Details for: CD44
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: early promyelocyte (CL0002154)
Fold Change: 4.78
Marker Score: 3,824 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 4.22
Marker Score: 4,775 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.99
Marker Score: 135,781 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 3.96
Marker Score: 3,511 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.73
Marker Score: 208,439 - Cell Name: mature T cell (CL0002419)
Fold Change: 3.67
Marker Score: 36,316 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 3.58
Marker Score: 14,932 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.48
Marker Score: 7,935 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.36
Marker Score: 8,211 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.35
Marker Score: 9,398 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 3.31
Marker Score: 175,094 - Cell Name: basophil (CL0000767)
Fold Change: 3.2
Marker Score: 1,518 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 3.17
Marker Score: 1,860 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.15
Marker Score: 15,465 - Cell Name: inflammatory cell (CL0009002)
Fold Change: 3.09
Marker Score: 1,331 - Cell Name: lung macrophage (CL1001603)
Fold Change: 3.05
Marker Score: 3,490 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 3.04
Marker Score: 9,603 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3
Marker Score: 12,858 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.95
Marker Score: 998 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.94
Marker Score: 3,831 - Cell Name: chromaffin cell (CL0000166)
Fold Change: 2.93
Marker Score: 4,116 - Cell Name: granulocyte (CL0000094)
Fold Change: 2.89
Marker Score: 1,296 - Cell Name: blood cell (CL0000081)
Fold Change: 2.81
Marker Score: 32,648 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.8
Marker Score: 7,721 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.76
Marker Score: 1,377 - Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.76
Marker Score: 2,580 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.75
Marker Score: 5,362 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.74
Marker Score: 17,828 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.7
Marker Score: 1,539 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.67
Marker Score: 2,275 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.67
Marker Score: 2,244 - Cell Name: lactocyte (CL0002325)
Fold Change: 2.65
Marker Score: 42,561 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.64
Marker Score: 67,511 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.62
Marker Score: 6,326 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.61
Marker Score: 808 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.58
Marker Score: 26,165 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.57
Marker Score: 2,020 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.57
Marker Score: 2,536 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.53
Marker Score: 6,311 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 2.53
Marker Score: 1,917 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.52
Marker Score: 1,989 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.49
Marker Score: 1,733 - Cell Name: reticular cell (CL0000432)
Fold Change: 2.49
Marker Score: 909 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.49
Marker Score: 4,339 - Cell Name: memory T cell (CL0000813)
Fold Change: 2.47
Marker Score: 1,062 - Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 2.47
Marker Score: 1,267 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.46
Marker Score: 2,624 - Cell Name: naive T cell (CL0000898)
Fold Change: 2.45
Marker Score: 1,578 - Cell Name: pneumocyte (CL0000322)
Fold Change: 2.44
Marker Score: 3,922 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.43
Marker Score: 5,974 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 2.41
Marker Score: 1,178 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.41
Marker Score: 15,418 - Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 2.4
Marker Score: 1,759 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.39
Marker Score: 2,521 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.39
Marker Score: 14,542 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.37
Marker Score: 10,235 - Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 2.37
Marker Score: 1,711 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 2.36
Marker Score: 591 - Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 2.35
Marker Score: 4,030 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.35
Marker Score: 978 - Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 2.34
Marker Score: 771 - Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 2.34
Marker Score: 816 - Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 2.33
Marker Score: 2,520 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.32
Marker Score: 825 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.3
Marker Score: 1,339 - Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 2.3
Marker Score: 1,667 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.29
