CD47 | ENSG00000196776 | NCBI 961

Details for: CD47

Associated with

Cell-cell communication
(R-HSA-1500931)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Extracellular matrix organization
(R-HSA-1474244)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Integrin cell surface interactions
(R-HSA-216083)
Neutrophil degranulation
(R-HSA-6798695)
Signal regulatory protein family interactions
(R-HSA-391160)
Angiogenesis
(GO:0001525)
Apoptotic process
(GO:0006915)
Atp export
(GO:1904669)
Cell-cell adhesion mediator activity
(GO:0098632)
Cell migration
(GO:0016477)
Cell surface
(GO:0009986)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to interleukin-12
(GO:0071349)
Cellular response to type ii interferon
(GO:0071346)
Extracellular exosome
(GO:0070062)
Fibrinogen binding
(GO:0070051)
Heterotypic cell-cell adhesion
(GO:0034113)
Inflammatory response
(GO:0006954)
Integrin-mediated signaling pathway
(GO:0007229)
Negative regulation of phagocytosis
(GO:0050765)
Plasma membrane
(GO:0005886)
Positive regulation of cell-cell adhesion
(GO:0022409)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of monocyte extravasation
(GO:2000439)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of stress fiber assembly
(GO:0051496)
Positive regulation of t cell activation
(GO:0050870)
Protein binding
(GO:0005515)
Protein binding involved in heterotypic cell-cell adhesion
(GO:0086080)
Regulation of fc receptor mediated stimulatory signaling pathway
(GO:0060368)
Regulation of interleukin-6 production
(GO:0032675)
Regulation of interleukin-10 production
(GO:0032653)
Regulation of interleukin-12 production
(GO:0032655)
Regulation of nitric oxide biosynthetic process
(GO:0045428)
Regulation of tumor necrosis factor production
(GO:0032680)
Regulation of type ii interferon production
(GO:0032649)
Specific granule membrane
(GO:0035579)
Tertiary granule membrane
(GO:0070821)
Thrombospondin receptor activity
(GO:0070053)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

