NR1D1 | ENSG00000126368 | NCBI 9572

Details for: NR1D1

Gene ID: 9572

Symbol: NR1D1

Ensembl ID: ENSG00000126368

Description: nuclear receptor subfamily 1 group D member 1

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Circadian clock
(R-HSA-400253)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Heme signaling
(R-HSA-9707616)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Mitochondrial biogenesis
(R-HSA-1592230)
Nr1d1 (rev-erba) represses gene expression
(R-HSA-1368071)
Nuclear receptor transcription pathway
(R-HSA-383280)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Rna polymerase ii transcription
(R-HSA-73857)
Transcriptional activation of mitochondrial biogenesis
(R-HSA-2151201)
Cell differentiation
(GO:0030154)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to tumor necrosis factor
(GO:0071356)
Cholesterol homeostasis
(GO:0042632)
Chromatin
(GO:0000785)
Circadian regulation of gene expression
(GO:0032922)
Circadian temperature homeostasis
(GO:0060086)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Dendritic spine
(GO:0043197)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
E-box binding
(GO:0070888)
Glycogen biosynthetic process
(GO:0005978)
Heme binding
(GO:0020037)
Hormone-mediated signaling pathway
(GO:0009755)
Intracellular glucose homeostasis
(GO:0001678)
Intracellular receptor signaling pathway
(GO:0030522)
Negative regulation of astrocyte activation
(GO:0061889)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of microglial cell activation
(GO:1903979)
Negative regulation of neuroinflammatory response
(GO:0150079)
Negative regulation of toll-like receptor 4 signaling pathway
(GO:0034144)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear body
(GO:0016604)
Nuclear receptor activity
(GO:0004879)
Nuclear steroid receptor activity
(GO:0003707)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of bile acid biosynthetic process
(GO:0070859)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Proteasomal protein catabolic process
(GO:0010498)
Protein binding
(GO:0005515)
Protein destabilization
(GO:0031648)
Regulation of circadian rhythm
(GO:0042752)
Regulation of circadian sleep/wake cycle
(GO:0042749)
Regulation of fat cell differentiation
(GO:0045598)
Regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0061178)
Regulation of lipid metabolic process
(GO:0019216)
Regulation of type b pancreatic cell proliferation
(GO:0061469)
Response to leptin
(GO:0044321)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific double-stranded dna binding
(GO:1990837)
Steroid hormone mediated signaling pathway
(GO:0043401)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription corepressor binding
(GO:0001222)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Nuclear receptor subfamily 1 group D member 1

Genular Protein ID: 2997291728

Symbol: NR1D1_HUMAN

Name: Nuclear receptor subfamily 1 group D member 1

UniProtKB Accession Codes:

P20393 Q0P5Z4 Q15304

Database IDs:

Citations:

PubMed ID: 2539258

Title: Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus.

PubMed ID: 2539258

DOI: 10.1016/0092-8674(89)90169-4

PubMed ID: 1971514

Title: Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone.

PubMed ID: 1971514

DOI: 10.1089/dna.1990.9.77

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1850510

Title: Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene.

PubMed ID: 1850510

DOI: 10.1093/nar/19.5.1105

PubMed ID: 12021280

Title: Orphan nuclear hormone receptor Rev-erbalpha regulates the human apolipoprotein CIII promoter.

PubMed ID: 12021280

DOI: 10.1074/jbc.m203421200

PubMed ID: 15761026

Title: The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene.

PubMed ID: 15761026

DOI: 10.1210/me.2005-0057

PubMed ID: 16968709

Title: The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1.

PubMed ID: 16968709

DOI: 10.1074/jbc.m607873200

PubMed ID: 16484495

Title: Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock.

PubMed ID: 16484495

DOI: 10.1126/science.1121613

PubMed ID: 17892483

Title: A zinc finger HIT domain-containing protein, ZNHIT-1, interacts with orphan nuclear hormone receptor Rev-erbbeta and removes Rev-erbbeta-induced inhibition of apoCIII transcription.

PubMed ID: 17892483

DOI: 10.1111/j.1742-4658.2007.06062.x

PubMed ID: 18006707

Title: Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways.

PubMed ID: 18006707

DOI: 10.1126/science.1150179

PubMed ID: 19710360

Title: Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha.

PubMed ID: 19710360

DOI: 10.1101/gad.1825809

PubMed ID: 20414452

Title: Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism.

PubMed ID: 20414452

DOI: 10.1621/nrs.08001

PubMed ID: 20534529

Title: E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha.

PubMed ID: 20534529

DOI: 10.1073/pnas.1000438107

PubMed ID: 21874017

Title: A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbalpha.

PubMed ID: 21874017

DOI: 10.1038/nn.2911

PubMed ID: 22170608

Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

PubMed ID: 22170608

DOI: 10.1038/nature10700

PubMed ID: 21479263

Title: Direct regulation of CLOCK expression by REV-ERB.

