Details for: CD48

Gene ID: 962

Symbol: CD48

Ensembl ID: ENSG00000117091

Description: CD48 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 132.9517
    Cell Significance Index: -20.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 84.3801
    Cell Significance Index: -34.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.5478
    Cell Significance Index: -35.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.3172
    Cell Significance Index: -16.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 55.4305
    Cell Significance Index: -26.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.4888
    Cell Significance Index: -20.3300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 10.5342
    Cell Significance Index: 28.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.6246
    Cell Significance Index: -26.4900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.9606
    Cell Significance Index: 128.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.6132
    Cell Significance Index: -22.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.4597
    Cell Significance Index: 160.3500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.6822
    Cell Significance Index: 14.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.9660
    Cell Significance Index: 99.1400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.7843
    Cell Significance Index: 37.9500
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.7791
    Cell Significance Index: 16.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2514
    Cell Significance Index: 147.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1302
    Cell Significance Index: 24.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0217
    Cell Significance Index: 65.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0124
    Cell Significance Index: 192.6700
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.8113
    Cell Significance Index: 4.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7383
    Cell Significance Index: 73.0300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.7205
    Cell Significance Index: 4.7800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.7043
    Cell Significance Index: 6.1600
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.6728
    Cell Significance Index: 2.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6674
    Cell Significance Index: 602.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4757
    Cell Significance Index: 12.7300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.3448
    Cell Significance Index: 1.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3337
    Cell Significance Index: 54.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3155
    Cell Significance Index: 66.4600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.2831
    Cell Significance Index: 2.9400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.1942
    Cell Significance Index: 1.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1274
    Cell Significance Index: 13.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0350
    Cell Significance Index: 21.8800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0171
    Cell Significance Index: 0.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -3.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0049
    Cell Significance Index: -9.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0105
    Cell Significance Index: -0.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0140
    Cell Significance Index: -25.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0173
    Cell Significance Index: -26.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0196
    Cell Significance Index: -26.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0197
    Cell Significance Index: -1.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0211
    Cell Significance Index: -11.9000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0220
    Cell Significance Index: -0.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0222
    Cell Significance Index: -0.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0234
    Cell Significance Index: -17.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0399
    Cell Significance Index: -1.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0496
    Cell Significance Index: -36.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0543
    Cell Significance Index: -3.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0563
    Cell Significance Index: -35.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0573
    Cell Significance Index: -25.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0618
    Cell Significance Index: -2.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0666
    Cell Significance Index: -23.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0693
    Cell Significance Index: -31.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0776
    Cell Significance Index: -13.2500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0818
    Cell Significance Index: -1.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0919
    Cell Significance Index: -3.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1036
    Cell Significance Index: -20.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1057
    Cell Significance Index: -30.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1134
    Cell Significance Index: -22.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1356
    Cell Significance Index: -13.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1384
    Cell Significance Index: -15.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1401
    Cell Significance Index: -8.5900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1412
    Cell Significance Index: -6.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1542
    Cell Significance Index: -27.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1671
    Cell Significance Index: -22.9500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1799
    Cell Significance Index: -20.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1920
    Cell Significance Index: -19.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1960
    Cell Significance Index: -25.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2143
    Cell Significance Index: -3.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2276
    Cell Significance Index: -27.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2300
    Cell Significance Index: -29.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2427
    Cell Significance Index: -35.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2723
    Cell Significance Index: -12.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3180
    Cell Significance Index: -19.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3308
    Cell Significance Index: -25.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3464
    Cell Significance Index: -11.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3573
    Cell Significance Index: -25.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3672
    Cell Significance Index: -24.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3998
    Cell Significance Index: -29.8000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.4105
    Cell Significance Index: -3.8400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.4235
    Cell Significance Index: -4.3900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.4236
    Cell Significance Index: -3.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4273
    Cell Significance Index: -22.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4598
    Cell Significance Index: -28.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4621
    Cell Significance Index: -25.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4631
    Cell Significance Index: -36.6800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.4965
    Cell Significance Index: -6.7600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.5012
    Cell Significance Index: -4.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5353
    Cell Significance Index: -24.9600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5693
    Cell Significance Index: -11.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6038
    Cell Significance Index: -12.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6086
    Cell Significance Index: -26.9200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.6376
    Cell Significance Index: -4.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6486
    Cell Significance Index: -22.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6527
    Cell Significance Index: -34.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6573
    Cell Significance Index: -18.3700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.6750
    Cell Significance Index: -6.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7071
    Cell Significance Index: -23.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7098
    Cell Significance Index: -26.8800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.7110
    Cell Significance Index: -11.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Surface Expression:** CD48 is predominantly expressed on the surface of mature T cells, gamma-delta T cells, and certain subsets of B cells, such as IgG-negative class-switched memory B cells. 2. **Ligand-Binding Properties:** CD48 interacts with its ligands, including CD229 (also known as LFA-3) and CD80, to modulate T cell activation and regulation. 3. **Expression on Immune Regulatory Cells:** CD48 is also expressed on T regulatory cells, double negative T regulatory cells, and DN3 thymocytes, highlighting its potential role in maintaining immune tolerance and preventing autoimmunity. 4. **Variable Expression on Hematopoietic Cells:** CD48 is also expressed on various hematopoietic cells, including blood cells, suggesting its involvement in hematopoiesis and immune cell development. **Pathways and Functions:** 1. **Cell Surface Interactions:** CD48 participates in the interaction between T cells and antigen-presenting cells (APCs), influencing T cell activation, proliferation, and differentiation. 2. **Defense Response:** CD48 plays a role in the defense response by modulating the activation and regulation of immune cells, such as T cells and B cells, in response to pathogens. 3. **Extracellular Exosome Signaling:** CD48 is involved in the regulation of immune cell communication through the extracellular exosome, influencing the exchange of signaling molecules and immune cell activation. 4. **Hemostasis and Hematopoiesis:** CD48's expression on hematopoietic cells suggests its involvement in maintaining blood cell homeostasis and preventing thrombosis. **Clinical Significance:** 1. **Autoimmune Diseases:** Alterations in CD48 expression or function may contribute to the development of autoimmune diseases, such as rheumatoid arthritis, lupus, or multiple sclerosis. 2. **Cancer Immunotherapy:** CD48's role in T cell regulation and activation makes it an attractive target for cancer immunotherapy, potentially enhancing the efficacy of checkpoint inhibitors. 3. **Infectious Diseases:** CD48's involvement in defense responses and immune cell communication may influence the course of infectious diseases, such as HIV or tuberculosis. 4. **Regulatory T Cell Function:** CD48's expression on T regulatory cells suggests its potential role in maintaining immune tolerance and preventing autoimmunity, highlighting its importance in immune homeostasis. In conclusion, CD48 is a multifunctional protein that plays a crucial role in the regulation of immune cell interactions, defense responses, and hematopoiesis. Its significance in various immune-related disorders and diseases underscores the need for further research into the molecular mechanisms underlying CD48 function and its potential as a therapeutic target.

