Details for: MTRF1

Gene ID: 9617

Symbol: MTRF1

Ensembl ID: ENSG00000120662

Description: mitochondrial translation release factor 1

Associated with

Other Information

Genular Protein ID: 1895625411

Symbol: RF1M_HUMAN

Name: N/A

UniProtKB Accession Codes:

O75570 B4DG01 Q5T6Y5 Q8IUQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 6 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 21 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9838146

Title: Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor.

PubMed ID: 9838146

DOI: 10.1016/s0167-4781(98)00223-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17803939

Title: mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG.

PubMed ID: 17803939

DOI: 10.1016/j.molcel.2007.06.031

PubMed ID: 22569235

Title: Structure based hypothesis of a mitochondrial ribosome rescue mechanism.

PubMed ID: 22569235

DOI: 10.1186/1745-6150-7-14

PubMed ID: 36302763

Title: Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control.

PubMed ID: 36302763

DOI: 10.1038/s41467-022-34088-w

PubMed ID: 35260756

Title: Mammalian HEMK1 methylates glutamine residue of the GGQ motif of mitochondrial release factors.

PubMed ID: 35260756

DOI: 10.1038/s41598-022-08061-y

PubMed ID: 36596788

Title: Human mitochondria require mtRF1 for translation termination at non-canonical stop codons.

PubMed ID: 36596788

DOI: 10.1038/s41467-022-35684-6

PubMed ID: 37141370

Title: Molecular basis of translation termination at noncanonical stop codons in human mitochondria.

PubMed ID: 37141370

DOI: 10.1126/science.adf9890

Sequence Information:

  • Length: 445
  • Mass: 52306
  • Checksum: 3DC637D90F04C6F7
  • Sequence:
    • MNRHLCVWLF RHPSLNGYLQ CHIQLHSHQF RQIHLDTRLQ VFRQNRNCIL HLLSKNWSRR 
YCHQDTKMLW KHKALQKYME NLSKEYQTLE QCLQHIPVNE ENRRSLNRRH AELAPLAAIY 
QEIQETEQAI EELESMCKSL NKQDEKQLQE LALEERQTID QKINMLYNEL FQSLVPKEKY 
DKNDVILEVT AGRTTGGDIC QQFTREIFDM YQNYSCYKHW QFELLNYTPA DYGGLHHAAA 
RISGDGVYKH LKYEGGIHRV QRIPEVGLSS RMQRIHTGTM SVIVLPQPDE VDVKLDPKDL 
RIDTFRAKGA GGQHVNKTDS AVRLVHIPTG LVVECQQERS QIKNKEIAFR VLRARLYQQI 
IEKDKRQQQS ARKLQVGTRA QSERIRTYNF TQDRVSDHRI AYEVRDIKEF LCGGKGLDQL 
IQRLLQSADE EAIAELLDEH LKSAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.