Details for: CD47

Gene ID: 961

Symbol: CD47

Ensembl ID: ENSG00000196776

Description: CD47 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 401.9410
    Cell Significance Index: -62.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 278.3436
    Cell Significance Index: -70.6000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 211.5439
    Cell Significance Index: -87.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 180.4030
    Cell Significance Index: -73.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 179.5296
    Cell Significance Index: -84.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 161.1730
    Cell Significance Index: -82.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 126.4191
    Cell Significance Index: -84.8300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 77.6439
    Cell Significance Index: -74.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 64.7955
    Cell Significance Index: -79.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.2682
    Cell Significance Index: -77.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.8651
    Cell Significance Index: -66.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.3277
    Cell Significance Index: -84.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.9542
    Cell Significance Index: -30.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.2150
    Cell Significance Index: 151.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.1374
    Cell Significance Index: 37.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.0104
    Cell Significance Index: 51.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6223
    Cell Significance Index: 526.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4628
    Cell Significance Index: 1344.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.2167
    Cell Significance Index: 139.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9187
    Cell Significance Index: 123.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5893
    Cell Significance Index: 74.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.5397
    Cell Significance Index: 45.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4452
    Cell Significance Index: 33.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2952
    Cell Significance Index: 464.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2688
    Cell Significance Index: 33.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.2290
    Cell Significance Index: 22.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0865
    Cell Significance Index: 140.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0823
    Cell Significance Index: 28.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0689
    Cell Significance Index: 59.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0521
    Cell Significance Index: 39.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9345
    Cell Significance Index: 26.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9311
    Cell Significance Index: 114.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9287
    Cell Significance Index: 109.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9023
    Cell Significance Index: 39.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8599
    Cell Significance Index: 52.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7785
    Cell Significance Index: 52.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6736
    Cell Significance Index: 121.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6657
    Cell Significance Index: 294.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6408
    Cell Significance Index: 33.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6203
    Cell Significance Index: 100.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5673
    Cell Significance Index: 392.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3782
    Cell Significance Index: 28.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3268
    Cell Significance Index: 7.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2801
    Cell Significance Index: 8.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1932
    Cell Significance Index: 24.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1396
    Cell Significance Index: 3.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1005
    Cell Significance Index: 17.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0755
    Cell Significance Index: 142.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0694
    Cell Significance Index: 52.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0679
    Cell Significance Index: 125.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0448
    Cell Significance Index: 1.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0292
    Cell Significance Index: 13.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0243
    Cell Significance Index: 2.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0096
    Cell Significance Index: 14.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0192
    Cell Significance Index: -3.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0212
    Cell Significance Index: -13.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0243
    Cell Significance Index: -3.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0370
    Cell Significance Index: -27.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0419
    Cell Significance Index: -1.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0423
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0461
    Cell Significance Index: -34.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0588
    Cell Significance Index: -79.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0633
    Cell Significance Index: -4.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0649
    Cell Significance Index: -12.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0755
    Cell Significance Index: -42.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0833
    Cell Significance Index: -52.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1264
    Cell Significance Index: -12.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2090
    Cell Significance Index: -4.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2269
    Cell Significance Index: -16.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2274
    Cell Significance Index: -47.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2554
    Cell Significance Index: -73.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2847
    Cell Significance Index: -33.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3106
    Cell Significance Index: -7.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3456
    Cell Significance Index: -50.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3541
    Cell Significance Index: -21.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3848
    Cell Significance Index: -11.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4052
    Cell Significance Index: -46.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4247
    Cell Significance Index: -10.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4985
    Cell Significance Index: -14.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6093
    Cell Significance Index: -19.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6993
    Cell Significance Index: -72.8100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7432
    Cell Significance Index: -4.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7698
    Cell Significance Index: -87.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8487
    Cell Significance Index: -44.2100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.8990
    Cell Significance Index: -11.1500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.9554
    Cell Significance Index: -14.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9821
    Cell Significance Index: -77.7800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.1098
    Cell Significance Index: -6.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1925
    Cell Significance Index: -29.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1980
    Cell Significance Index: -20.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3660
    Cell Significance Index: -83.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4090
    Cell Significance Index: -37.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.4333
    Cell Significance Index: -30.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4905
    Cell Significance Index: -47.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.5426
    Cell Significance Index: -50.5100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.5867
    Cell Significance Index: -12.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.6269
    Cell Significance Index: -41.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.7879
    Cell Significance Index: -62.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.8483
    Cell Significance Index: -64.7500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.9406
    Cell Significance Index: -41.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CD47 is a 40-kDa transmembrane protein that is widely expressed on the surface of various cell types, including: * Immune cells: CD47 is expressed on mature alpha-beta T cells, gamma-delta T cells, and classical monocytes. * Epithelial cells: CD47 is expressed on epithelial cells of the lower respiratory tract and prostate epithelium. * Hematopoietic progenitor cells: CD47 is expressed on early promyelocytes and pro-T cells. CD47's extracellular domain is rich in arginine and lysine residues, which are essential for binding to SIRPβ. The intracellular domain of CD47 contains a cytoplasmic tail that interacts with various signaling molecules, including integrins and the actin cytoskeleton. **Pathways and Functions** CD47's primary function is to regulate phagocytosis by binding to SIRPβ, which inhibits the phagocytic activity of macrophages and other phagocytic cells. This interaction is mediated by the extracellular domain of CD47, which binds to SIRPβ through a process called "reverse signaling". The binding of CD47 to SIRPβ triggers a signaling cascade that inhibits the expression of genes involved in phagocytosis, such as CD68 and CD14. In addition to regulating phagocytosis, CD47 also plays a role in: * Cell survival: CD47's interaction with SIRPβ promotes cell survival by inhibiting the activation of pro-apoptotic signaling pathways. * Cell adhesion: CD47's interaction with integrins promotes cell adhesion to the extracellular matrix. * Immune tolerance: CD47's interaction with SIRPβ promotes immune tolerance by inhibiting the activation of effector T cells. **Clinical Significance** Dysregulation of CD47 has been implicated in various diseases, including: * Cancer: CD47's interaction with SIRPβ promotes tumor cell evasion from immune surveillance, leading to tumor progression and metastasis. * Autoimmune diseases: CD47's interaction with SIRPβ promotes immune tolerance, leading to the suppression of autoimmune responses. * Inflammatory diseases: CD47's interaction with SIRPβ promotes inflammation by inhibiting the clearance of apoptotic cells. CD47 has also been identified as a potential therapeutic target for various diseases, including cancer, autoimmune diseases, and inflammatory diseases. Inhibition of CD47 signaling has been shown to enhance phagocytosis and reduce tumor growth in animal models. In conclusion, CD47 is a critical regulator of immune responses, cell survival, and tissue homeostasis. Its dysregulation has been implicated in various diseases, and inhibition of CD47 signaling has shown promise as a therapeutic strategy for various diseases. Further research is needed to fully elucidate the mechanisms of CD47's functions and to explore its potential as a therapeutic target.