Genular Protein ID: 89854198

Symbol: CD48_HUMAN

Name: CD48 antigen

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1999351

Title: The isolation of cDNA clones for CD48.

PubMed ID: 1999351

DOI: 10.1007/bf00210824

PubMed ID: 1999350

Title: The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1.

PubMed ID: 1999350

DOI: 10.1007/bf00210823

PubMed ID: 2828034

Title: Molecular cloning of the lymphocyte activation marker Blast-1.

PubMed ID: 2828034

DOI: 10.1002/j.1460-2075.1987.tb02703.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1847502

Title: Characterization of the Epstein-Barr virus-inducible gene encoding the human leukocyte adhesion and activation antigen BLAST-1 (CD48).

PubMed ID: 1847502

DOI: 10.1128/mcb.11.3.1614-1623.1991

PubMed ID: 1827826

Title: TCT.1, a target molecule for gamma/delta T cells, is encoded by an immunoglobulin superfamily gene (Blast-1) located in the CD1 region of human chromosome 1.

PubMed ID: 1827826

DOI: 10.1084/jem.173.6.1339

PubMed ID: 9418191

Title: Detection of a soluble form of the leukocyte surface antigen CD48 in plasma and its elevation in patients with lymphoid leukemias and arthritis.

PubMed ID: 9418191

DOI: 10.1023/a:1027327912204

PubMed ID: 9041467

Title: Both human alpha/beta and gamma interferons upregulate the expression of CD48 cell surface molecules.

PubMed ID: 9041467

DOI: 10.1089/jir.1997.17.17

PubMed ID: 9893294

Title: CD48 expression on leukocytes in infectious diseases: flow cytometric analysis of surface antigen.

PubMed ID: 9893294

DOI: 10.1111/j.1442-200x.1998.tb01994.x

PubMed ID: 9841922

Title: 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48.

PubMed ID: 9841922

DOI: 10.1084/jem.188.11.2083

PubMed ID: 12007789

Title: The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling.

PubMed ID: 12007789

DOI: 10.1016/s0167-4889(02)00165-9

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19494291

Title: Sequential cooperation of CD2 and CD48 in the buildup of the early TCR signalosome.

PubMed ID: 19494291

DOI: 10.4049/jimmunol.0800691

PubMed ID: 27249817

Title: Modulation of natural killer cell functions by interactions between 2B4 and CD48 in cis and in trans.

PubMed ID: 27249817

DOI: 10.1098/rsob.160010

Sequence Information:

  • Length: 243
  • Mass: 27683
  • Checksum: 9E46D76FC36A512C
  • Sequence:
  • MCSRGWDSCL ALELLLLPLS LLVTSIQGHL VHMTVVSGSN VTLNISESLP ENYKQLTWFY 
    TFDQKIVEWD SRKSKYFESK FKGRVRLDPQ SGALYISKVQ KEDNSTYIMR VLKKTGNEQE 
    WKIKLQVLDP VPKPVIKIEK IEDMDDNCYL KLSCVIPGES VNYTWYGDKR PFPKELQNSV 
    LETTLMPHNY SRCYTCQVSN SVSSKNGTVC LSPPCTLARS FGVEWIASWL VVTVPTILGL 
    LLT

Genular Protein ID: 3189685683

Symbol: A0A087X1S7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 252
  • Mass: 28855
  • Checksum: 897220C3C065C048
  • Sequence:
  • MCSRGWDSCL ALELLLLPLS LLVTSIQGHL VHMTVVSGSN VTLNISESLP ENYKQLTWFY 
    TFDQKIVEWD SRKSKYFESK FKGRVRLDPQ SGALYISKVQ KEDNSTYIMR VLKKTGNEQE 
    WKIKLQVLDP VPKPVIKIEK IEDMDDNCYL KLSCVIPGES VNYTWYGDKR PFPKELQNSV 
    LETTLMPHNY SRCYTCQVSN SVSSKNGTVC LSPPCTLGKK DPWELRGAQG NWSCFEQRKA 
    GGPIQPPCTV WW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.