fallopian tube secretory epithelial cell CL4030006

CSI 82.22

rCSI 79.15%

PRS 13.16
ciliated epithelial cell CL0000067

CSI 53.78

rCSI 47.29%

PRS 9.22
lamp5 GABAergic cortical interneuron CL4023011

CSI 41.23

rCSI 69.2%

PRS 7.47
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 37.72

rCSI 91.66%

PRS 7.27
Hofbauer cell CL3000001

CSI 32.62

rCSI 61.58%

PRS 15.76
CD14-low, CD16-positive monocyte CL0002396

CSI 31.91

rCSI 24.59%

PRS 11.52
L6b glutamatergic cortical neuron CL4023038

CSI 30.28

rCSI 94.64%

PRS 7.99
pvalb GABAergic cortical interneuron CL4023018

CSI 29.32

rCSI 36.47%

PRS 6.95
pancreatic ductal cell CL0002079

CSI 28.59

rCSI 55.61%

PRS 12.98
megakaryocyte-erythroid progenitor cell CL0000050

CSI 26.95

rCSI 24.34%

PRS 11.24
retina horizontal cell CL0000745

CSI 26.28

rCSI 40.06%

PRS 11.89
near-projecting glutamatergic cortical neuron CL4023012

CSI 24.61

rCSI 93.02%

PRS 7.61
pancreatic acinar cell CL0002064

CSI 24.23

rCSI 32.21%

PRS 13.89
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 24.01

rCSI 75.1%

PRS 8.57
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 23.9

rCSI 86%

PRS 6.92
pancreatic A cell CL0000171

CSI 22.52

rCSI 23.59%

PRS 13.59
CD4-positive helper T cell CL0000492

CSI 18.59

rCSI 14.06%

PRS 17.57
sst GABAergic cortical interneuron CL4023017

CSI 17.89

rCSI 23.06%

PRS 7.82
VIP GABAergic cortical interneuron CL4023016

CSI 15.85

rCSI 18.93%

PRS 7.33
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 15.72

rCSI 92.54%

PRS 7.81
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 15.44

rCSI 33.49%

PRS 6.97
mammary gland epithelial cell CL0002327

CSI 14.9

rCSI 52.27%

PRS 23.03
promyelocyte CL0000836

CSI 14.43

rCSI 20.81%

PRS 17.68
pancreatic D cell CL0000173

CSI 14.36

rCSI 14.12%

PRS 13.82
basal cell of prostate epithelium CL0002341

CSI 14.18

rCSI 41.03%

PRS 28.2
neuron CL0000540

CSI 13.43

rCSI 35.77%

PRS 10.01
common dendritic progenitor CL0001029

CSI 13.28

rCSI 16.67%

PRS 16.18
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 13.09

rCSI 43.03%

PRS 6.54
transitional stage B cell CL0000818

CSI 13.05

rCSI 42.73%

PRS 35.47
peripheral nervous system neuron CL2000032

CSI 12.55

rCSI 17.1%

PRS 11.34
H2 horizontal cell CL0004218

CSI 11.3

rCSI 56.17%

PRS 13.84
hematopoietic stem cell CL0000037

CSI 10.74

rCSI 7.14%

PRS 15.15
endothelial cell of placenta CL0009092

CSI 10.49

rCSI 51.7%

PRS 17.3
placental villous trophoblast CL2000060

CSI 10.37

rCSI 16.03%

PRS 11.9
elicited macrophage CL0000861

CSI 10.27

rCSI 9.43%

PRS 14.54
pulmonary alveolar type 2 cell CL0002063

CSI 10.27

rCSI 15.93%

PRS 19.32
retinal rod cell CL0000604

CSI 10.11

rCSI 17.81%

PRS 12.55
fraction A pre-pro B cell CL0002045

CSI 9.98

rCSI 11.43%

PRS 26.07
H1 horizontal cell CL0004217

CSI 9.84

rCSI 38.98%

PRS 18
myeloid lineage restricted progenitor cell CL0000839

CSI 9.81

rCSI 50.67%

PRS 24.97
large pre-B-II cell CL0000957

CSI 9.08

rCSI 25.92%

PRS 21.94
plasmacytoid dendritic cell, human CL0001058

CSI 8.83

rCSI 6.17%

PRS 13.32
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 8.23

rCSI 11.31%

PRS 26.18
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 8.2

rCSI 5.46%

PRS 33.05
intrahepatic cholangiocyte CL0002538

CSI 7.91

rCSI 18.97%

PRS 23.05
megakaryocyte CL0000556

CSI 7.79

rCSI 33.79%

PRS 22.82
central nervous system neuron CL2000029

CSI 7.68

rCSI 56.49%

PRS 6.48
eye photoreceptor cell CL0000287

CSI 7.39

rCSI 83.15%

PRS 31.95
retinal cone cell CL0000573

CSI 7.17

rCSI 11.54%

PRS 9.77
pulmonary alveolar type 1 cell CL0002062

CSI 6.97

rCSI 40.19%

PRS 16.91
syncytiotrophoblast cell CL0000525

CSI 6.92

rCSI 19.92%

PRS 24.67
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 6.23

rCSI 14.9%

PRS 6.98
