Details for: CD40LG

Gene ID: 959

Symbol: CD40LG

Ensembl ID: ENSG00000102245

Description: CD40 ligand

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.02
    Marker Score: 12908
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2
    Marker Score: 1448
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.63
    Marker Score: 955
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.53
    Marker Score: 1197
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.19
    Marker Score: 2677
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.18
    Marker Score: 62254
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.12
    Marker Score: 1928
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.11
    Marker Score: 926
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.09
    Marker Score: 4686
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.05
    Marker Score: 984
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251809
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.99
    Marker Score: 494
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.96
    Marker Score: 2427
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5324
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.91
    Marker Score: 584
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.85
    Marker Score: 625
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.83
    Marker Score: 8196
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.81
    Marker Score: 876
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.81
    Marker Score: 250
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.78
    Marker Score: 694
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.65
    Marker Score: 333
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.63
    Marker Score: 1225
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 472
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.55
    Marker Score: 418
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.51
    Marker Score: 724
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.49
    Marker Score: 300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.43
    Marker Score: 238
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.42
    Marker Score: 162
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.39
    Marker Score: 4520
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.38
    Marker Score: 115
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.36
    Marker Score: 183
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 151
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.35
    Marker Score: 255
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.35
    Marker Score: 382
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 207
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.34
    Marker Score: 225
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.32
    Marker Score: 344
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.31
    Marker Score: 81
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.3
    Marker Score: 135
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.29
    Marker Score: 221
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.28
    Marker Score: 388
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.28
    Marker Score: 484
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.28
    Marker Score: 235
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.27
    Marker Score: 72
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.27
    Marker Score: 659
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.26
    Marker Score: 190
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.25
    Marker Score: 219
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.23
    Marker Score: 303
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.22
    Marker Score: 364
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.22
    Marker Score: 190
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.2
    Marker Score: 99.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.18
    Marker Score: 63
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.17
    Marker Score: 46
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.17
    Marker Score: 59
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.17
    Marker Score: 53
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.16
    Marker Score: 157
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.16
    Marker Score: 93
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.16
    Marker Score: 36
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.15
    Marker Score: 34
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.15
    Marker Score: 69
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.15
    Marker Score: 65.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.15
    Marker Score: 87
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.15
    Marker Score: 128
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.15
    Marker Score: 142
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.14
    Marker Score: 79
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.14
    Marker Score: 59
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.14
    Marker Score: 283
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.14
    Marker Score: 49
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.13
    Marker Score: 251
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.12
    Marker Score: 1846
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.11
    Marker Score: 62
  • Cell Name: group 2 innate lymphoid cell (CL0001069)
    Fold Change: 0.11
    Marker Score: 37
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.11
    Marker Score: 84
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.11
    Marker Score: 61
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.1
    Marker Score: 183.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.1
    Marker Score: 676
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1
    Marker Score: 52
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 107
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.1
    Marker Score: 91
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.09
    Marker Score: 53

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Other Information

**Key characteristics:** * CD40 is a glycoprotein with a molecular weight of approximately 40 kDa. * It is expressed in high levels on activated T cells and some other immune cells. * CD40 is a member of the TNF receptor superfamily (TNFRs). * It is involved in both the adaptive and innate immune responses. **Pathways and functions:** * CD40 signaling pathway: CD40 binds to CD40 receptor on antigen-presenting cells, triggering the activation of T cells. * Immune regulation: CD40 signaling can inhibit the activation of T cells and promote immune tolerance. * Regulation of immunoglobulin production: CD40 signaling is essential for the regulation of immunoglobulin production by B cells. **Clinical significance:** * CD40 is a potential therapeutic target for autoimmune diseases, such as rheumatoid arthritis and lupus. * Blockade of CD40 signaling has been shown to suppress T cell activity and improve disease symptoms in animal models of autoimmune diseases. **Other important points:** * CD40 is also expressed on activated B cells and may regulate B cell activation. * It is involved in the regulation of T cell responses to cytokines. * Mutations in the CD40 gene have been linked to certain autoimmune disorders.

Genular Protein ID: 601203966

Symbol: CD40L_HUMAN

Name: CD40 ligand

UniProtKB Accession Codes:

P29965

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 7 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1280226

Title: Cloning of TRAP, a ligand for CD40 on human T cells.

PubMed ID: 1280226

DOI: 10.1002/eji.1830221226

PubMed ID: 1385114

Title: The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

PubMed ID: 1385114

DOI: 10.1002/j.1460-2075.1992.tb05530.x

PubMed ID: 7678782

Title: The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome.

