ABCG1 | ENSG00000160179 | NCBI 9619

Details for: ABCG1

Gene ID: 9619

Symbol: ABCG1

Ensembl ID: ENSG00000160179

Description: ATP binding cassette subfamily G member 1

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporters in lipid homeostasis
(R-HSA-1369062)
Hdl remodeling
(R-HSA-8964058)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein remodeling
(R-HSA-8963899)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Transport of small molecules
(R-HSA-382551)
Abc-type sterol transporter activity
(GO:0034041)
Adp binding
(GO:0043531)
Amyloid precursor protein catabolic process
(GO:0042987)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cellular response to high density lipoprotein particle stimulus
(GO:0071403)
Cholesterol binding
(GO:0015485)
Cholesterol efflux
(GO:0033344)
Cholesterol homeostasis
(GO:0042632)
Cholesterol metabolic process
(GO:0008203)
Cholesterol transfer activity
(GO:0120020)
Endoplasmic reticulum membrane
(GO:0005789)
Endosome
(GO:0005768)
External side of plasma membrane
(GO:0009897)
Floppase activity
(GO:0140328)
Glycoprotein transport
(GO:0034436)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
High-density lipoprotein particle remodeling
(GO:0034375)
Intermembrane lipid transfer
(GO:0120009)
Intracellular cholesterol transport
(GO:0032367)
Lipid translocation
(GO:0034204)
Low-density lipoprotein particle remodeling
(GO:0034374)
Mitochondrion
(GO:0005739)
Negative regulation of cholesterol storage
(GO:0010887)
Negative regulation of macrophage derived foam cell differentiation
(GO:0010745)
Phosphatidylcholine floppase activity
(GO:0090554)
Phospholipid binding
(GO:0005543)
Phospholipid efflux
(GO:0033700)
Phospholipid homeostasis
(GO:0055091)
Plasma membrane
(GO:0005886)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of cholesterol biosynthetic process
(GO:0045542)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of protein secretion
(GO:0050714)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Recycling endosome
(GO:0055037)
Regulation of cholesterol metabolic process
(GO:0090181)
Response to lipid
(GO:0033993)
Response to organic substance
(GO:0010033)
Reverse cholesterol transport
(GO:0043691)
Toxin transmembrane transporter activity
(GO:0019534)
Toxin transport
(GO:1901998)
Transmembrane transport
(GO:0055085)

Other Information

Proteins

ATP-binding cassette transporter 8

Genular Protein ID: 4125056116

Symbol: ABCG1_HUMAN

Name: ATP-binding cassette transporter 8

UniProtKB Accession Codes:

P45844 Q86SU8 Q96L76 Q9BXK6 Q9BXK7 Q9BXK8 Q9BXK9 Q9BXL0 Q9BXL1 Q9BXL2 Q9BXL3 Q9BXL4

Database IDs:

Citations:

PubMed ID: 8659545

Title: Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3.

PubMed ID: 8659545

PubMed ID: 10950923

Title: Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region.

PubMed ID: 10950923

DOI: 10.1006/geno.2000.6253

PubMed ID: 11279031

Title: The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux.

PubMed ID: 11279031

DOI: 10.1074/jbc.m100218200

PubMed ID: 11162488

Title: Genomic sequence and structure of the human ABCG1 (ABC8) gene.

PubMed ID: 11162488

DOI: 10.1006/bbrc.2000.4089

PubMed ID: 11500512

Title: Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein.

PubMed ID: 11500512

DOI: 10.1074/jbc.m105863200

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9034316

Title: Isolation and characterization of a mammalian homolog of the Drosophila white gene.

PubMed ID: 9034316

DOI: 10.1016/s0378-1119(96)00633-6

PubMed ID: 10799558

Title: Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols.

PubMed ID: 10799558

DOI: 10.1074/jbc.275.19.14700

PubMed ID: 10639163

Title: ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport.

PubMed ID: 10639163

DOI: 10.1073/pnas.97.2.817

PubMed ID: 12032171

Title: Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway.

PubMed ID: 12032171

PubMed ID: 11590207

Title: Role of ABCG1 and other ABCG family members in lipid metabolism.

PubMed ID: 11590207

PubMed ID: 11350058

Title: Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease.