lung ciliated cell CL1000271

CSI 6.16

rCSI 7.12%

PRS 9.31
M cell of gut CL0000682

CSI 6.06

rCSI 6.44%

PRS 22.59
double negative thymocyte CL0002489

CSI 6.01

rCSI 4.18%

PRS 14.88
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 5.69

rCSI 9.73%

PRS 25.33
extravillous trophoblast CL0008036

CSI 5.61

rCSI 6.94%

PRS 11.15
epithelial cell of lower respiratory tract CL0002632

CSI 5.58

rCSI 4.32%

PRS 12.11
T follicular helper cell CL0002038

CSI 5.57

rCSI 4.17%

PRS 20.6
neural crest cell CL0011012

CSI 5.2

rCSI 4.11%

PRS 8.73
eosinophil CL0000771

CSI 5.05

rCSI 33.15%

PRS 32.76
club cell CL0000158

CSI 4.6

rCSI 6.74%

PRS 14.85
hematopoietic precursor cell CL0008001

CSI 4.49

rCSI 4.62%

PRS 20.72
hepatic stellate cell CL0000632

CSI 4.31

rCSI 16.15%

PRS 10.77
invaginating midget bipolar cell CL4033034

CSI 4.24

rCSI 25.02%

PRS 13.26
blood vessel smooth muscle cell CL0019018

CSI 4.17

rCSI 33.88%

PRS 13.15
lymphoid lineage restricted progenitor cell CL0000838

CSI 4.11

rCSI 16%

PRS 20.83
perivascular cell CL4033054

CSI 4.1

rCSI 5.61%

PRS 14.42
stem cell CL0000034

CSI 4.09

rCSI 3.94%

PRS 8.75
common myeloid progenitor CL0000049

CSI 4.07

rCSI 3.29%

PRS 12.54
cerebellar granule cell CL0001031

CSI 4.07

rCSI 5.99%

PRS 11.64
transit amplifying cell of colon CL0009011

CSI 4.05

rCSI 4.75%

PRS 14.96
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 4.04

rCSI 7.13%

PRS 7.43
class switched memory B cell CL0000972

CSI 3.9

rCSI 2.91%

PRS 21.31
double-positive, alpha-beta thymocyte CL0000809

CSI 3.8

rCSI 3.87%

PRS 18.16
direct pathway medium spiny neuron CL4023026

CSI 3.8

rCSI 90.93%

PRS 5.75
indirect pathway medium spiny neuron CL4023029

CSI 3.75

rCSI 90.44%

PRS 6.63
podocyte CL0000653

CSI 3.7

rCSI 16.44%

PRS 12.54
duct epithelial cell CL0000068

CSI 3.7

rCSI 5.41%

PRS 13.43
intestinal tuft cell CL0019032

CSI 3.68

rCSI 5.63%

PRS 14.55
respiratory epithelial cell CL0002368

CSI 3.68

rCSI 22.72%

PRS 41.09
myofibroblast cell CL0000186

CSI 3.64

rCSI 5.04%

PRS 18.29
epithelial cell of lung CL0000082

CSI 3.6

rCSI 2.98%

PRS 11.99
mature B cell CL0000785

CSI 3.57

rCSI 3.11%

PRS 15.68
alpha-beta T cell CL0000789

CSI 3.53

rCSI 4.14%

PRS 16.96
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 3.52

rCSI 2.47%

PRS 32.74
secretory cell CL0000151

CSI 3.44

rCSI 3.58%

PRS 13.02
melanocyte CL0000148

CSI 3.35

rCSI 2.48%

PRS 11.28
thymocyte CL0000893

CSI 3.33

rCSI 11.83%

PRS 39.37
activated type II NK T cell CL0000931

CSI 3.26

rCSI 3.67%

PRS 20.33
CD4-positive, alpha-beta memory T cell CL0000897

CSI 3.2

rCSI 2.3%

PRS 17.26
pancreatic PP cell CL0002275

CSI 3.19

rCSI 12.69%

PRS 22.37
mesenchymal stem cell CL0000134

CSI 3.1

rCSI 33.93%

PRS 22.94
memory T cell CL0000813

CSI 3.09

rCSI 5.95%

PRS 28.41
naive T cell CL0000898

CSI 3.08

rCSI 2.14%

PRS 18.05
Cajal-Retzius cell CL0000695

CSI 3.06

rCSI 23.97%

PRS 27.59
naive B cell CL0000788

CSI 2.93

rCSI 2.51%

PRS 22.31
epithelial cell of urethra CL1000296

CSI 2.93

rCSI 73.82%

PRS 40.16
mature NK T cell CL0000814

CSI 2.8

rCSI 3.59%

PRS 49.77
chondrocyte CL0000138

CSI 2.8

rCSI 4.45%

PRS 10.9

colonocyte CL1000347

CSI -9.5

rCSI -13.7%

PRS 17.4%
dopaminergic neuron CL0000700

CSI -3.8

rCSI -21.5%

PRS 5.2%
late pro-B cell CL0002048

CSI -3.6

rCSI -9.1%

PRS 36.8%
fibroblast of cardiac tissue CL0002548

CSI -2.9

rCSI -14.0%

PRS 8.4%
retinal pigment epithelial cell CL0002586

CSI -2.9

rCSI -5.8%

PRS 13.5%
lung neuroendocrine cell CL1000223

CSI -2.5

rCSI -3.7%

PRS 14.7%
pulmonary capillary endothelial cell CL4028001

CSI -2.0

rCSI -3.9%

PRS 20.2%
alveolar adventitial fibroblast CL4028006

CSI -1.7

rCSI -2.7%

PRS 12.7%
exhausted T cell CL0011025

CSI -1.5

rCSI -25.6%

PRS 48.5%
adventitial cell CL0002503

