Details for: CD44

Gene ID: 960

Symbol: CD44

Ensembl ID: ENSG00000026508

Description: CD44 molecule (IN blood group)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 356.4237
    Cell Significance Index: -55.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 166.0599
    Cell Significance Index: -42.1200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 160.3602
    Cell Significance Index: -66.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 154.4096
    Cell Significance Index: -62.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 133.8212
    Cell Significance Index: -63.1800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 129.5916
    Cell Significance Index: -66.6600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 94.7584
    Cell Significance Index: -63.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 66.6148
    Cell Significance Index: -63.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 48.2661
    Cell Significance Index: -59.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.2871
    Cell Significance Index: -44.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.1370
    Cell Significance Index: -61.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.7128
    Cell Significance Index: -47.4500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 16.5568
    Cell Significance Index: 49.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.1883
    Cell Significance Index: -63.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 9.1048
    Cell Significance Index: 168.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 8.7366
    Cell Significance Index: 250.4400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 7.4200
    Cell Significance Index: 65.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 7.0896
    Cell Significance Index: 198.1300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.7017
    Cell Significance Index: 28.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.2210
    Cell Significance Index: 198.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.0749
    Cell Significance Index: 262.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.5313
    Cell Significance Index: 103.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.3780
    Cell Significance Index: 157.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.7485
    Cell Significance Index: 37.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.5290
    Cell Significance Index: 2283.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.2401
    Cell Significance Index: 43.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.0781
    Cell Significance Index: 154.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.8725
    Cell Significance Index: 203.6800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.6438
    Cell Significance Index: 7.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.6127
    Cell Significance Index: 37.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.5651
    Cell Significance Index: 79.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4793
    Cell Significance Index: 88.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3392
    Cell Significance Index: 592.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3367
    Cell Significance Index: 172.7000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.2179
    Cell Significance Index: 25.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1554
    Cell Significance Index: 142.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0658
    Cell Significance Index: 202.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8106
    Cell Significance Index: 57.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7494
    Cell Significance Index: 409.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6908
    Cell Significance Index: 124.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5157
    Cell Significance Index: 83.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4875
    Cell Significance Index: 13.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.4099
    Cell Significance Index: 46.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3536
    Cell Significance Index: 60.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.3129
    Cell Significance Index: 35.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2398
    Cell Significance Index: 12.4600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.2075
    Cell Significance Index: 1.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2046
    Cell Significance Index: 154.8500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1423
    Cell Significance Index: 0.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0661
    Cell Significance Index: 42.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0591
    Cell Significance Index: 8.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0177
    Cell Significance Index: 12.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0068
    Cell Significance Index: -12.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0196
    Cell Significance Index: -14.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0333
    Cell Significance Index: -18.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0368
    Cell Significance Index: -1.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0413
    Cell Significance Index: -76.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0434
    Cell Significance Index: -4.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0453
    Cell Significance Index: -69.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0570
    Cell Significance Index: -6.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0570
    Cell Significance Index: -77.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0627
    Cell Significance Index: -39.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0733
    Cell Significance Index: -14.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0852
    Cell Significance Index: -62.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0964