Marker Score: 1,276 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.28
Marker Score: 1,376 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 2.27
Marker Score: 1,394 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.26
Marker Score: 4,010 - Cell Name: exhausted T cell (CL0011025)
Fold Change: 2.26
Marker Score: 1,298 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.25
Marker Score: 796 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.25
Marker Score: 17,532 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 2.23
Marker Score: 803 - Cell Name: IgA plasma cell (CL0000987)
Fold Change: 2.23
Marker Score: 1,900 - Cell Name: regulatory T cell (CL0000815)
Fold Change: 2.22
Marker Score: 2,459 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.22
Marker Score: 16,539 - Cell Name: basal cell (CL0000646)
Fold Change: 2.22
Marker Score: 2,867 - Cell Name: myelocyte (CL0002193)
Fold Change: 2.21
Marker Score: 955 - Cell Name: memory B cell (CL0000787)
Fold Change: 2.2
Marker Score: 1,668 - Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 2.2
Marker Score: 4,958 - Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 2.2
Marker Score: 1,953 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.18
Marker Score: 5,654 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 2.18
Marker Score: 427 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.14
Marker Score: 2,957 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.14
Marker Score: 24,124 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.14
Marker Score: 737 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.14
Marker Score: 8,241 - Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 2.12
Marker Score: 528 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.11
Marker Score: 5,532 - Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.11
Marker Score: 1,527 - Cell Name: prostate stromal cell (CL0002622)
Fold Change: 2.1
Marker Score: 528 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 2.08
Marker Score: 2,163 - Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 2.08
Marker Score: 631 - Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 2.06
Marker Score: 546 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.04
Marker Score: 2,466 - Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.02
Marker Score: 3,612 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.02
Marker Score: 2,975 - Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 2.02
Marker Score: 444 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2
Marker Score: 10,524
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1597275826
Symbol: CD44_HUMAN
Name: CD44 antigen
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2466575
Title: A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family.
PubMed ID: 2466575
PubMed ID: 1840487
Title: The multispecific cell adhesion molecule CD44 is represented in reticulocyte cDNA.
PubMed ID: 1840487
PubMed ID: 1991450
Title: The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells.
PubMed ID: 1991450
PubMed ID: 2056274
Title: Molecular cloning of CD44R1 and CD44R2, two novel isoforms of the human CD44 lymphocyte 'homing' receptor expressed by hemopoietic cells.
PubMed ID: 2056274
DOI: 10.1084/jem.174.1.1
PubMed ID: 1281868
Title: The core protein of epican, a heparan sulfate proteoglycan on keratinocytes, is an alternative form of CD44.
PubMed ID: 1281868
PubMed ID: 1465456
Title: Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.
PubMed ID: 1465456
PubMed ID: 7508842
Title: CD44: a multitude of isoforms with diverse functions.
PubMed ID: 7508842
PubMed ID: 8352881
Title: Novel variants of CD44 arising from alternative splicing: changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase.
PubMed ID: 8352881
PubMed ID: 10933060
Title: Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44.
PubMed ID: 10933060
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1922057
Title: Expression of CD44 is repressed in neuroblastoma cells.
PubMed ID: 1922057
PubMed ID: 2466576
Title: A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins.
PubMed ID: 2466576
PubMed ID: 7527301
Title: Anti-(glioma surface antigen) monoclonal antibody G-22 recognizes overexpressed CD44 in glioma cells.
PubMed ID: 7527301
DOI: 10.1007/bf01519984
PubMed ID: 7508992
Title: A monoclonal antibody that blocks poliovirus attachment recognizes the lymphocyte homing receptor CD44.
PubMed ID: 7508992
PubMed ID: 2007624
Title: Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons.
PubMed ID: 2007624
PubMed ID: 8148709
Title: Non-invasive detection of malignancy by identification of unusual CD44 gene activity in exfoliated cancer cells.
PubMed ID: 8148709
PubMed ID: 1717145
Title: CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines.
PubMed ID: 1717145
PubMed ID: 7528188
Title: Stimulation of T cells via CD44 requires leukocyte-function-associated antigen interactions and interleukin-2 production.
PubMed ID: 7528188
PubMed ID: 12511867
Title: CD44: from adhesion molecules to signalling regulators.
PubMed ID: 12511867
DOI: 10.1038/nrm1004
PubMed ID: 9580567
Title: Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325.
PubMed ID: 9580567
PubMed ID: 12032545
Title: A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility.
