CD47 | ENSG00000196776 | NCBI 961

Details for: CD47

Gene ID: 961

Symbol: CD47

Ensembl ID: ENSG00000196776

Description: CD47 molecule

Associated with

Cell-cell communication
(R-HSA-1500931)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Extracellular matrix organization
(R-HSA-1474244)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Integrin cell surface interactions
(R-HSA-216083)
Neutrophil degranulation
(R-HSA-6798695)
Signal regulatory protein family interactions
(R-HSA-391160)
Angiogenesis
(GO:0001525)
Apoptotic process
(GO:0006915)
Atp export
(GO:1904669)
Cell-cell adhesion mediator activity
(GO:0098632)
Cell migration
(GO:0016477)
Cell surface
(GO:0009986)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to interleukin-12
(GO:0071349)
Cellular response to type ii interferon
(GO:0071346)
Extracellular exosome
(GO:0070062)
Heterotypic cell-cell adhesion
(GO:0034113)
Inflammatory response
(GO:0006954)
Integrin-mediated signaling pathway
(GO:0007229)
Negative regulation of phagocytosis
(GO:0050765)
Plasma membrane
(GO:0005886)
Positive regulation of cell-cell adhesion
(GO:0022409)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of monocyte extravasation
(GO:2000439)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of stress fiber assembly
(GO:0051496)
Positive regulation of t cell activation
(GO:0050870)
Protein binding
(GO:0005515)
Protein binding involved in heterotypic cell-cell adhesion
(GO:0086080)
Regulation of fc receptor mediated stimulatory signaling pathway
(GO:0060368)
Regulation of interleukin-6 production
(GO:0032675)
Regulation of interleukin-10 production
(GO:0032653)
Regulation of interleukin-12 production
(GO:0032655)
Regulation of nitric oxide biosynthetic process
(GO:0045428)
Regulation of tumor necrosis factor production
(GO:0032680)
Regulation of type ii interferon production
(GO:0032649)
Specific granule membrane
(GO:0035579)
Tertiary granule membrane
(GO:0070821)
Thrombospondin receptor activity
(GO:0070053)

Other Information

Proteins

Leukocyte surface antigen CD47
A0A0A1TSG4_HUMAN

Genular Protein ID: 1440314806

Symbol: CD47_HUMAN

Name: Leukocyte surface antigen CD47

UniProtKB Accession Codes:

Q08722 A8K198 D3DN59 Q53Y71 Q96A60

Database IDs:

Citations:

PubMed ID: 1394148

Title: An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains.

PubMed ID: 1394148

PubMed ID: 7691831

Title: Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v beta-3-dependent ligand binding.

PubMed ID: 7691831

DOI: 10.1083/jcb.123.2.485

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7998989

Title: Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3.

PubMed ID: 7998989

DOI: 10.1042/bj3040525

PubMed ID: 8550562

Title: Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin.

PubMed ID: 8550562

DOI: 10.1074/jbc.271.1.21

PubMed ID: 10549293

Title: Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane.

PubMed ID: 10549293

DOI: 10.1016/s1097-2765(00)80212-9

PubMed ID: 11454874

Title: Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains.

PubMed ID: 11454874

DOI: 10.1074/jbc.m106107200

PubMed ID: 11509594

Title: Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation.

PubMed ID: 11509594

DOI: 10.4049/jimmunol.167.5.2547

PubMed ID: 15383453

Title: Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation.

PubMed ID: 15383453

DOI: 10.1182/blood-2004-07-2823

PubMed ID: 15917238

Title: CD47 augments Fas/CD95-mediated apoptosis.

PubMed ID: 15917238

DOI: 10.1074/jbc.m500922200

PubMed ID: 19004835

Title: Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses.

PubMed ID: 19004835

DOI: 10.1074/jbc.m804860200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 22079249

Title: Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane.

PubMed ID: 22079249

DOI: 10.1016/j.bbamem.2011.10.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27742621

Title: TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction.

PubMed ID: 27742621

DOI: 10.1093/cvr/cvw218

PubMed ID: 32679764

Title: CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis.

PubMed ID: 32679764

DOI: 10.3390/cells9071695

PubMed ID: 18657508

Title: Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.

PubMed ID: 18657508

DOI: 10.1016/j.molcel.2008.05.026

Sequence Information:

Length: 323
Mass: 35214
Checksum: 5D20730A2632D550
Sequence:

MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN TTEVYVKWKF 
KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM DKSDAVSHTG NYTCEVTELT 
REGETIIELK YRVVSWFSPN ENILIVIFPI FAILLFWGQF GIKTLKYRSG GMDEKTIALL 
VAGLVITVIV IVGAILFVPG EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA 
ILVIQVIAYI LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ 
PPRKAVEEPL NAFKESKGMM NDE

Genular Protein ID: 272715215

Symbol: A0A0A1TSG4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A1TSG4

Database IDs:

Sequence Information:

Length: 293
Mass: 31872
Checksum: E841A2F6696D11F4
Sequence:

MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN TTEVYVKWKF 
KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM DKSDAVSHTG NYTCEVTELT 
REGETIIELK YRVVSWFSPN ENILIVIFPI FAILLFWGQF GIKTLKYRSG GMDEKTIALL 
VAGLVITVIV IVGAILFVPG EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA 
ILVIQVIAYI LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD47

Associated with

Other Information

An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains. PubMed ID: 1394148

Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v beta-3-dependent ligand binding. PubMed ID: 7691831

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3. PubMed ID: 7998989

Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin. PubMed ID: 8550562

Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. PubMed ID: 10549293

Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains. PubMed ID: 11454874

Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation. PubMed ID: 11509594

Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. PubMed ID: 15383453

CD47 augments Fas/CD95-mediated apoptosis. PubMed ID: 15917238

Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses. PubMed ID: 19004835

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane. PubMed ID: 22079249

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction. PubMed ID: 27742621

CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis. PubMed ID: 32679764

Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. PubMed ID: 18657508