Details for: SNCAIP

Gene ID: 9627

Symbol: SNCAIP

Ensembl ID: ENSG00000064692

Description: synuclein alpha interacting protein

Associated with

Other Information

Genular Protein ID: 4230995985

Symbol: SNCAP_HUMAN

Name: Synphilin-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10319874

Title: Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.

PubMed ID: 10319874

DOI: 10.1038/8820

PubMed ID: 10967135

Title: Organization of the human synphilin-1 gene, a candidate for Parkinson's disease.

PubMed ID: 10967135

DOI: 10.1007/s003350010123

PubMed ID: 16595633

Title: Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients.

PubMed ID: 16595633

DOI: 10.1073/pnas.0509707103

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11590439

Title: Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease.

PubMed ID: 11590439

DOI: 10.1038/nm1001-1144

PubMed ID: 12750386

Title: Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1.

PubMed ID: 12750386

DOI: 10.1074/jbc.m302763200

PubMed ID: 14506261

Title: Siah-1 facilitates ubiquitination and degradation of synphilin-1.

PubMed ID: 14506261

DOI: 10.1074/jbc.m306347200

PubMed ID: 15064394

Title: Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.

PubMed ID: 15064394

DOI: 10.1073/pnas.0401081101

PubMed ID: 19224863

Title: Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation.

PubMed ID: 19224863

DOI: 10.1074/jbc.m805990200

PubMed ID: 19762560

Title: Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication.

PubMed ID: 19762560

DOI: 10.1096/fj.09-133082

PubMed ID: 12761037

Title: Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.

PubMed ID: 12761037

DOI: 10.1093/hmg/ddg134

PubMed ID: 18366718

Title: Genetic association study of synphilin-1 in idiopathic Parkinson's disease.

PubMed ID: 18366718

DOI: 10.1186/1471-2350-9-19

Sequence Information:

  • Length: 919
  • Mass: 100409
  • Checksum: 55C5316F250D0480
  • Sequence:
  • MEAPEYLDLD EIDFSDDISY SVTSLKTIPE LCRRCDTQNE DRSVSSSSWN CGISTLITNT 
    QKPTGIADVY SKFRPVKRVS PLKHQPETLE NNESDDQKNQ KVVEYQKGGE SDLGPQPQEL 
    GPGDGVGGPP GKSSEPSTSL GELEHYDLDM DEILDVPYIK SSQQLASFTK VTSEKRILGL 
    CTTINGLSGK ACSTGSSESS SSNMAPFCVL SPVKSPHLRK ASAVIHDQHK LSTEETEISP 
    PLVKCGSAYE PENQSKDFLN KTFSDPHGRK VEKTTPDCQL RAFHLQSSAA ESKPEEQVSG 
    LNRTSSQGPE ERSEYLKKVK SILNIVKEGQ ISLLPHLAAD NLDKIHDENG NNLLHIAASQ 
    GHAECLQHLT SLMGEDCLNE RNTEKLTPAG LAIKNGQLEC VRWMVSETEA IAELSCSKDF 
    PSLIHYAGCY GQEKILLWLL QFMQEQGISL DEVDQDGNSA VHVASQHGYL GCIQTLVEYG 
    ANVTMQNHAG EKPSQSAERQ GHTLCSRYLV VVETCMSLAS QVVKLTKQLK EQTVERVTLQ 
    NQLQQFLEAQ KSEGKSLPSS PSSPSSPASR KSQWKSPDAD DDSVAKSKPG VQEGIQVLGS 
    LSASSRARPK AKDEDSDKIL RQLLGKEISE NVCTQEKLSL EFQDAQASSR NSKKIPLEKR 
    ELKLARLRQL MQRSLSESDT DSNNSEDPKT TPVRKADRPR PQPIVESVES MDSAESLHLM 
    IKKHTLASGG RRFPFSIKAS KSLDGHSPSP TSESSEPDLE SQYPGSGSIP PNQPSGDPQQ 
    PSPDSTAAQK VATSPKSALK SPSSKRRTSQ NLKLRVTFEE PVVQMEQPSL ELNGEKDKDK 
    GRTLQRTSTS NESGDQLKRP FGAFRSIMET LSGNQNNNNN YQAANQLKTS TLPLTSLGRK 
    TDAKGNPASS ASKGKNKAA