CSI -1.3

rCSI -3.1%

PRS 19.8%
CD14-positive, CD16-positive monocyte CL0002397

CSI -1.1

rCSI -1.4%

PRS 17.8%
vein endothelial cell of respiratory system CL4033008

CSI -0.9

rCSI -6.0%

PRS 24.9%
inflammatory macrophage CL0000863

CSI -0.8

rCSI -1.3%

PRS 25.5%
glioblast CL0000030

CSI -0.4

rCSI -0.6%

PRS 10.9%
serous secreting cell CL0000313

CSI -0.3

rCSI -1.7%

PRS 49.7%
neural cell CL0002319

CSI -0.1

rCSI -0.5%

PRS 19.3%
endothelial cell of uterus CL0009095

CSI -0.1

rCSI -0.8%

PRS 34.5%
tracheobronchial serous cell CL0019001

CSI 0.1

rCSI 0.2%

PRS 24.3%
regular ventricular cardiac myocyte CL0002131

CSI 0.1

rCSI 0.3%

PRS 9.9%
megakaryocyte progenitor cell CL0000553

CSI 0.1

rCSI 1.1%

PRS 36.2%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.1

rCSI 0.3%

PRS 16.4%
cytotoxic T cell CL0000910

CSI 0.1

rCSI 0.6%

PRS 18.6%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 0.1

rCSI 1.2%

PRS 47.4%
pre-conventional dendritic cell CL0002010

CSI 0.1

rCSI 1.8%

PRS 40.8%
cone retinal bipolar cell CL0000752

CSI 0.1

rCSI 1.8%

PRS 46.9%
macroglial cell CL0000126

CSI 0.1

rCSI 0.4%

PRS 17.9%
regular atrial cardiac myocyte CL0002129

CSI 0.1

rCSI 0.5%

PRS 13.6%
parietal cell CL0000162

CSI 0.1

rCSI 1.2%

PRS 60.5%
group 2 innate lymphoid cell CL0001069

CSI 0.2

rCSI 0.8%

PRS 42.4%
myeloid dendritic cell CL0000782

CSI 0.2

rCSI 0.2%

PRS 18.7%
kidney connecting tubule epithelial cell CL1000768

CSI 0.2

rCSI 0.4%

PRS 9.7%
glycinergic amacrine cell CL4030028

CSI 0.2

rCSI 0.4%

PRS 12.5%
enterocyte of epithelium of small intestine CL1000334

CSI 0.2

rCSI 2.5%

PRS 31.4%
bronchiolar smooth muscle cell CL4033017

CSI 0.2

rCSI 2.6%

PRS 39.4%
germinal center B cell CL0000844

CSI 0.2

rCSI 0.5%

PRS 31.4%
interstitial cell of Cajal CL0002088

CSI 0.2

rCSI 0.2%

PRS 14.8%
ON midget ganglion cell CL4033046

CSI 0.2

rCSI 3.8%

PRS 9.8%
hepatocyte CL0000182

CSI 0.2

rCSI 0.4%

PRS 11.9%
bronchial goblet cell CL1000312

CSI 0.2

rCSI 0.8%

PRS 27.8%
mucus secreting cell CL0000319

CSI 0.2

rCSI 0.3%

PRS 16.4%
parietal epithelial cell CL1000452

CSI 0.2

rCSI 0.7%

PRS 10.8%
cerebral cortex pyramidal neuron CL4023111

CSI 0.3

rCSI 1.6%

PRS 34.9%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 0.3

rCSI 0.5%

PRS 10.4%
erythroid progenitor cell CL0000038

CSI 0.3

rCSI 1.5%

PRS 19.6%
colon macrophage CL0009038

CSI 0.3

rCSI 1.2%

PRS 26.3%
myelocyte CL0002193

CSI 0.3

rCSI 1.7%

PRS 40.3%
foveolar cell of stomach CL0002179

CSI 0.3

rCSI 0.6%

PRS 20.5%
tracheobronchial smooth muscle cell CL0019019

CSI 0.3

rCSI 0.5%

PRS 16.8%
intestinal crypt stem cell of colon CL0009043

CSI 0.3

rCSI 2.1%

PRS 23.3%
stromal cell of ovary CL0002132

CSI 0.3

rCSI 0.8%

PRS 20.9%
peptic cell CL0000155

CSI 0.3

rCSI 2.8%

PRS 37.2%
lung pericyte CL0009089

CSI 0.3

rCSI 0.8%

PRS 15.2%
colon goblet cell CL0009039

CSI 0.3

rCSI 0.7%

PRS 19.2%
B-2 B cell CL0000822

CSI 0.3

rCSI 6.5%

PRS 60.6%
erythroblast CL0000765

CSI 0.3

rCSI 0.9%

PRS 20.9%
cardiac muscle cell CL0000746

CSI 0.3

rCSI 0.5%

PRS 9.9%
alveolar type 1 fibroblast cell CL4028004

CSI 0.3

rCSI 0.4%

PRS 14.5%
type B pancreatic cell CL0000169

CSI 0.3

rCSI 0.8%

PRS 11.8%
cardiac neuron CL0010022

CSI 0.3

rCSI 1.1%

PRS 9.1%
microcirculation associated smooth muscle cell CL0008035

CSI 0.4

rCSI 1.1%

PRS 14.4%
cord blood hematopoietic stem cell CL2000095

CSI 0.4

rCSI 7.2%

PRS 71.4%
intermediate monocyte CL0002393

CSI 0.4

rCSI 0.6%

PRS 12.5%
type L enteroendocrine cell CL0002279

CSI 0.4

rCSI 0.7%

PRS 25.1%
pancreatic epsilon cell CL0005019

CSI 0.4

rCSI 1.9%

PRS 30.3%
deuterosomal cell CL4033044

CSI 0.4

rCSI 1.4%

PRS 21.4%
myeloid dendritic cell, human CL0001057

CSI 0.4

rCSI 2.3%

PRS 39.7%
OFF midget ganglion cell CL4033047

