aid-mc10>3.3.co;2-q

PubMed ID: 15698960

Title: Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase.

PubMed ID: 15698960

DOI: 10.1016/j.bbapap.2004.11.017

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10400613

Title: CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates.

PubMed ID: 10400613

DOI: 10.1074/jbc.274.29.20064

PubMed ID: 11041857

Title: Biochemical characterization of CD39L4.

PubMed ID: 11041857

DOI: 10.1021/bi000960y

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21074248

Title: The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway.

PubMed ID: 21074248

DOI: 10.1016/j.cell.2010.10.010

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 428
  • Mass: 47517
  • Checksum: 830437A155DE4DDD
  • Sequence:
  • MATSWGTVFF MLVVSCVCSA VSHRNQQTWF EGIFLSSMCP INVSASTLYG IMFDAGSTGT 
    RIHVYTFVQK MPGQLPILEG EVFDSVKPGL SAFVDQPKQG AETVQGLLEV AKDSIPRSHW 
    KKTPVVLKAT AGLRLLPEHK AKALLFEVKE IFRKSPFLVP KGSVSIMDGS DEGILAWVTV 
    NFLTGQLHGH RQETVGTLDL GGASTQITFL PQFEKTLEQT PRGYLTSFEM FNSTYKLYTH 
    SYLGFGLKAA RLATLGALET EGTDGHTFRS ACLPRWLEAE WIFGGVKYQY GGNQEGEVGF 
    EPCYAEVLRV VRGKLHQPEE VQRGSFYAFS YYYDRAVDTD MIDYEKGGIL KVEDFERKAR 
    EVCDNLENFT SGSPFLCMDL SYITALLKDG FGFADSTVLQ LTKKVNNIET GWALGATFHL 
    LQSLGISH

Genular Protein ID: 199512354

Symbol: G3V4I0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 407
  • Mass: 45336
  • Checksum: D92A5F7DC9EC9E5B
  • Sequence:
  • MATSWGTVFF MLVVSCVCSA VSHRNQQTWF EGIFLSSMCP INVSASTLYG IMFDAGSTGT 
    RIHVYTFVQK MPGQLPILEG EVFDSVKPGL SAFVDQPKQG AETVQGLLEV AKDSIPRSHW 
    KKTPVVLKAT AGLRLLPEHK AKALLFEVKE IFRKSPFLVP KGSVSIMDGS DEGILAWVTV 
    NFLTGQLHGH RQETVGTLDL GGASTQITFL PQFEKTLEQT PRGYLTSFEM FNSTYKLYTH 
    SYLGFGLKAA RLATLGALET EGTDGHTFRS ACLPRWLEAE WIFGGVKYQY GGNQEGEVGF 
    EPCYAEVLRV VRGKLHQPEE VQRGSFYAFS YYYDRAVDTD MIDYEKGGIL KVEDFERKAR 
    EVCDNLENFT SGSPFLCMDL SYITALLKDG FGFADSTVLQ HIISWVN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.