    Cell Significance Index: -2.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1122
    Cell Significance Index: -11.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1267
    Cell Significance Index: -57.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1469
    Cell Significance Index: -3.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1542
    Cell Significance Index: -5.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1688
    Cell Significance Index: -60.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1710
    Cell Significance Index: -49.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1746
    Cell Significance Index: -25.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1977
    Cell Significance Index: -41.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2121
    Cell Significance Index: -24.7200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2494
    Cell Significance Index: -4.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2713
    Cell Significance Index: -34.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2826
    Cell Significance Index: -56.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4259
    Cell Significance Index: -13.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5687
    Cell Significance Index: -12.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5760
    Cell Significance Index: -59.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6044
    Cell Significance Index: -15.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6963
    Cell Significance Index: -39.0700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.7171
    Cell Significance Index: -3.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7436
    Cell Significance Index: -57.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7560
    Cell Significance Index: -46.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8206
    Cell Significance Index: -64.9900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.9459
    Cell Significance Index: -16.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9483
    Cell Significance Index: -63.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9509
    Cell Significance Index: -49.5300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.9866
    Cell Significance Index: -14.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0577
    Cell Significance Index: -65.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0746
    Cell Significance Index: -17.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1143
    Cell Significance Index: -70.2300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.1732
    Cell Significance Index: -16.4100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -1.2113
    Cell Significance Index: -12.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.2909
    Cell Significance Index: -34.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2995
    Cell Significance Index: -68.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.3293
    Cell Significance Index: -54.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.3562
    Cell Significance Index: -23.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.3727
    Cell Significance Index: -29.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell surface glycoprotein**: CD44 is a transmembrane glycoprotein composed of 10 immunoglobulin-like domains, which interact with hyaluronic acid and other ligands. 2. **Multifunctional role**: CD44 is involved in various cellular processes, including cell adhesion, migration, signaling, and cytokine-mediated responses. 3. **Widespread expression**: CD44 is expressed in numerous cell types, including immune cells, epithelial cells, and fibroblasts. 4. **Hyaluronic acid interaction**: CD44 binds to hyaluronic acid, facilitating its degradation and uptake, which is essential for immune responses and tissue remodeling. **Pathways and Functions:** 1. **Cell adhesion and migration**: CD44 plays a critical role in cell adhesion, migration, and homing, facilitating the recruitment of immune cells to sites of inflammation. 2. **Cytokine signaling**: CD44 mediates cytokine signaling, influencing the production of pro-inflammatory and anti-inflammatory cytokines. 3. **Hyaluronic acid metabolism**: CD44 is involved in the degradation and uptake of hyaluronic acid, which is essential for immune responses and tissue remodeling. 4. **Cell surface interactions**: CD44 interacts with various ligands, including hyaluronic acid, collagen, and glycosaminoglycans, facilitating cell surface interactions and signaling. 5. **Inflammatory response**: CD44 is involved in the regulation of the inflammatory response, influencing the production of pro-inflammatory cytokines and the recruitment of immune cells. 6. **Tissue remodeling**: CD44 plays a role in tissue remodeling, facilitating the degradation and uptake of extracellular matrix components. **Clinical Significance:** CD44's involvement in immune responses, inflammation, and cancer metastasis makes it a valuable target for therapeutic interventions. Abnormal expression or function of CD44 has been implicated in various diseases, including: 1. **Cancer**: CD44's role in cancer metastasis and immune evasion has been extensively studied, with implications for cancer therapy. 2. **Autoimmune diseases**: CD44's involvement in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, has been explored, with potential therapeutic applications. 3. **Inflammatory disorders**: CD44's role in inflammatory disorders, such as atherosclerosis and inflammatory bowel disease, has been investigated, with implications for therapeutic interventions. 4. **Immunodeficiency disorders**: CD44's expression in immunodeficiency disorders, such as leukocyte adhesion deficiency, has been studied, with potential therapeutic applications. In conclusion, CD44's complex role in the immune system highlights its importance as a therapeutic target for various diseases. Further research is necessary to fully elucidate the mechanisms underlying CD44's functions and to explore its potential as a therapeutic agent.