CSI 0.4

rCSI 8.5%

PRS 10.7%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.4

rCSI 0.5%

PRS 16.9%
respiratory goblet cell CL0002370

CSI 0.5

rCSI 5.0%

PRS 24.5%
transit amplifying cell CL0009010

CSI 0.5

rCSI 0.7%

PRS 20.7%
colon epithelial cell CL0011108

CSI 0.5

rCSI 0.5%

PRS 11.8%
mesodermal cell CL0000222

CSI 0.5

rCSI 0.6%

PRS 12.6%
T-helper 17 cell CL0000899

CSI 0.5

rCSI 0.4%

PRS 22.4%
skeletal muscle satellite cell CL0000594

CSI 0.5

rCSI 1.5%

PRS 40.6%
pancreatic stellate cell CL0002410

CSI 0.5

rCSI 3.0%

PRS 19.1%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.5

rCSI 1.3%

PRS 20.1%
professional antigen presenting cell CL0000145

CSI 0.5

rCSI 1.8%

PRS 46.7%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.5

rCSI 3.2%

PRS 28.2%
keratocyte CL0002363

CSI 0.5

rCSI 1.3%

PRS 19.0%
respiratory basal cell CL0002633

CSI 0.5

rCSI 0.6%

PRS 14.9%
amacrine cell CL0000561

CSI 0.6

rCSI 1.6%

PRS 9.9%
ON parasol ganglion cell CL4033052

CSI 0.6

rCSI 8.1%

PRS 8.8%
pulmonary ionocyte CL0017000

CSI 0.6

rCSI 0.7%

PRS 16.0%
choroid plexus epithelial cell CL0000706

CSI 0.6

rCSI 0.9%

PRS 9.8%
neuroendocrine cell CL0000165

CSI 0.6

rCSI 2.3%

PRS 26.2%
retinal ganglion cell CL0000740

CSI 0.6

rCSI 1.3%

PRS 9.2%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 0.6

rCSI 0.8%

PRS 11.8%
paneth cell of epithelium of small intestine CL1000343

CSI 0.6

rCSI 1.7%

PRS 19.6%
diffuse bipolar 3b cell CL4033030

CSI 0.6

rCSI 4.0%

PRS 12.9%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 0.6

rCSI 3.4%

PRS 46.6%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 0.6

rCSI 1.6%

PRS 11.9%
brush cell CL0002204

CSI 0.6

rCSI 1.2%

PRS 33.1%
basophil CL0000767

CSI 0.6

rCSI 1.3%

PRS 25.7%
IgA plasma cell CL0000987

CSI 0.6

rCSI 0.7%

PRS 23.6%
forebrain radial glial cell CL0013000

CSI 0.6

rCSI 2.1%

PRS 18.6%
IgM plasma cell CL0000986

CSI 0.7

rCSI 3.0%

PRS 55.5%
kidney interstitial alternatively activated macrophage CL1000695

CSI 0.7

rCSI 1.7%

PRS 11.7%
stratified epithelial cell CL0000079

CSI 0.7

rCSI 4.1%

PRS 49.1%
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 0.7

rCSI 0.9%

PRS 30.5%
endocardial cell CL0002350

CSI 0.7

rCSI 3.3%

PRS 16.3%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [CD47](/details-gene/961), also known as Integrin-Associated Protein (IAP), is a multi-spanning transmembrane protein belonging to the immunoglobulin superfamily. It functions as a critical cell surface receptor involved in a wide array of biological processes, including cell adhesion, migration, apoptosis, and immune regulation. Most notably, [CD47](/details-gene/961) acts as a ligand for signal-regulatory protein alpha (SIRPα), an interaction that transmits a "don't eat me" signal to phagocytic cells, thereby protecting host cells from clearance. The gene's expression profile is remarkably broad, showing high significance across diverse cell types including epithelial, neuronal, and hematopoietic cells, underscoring its fundamental role in self-recognition and tissue homeostasis. Its clinical relevance is significant, particularly in oncology, where its overexpression on tumor cells represents a key mechanism of immune evasion ([OMIM: [601028](https://omim.org/entry/601028)]). ## Cellular Roles and Expression Landscape The expression landscape of [CD47](/details-gene/961) highlights its ubiquitous yet differentially regulated nature. **Overall**, the gene shows the highest significance in non-immune cell types, suggesting a broad role beyond its well-characterized immunological functions. * **Epithelial and Secretory Cells:** The most significant expression is observed in `fallopian tube secretory epithelial cell` ([CL4030006](/details-cell/CL4030006)) and `ciliated epithelial