Details for: ISG15
Associated with
Other Information
Genular Protein ID: 2454606189
Symbol: ISG15_HUMAN
Name: Ubiquitin-like protein ISG15
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3087979
Title: Molecular characterization of the interferon-induced 15-kDa protein. Molecular cloning and nucleotide and amino acid sequence.
PubMed ID: 3087979
PubMed ID: 3476954
Title: Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.
PubMed ID: 3476954
PubMed ID: 3350799
Title: A 15-kDa interferon-induced protein is derived by COOH-terminal processing of a 17-kDa precursor.
PubMed ID: 3350799
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2477469
Title: A 15-kD interferon-induced protein and its 17-kD precursor: expression in Escherichia coli, purification, and characterization.
PubMed ID: 2477469
PubMed ID: 2440890
Title: Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin.
PubMed ID: 2440890
PubMed ID: 1373138
Title: The interferon-inducible 15-kDa ubiquitin homolog conjugates to intracellular proteins.
PubMed ID: 1373138
PubMed ID: 7526157
Title: Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern.
PubMed ID: 7526157
PubMed ID: 8550581
Title: Conjugation of the 15-kDa interferon-induced ubiquitin homolog is distinct from that of ubiquitin.
PubMed ID: 8550581
PubMed ID: 2005397
Title: IFN-induced 15-kDa protein is released from human lymphocytes and monocytes.
PubMed ID: 2005397
PubMed ID: 7490683
Title: Immunohistochemical localization of ubiquitin cross-reactive protein in human tissues.
PubMed ID: 7490683
PubMed ID: 11157743
Title: Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein.
PubMed ID: 11157743
PubMed ID: 11788588
Title: UBP43 (USP18) specifically removes ISG15 from conjugated proteins.
PubMed ID: 11788588
PubMed ID: 15131269
Title: The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein.
PubMed ID: 15131269
PubMed ID: 16112642
Title: ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity.
PubMed ID: 16112642
PubMed ID: 16428300
Title: Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme.
PubMed ID: 16428300
DOI: 10.1093/jb/mvi172
PubMed ID: 16009940
Title: Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.
PubMed ID: 16009940
PubMed ID: 16872604
Title: Negative regulation of protein phosphatase 2Cbeta by ISG15 conjugation.
PubMed ID: 16872604
PubMed ID: 16434471
Title: Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15.
PubMed ID: 16434471
PubMed ID: 18356159
Title: Different roles for two ubiquitin-like domains of ISG15 in protein modification.
PubMed ID: 18356159
PubMed ID: 18606809
Title: Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation.
PubMed ID: 18606809
PubMed ID: 18305167
Title: ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity.
PubMed ID: 18305167
PubMed ID: 19270716
Title: ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway.
PubMed ID: 19270716
PubMed ID: 19680460
Title: Antiviral activity of innate immune protein ISG15.
PubMed ID: 19680460
DOI: 10.1159/000226245
PubMed ID: 19357168
Title: Interferon-induced ISG15 conjugation inhibits influenza A virus gene expression and replication in human cells.
PubMed ID: 19357168
DOI: 10.1128/jvi.01667-08
PubMed ID: 20153823
PubMed ID: 20946978
Title: Emerging role of ISG15 in antiviral immunity.
PubMed ID: 20946978
PubMed ID: 20639253
Title: The interferon stimulated gene 15 functions as a proviral factor for the hepatitis C virus and as a regulator of the IFN response.
PubMed ID: 20639253
PubMed ID: 20308324
Title: Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification.
PubMed ID: 20308324
DOI: 10.1128/mcb.01466-09
PubMed ID: 20133869
Title: ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells.
PubMed ID: 20133869
PubMed ID: 21994614
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21190487
Title: Interferon-stimulated gene 15 and the protein ISGylation system.
PubMed ID: 21190487
PubMed ID: 21543490
Title: Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15.
PubMed ID: 21543490
DOI: 10.1128/jvi.02610-10
PubMed ID: 21266548
Title: Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
PubMed ID: 21266548
PubMed ID: 21245344
Title: Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease.
PubMed ID: 21245344
PubMed ID: 22666250
Title: Budding of enveloped viruses: interferon-induced ISG15-antivirus mechanisms targeting the release process.
PubMed ID: 22666250
DOI: 10.1155/2012/532723
PubMed ID: 22906767
Title: IFNs, ISGylation and cancer: Cui prodest?
PubMed ID: 22906767
PubMed ID: 22693631
Title: Covalent protein modification with ISG15 via a conserved cysteine in the hinge region.
PubMed ID: 22693631
PubMed ID: 22859821
Title: Mycobacterial disease and impaired IFN-gamma immunity in humans with inherited ISG15 deficiency.
PubMed ID: 22859821
PubMed ID: 22964713
Title: ISG15 regulates IFN-? immunity in human mycobacterial disease.
PubMed ID: 22964713
DOI: 10.1038/cr.2012.133
PubMed ID: 23579383
Title: ISG15: leading a double life as a secreted molecule.
PubMed ID: 23579383
DOI: 10.1038/emm.2013.36
PubMed ID: 23229543
Title: Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation.
PubMed ID: 23229543
PubMed ID: 23414970
Title: Interferon-induced ISG15 pathway: an ongoing virus-host battle.
PubMed ID: 23414970
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24257616
Title: ISG15 is counteracted by vaccinia virus E3 protein and controls the proinflammatory response against viral infection.
PubMed ID: 24257616
DOI: 10.1128/jvi.03293-13
PubMed ID: 27564865
Title: Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators.
PubMed ID: 27564865
PubMed ID: 29100055
Title: Extracellular ISG15 signals cytokine secretion through the LFA-1 integrin receptor.
PubMed ID: 29100055
PubMed ID: 33727702
Title: ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.
PubMed ID: 33727702
PubMed ID: 15917233
Title: Crystal structure of the interferon-induced ubiquitin-like protein ISG15.
PubMed ID: 15917233
Sequence Information:
- Length: 165
- Mass: 17888
- Checksum: B6858A15AB0FFFDE
- Sequence:
MGWDLTVKML AGNEFQVSLS SSMSVSELKA QITQKIGVHA FQQRLAVHPS GVALQDRVPL ASQGLGPGST VLLVVDKCDE PLSILVRNNK GRSSTYEVRL TQTVAHLKQQ VSGLEGVQDD LFWLTFEGKP LEDQLPLGEY GLKPLSTVFM NLRLRGGGTE PGGRS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.