TRAF4 | ENSG00000076604 | NCBI 9618

Details for: TRAF4

Gene ID: 9618

Symbol: TRAF4

Ensembl ID: ENSG00000076604

Description: TNF receptor associated factor 4

Associated with

Apoptotic process
(GO:0006915)
Bicellular tight junction
(GO:0005923)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Fibrillar center
(GO:0001650)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Plasma membrane signaling receptor complex
(GO:0098802)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of protein kinase activity
(GO:0045860)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of apoptotic process
(GO:0042981)
Regulation of canonical nf-kappab signal transduction
(GO:0043122)
Respiratory gaseous exchange by respiratory system
(GO:0007585)
Respiratory tube development
(GO:0030323)
Signal transduction
(GO:0007165)
Thioesterase binding
(GO:0031996)
Transferase activity
(GO:0016740)
Tumor necrosis factor receptor binding
(GO:0005164)
Ubiquitin protein ligase binding
(GO:0031625)
Ww domain binding
(GO:0050699)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

TNF receptor-associated factor 4

Genular Protein ID: 2060324389

Symbol: TRAF4_HUMAN

Name: TNF receptor-associated factor 4

UniProtKB Accession Codes:

Q9BUZ4 O75615 Q14848 Q2KJU4 Q2PJN8

Database IDs:

Citations:

PubMed ID: 7490069

Title: Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.

PubMed ID: 7490069

DOI: 10.1006/geno.1995.1163

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7592751

Title: Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma.

PubMed ID: 7592751

DOI: 10.1074/jbc.270.43.25715

PubMed ID: 9626059

Title: TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues.

PubMed ID: 9626059

PubMed ID: 10514511

Title: TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.

PubMed ID: 10514511

DOI: 10.1074/jbc.274.42.30202

PubMed ID: 12023963

Title: Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase.

PubMed ID: 12023963

DOI: 10.1074/jbc.m202665200

PubMed ID: 12801526

Title: Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase.

PubMed ID: 12801526

DOI: 10.1016/s0145-2126(02)00325-9

PubMed ID: 16052631

Title: TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.

PubMed ID: 16052631

DOI: 10.1002/eji.200526151

PubMed ID: 16157600

Title: MEKK4 is an effector of the embryonic TRAF4 for JNK activation.

PubMed ID: 16157600

DOI: 10.1074/jbc.c500260200

PubMed ID: 16330715

Title: Subcellular targeting of oxidants during endothelial cell migration.

PubMed ID: 16330715

DOI: 10.1083/jcb.200507004

PubMed ID: 18087216

Title: TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN.

PubMed ID: 18087216

DOI: 10.4161/cbt.6.12.5002

PubMed ID: 18953416

Title: Tumor necrosis factor receptor-associated factor 4 is a dynamic tight junction-related shuttle protein involved in epithelium homeostasis.

PubMed ID: 18953416

DOI: 10.1371/journal.pone.0003518

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19937093

Title: Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation.

PubMed ID: 19937093

DOI: 10.1007/s11010-009-0315-y

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20946164

Title: TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets.

PubMed ID: 20946164

DOI: 10.1111/j.1538-7836.2010.04091.x

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30352854

Title: TRAF4 binds to the juxtamembrane region of EGFR directly and promotes kinase activation.

PubMed ID: 30352854

DOI: 10.1073/pnas.1809599115

PubMed ID: 31076633

Title: TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2.

PubMed ID: 31076633

DOI: 10.1038/s41418-019-0328-3

PubMed ID: 32357935

Title: Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation.

PubMed ID: 32357935

DOI: 10.1186/s13045-020-00869-3

PubMed ID: 32268273

Title: TRAF4 acts as a fate checkpoint to regulate the adipogenic differentiation of MSCs by activating PKM2.

PubMed ID: 32268273

DOI: 10.1016/j.ebiom.2020.102722

PubMed ID: 33991522

Title: The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1.

PubMed ID: 33991522

DOI: 10.1016/j.jbc.2021.100739

PubMed ID: 29073066

Title: Molecular basis for unique specificity of human TRAF4 for platelets GPIbbeta and GPVI.

PubMed ID: 29073066

DOI: 10.1073/pnas.1708688114

Sequence Information:

Length: 470
Mass: 53543
Checksum: A3F57E0E1081AB88
Sequence:

MPGFDYKFLE KPKRRLLCPL CGKPMREPVQ VSTCGHRFCD TCLQEFLSEG VFKCPEDQLP 
LDYAKIYPDP ELEVQVLGLP IRCIHSEEGC RWSGPLRHLQ GHLNTCSFNV IPCPNRCPMK 
LSRRDLPAHL QHDCPKRRLK CEFCGCDFSG EAYESHEGMC PQESVYCENK CGARMMRRLL 
AQHATSECPK RTQPCTYCTK EFVFDTIQSH QYQCPRLPVA CPNQCGVGTV AREDLPGHLK 
DSCNTALVLC PFKDSGCKHR CPKLAMARHV EESVKPHLAM MCALVSRQRQ ELQELRRELE 
ELSVGSDGVL IWKIGSYGRR LQEAKAKPNL ECFSPAFYTH KYGYKLQVSA FLNGNGSGEG 
THLSLYIRVL PGAFDNLLEW PFARRVTFSL LDQSDPGLAK PQHVTETFHP DPNWKNFQKP 
GTWRGSLDES SLGFGYPKFI SHQDIRKRNY VRDDAVFIRA AVELPRKILS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TRAF4

Associated with

Other Information

Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. PubMed ID: 7490069

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. PubMed ID: 7592751

TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. PubMed ID: 9626059

TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. PubMed ID: 10514511

Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. PubMed ID: 12023963

Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase. PubMed ID: 12801526

TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF. PubMed ID: 16052631

MEKK4 is an effector of the embryonic TRAF4 for JNK activation. PubMed ID: 16157600

Subcellular targeting of oxidants during endothelial cell migration. PubMed ID: 16330715

TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN. PubMed ID: 18087216

Tumor necrosis factor receptor-associated factor 4 is a dynamic tight junction-related shuttle protein involved in epithelium homeostasis. PubMed ID: 18953416

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation. PubMed ID: 19937093

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. PubMed ID: 20946164

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

TRAF4 binds to the juxtamembrane region of EGFR directly and promotes kinase activation. PubMed ID: 30352854

TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2. PubMed ID: 31076633

Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation. PubMed ID: 32357935

TRAF4 acts as a fate checkpoint to regulate the adipogenic differentiation of MSCs by activating PKM2. PubMed ID: 32268273

The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1. PubMed ID: 33991522

Molecular basis for unique specificity of human TRAF4 for platelets GPIbbeta and GPVI. PubMed ID: 29073066