Details for: CD53

Gene ID: 963

Symbol: CD53

Ensembl ID: ENSG00000143119

Description: CD53 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 155.0031
    Cell Significance Index: -24.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 87.6046
    Cell Significance Index: -35.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 71.1723
    Cell Significance Index: -36.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.7257
    Cell Significance Index: -28.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.0262
    Cell Significance Index: -37.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.2754
    Cell Significance Index: -5.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.4654
    Cell Significance Index: -24.0000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 14.7562
    Cell Significance Index: 39.5300
  • Cell Name: centroblast (CL0009112)
    Fold Change: 11.9521
    Cell Significance Index: 27.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.6171
    Cell Significance Index: -32.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.0371
    Cell Significance Index: -17.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4647
    Cell Significance Index: -25.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.2695
    Cell Significance Index: 154.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.6766
    Cell Significance Index: 551.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.3078
    Cell Significance Index: 79.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.3818
    Cell Significance Index: 218.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.3260
    Cell Significance Index: 62.2200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 2.1853
    Cell Significance Index: 9.1000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.5812
    Cell Significance Index: 10.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1346
    Cell Significance Index: 215.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8972
    Cell Significance Index: 88.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7710
    Cell Significance Index: 696.1100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.3767
    Cell Significance Index: 2.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3568
    Cell Significance Index: 58.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1897
    Cell Significance Index: 20.6400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0389
    Cell Significance Index: 0.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0156
    Cell Significance Index: 3.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0057
    Cell Significance Index: -10.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0084
    Cell Significance Index: -15.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0097
    Cell Significance Index: -0.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0118
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0147
    Cell Significance Index: -10.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0147
    Cell Significance Index: -22.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0149
    Cell Significance Index: -20.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0167
    Cell Significance Index: -10.4300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0178
    Cell Significance Index: -0.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0203
    Cell Significance Index: -11.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0211
    Cell Significance Index: -15.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0248
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0328
    Cell Significance Index: -6.9000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0348
    Cell Significance Index: -0.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0469
    Cell Significance Index: -25.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0500
    Cell Significance Index: -36.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0539
    Cell Significance Index: -34.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0579
    Cell Significance Index: -5.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0585
    Cell Significance Index: -4.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0611
    Cell Significance Index: -1.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0616
    Cell Significance Index: -22.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0695
    Cell Significance Index: -30.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0713
    Cell Significance Index: -32.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0730
    Cell Significance Index: -14.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0788
    Cell Significance Index: -3.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0935
    Cell Significance Index: -15.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0937
    Cell Significance Index: -26.9600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1231
    Cell Significance Index: -2.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1312
    Cell Significance Index: -19.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1490
    Cell Significance Index: -26.8600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1647
    Cell Significance Index: -2.8400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1656
    Cell Significance Index: -7.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1776
    Cell Significance Index: -24.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1855
    Cell Significance Index: -11.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1889
    Cell Significance Index: -6.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2102
    Cell Significance Index: -23.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2325
    Cell Significance Index: -27.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2330
    Cell Significance Index: -28.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2333
    Cell Significance Index: -4.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2386
    Cell Significance Index: -24.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2438
    Cell Significance Index: -31.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2469
    Cell Significance Index: -31.9000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2508
    Cell Significance Index: -12.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2622
    Cell Significance Index: -5.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2678
    Cell Significance Index: -30.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2823
    Cell Significance Index: -13.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3286
    Cell Significance Index: -25.2200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3446
    Cell Significance Index: -20.6900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.3691
    Cell Significance Index: -2.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3990
    Cell Significance Index: -26.8300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4125
    Cell Significance Index: -16.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4316
    Cell Significance Index: -32.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4363
    Cell Significance Index: -30.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4634
    Cell Significance Index: -36.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4671
    Cell Significance Index: -29.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4822
    Cell Significance Index: -29.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4924
    Cell Significance Index: -25.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5144
    Cell Significance Index: -28.8700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5408
    Cell Significance Index: -4.4100
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: -0.5411
    Cell Significance Index: -2.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5487
    Cell Significance Index: -28.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5797
    Cell Significance Index: -15.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6222
    Cell Significance Index: -27.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6414
    Cell Significance Index: -33.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6535
    Cell Significance Index: -30.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6602
    Cell Significance Index: -18.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6762
    Cell Significance Index: -23.6900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.7135
    Cell Significance Index: -13.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7215
    Cell Significance Index: -15.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7249
    Cell Significance Index: -27.4500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.7533
    Cell Significance Index: -5.8600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.7646
    Cell Significance Index: -10.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7685
    Cell Significance Index: -25.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CD53 is a transmembrane protein with a molecular weight of approximately 55 kDa. It contains four Ig-like domains in its extracellular region, which mediate interactions with other proteins and ligands. The transmembrane domain is followed by a cytoplasmic tail that interacts with intracellular signaling pathways. CD53 is highly expressed on the surface of immune cells, including innate lymphoid cells, T cells, monocytes, and B cells. It is also found on the surface of myeloid leukocytes and is expressed in specific granule membranes. **Pathways and Functions:** CD53 is involved in several signaling pathways, including: 1. **Immune system**: CD53 plays a crucial role in the formation of the immunological synapse, which is essential for effective T cell activation and cytokine production. 2. **Cell-cell junction**: CD53 mediates interactions between immune cells, including adhesion, migration, and signaling. 3. **Signal transduction**: CD53 interacts with intracellular signaling molecules, such as PI3K and MAPK, to regulate cellular responses. 4. **Protein binding**: CD53 binds to various proteins, including integrins, adhesion molecules, and signaling molecules, to regulate immune responses. CD53 also plays a role in specific granule membrane functions, including neutrophil degranulation and myoblast fusion. **Clinical Significance:** Alterations in CD53 expression or function have been associated with various immune-related disorders and diseases, including: 1. **Immunodeficiency**: CD53-deficient mice exhibit impaired immune responses and increased susceptibility to infections. 2. **Autoimmune diseases**: CD53 expression is altered in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: CD53 is overexpressed in certain types of cancer, including lymphoma and leukemia. 4. **Transplantation**: CD53 is involved in the rejection of transplanted organs, and its expression is altered in response to transplantation. In conclusion, CD53 is a critical component of the immune system, involved in cell-cell interactions, signal transduction, and protein binding. Its unique characteristics and functions make it a valuable target for the development of immunotherapies and diagnostic tools for immune-related disorders and diseases.