cell` ([CL0000067](/details-cell/CL0000067)), as well as `pancreatic ductal cell` ([CL0002079](/details-cell/CL0002079)) and `pancreatic acinar cell` ([CL0002064](/details-cell/CL0002064)). This is consistent with its original identification as an ovarian tumor marker ([Link](https://pubmed.ncbi.nlm.nih.gov/1394148/)) and suggests a critical role in maintaining the integrity and immune privilege of glandular and mucosal tissues. * **Nervous System:** [CD47](/details-gene/961) is highly significant in multiple neuronal subtypes, including `lamp5 GABAergic cortical interneuron` ([CL4023011](/details-cell/CL4023011)), `L2/3-6 intratelencephalic projecting glutamatergic neuron` ([CL4023040](/details-cell/CL4023040)), and `retina horizontal cell` ([CL0000745](/details-cell/CL0000745)). This pattern suggests a potential role in neuronal self-recognition, synaptic organization, and protection against aberrant microglial phagocytosis during development and homeostasis. * **Myeloid and Hematopoietic Cells:** The gene is also a significant marker for myeloid cells such as `Hofbauer cell` ([CL3000001](/details-cell/CL3000001)) and `CD14-low, CD16-positive monocyte` ([CL0002396](/details-cell/CL0002396)), as well as `megakaryocyte-erythroid progenitor cell` ([CL0000050](/details-cell/CL0000050)). This is in line with its established function in regulating phagocytosis and its role as a receptor for thrombospondin ([Link](https://doi.org/10.1074/jbc.271.1.21)). * **Specificity and Anti-Markers:** Notably, [CD47](/details-gene/961) shows low to negative significance in certain differentiated or specialized cell types, such as `colonocyte` ([CL1000347](/details-cell/CL1000347)), `late pro-B cell` ([CL0002048](/details-cell/CL0002048)), and `exhausted T cell` ([CL0011025](/details-cell/CL0011025)). This suggests its expression is dynamically regulated during cellular differentiation and exhaustion, potentially lowering the threshold for clearance of senescent or terminally differentiated cells. ## Pathways and Molecular Function Functional annotations reveal [CD47](/details-gene/961) as a pleiotropic cell surface molecule with extensive roles in cell-cell communication and immune regulation. * **Immune Checkpoint and Phagocytosis:** The primary function of [CD47](/details-gene/961) is the `Negative regulation of phagocytosis` ([GO:0050765](https://www.ebi.ac.uk/QuickGO/term/GO:0050765)) through its interaction with SIRP family proteins, a key axis in the `Innate immune system` ([R-HSA-168249](https://reactome.org/content/detail/R-HSA-168249)) pathway `Signal regulatory protein family interactions` ([R-HSA-391160](https://reactome.org/content/detail/R-HSA-391160)). However, it is also implicated in the `Positive regulation of phagocytosis` ([GO:0050766](https://www.ebi.ac.uk/QuickGO/term/GO:0050766)) under different contexts, highlighting its complex regulatory roles. * **Cell Adhesion and Migration:** As its alias IAP suggests, [CD47](/details-gene/961) is involved in `Integrin-mediated signaling pathway` ([GO:0007229](https://www.ebi.ac.uk/QuickGO/term/GO:0007229)) and `Heterotypic cell-cell adhesion` ([GO:0034113](https://www.ebi.ac.uk/QuickGO/term/GO:0034113)). It functions as a `Thrombospondin receptor` ([GO:0070053](https://www.ebi.ac.uk/QuickGO/term/GO:0070053)) and engages in `Integrin cell surface interactions` ([R-HSA-216083](https://reactome.org/content/detail/R-HSA-216083)), contributing to processes like `Cell migration` ([GO:0016477](https://www.ebi.ac.uk/QuickGO/term/GO:0016477)) and `Hemostasis` ([R-HSA-109582](https://reactome.org/content/detail/R-HSA-109582)). * **T-Cell Regulation:** Beyond its innate immune function, [CD47](/details-gene/961) participates in adaptive immunity. It has been shown to be involved in the `Positive regulation of t cell