Genular Protein ID: 1440314806

Symbol: CD47_HUMAN

Name: Leukocyte surface antigen CD47

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1394148

Title: An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains.

PubMed ID: 1394148

PubMed ID: 7691831

Title: Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v beta-3-dependent ligand binding.

PubMed ID: 7691831

DOI: 10.1083/jcb.123.2.485

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7998989

Title: Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3.

PubMed ID: 7998989

DOI: 10.1042/bj3040525

PubMed ID: 8550562

Title: Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin.

PubMed ID: 8550562

DOI: 10.1074/jbc.271.1.21

PubMed ID: 10549293

Title: Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane.

PubMed ID: 10549293

DOI: 10.1016/s1097-2765(00)80212-9

PubMed ID: 11454874

Title: Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains.

PubMed ID: 11454874

DOI: 10.1074/jbc.m106107200

PubMed ID: 11509594

Title: Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation.

PubMed ID: 11509594

DOI: 10.4049/jimmunol.167.5.2547

PubMed ID: 15383453

Title: Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation.

PubMed ID: 15383453

DOI: 10.1182/blood-2004-07-2823

PubMed ID: 15917238

Title: CD47 augments Fas/CD95-mediated apoptosis.

PubMed ID: 15917238

DOI: 10.1074/jbc.m500922200

PubMed ID: 19004835

Title: Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses.

PubMed ID: 19004835

DOI: 10.1074/jbc.m804860200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 22079249

Title: Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane.

PubMed ID: 22079249

DOI: 10.1016/j.bbamem.2011.10.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27742621

Title: TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction.

PubMed ID: 27742621

DOI: 10.1093/cvr/cvw218

PubMed ID: 32679764

Title: CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis.

PubMed ID: 32679764

DOI: 10.3390/cells9071695

PubMed ID: 18657508

Title: Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.

PubMed ID: 18657508

DOI: 10.1016/j.molcel.2008.05.026

Sequence Information:

  • Length: 323
  • Mass: 35214
  • Checksum: 5D20730A2632D550
  • Sequence:
  • MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN TTEVYVKWKF 
    KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM DKSDAVSHTG NYTCEVTELT 
    REGETIIELK YRVVSWFSPN ENILIVIFPI FAILLFWGQF GIKTLKYRSG GMDEKTIALL 
    VAGLVITVIV IVGAILFVPG EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA 
    ILVIQVIAYI LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ 
    PPRKAVEEPL NAFKESKGMM NDE

Genular Protein ID: 272715215

Symbol: A0A0A1TSG4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 293
  • Mass: 31872
  • Checksum: E841A2F6696D11F4
  • Sequence:
  • MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN TTEVYVKWKF 
    KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM DKSDAVSHTG NYTCEVTELT 
    REGETIIELK YRVVSWFSPN ENILIVIFPI FAILLFWGQF GIKTLKYRSG GMDEKTIALL 
    VAGLVITVIV IVGAILFVPG EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA 
    ILVIQVIAYI LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.