Details for: ENTPD5

Gene ID: 957

Symbol: ENTPD5

Ensembl ID: ENSG00000187097

Description: ectonucleoside triphosphate diphosphohydrolase 5 (inactive)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.51
    Marker Score: 4756
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168842
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.44
    Marker Score: 6913
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.41
    Marker Score: 3314
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.4
    Marker Score: 4596
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.34
    Marker Score: 1972
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.21
    Marker Score: 7738
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.18
    Marker Score: 7616
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.16
    Marker Score: 1070
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.16
    Marker Score: 1157
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.15
    Marker Score: 4962
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.14
    Marker Score: 4065
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.11
    Marker Score: 773
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.09
    Marker Score: 1048
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.05
    Marker Score: 614
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.03
    Marker Score: 2543
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.01
    Marker Score: 1763
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71778
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48002
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.98
    Marker Score: 243
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5307
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1505
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.92
    Marker Score: 4973
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2726
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.78
    Marker Score: 1776
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 583
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.76
    Marker Score: 1167
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11597
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 284
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 453
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2964
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.71
    Marker Score: 590
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 631
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.68
    Marker Score: 456
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.68
    Marker Score: 196
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.68
    Marker Score: 1606
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.67
    Marker Score: 1360.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.65
    Marker Score: 445
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.65
    Marker Score: 559
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.62
    Marker Score: 308
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.61
    Marker Score: 191
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.61
    Marker Score: 147
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.6
    Marker Score: 192
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.59
    Marker Score: 12694
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.59
    Marker Score: 6116
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.58
    Marker Score: 889
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.58
    Marker Score: 241
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.57
    Marker Score: 1046
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.57
    Marker Score: 1300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.56
    Marker Score: 374
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.56
    Marker Score: 113
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.56
    Marker Score: 599.5
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.55
    Marker Score: 152
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.55
    Marker Score: 2237
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.54
    Marker Score: 203
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.53
    Marker Score: 32700
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.52
    Marker Score: 566
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.51
    Marker Score: 147
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.51
    Marker Score: 299
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.51
    Marker Score: 391
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.51
    Marker Score: 973
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.5
    Marker Score: 18269
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.49
    Marker Score: 875
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.48
    Marker Score: 182
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.48
    Marker Score: 113
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.48
    Marker Score: 7145
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.48
    Marker Score: 675
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.47
    Marker Score: 1252
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.46
    Marker Score: 3992
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.46
    Marker Score: 307
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.46
    Marker Score: 400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.46
    Marker Score: 970
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.46
    Marker Score: 2739
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.46
    Marker Score: 221
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.45
    Marker Score: 461
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.45
    Marker Score: 239
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 272
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.45
    Marker Score: 4291
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.45
    Marker Score: 131
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.44
    Marker Score: 109
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.44
    Marker Score: 161
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.43
    Marker Score: 625
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.43
    Marker Score: 3736
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.43
    Marker Score: 177
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.43
    Marker Score: 535
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 178
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 240
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.42
    Marker Score: 334
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.42
    Marker Score: 169
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.41
    Marker Score: 113
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.41
    Marker Score: 109

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Other Information

**Key characteristics:** * ENTPD5 is a protein of 1103 amino acids. * It is expressed in a variety of cell types, including epithelial cells, immune cells, and cancer cells. * It is a key regulator of inflammation and cell migration. * It is involved in the regulation of the immune response to infection. **Pathways and functions:** * ENTPD5 is involved in the regulation of the inflammatory response to infection. It is a key regulator of the recruitment of immune cells to sites of infection. * It is also involved in the regulation of cell migration and invasion. * It is involved in the regulation of cell proliferation and differentiation. * It is also involved in the regulation of apoptosis. **Clinical significance:** * Mutations in ENTPD5 have been linked to a number of diseases, including cancer, rheumatoid arthritis, and inflammatory bowel disease. * Inhibition of ENTPD5 has been shown to be effective in reducing inflammation and cancer growth. * Therefore, ENTPD5 is a promising target for the treatment of inflammatory diseases. **Additional notes:** * ENTPD5 is a highly conserved protein, with similar genes found in other vertebrates. * It is a multi-functional protein that can interact with a variety of proteins. * It is a key regulator of inflammation and cell signaling.

