Details for: CD47

Gene ID: 961

Symbol: CD47

Ensembl ID: ENSG00000196776

Description: CD47 molecule

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 3.79
    Marker Score: 3035
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.57
    Marker Score: 26881
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.32
    Marker Score: 3994
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.89
    Marker Score: 161751
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.86
    Marker Score: 151456
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.85
    Marker Score: 6949
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.79
    Marker Score: 8797
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.62
    Marker Score: 90872.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.59
    Marker Score: 10807
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.46
    Marker Score: 10055
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.42
    Marker Score: 12703
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.4
    Marker Score: 715.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.37
    Marker Score: 38020
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.33
    Marker Score: 12524
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.33
    Marker Score: 15195
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.33
    Marker Score: 1835
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.31
    Marker Score: 6736
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.3
    Marker Score: 10618
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.26
    Marker Score: 22429
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.22
    Marker Score: 2682
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.21
    Marker Score: 11615
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.21
    Marker Score: 6295
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.19
    Marker Score: 5248
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.16
    Marker Score: 21903
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.16
    Marker Score: 932
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.13
    Marker Score: 42385
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.11
    Marker Score: 13467
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.09
    Marker Score: 1217
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.09
    Marker Score: 1522
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.09
    Marker Score: 17978
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.07
    Marker Score: 2103
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.05
    Marker Score: 3751
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.05
    Marker Score: 490
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.04
    Marker Score: 3623
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.04
    Marker Score: 75374
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.04
    Marker Score: 2011
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.04
    Marker Score: 77464
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.04
    Marker Score: 1064
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.03
    Marker Score: 5535
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.01
    Marker Score: 8348
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2
    Marker Score: 1247
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.99
    Marker Score: 2930
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.99
    Marker Score: 50867
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.98
    Marker Score: 18618
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.97
    Marker Score: 3134
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.97
    Marker Score: 697
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.95
    Marker Score: 1691
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.94
    Marker Score: 3389
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.94
    Marker Score: 1170
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.94
    Marker Score: 1815
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.94
    Marker Score: 41330
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.93
    Marker Score: 8295
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.93
    Marker Score: 3098
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.93
    Marker Score: 28817
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.92
    Marker Score: 683
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.92
    Marker Score: 118089
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.92
    Marker Score: 1333
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.91
    Marker Score: 480
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.9
    Marker Score: 4367
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.89
    Marker Score: 2443
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.89
    Marker Score: 2785
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.89
    Marker Score: 1904
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.89
    Marker Score: 2206
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.89
    Marker Score: 25386
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.88
    Marker Score: 1683
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.88
    Marker Score: 845
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.88
    Marker Score: 5191
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.87
    Marker Score: 684
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.87
    Marker Score: 7340
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.87
    Marker Score: 21683
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.86
    Marker Score: 1562.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.85
    Marker Score: 684
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.85
    Marker Score: 2010
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.84
    Marker Score: 401
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.84
    Marker Score: 1394
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.84
    Marker Score: 618
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.84
    Marker Score: 1217
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.83
    Marker Score: 2531.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.83
    Marker Score: 4988
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.83
    Marker Score: 17411
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.83
    Marker Score: 400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.82
    Marker Score: 862
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.8
    Marker Score: 475
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.8
    Marker Score: 14029
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.79
    Marker Score: 3940
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.79
    Marker Score: 625
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.79
    Marker Score: 7282.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.79
    Marker Score: 724
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.78
    Marker Score: 4999
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.77
    Marker Score: 15239
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.77
    Marker Score: 4745
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.77
    Marker Score: 3702
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.76
    Marker Score: 1292
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.75
    Marker Score: 964
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.74
    Marker Score: 605
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.74
    Marker Score: 1743
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.73
    Marker Score: 955
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.73
    Marker Score: 459
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.73
    Marker Score: 705
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.72
    Marker Score: 429