PubMed ID: 12032545
DOI: 10.1038/ncb797
PubMed ID: 12883358
Title: CD44s adhesive function spontaneous and PMA-inducible CD44 cleavage are regulated at post-translational level in cells of melanocytic lineage.
PubMed ID: 12883358
PubMed ID: 15123640
Title: Hyaluronan-CD44 interaction with Rac1-dependent protein kinase N-gamma promotes phospholipase Cgamma1 activation, Ca(2+) signaling, and cortactin-cytoskeleton function leading to keratinocyte adhesion and differentiation.
PubMed ID: 15123640
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16541107
Title: RNA-binding IMPs promote cell adhesion and invadopodia formation.
PubMed ID: 16541107
PubMed ID: 19367720
Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
PubMed ID: 19367720
DOI: 10.1021/pr800500r
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19381274
Title: Unc119 protects from Shigella infection by inhibiting the Abl family kinases.
PubMed ID: 19381274
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19703720
Title: Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.
PubMed ID: 19703720
PubMed ID: 18757307
Title: Hyaluronan fragments/CD44 mediate oxidative stress-induced MUC5B up-regulation in airway epithelium.
PubMed ID: 18757307
PubMed ID: 20962267
Title: Podoplanin associates with CD44 to promote directional cell migration.
PubMed ID: 20962267
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22171320
Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.
PubMed ID: 22171320
PubMed ID: 22726066
Title: CD44 in human glioma correlates with histopathological grade and cell migration.
PubMed ID: 22726066
PubMed ID: 23589287
Title: Transforming growth factor-beta1 (TGF-beta1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts.
PubMed ID: 23589287
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25326458
Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.
PubMed ID: 25326458
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 29777959
Title: Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix.
PubMed ID: 29777959
PubMed ID: 32337544
Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.
PubMed ID: 32337544
PubMed ID: 36213313
Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.
PubMed ID: 36213313
PubMed ID: 37453717
Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.
PubMed ID: 37453717
PubMed ID: 14992719
Title: Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.
PubMed ID: 14992719
PubMed ID: 17085435
Title: Ligand-induced structural changes of the CD44 hyaluronan-binding domain revealed by NMR.
PubMed ID: 17085435
PubMed ID: 25195884
Title: High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction.
PubMed ID: 25195884
PubMed ID: 8636151
Title: A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding.
PubMed ID: 8636151
Sequence Information:
- Length: 742
- Mass: 81538
- Checksum: BB9B66B19B970349
- Sequence:
MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA DLCKAFNSTL PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN NTGVYILTSN TSQYDTYCFN ASAPPEEDCT SVTDLPNAFD GPITITIVNR DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS GSSSERSSTS GGYIFYTFST VHPIPDEDSP WITDSTDRIP ATTLMSTSAT ATETATKRQE TWDWFSWLFL PSESKNHLHT TTQMAGTSSN TISAGWEPNE ENEDERDRHL SFSGSGIDDD EDFISSTIST TPRAFDHTKQ NQDWTQWNPS HSNPEVLLQT TTRMTDVDRN GTTAYEGNWN PEAHPPLIHH EHHEEEETPH STSTIQATPS STTEETATQK EQWFGNRWHE GYRQTPKEDS HSTTGTAAAS AHTSHPMQGR TTPSPEDSSW TDFFNPISHP MGRGHQAGRR MDMDSSHSIT LQPTANPNTG LVEDLDRTGP LSMTTQQSNS QSFSTSHEGL EEDKDHPTTS TLTSSNRNDV TGGRRDPNHS EGSTTLLEGY TSHYPHTKES RTFIPVTSAK TGSFGVTAVT VGDSNSNVNR SLSGDQDTFH PSGGSHTTHG SESDGHSHGS QEGGANTTSG PIRTPQIPEW LIILASLLAL ALILAVCIAV NSRRRCGQKK KLVINSGNGA VEDRKPSGLN GEASKSQEMV HLVNKESSET PDQFMTADET RNLQNVDMKI GV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.