Details for: PPM1F

Gene ID: 9647

Symbol: PPM1F

Ensembl ID: ENSG00000100034

Description: protein phosphatase, Mg2+/Mn2+ dependent 1F

Associated with

  • Activation of nmda receptors and postsynaptic events
    (R-HSA-442755)
  • Negative regulation of nmda receptor-mediated neuronal transmission
    (R-HSA-9617324)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Calmodulin-dependent protein phosphatase activity
    (GO:0033192)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Cytosol
    (GO:0005829)
  • Intrinsic apoptotic signaling pathway
    (GO:0097193)
  • Metal ion binding
    (GO:0046872)
  • Myosin phosphatase activity
    (GO:0017018)
  • Negative regulation of cell-cell adhesion mediated by cadherin
    (GO:2000048)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of peptidyl-serine phosphorylation
    (GO:0033137)
  • Negative regulation of protein kinase activity
    (GO:0006469)
  • Negative regulation of protein kinase activity by regulation of protein phosphorylation
    (GO:0044387)
  • Negative regulation of protein transport
    (GO:0051224)
  • Nucleus
    (GO:0005634)
  • Peptidyl-serine dephosphorylation
    (GO:0070262)
  • Peptidyl-threonine dephosphorylation
    (GO:0035970)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Positive regulation of cell-substrate adhesion
    (GO:0010811)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of chemotaxis
    (GO:0050921)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of epithelial cell migration
    (GO:0010634)
  • Positive regulation of focal adhesion assembly
    (GO:0051894)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of growth
    (GO:0045927)
  • Positive regulation of stress fiber assembly
    (GO:0051496)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Protein dephosphorylation
    (GO:0006470)
  • Protein serine/threonine phosphatase activity
    (GO:0004722)
  • Protein tyrosine/serine/threonine phosphatase activity
    (GO:0008138)
  • Regulation of protein localization
    (GO:0032880)

Other Information

Genular Protein ID: 3226825741

Symbol: PPM1F_HUMAN

Name: Protein phosphatase 1F

UniProtKB Accession Codes:

P49593 A8K6G3 B7Z2C3 Q96PM2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 15 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 9 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11559703

Title: The Caenorhabditis elegans sex-determining protein fem-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis.

PubMed ID: 11559703

DOI: 10.1074/jbc.m105880200

PubMed ID: 11864573

Title: The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family.

PubMed ID: 11864573

DOI: 10.1016/s0960-9822(02)00652-8

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 30250217

Title: Identification of novel loci for pediatric cholestatic liver disease defined by KIF12, PPM1F, USP53, LSR, and WDR83OS pathogenic variants.

PubMed ID: 30250217

DOI: 10.1038/s41436-018-0288-x

Sequence Information:

  • Length: 454
  • Mass: 49831
  • Checksum: 2B49262333D4C9CF
  • Sequence:
    • MSSGAPQKSS PMASGAEETP GFLDTLLQDF PALLNPEDPL PWKAPGTVLS QEEVEGELAE 
LAMGFLGSRK APPPLAAALA HEAVSQLLQT DLSEFRKLPR EEEEEEEDDD EEEKAPVTLL 
DAQSLAQSFF NRLWEVAGQW QKQVPLAARA SQRQWLVSIH AIRNTRRKME DRHVSLPSFN 
QLFGLSDPVN RAYFAVFDGH GGVDAARYAA VHVHTNAARQ PELPTDPEGA LREAFRRTDQ 
MFLRKAKRER LQSGTTGVCA LIAGATLHVA WLGDSQVILV QQGQVVKLME PHRPERQDEK 
ARIEALGGFV SHMDCWRVNG TLAVSRAIGD VFQKPYVSGE ADAASRALTG SEDYLLLACD 
GFFDVVPHQE VVGLVQSHLT RQQGSGLRVA EELVAAARER GSHDNITVMV VFLRDPQELL 
EGGNQGEGDP QAEGRRQDLP SSLPEPETQA PPRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.