PubMed ID: 7678782

DOI: 10.1016/0092-8674(93)90668-g

PubMed ID: 1281209

Title: Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion.

PubMed ID: 1281209

DOI: 10.1084/jem.176.6.1543

PubMed ID: 7678552

Title: Human CD40-ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production.

PubMed ID: 7678552

DOI: 10.1016/0014-5793(93)81175-y

PubMed ID: 7999797

Title: Structural organization of the gene for CD40 ligand: molecular analysis for diagnosis of X-linked hyper-IgM syndrome.

PubMed ID: 7999797

DOI: 10.1016/0167-4781(94)00179-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8626375

Title: Human native soluble CD40L is a biologically active trimer, processed inside microsomes.

PubMed ID: 8626375

DOI: 10.1074/jbc.271.11.5965

PubMed ID: 8617933

Title: Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis.

PubMed ID: 8617933

PubMed ID: 11676606

Title: Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells.

PubMed ID: 11676606

DOI: 10.1006/prep.2001.1501

PubMed ID: 15193700

Title: Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization.

PubMed ID: 15193700

DOI: 10.1016/j.jacc.2003.12.055

PubMed ID: 15067037

Title: The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells.

PubMed ID: 15067037

DOI: 10.1084/jem.20031705

PubMed ID: 31331973

Title: Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.

PubMed ID: 31331973

DOI: 10.4049/jimmunol.1801630

PubMed ID: 8589998

Title: 2-A crystal structure of an extracellular fragment of human CD40 ligand.

PubMed ID: 8589998

DOI: 10.1016/s0969-2126(01)00239-8

PubMed ID: 9605317

Title: The role of polar interactions in the molecular recognition of CD40L with its receptor CD40.

PubMed ID: 9605317

DOI: 10.1002/pro.5560070506

PubMed ID: 7679206

Title: Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM.

PubMed ID: 7679206

DOI: 10.1038/361539a0

PubMed ID: 8094231

Title: CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM.

PubMed ID: 8094231

DOI: 10.1038/361541a0

PubMed ID: 7679801

Title: CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome.

PubMed ID: 7679801

DOI: 10.1126/science.7679801

PubMed ID: 7717401

Title: Characterization of nine novel mutations in the CD40 ligand gene in patients with X-linked hyper IgM syndrome of various ancestry.

PubMed ID: 7717401

PubMed ID: 7532185

Title: Signaling through CD40 rescues IgE but not IgG or IgA secretion in X-linked immunodeficiency with hyper-IgM.

PubMed ID: 7532185

DOI: 10.1172/jci117692

PubMed ID: 8889581

Title: Mutation analysis in CD40 ligand deficiency leading to X-linked hypogammaglobulinemia with hyper IgM syndrome.

PubMed ID: 8889581

DOI: 10.1002/(sici)1098-1004(1996)8:3<223::aid-humu5>3.0.co;2-a

PubMed ID: 8550833

Title: A single strand conformation polymorphism study of CD40 ligand. Efficient mutation analysis and carrier detection for X-linked hyper IgM syndrome.

PubMed ID: 8550833

DOI: 10.1172/jci118389

PubMed ID: 9150729

Title: Mutations of the CD40 ligand gene in 13 Japanese patients with X-linked hyper-IgM syndrome.

PubMed ID: 9150729

DOI: 10.1007/s004390050417

PubMed ID: 9746782

Title: Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome.

PubMed ID: 9746782

PubMed ID: 26545377

Title: Novel and recurrent AID mutations underlie prevalent autosomal recessive form of HIGM in consanguineous patients.

PubMed ID: 26545377

DOI: 10.1007/s00251-015-0878-6

Sequence Information:

  • Length: 261
  • Mass: 29274
  • Checksum: 16F5CEB093BCC2BB
  • Sequence:
    • MIETYNQTSP RSAATGLPIS MKIFMYLLTV FLITQMIGSA LFAVYLHRRL DKIEDERNLH 
EDFVFMKTIQ RCNTGERSLS LLNCEEIKSQ FEGFVKDIML NKEETKKENS FEMQKGDQNP 
QIAAHVISEA SSKTTSVLQW AEKGYYTMSN NLVTLENGKQ LTVKRQGLYY IYAQVTFCSN 
REASSQAPFI ASLCLKSPGR FERILLRAAN THSSAKPCGQ QSIHLGGVFE LQPGASVFVN 
VTDPSQVSHG TGFTSFGLLK L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.