activation` ([GO:0050870](https://www.ebi.ac.uk/QuickGO/term/GO:0050870)) through interaction with SIRPβ2 ([Link](https://doi.org/10.1182/blood-2004-07-2823)), while also participating in bidirectional negative regulation of T cells and dendritic cells ([Link](https://doi.org/10.4049/jimmunol.167.5.2547)). * **Inflammatory Signaling:** The gene is linked to the regulation of numerous cytokine pathways, including those for interleukin-1, -6, -10, -12, and TNF, as well as type II interferon ([GO:0071347](https://www.ebi.ac.uk/QuickGO/term/GO:0071347), [GO:0032675](https://www.ebi.ac.uk/QuickGO/term/GO:0032675), [GO:0032653](https://www.ebi.ac.uk/QuickGO/term/GO:0032653), [GO:0032655](https://www.ebi.ac.uk/QuickGO/term/GO:0032655), [GO:0032680](https://www.ebi.ac.uk/QuickGO/term/GO:0032680), [GO:0032649](https://www.ebi.ac.uk/QuickGO/term/GO:0032649)), positioning it as a key modulator of the `Inflammatory response` ([GO:0006954](https://www.ebi.ac.uk/QuickGO/term/GO:0006954)). ## Research Directions The widespread expression and multifaceted functions of [CD47](/details-gene/961) present numerous avenues for future investigation, particularly concerning its roles in tissue-specific contexts and disease. * **Proposed Hypotheses:** 1. Given its high significance in a wide range of cortical neurons (`lamp5 GABAergic cortical interneuron`, `L2/3-6 intratelencephalic projecting glutamatergic neuron`, etc.), it is hypothesized that [CD47](/details-gene/961) serves as a critical "don't prune me" signal during neural development and aging, protecting active and healthy synapses from excessive microglial elimination. Downregulation of [CD47](/details-gene/961) on specific neurons or synapses may be a key signal initiating their targeted removal in neurodegenerative diseases. 2. The exceptionally high expression in `fallopian tube secretory epithelial cell` ([CL4030006](/details-cell/CL4030006)), a cell of origin for many high-grade serous ovarian cancers, suggests that baseline [CD47](/details-gene/961) levels in this tissue provide a pre-existing mechanism for immune evasion that can be co-opted and enhanced during malignant transformation. * **Key Experimental Approach:** To test the second hypothesis, an initial study would use spatial transcriptomics and immunohistochemistry to precisely map [CD47](/details-gene/961) expression in healthy fallopian tube tissue, pre-cancerous lesions, and diagnosed ovarian cancer samples. This would establish if expression is universally high in precursor cells and maintained or amplified in tumors. Subsequently, patient-derived organoids from fallopian tube epithelia could be generated and subjected to CRISPR-Cas9-mediated knockdown of [CD47](/details-gene/961). Co-culture of these knockdown organoids with autologous macrophages, followed by time-lapse imaging and flow cytometry-based phagocytosis assays, would directly test whether reducing [CD47](/details-gene/961) levels increases immune-mediated clearance of these cancer-precursor cells. * **Therapeutic Potential:** [CD47](/details-gene/961) is a major therapeutic target in oncology. Its role as a "don't eat me" signal makes it a prime candidate for **inhibition** to promote anti-tumor immunity. Therapeutic strategies focus on blocking the [CD47](/details-gene/961)-SIRPα interaction using monoclonal antibodies, fusion proteins, or small molecules. This approach is designed to "unmask" cancer cells, allowing them to be recognized and eliminated by phagocytes like macrophages and dendritic cells. Such therapies are in clinical development for a variety of hematological and solid tumors, often in combination with other immunotherapies or standard-of-care agents.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Leukocyte surface antigen CD47
A0A0A1TSG4_HUMAN