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Other Information

**Key characteristics:** - CD47 is a glycoprotein with a molecular weight of approximately 120 kDa. - It is a transmembrane protein that is expressed on the surface of cells. - It is a member of the Integrin family of cell adhesion molecules. - CD47 is involved in the regulation of angiogenesis, cell adhesion, and migration. **Pathways and functions:** - CD47 is involved in the regulation of angiogenesis. It is expressed on endothelial cells, which are responsible for the formation and development of new blood vessels. When CD47 is bound by its ligand, vascular endothelial growth factor-2 (VEGF-2), it promotes the migration and proliferation of endothelial cells, leading to the formation of new blood vessels. - CD47 is also involved in cell adhesion and migration. It is expressed on various cell types, including monocytes and macrophages, and it plays a role in the adhesion of these cells to extracellular matrix proteins. This adhesion is essential for the migration of immune cells to sites of inflammation or infection. - CD47 is a key regulator of cell-cell adhesion. It is expressed on various cell types, including endothelial cells, epithelial cells, and immune cells. When CD47 binds to its ligand, E-cadherin, it promotes cell adhesion between endothelial cells and epithelial cells. This adhesion is essential for the formation of tissue and organ structures. **Clinical significance:** CD47 is a potential therapeutic target for cancer. Inhibition of CD47 signaling has been shown to inhibit the growth of cancer cells. This is because CD47 is involved in the migration and proliferation of cancer cells. By blocking CD47 signaling, it can be prevented the growth of cancer tumors. **Additional notes:** - CD47 is a highly conserved protein, with a similar protein found in mice and humans. - CD47 is a member of the Integrin family of cell adhesion molecules. Integrins are a large family of cell adhesion molecules that are involved in a variety of cellular processes, including cell adhesion, migration, and signaling. - CD47 is a key regulator of inflammation. It is expressed on immune cells, and it plays a role in the recruitment of immune cells to sites of inflammation.

Genular Protein ID: 1440314806

Symbol: CD47_HUMAN

Name: Leukocyte surface antigen CD47

UniProtKB Accession Codes:

Q08722 A8K198 D3DN59 Q53Y71 Q96A60

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 13 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1394148

Title: An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains.

PubMed ID: 1394148

PubMed ID: 7691831

Title: Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v beta-3-dependent ligand binding.

PubMed ID: 7691831

DOI: 10.1083/jcb.123.2.485

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7998989

Title: Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3.

PubMed ID: 7998989

DOI: 10.1042/bj3040525

PubMed ID: 8550562

Title: Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin.

PubMed ID: 8550562

DOI: 10.1074/jbc.271.1.21

PubMed ID: 10549293

Title: Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane.

PubMed ID: 10549293

DOI: 10.1016/s1097-2765(00)80212-9

PubMed ID: 11454874

Title: Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains.

PubMed ID: 11454874

DOI: 10.1074/jbc.m106107200

PubMed ID: 11509594

Title: Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation.

PubMed ID: 11509594

DOI: 10.4049/jimmunol.167.5.2547

PubMed ID: 15383453

Title: Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation.

PubMed ID: 15383453

DOI: 10.1182/blood-2004-07-2823

PubMed ID: 15917238

Title: CD47 augments Fas/CD95-mediated apoptosis.

PubMed ID: 15917238

DOI: 10.1074/jbc.m500922200

PubMed ID: 19004835

Title: Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses.

PubMed ID: 19004835

DOI: 10.1074/jbc.m804860200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 22079249

Title: Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane.

PubMed ID: 22079249

DOI: 10.1016/j.bbamem.2011.10.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27742621

Title: TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction.

PubMed ID: 27742621

DOI: 10.1093/cvr/cvw218

PubMed ID: 32679764

Title: CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis.

PubMed ID: 32679764

DOI: 10.3390/cells9071695

PubMed ID: 18657508

Title: Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.

PubMed ID: 18657508

DOI: 10.1016/j.molcel.2008.05.026

Sequence Information:

  • Length: 323
  • Mass: 35214
  • Checksum: 5D20730A2632D550
  • Sequence:
    • MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN TTEVYVKWKF 
KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM DKSDAVSHTG NYTCEVTELT 
REGETIIELK YRVVSWFSPN ENILIVIFPI FAILLFWGQF GIKTLKYRSG GMDEKTIALL 
VAGLVITVIV IVGAILFVPG EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA 
ILVIQVIAYI LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ 
PPRKAVEEPL NAFKESKGMM NDE

Genular Protein ID: 272715215

Symbol: A0A0A1TSG4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A1TSG4

Database IDs:

ARBA 15 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 6 Gene3D 1 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 293
  • Mass: 31872
  • Checksum: E841A2F6696D11F4
  • Sequence:
    • MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN TTEVYVKWKF 
KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM DKSDAVSHTG NYTCEVTELT 
REGETIIELK YRVVSWFSPN ENILIVIFPI FAILLFWGQF GIKTLKYRSG GMDEKTIALL 
VAGLVITVIV IVGAILFVPG EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA 
ILVIQVIAYI LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.