Genular Protein ID: 1597275826

Symbol: CD44_HUMAN

Name: CD44 antigen

UniProtKB Accession Codes:

P16070 A5YRN9 B6EAT9 D3DR12 D3DR13 O95370 P22511 Q04858 Q13419 Q13957 Q13958 Q13959 Q13960 Q13961 Q13967 Q13968 Q13980 Q15861 Q16064 Q16065 Q16066 Q16208 Q16522 Q86T72 Q86Z27 Q8N694 Q92493 Q96J24 Q9H5A5 Q9UC28 Q9UC29 Q9UC30 Q9UCB0 Q9UJ36

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 7 CDD 1 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 ELM 1 EMBL 100 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 8 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 18 Pumba 1 RNAct 1 Reactome 6 RefSeq 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 5 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2466575

Title: A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family.

PubMed ID: 2466575

DOI: 10.1016/0092-8674(89)90638-7

PubMed ID: 1840487

Title: The multispecific cell adhesion molecule CD44 is represented in reticulocyte cDNA.

PubMed ID: 1840487

DOI: 10.1016/0006-291x(91)91009-2

PubMed ID: 1991450

Title: The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells.

PubMed ID: 1991450

DOI: 10.1002/j.1460-2075.1991.tb07955.x

PubMed ID: 2056274

Title: Molecular cloning of CD44R1 and CD44R2, two novel isoforms of the human CD44 lymphocyte 'homing' receptor expressed by hemopoietic cells.

PubMed ID: 2056274

DOI: 10.1084/jem.174.1.1

PubMed ID: 1281868

Title: The core protein of epican, a heparan sulfate proteoglycan on keratinocytes, is an alternative form of CD44.

PubMed ID: 1281868

DOI: 10.1111/1523-1747.ep12614896

PubMed ID: 1465456

Title: Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.

PubMed ID: 1465456

DOI: 10.1073/pnas.89.24.12160

PubMed ID: 7508842

Title: CD44: a multitude of isoforms with diverse functions.

PubMed ID: 7508842

DOI: 10.1007/978-3-642-78253-4_4

PubMed ID: 8352881

Title: Novel variants of CD44 arising from alternative splicing: changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase.

PubMed ID: 8352881

DOI: 10.1002/mc.2940070403

PubMed ID: 10933060

Title: Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44.

PubMed ID: 10933060

DOI: 10.1038/sj.neo.7900045

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1922057

Title: Expression of CD44 is repressed in neuroblastoma cells.

PubMed ID: 1922057

DOI: 10.1128/mcb.11.11.5446-5453.1991

PubMed ID: 2466576

Title: A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins.

PubMed ID: 2466576

DOI: 10.1016/0092-8674(89)90639-9

PubMed ID: 7527301

Title: Anti-(glioma surface antigen) monoclonal antibody G-22 recognizes overexpressed CD44 in glioma cells.

PubMed ID: 7527301

DOI: 10.1007/bf01519984

PubMed ID: 7508992

Title: A monoclonal antibody that blocks poliovirus attachment recognizes the lymphocyte homing receptor CD44.

PubMed ID: 7508992

DOI: 10.1128/jvi.68.3.1301-1308.1994

PubMed ID: 2007624

Title: Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons.

PubMed ID: 2007624

DOI: 10.1083/jcb.113.1.207

PubMed ID: 8148709

Title: Non-invasive detection of malignancy by identification of unusual CD44 gene activity in exfoliated cancer cells.

PubMed ID: 8148709

DOI: 10.1136/bmj.308.6929.619

PubMed ID: 1717145

Title: CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines.

PubMed ID: 1717145

PubMed ID: 7528188

Title: Stimulation of T cells via CD44 requires leukocyte-function-associated antigen interactions and interleukin-2 production.

PubMed ID: 7528188

DOI: 10.1016/0198-8859(94)90026-4

PubMed ID: 12511867

Title: CD44: from adhesion molecules to signalling regulators.

PubMed ID: 12511867

DOI: 10.1038/nrm1004

PubMed ID: 9580567

Title: Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325.

PubMed ID: 9580567

DOI: 10.1242/jcs.111.11.1595

PubMed ID: 12032545

Title: A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility.

PubMed ID: 12032545

DOI: 10.1038/ncb797

PubMed ID: 12883358

Title: CD44s adhesive function spontaneous and PMA-inducible CD44 cleavage are regulated at post-translational level in cells of melanocytic lineage.

PubMed ID: 12883358

DOI: 10.1097/00008390-200308000-00001

PubMed ID: 15123640

Title: Hyaluronan-CD44 interaction with Rac1-dependent protein kinase N-gamma promotes phospholipase Cgamma1 activation, Ca(2+) signaling, and cortactin-cytoskeleton function leading to keratinocyte adhesion and differentiation.