PubMed ID: 21479263

DOI: 10.1371/journal.pone.0017290

PubMed ID: 22682217

Title: REV-ERBs: more than the sum of the individual parts.

PubMed ID: 22682217

DOI: 10.1016/j.cmet.2012.05.006

PubMed ID: 22613952

Title: REV-ERB-erating nuclear receptor functions in circadian metabolism and physiology.

PubMed ID: 22613952

DOI: 10.1038/cr.2012.81

PubMed ID: 22184247

Title: The nuclear receptor REV-ERBalpha mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines.

PubMed ID: 22184247

DOI: 10.1073/pnas.1106750109

PubMed ID: 23398316

Title: DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbalpha.

PubMed ID: 23398316

DOI: 10.1042/bj20121085

PubMed ID: 24415752

Title: Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis.

PubMed ID: 24415752

DOI: 10.1074/jbc.m113.512913

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26392558

Title: Ubiquitin ligase Siah2 regulates RevErbalpha degradation and the mammalian circadian clock.

PubMed ID: 26392558

DOI: 10.1073/pnas.1501204112

PubMed ID: 27238018

Title: Circadian amplitude regulation via FBXW7-targeted REV-ERBalpha degradation.

PubMed ID: 27238018

DOI: 10.1016/j.cell.2016.05.012

PubMed ID: 9660968

Title: Structural elements of an orphan nuclear receptor-DNA complex.

PubMed ID: 9660968

DOI: 10.1016/s1097-2765(00)80084-2

Sequence Information:

Length: 614
Mass: 66805
Checksum: 67C71758E166508A
Sequence:

MTTLDSNNNT GGVITYIGSS GSSPSRTSPE SLYSDNSNGS FQSLTQGCPT YFPPSPTGSL 
TQDPARSFGS IPPSLSDDGS PSSSSSSSSS SSSFYNGSPP GSLQVAMEDS SRVSPSKSTS 
NITKLNGMVL LCKVCGDVAS GFHYGVHACE GCKGFFRRSI QQNIQYKRCL KNENCSIVRI 
NRNRCQQCRF KKCLSVGMSR DAVRFGRIPK REKQRMLAEM QSAMNLANNQ LSSQCPLETS 
PTQHPTPGPM GPSPPPAPVP SPLVGFSQFP QQLTPPRSPS PEPTVEDVIS QVARAHREIF 
TYAHDKLGSS PGNFNANHAS GSPPATTPHR WENQGCPPAP NDNNTLAAQR HNEALNGLRQ 
APSSYPPTWP PGPAHHSCHQ SNSNGHRLCP THVYAAPEGK APANSPRQGN SKNVLLACPM 
NMYPHGRSGR TVQEIWEDFS MSFTPAVREV VEFAKHIPGF RDLSQHDQVT LLKAGTFEVL 
MVRFASLFNV KDQTVMFLSR TTYSLQELGA MGMGDLLSAM FDFSEKLNSL ALTEEELGLF 
TAVVLVSADR SGMENSASVE QLQETLLRAL RALVLKNRPL ETSRFTKLLL KLPDLRTLNN 
MHSEKLLSFR VDAQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NR1D1

Associated with

Other Information

Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. PubMed ID: 2539258

Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone. PubMed ID: 1971514

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene. PubMed ID: 1850510

Orphan nuclear hormone receptor Rev-erbalpha regulates the human apolipoprotein CIII promoter. PubMed ID: 12021280

The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene. PubMed ID: 15761026

The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1. PubMed ID: 16968709

Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock. PubMed ID: 16484495

A zinc finger HIT domain-containing protein, ZNHIT-1, interacts with orphan nuclear hormone receptor Rev-erbbeta and removes Rev-erbbeta-induced inhibition of apoCIII transcription. PubMed ID: 17892483

Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. PubMed ID: 18006707

Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha. PubMed ID: 19710360

Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism. PubMed ID: 20414452

E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha. PubMed ID: 20534529

A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbalpha. PubMed ID: 21874017

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. PubMed ID: 22170608

Direct regulation of CLOCK expression by REV-ERB. PubMed ID: 21479263

REV-ERBs: more than the sum of the individual parts. PubMed ID: 22682217

REV-ERB-erating nuclear receptor functions in circadian metabolism and physiology. PubMed ID: 22613952

The nuclear receptor REV-ERBalpha mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines. PubMed ID: 22184247

DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbalpha. PubMed ID: 23398316

Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis. PubMed ID: 24415752

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Ubiquitin ligase Siah2 regulates RevErbalpha degradation and the mammalian circadian clock. PubMed ID: 26392558

Circadian amplitude regulation via FBXW7-targeted REV-ERBalpha degradation. PubMed ID: 27238018

Structural elements of an orphan nuclear receptor-DNA complex. PubMed ID: 9660968