CD40LG | ENSG00000102245 | NCBI 959

Details for: CD40LG

Gene ID: 959

Symbol: CD40LG

Ensembl ID: ENSG00000102245

Description: CD40 ligand

Associated with

Adaptive immune system
(R-HSA-1280218)
Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
(R-HSA-5676594)
B cell differentiation
(GO:0030183)
B cell proliferation
(GO:0042100)
Cd40 receptor binding
(GO:0005174)
Cd40 signaling pathway
(GO:0023035)
Cell surface
(GO:0009986)
Cytokine activity
(GO:0005125)
External side of plasma membrane
(GO:0009897)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Inflammatory response
(GO:0006954)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Isotype switching
(GO:0045190)
Leukocyte cell-cell adhesion
(GO:0007159)
Membrane
(GO:0016020)
Negative regulation of apoptotic process
(GO:0043066)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Positive regulation of endothelial cell apoptotic process
(GO:2000353)
Positive regulation of interleukin-4 production
(GO:0032753)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of t cell proliferation
(GO:0042102)
Protein binding
(GO:0005515)
Protein serine/threonine kinase activator activity
(GO:0043539)
Regulation of immunoglobulin production
(GO:0002637)
T cell costimulation
(GO:0031295)
Tumor necrosis factor receptor binding
(GO:0005164)

Other Information

Proteins

CD40 ligand

Genular Protein ID: 601203966

Symbol: CD40L_HUMAN

Name: CD40 ligand

UniProtKB Accession Codes:

P29965

Database IDs:

Citations:

PubMed ID: 1280226

Title: Cloning of TRAP, a ligand for CD40 on human T cells.

PubMed ID: 1280226

DOI: 10.1002/eji.1830221226

PubMed ID: 1385114

Title: The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

PubMed ID: 1385114

DOI: 10.1002/j.1460-2075.1992.tb05530.x

PubMed ID: 7678782

Title: The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome.

PubMed ID: 7678782

DOI: 10.1016/0092-8674(93)90668-g

PubMed ID: 1281209

Title: Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion.

PubMed ID: 1281209

DOI: 10.1084/jem.176.6.1543

PubMed ID: 7678552

Title: Human CD40-ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production.

PubMed ID: 7678552

DOI: 10.1016/0014-5793(93)81175-y

PubMed ID: 7999797

Title: Structural organization of the gene for CD40 ligand: molecular analysis for diagnosis of X-linked hyper-IgM syndrome.

PubMed ID: 7999797

DOI: 10.1016/0167-4781(94)00179-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8626375

Title: Human native soluble CD40L is a biologically active trimer, processed inside microsomes.

PubMed ID: 8626375

DOI: 10.1074/jbc.271.11.5965

PubMed ID: 8617933

Title: Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis.

PubMed ID: 8617933

PubMed ID: 11676606

Title: Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells.

PubMed ID: 11676606

DOI: 10.1006/prep.2001.1501

PubMed ID: 15193700

Title: Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization.

PubMed ID: 15193700

DOI: 10.1016/j.jacc.2003.12.055

PubMed ID: 15067037

Title: The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells.

PubMed ID: 15067037

DOI: 10.1084/jem.20031705

PubMed ID: 31331973

Title: Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.

PubMed ID: 31331973

DOI: 10.4049/jimmunol.1801630

PubMed ID: 8589998

Title: 2-A crystal structure of an extracellular fragment of human CD40 ligand.

PubMed ID: 8589998

DOI: 10.1016/s0969-2126(01)00239-8

PubMed ID: 9605317

Title: The role of polar interactions in the molecular recognition of CD40L with its receptor CD40.

PubMed ID: 9605317

DOI: 10.1002/pro.5560070506

PubMed ID: 7679206

Title: Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM.

PubMed ID: 7679206

DOI: 10.1038/361539a0

PubMed ID: 8094231

Title: CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM.

PubMed ID: 8094231

DOI: 10.1038/361541a0

PubMed ID: 7679801

Title: CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome.

PubMed ID: 7679801

DOI: 10.1126/science.7679801

PubMed ID: 7717401

Title: Characterization of nine novel mutations in the CD40 ligand gene in patients with X-linked hyper IgM syndrome of various ancestry.