PubMed ID: 15123640

DOI: 10.1074/jbc.m403608200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16541107

Title: RNA-binding IMPs promote cell adhesion and invadopodia formation.

PubMed ID: 16541107

DOI: 10.1038/sj.emboj.7601039

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19381274

Title: Unc119 protects from Shigella infection by inhibiting the Abl family kinases.

PubMed ID: 19381274

DOI: 10.1371/journal.pone.0005211

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19703720

Title: Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.

PubMed ID: 19703720

DOI: 10.1016/j.jhep.2009.06.021

PubMed ID: 18757307

Title: Hyaluronan fragments/CD44 mediate oxidative stress-induced MUC5B up-regulation in airway epithelium.

PubMed ID: 18757307

DOI: 10.1165/rcmb.2008-0073oc

PubMed ID: 20962267

Title: Podoplanin associates with CD44 to promote directional cell migration.

PubMed ID: 20962267

DOI: 10.1091/mbc.e10-06-0489

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 22726066

Title: CD44 in human glioma correlates with histopathological grade and cell migration.

PubMed ID: 22726066

DOI: 10.1111/j.1440-1827.2012.02823.x

PubMed ID: 23589287

Title: Transforming growth factor-beta1 (TGF-beta1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts.

PubMed ID: 23589287

DOI: 10.1074/jbc.m113.451336

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29777959

Title: Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix.

PubMed ID: 29777959

DOI: 10.1016/j.actbio.2018.05.023

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 36213313

Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.

PubMed ID: 36213313

DOI: 10.1007/s42485-022-00092-3

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

PubMed ID: 14992719

Title: Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.

PubMed ID: 14992719

DOI: 10.1016/s1097-2765(04)00080-2

PubMed ID: 17085435

Title: Ligand-induced structural changes of the CD44 hyaluronan-binding domain revealed by NMR.

PubMed ID: 17085435

DOI: 10.1074/jbc.m608425200

PubMed ID: 25195884

Title: High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction.

PubMed ID: 25195884

DOI: 10.1107/s2053230x14015532

PubMed ID: 8636151

Title: A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding.

PubMed ID: 8636151

DOI: 10.1074/jbc.271.12.7147

Sequence Information:

  • Length: 742
  • Mass: 81538
  • Checksum: BB9B66B19B970349
  • Sequence:
    • MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA DLCKAFNSTL 
PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN NTGVYILTSN TSQYDTYCFN 
ASAPPEEDCT SVTDLPNAFD GPITITIVNR DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS 
GSSSERSSTS GGYIFYTFST VHPIPDEDSP WITDSTDRIP ATTLMSTSAT ATETATKRQE 
TWDWFSWLFL PSESKNHLHT TTQMAGTSSN TISAGWEPNE ENEDERDRHL SFSGSGIDDD 
EDFISSTIST TPRAFDHTKQ NQDWTQWNPS HSNPEVLLQT TTRMTDVDRN GTTAYEGNWN 
PEAHPPLIHH EHHEEEETPH STSTIQATPS STTEETATQK EQWFGNRWHE GYRQTPKEDS 
HSTTGTAAAS AHTSHPMQGR TTPSPEDSSW TDFFNPISHP MGRGHQAGRR MDMDSSHSIT 
LQPTANPNTG LVEDLDRTGP LSMTTQQSNS QSFSTSHEGL EEDKDHPTTS TLTSSNRNDV 
TGGRRDPNHS EGSTTLLEGY TSHYPHTKES RTFIPVTSAK TGSFGVTAVT VGDSNSNVNR 
SLSGDQDTFH PSGGSHTTHG SESDGHSHGS QEGGANTTSG PIRTPQIPEW LIILASLLAL 
ALILAVCIAV NSRRRCGQKK KLVINSGNGA VEDRKPSGLN GEASKSQEMV HLVNKESSET 
PDQFMTADET RNLQNVDMKI GV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.