Genular Protein ID: 19239869

Symbol: B7Z616_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 477
  • Mass: 51861
  • Checksum: A67FB9ACA4EE5F60
  • Sequence:
  • MQEQGISLDE VDQDGNSAVH VASQHGYLGC IQTLVEYGAN VTMQNHAGEK PSQSAERQGH 
    TLCSRYLVVV ETCMSLASQV VKLTKQLKEQ TVERVTLQNQ LQQFLEAQKS EGKSLPSSPS 
    SPSSPASRKS QWKSPDADDD SVAKSKPGVQ EGIQVLGSLS ASSRARPKAK DEDSDKILRQ 
    LLGKEISENV CTQEKLSLEF QDAQASSRNS KKIPLEKREL KLARLRQLMQ RSLSESDTDS 
    NNSEDPKTTP VRKADRPRPQ PIVESVESMD SAESLHLMIK KHTLASGGRR FPFSIKASKS 
    LDGHSPSPTS ESSEPDLESQ YPGSGSIPPN QPSGDPQQPS PDSTAAQKVA TSPKSALKSP 
    SSKRRTSQNL KLRVTFEEPV VQMEQPSLEL NGEKDKDKGR TLQRTSTSNE SGDQLKRPFG 
    AFRSIMETLS GNQNNNNNYQ AANQLKTSTL PLTSLGRKTD AKGNPASSAS KGKNKAA

Genular Protein ID: 2884855244

Symbol: Q6L981_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 88
  • Mass: 10219
  • Checksum: BFB7464F099FB1E5
  • Sequence:
  • MEAPEYLDLD EIDFSDDISY SVTSLKTIPE LCRRCDTQNE DRSATPSCRQ SRQNSRRKWK 
    QSITYCGVTG TRRVSTAPHF FDGRRLPQ

Genular Protein ID: 1617641917

Symbol: B7Z995_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 521
  • Mass: 57160
  • Checksum: 533D2341C0645CFC
  • Sequence:
  • MKLTLVMTYL IQSHHSRRSQ NCAEDVIRKT KTDQEKILLW LLQFMQEQGI SLDEVDQDGN 
    SAVHVASQHG YLGCIQTLVE YGANVTMQNH AGEKPSQSAE RQGHTLCSRY LVVVETCMSL 
    ASQVVKLTKQ LKEQTVERVT LQNQLQQFLE AQKSEGKSLP SSPSSPSSPA SRKSQWKSPD 
    ADDDSVAKSK PGVQEGIQVL GSLSASSRAR PKAKDEDSDK ILRQLLGKEI SENVCTQEKL 
    SLEFQDAQAS SRNSKKIPLE KRELKLARLR QLMQRSLSES DTDSNNSEDP KTTPVRKADR 
    PRPQPIVESV ESMDSAESLH LMIKKHTLAS GGRRFPFSIK ASKSLDGHSP SPTSESSEPD 
    LESQYPGSGS IPPNQPSGDP QQPSPDSTAA QKVATSPKSA LKSPSSKRRT SQNLKLRVTF 
    EEPVVQMEQP SLELNGEKDK DKGRTLQRTS TSNESGDQLK RPFGAFRSIM ETLSGNQNNN 
    NNYQAANQLK TSTLPLTSLG RKTDAKGNPA SSASKGKNKA A

Genular Protein ID: 1678749930

Symbol: Q6L983_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 113
  • Mass: 12838
  • Checksum: B80ABF7E3BEDFEE1
  • Sequence:
  • MEAPEYLDLD EIDFSDDISD NRSQGNRLQK LGLEDTDRED AMGFGSHRAK LTVVAALGAC 
    HCPENEYSVT SLKTIPELCR RCDTQNEDRS EWSVGVRTLD GERNRSHCRT ELF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.