PubMed ID: 7717401

PubMed ID: 7532185

Title: Signaling through CD40 rescues IgE but not IgG or IgA secretion in X-linked immunodeficiency with hyper-IgM.

PubMed ID: 7532185

DOI: 10.1172/jci117692

PubMed ID: 8889581

Title: Mutation analysis in CD40 ligand deficiency leading to X-linked hypogammaglobulinemia with hyper IgM syndrome.

PubMed ID: 8889581

DOI: 10.1002/(sici)1098-1004(1996)8:3<223::aid-humu5>3.0.co;2-a

PubMed ID: 8550833

Title: A single strand conformation polymorphism study of CD40 ligand. Efficient mutation analysis and carrier detection for X-linked hyper IgM syndrome.

PubMed ID: 8550833

DOI: 10.1172/jci118389

PubMed ID: 9150729

Title: Mutations of the CD40 ligand gene in 13 Japanese patients with X-linked hyper-IgM syndrome.

PubMed ID: 9150729

DOI: 10.1007/s004390050417

PubMed ID: 9746782

Title: Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome.

PubMed ID: 9746782

PubMed ID: 26545377

Title: Novel and recurrent AID mutations underlie prevalent autosomal recessive form of HIGM in consanguineous patients.

PubMed ID: 26545377

DOI: 10.1007/s00251-015-0878-6

Sequence Information:

Length: 261
Mass: 29274
Checksum: 16F5CEB093BCC2BB
Sequence:

MIETYNQTSP RSAATGLPIS MKIFMYLLTV FLITQMIGSA LFAVYLHRRL DKIEDERNLH 
EDFVFMKTIQ RCNTGERSLS LLNCEEIKSQ FEGFVKDIML NKEETKKENS FEMQKGDQNP 
QIAAHVISEA SSKTTSVLQW AEKGYYTMSN NLVTLENGKQ LTVKRQGLYY IYAQVTFCSN 
REASSQAPFI ASLCLKSPGR FERILLRAAN THSSAKPCGQ QSIHLGGVFE LQPGASVFVN 
VTDPSQVSHG TGFTSFGLLK L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD40LG

Associated with

Other Information

Cloning of TRAP, a ligand for CD40 on human T cells. PubMed ID: 1280226

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. PubMed ID: 1385114

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. PubMed ID: 7678782

Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion. PubMed ID: 1281209

Human CD40-ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production. PubMed ID: 7678552

Structural organization of the gene for CD40 ligand: molecular analysis for diagnosis of X-linked hyper-IgM syndrome. PubMed ID: 7999797

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human native soluble CD40L is a biologically active trimer, processed inside microsomes. PubMed ID: 8626375

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis. PubMed ID: 8617933

Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells. PubMed ID: 11676606

Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization. PubMed ID: 15193700

The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells. PubMed ID: 15067037

Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling. PubMed ID: 31331973

2-A crystal structure of an extracellular fragment of human CD40 ligand. PubMed ID: 8589998

The role of polar interactions in the molecular recognition of CD40L with its receptor CD40. PubMed ID: 9605317

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. PubMed ID: 7679206

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM. PubMed ID: 8094231

CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. PubMed ID: 7679801

Characterization of nine novel mutations in the CD40 ligand gene in patients with X-linked hyper IgM syndrome of various ancestry. PubMed ID: 7717401

Signaling through CD40 rescues IgE but not IgG or IgA secretion in X-linked immunodeficiency with hyper-IgM. PubMed ID: 7532185

Mutation analysis in CD40 ligand deficiency leading to X-linked hypogammaglobulinemia with hyper IgM syndrome. PubMed ID: 8889581

A single strand conformation polymorphism study of CD40 ligand. Efficient mutation analysis and carrier detection for X-linked hyper IgM syndrome. PubMed ID: 8550833

Mutations of the CD40 ligand gene in 13 Japanese patients with X-linked hyper-IgM syndrome. PubMed ID: 9150729

Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome. PubMed ID: 9746782

Novel and recurrent AID mutations underlie prevalent autosomal recessive form of HIGM in consanguineous patients. PubMed ID: 26545377