Genular Protein ID: 199272517

Symbol: ENTP5_HUMAN

Name: CD39 antigen-like 4

UniProtKB Accession Codes:

O75356 A1L4C5 Q96RX0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 32 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 6 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 7 Rhea 12 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9676430

Title: The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster.

PubMed ID: 9676430

DOI: 10.1006/geno.1998.5317

PubMed ID: 10708485

Title: The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells.

PubMed ID: 10708485

DOI: 10.1002/(sici)1098-2744(200003)27:3<229::aid-mc10>3.3.co;2-q

PubMed ID: 15698960

Title: Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase.

PubMed ID: 15698960

DOI: 10.1016/j.bbapap.2004.11.017

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10400613

Title: CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates.

PubMed ID: 10400613

DOI: 10.1074/jbc.274.29.20064

PubMed ID: 11041857

Title: Biochemical characterization of CD39L4.

PubMed ID: 11041857

DOI: 10.1021/bi000960y

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21074248

Title: The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway.

PubMed ID: 21074248

DOI: 10.1016/j.cell.2010.10.010

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 428
  • Mass: 47517
  • Checksum: 830437A155DE4DDD
  • Sequence:
    • MATSWGTVFF MLVVSCVCSA VSHRNQQTWF EGIFLSSMCP INVSASTLYG IMFDAGSTGT 
RIHVYTFVQK MPGQLPILEG EVFDSVKPGL SAFVDQPKQG AETVQGLLEV AKDSIPRSHW 
KKTPVVLKAT AGLRLLPEHK AKALLFEVKE IFRKSPFLVP KGSVSIMDGS DEGILAWVTV 
NFLTGQLHGH RQETVGTLDL GGASTQITFL PQFEKTLEQT PRGYLTSFEM FNSTYKLYTH 
SYLGFGLKAA RLATLGALET EGTDGHTFRS ACLPRWLEAE WIFGGVKYQY GGNQEGEVGF 
EPCYAEVLRV VRGKLHQPEE VQRGSFYAFS YYYDRAVDTD MIDYEKGGIL KVEDFERKAR 
EVCDNLENFT SGSPFLCMDL SYITALLKDG FGFADSTVLQ LTKKVNNIET GWALGATFHL 
LQSLGISH

Genular Protein ID: 199512354

Symbol: G3V4I0_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V4I0

Database IDs:

ARBA 17 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 33 ChiTaRS 1 DNASU 1 EC 6 EMBL 4 EPD 1 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 2 PROSITE 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 3 Rhea 12 RuleBase 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 407
  • Mass: 45336
  • Checksum: D92A5F7DC9EC9E5B
  • Sequence:
    • MATSWGTVFF MLVVSCVCSA VSHRNQQTWF EGIFLSSMCP INVSASTLYG IMFDAGSTGT 
RIHVYTFVQK MPGQLPILEG EVFDSVKPGL SAFVDQPKQG AETVQGLLEV AKDSIPRSHW 
KKTPVVLKAT AGLRLLPEHK AKALLFEVKE IFRKSPFLVP KGSVSIMDGS DEGILAWVTV 
NFLTGQLHGH RQETVGTLDL GGASTQITFL PQFEKTLEQT PRGYLTSFEM FNSTYKLYTH 
SYLGFGLKAA RLATLGALET EGTDGHTFRS ACLPRWLEAE WIFGGVKYQY GGNQEGEVGF 
EPCYAEVLRV VRGKLHQPEE VQRGSFYAFS YYYDRAVDTD MIDYEKGGIL KVEDFERKAR 
EVCDNLENFT SGSPFLCMDL SYITALLKDG FGFADSTVLQ HIISWVN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.