PubMed ID: 11350058

DOI: 10.1006/bbrc.2001.4863

PubMed ID: 16702602

Title: Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1.

PubMed ID: 16702602

DOI: 10.1194/jlr.m500546-jlr200

PubMed ID: 17408620

Title: Expression of ATP binding cassette-transporter ABCG1 prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol.

PubMed ID: 17408620

DOI: 10.1016/j.febslet.2007.03.038

PubMed ID: 22042635

Title: Antibody-based protein profiling of the human chromosome 21.

PubMed ID: 22042635

DOI: 10.1074/mcp.m111.013458

PubMed ID: 23388354

Title: Characterization of palmitoylation of ATP binding cassette transporter G1: Effect on protein trafficking and function.

PubMed ID: 23388354

DOI: 10.1016/j.bbalip.2013.01.019

PubMed ID: 24576892

Title: Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux.

PubMed ID: 24576892

DOI: 10.1016/j.bbalip.2014.02.002

PubMed ID: 27228027

Title: Functional Cooperativity between ABCG4 and ABCG1 Isoforms.

PubMed ID: 27228027

DOI: 10.1371/journal.pone.0156516

Sequence Information:

Length: 678
Mass: 75592
Checksum: B901CABDA6C19E09
Sequence:

MACLMAAFSV GTAMNASSYS AEMTEPKSVC VSVDEVVSSN MEATETDLLN GHLKKVDNNL 
TEAQRFSSLP RRAAVNIEFR DLSYSVPEGP WWRKKGYKTL LKGISGKFNS GELVAIMGPS 
GAGKSTLMNI LAGYRETGMK GAVLINGLPR DLRCFRKVSC YIMQDDMLLP HLTVQEAMMV 
SAHLKLQEKD EGRREMVKEI LTALGLLSCA NTRTGSLSGG QRKRLAIALE LVNNPPVMFF 
DEPTSGLDSA SCFQVVSLMK GLAQGGRSII CTIHQPSAKL FELFDQLYVL SQGQCVYRGK 
VCNLVPYLRD LGLNCPTYHN PADFVMEVAS GEYGDQNSRL VRAVREGMCD SDHKRDLGGD 
AEVNPFLWHR PSEEVKQTKR LKGLRKDSSS MEGCHSFSAS CLTQFCILFK RTFLSIMRDS 
VLTHLRITSH IGIGLLIGLL YLGIGNEAKK VLSNSGFLFF SMLFLMFAAL MPTVLTFPLE 
MGVFLREHLN YWYSLKAYYL AKTMADVPFQ IMFPVAYCSI VYWMTSQPSD AVRFVLFAAL 
GTMTSLVAQS LGLLIGAAST SLQVATFVGP VTAIPVLLFS GFFVSFDTIP TYLQWMSYIS 
YVRYGFEGVI LSIYGLDRED LHCDIDETCH FQKSEAILRE LDVENAKLYL DFIVLGIFFI 
SLRLIAYFVL RYKIRAER

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ABCG1

Associated with

Other Information

Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3. PubMed ID: 8659545

Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region. PubMed ID: 10950923

The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux. PubMed ID: 11279031

Genomic sequence and structure of the human ABCG1 (ABC8) gene. PubMed ID: 11162488

Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein. PubMed ID: 11500512

The DNA sequence of human chromosome 21. PubMed ID: 10830953

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and characterization of a mammalian homolog of the Drosophila white gene. PubMed ID: 9034316

Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. PubMed ID: 10799558

ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. PubMed ID: 10639163

Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway. PubMed ID: 12032171

Role of ABCG1 and other ABCG family members in lipid metabolism. PubMed ID: 11590207

Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease. PubMed ID: 11350058

Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1. PubMed ID: 16702602

Expression of ATP binding cassette-transporter ABCG1 prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol. PubMed ID: 17408620

Antibody-based protein profiling of the human chromosome 21. PubMed ID: 22042635

Characterization of palmitoylation of ATP binding cassette transporter G1: Effect on protein trafficking and function. PubMed ID: 23388354

Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux. PubMed ID: 24576892

Functional Cooperativity between ABCG4 and ABCG1 Isoforms. PubMed ID: 27228027