Genular Protein ID: 4028338803

Symbol: CD53_HUMAN

Name: Leukocyte surface antigen CD53

UniProtKB Accession Codes:

P19397 B2R905 Q5U0D6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1700763

Title: The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens.

PubMed ID: 1700763

DOI: 10.1007/bf00187099

PubMed ID: 2258620

Title: Identification and analysis of cDNA clones encoding CD53. A pan-leukocyte antigen related to membrane transport proteins.

PubMed ID: 2258620

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8335905

Title: CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells.

PubMed ID: 8335905

PubMed ID: 21930792

Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.

PubMed ID: 21930792

DOI: 10.1128/mcb.05817-11

PubMed ID: 28487417

Title: Tetraspanin microdomains control localized protein kinase C signaling in B cells.

PubMed ID: 28487417

DOI: 10.1126/scisignal.aag2755

PubMed ID: 35767951

Title: Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function.

PubMed ID: 35767951

DOI: 10.1016/j.celrep.2022.111006

PubMed ID: 32974937

Title: Open conformation of tetraspanins shapes interaction partner networks on cell membranes.

PubMed ID: 32974937

DOI: 10.15252/embj.2020105246

Sequence Information:

  • Length: 219
  • Mass: 24341
  • Checksum: 48D4633DBC9110B6
  • Sequence:
    • MGMSSLKLLK YVLFFFNLLF WICGCCILGF GIYLLIHNNF GVLFHNLPSL TLGNVFVIVG 
SIIMVVAFLG CMGSIKENKC LLMSFFILLL IILLAEVTLA ILLFVYEQKL NEYVAKGLTD 
SIHRYHSDNS TKAAWDSIQS FLQCCGINGT SDWTSGPPAS CPSDRKVEGC YAKARLWFHS 
NFLYIGIITI CVCVIEVLGM SFALTLNCQI DKTSQTIGL

Genular Protein ID: 1015913375

Symbol: B4DQB5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DQB5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 160
  • Mass: 17913
  • Checksum: 2EE31316F689E72B
  • Sequence:
    • MGMSSLKLLK YVLFFFNLLF WICGCCILGF GIYLLIHNNF GVLFHNLPSL TLGNVFVIVG 
SIIMVVAFLG CMGSIKENKC LLMSFFILLL IILLAEVTLA ILLFVYEQKG CYAKARLWFH 
SNFLYIGIIT ICVCVIEVLG MSFALTLNCQ IDKTSQTIGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.