Genular Protein ID: 1440314806

Symbol: CD47_HUMAN

Name: Leukocyte surface antigen CD47

UniProtKB Accession Codes:

Q08722 A8K198 D3DN59 Q53Y71 Q96A60

Database IDs:

Citations:

PubMed ID: 1394148

Title: An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains.

PubMed ID: 1394148

PubMed ID: 7691831

Title: Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v beta-3-dependent ligand binding.

PubMed ID: 7691831

DOI: 10.1083/jcb.123.2.485

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7998989

Title: Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3.

PubMed ID: 7998989

DOI: 10.1042/bj3040525

PubMed ID: 8550562

Title: Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin.

PubMed ID: 8550562

DOI: 10.1074/jbc.271.1.21

PubMed ID: 10549293

Title: Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane.

PubMed ID: 10549293

DOI: 10.1016/s1097-2765(00)80212-9

PubMed ID: 11454874

Title: Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains.

PubMed ID: 11454874

DOI: 10.1074/jbc.m106107200

PubMed ID: 11509594

Title: Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation.

PubMed ID: 11509594

DOI: 10.4049/jimmunol.167.5.2547

PubMed ID: 15383453

Title: Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation.

PubMed ID: 15383453

DOI: 10.1182/blood-2004-07-2823

PubMed ID: 15917238

Title: CD47 augments Fas/CD95-mediated apoptosis.

PubMed ID: 15917238

DOI: 10.1074/jbc.m500922200

PubMed ID: 19004835

Title: Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses.

PubMed ID: 19004835

DOI: 10.1074/jbc.m804860200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 22079249

Title: Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane.

PubMed ID: 22079249

DOI: 10.1016/j.bbamem.2011.10.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27742621

Title: TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction.

PubMed ID: 27742621

DOI: 10.1093/cvr/cvw218

PubMed ID: 32679764

Title: CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis.

PubMed ID: 32679764

DOI: 10.3390/cells9071695

PubMed ID: 18657508

Title: Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.

PubMed ID: 18657508

DOI: 10.1016/j.molcel.2008.05.026

Sequence Information:

Length: 323
Mass: 35214
Checksum: 5D20730A2632D550
Sequence:

MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN TTEVYVKWKF 
KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM DKSDAVSHTG NYTCEVTELT 
REGETIIELK YRVVSWFSPN ENILIVIFPI FAILLFWGQF GIKTLKYRSG GMDEKTIALL 
VAGLVITVIV IVGAILFVPG EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA 
ILVIQVIAYI LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ 
PPRKAVEEPL NAFKESKGMM NDE

Genular Protein ID: 272715215

Symbol: A0A0A1TSG4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A1TSG4

Database IDs:

Sequence Information:

Length: 293
Mass: 31872
Checksum: E841A2F6696D11F4
Sequence:

MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN TTEVYVKWKF 
KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM DKSDAVSHTG NYTCEVTELT 
REGETIIELK YRVVSWFSPN ENILIVIFPI FAILLFWGQF GIKTLKYRSG GMDEKTIALL 
VAGLVITVIV IVGAILFVPG EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA 
ILVIQVIAYI LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVE

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Ascending colon UBERON0001156
	Atherosclerosis MONDO0005311
	Axilla UBERON0009472
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Pancreas UBERON0001264
	\|— Pancreas Healthy UBERON0001264_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	\|— Prefrontal cortex Healthy UBERON0000451_PATO0000461
	Primary motor cortex UBERON0001384
	\|— Primary motor cortex Healthy UBERON0001384_PATO0000461
	Primary visual cortex UBERON0002436
	\|— Primary visual cortex Healthy UBERON0002436_PATO0000461
	Prostate gland UBERON0002367
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	\|— Stomach Healthy UBERON0000945_PATO0000461
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	Transverse colon UBERON0001157
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648

Details for: CD47

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains. PubMed ID: 1394148

Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v beta-3-dependent ligand binding. PubMed ID: 7691831

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3. PubMed ID: 7998989

Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin. PubMed ID: 8550562

Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. PubMed ID: 10549293

Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains. PubMed ID: 11454874

Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation. PubMed ID: 11509594

Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. PubMed ID: 15383453

CD47 augments Fas/CD95-mediated apoptosis. PubMed ID: 15917238

Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses. PubMed ID: 19004835

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane. PubMed ID: 22079249

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction. PubMed ID: 27742621

CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis. PubMed ID: 32679764

Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. PubMed ID: 18657508