Details for: CD58

Gene ID: 965

Symbol: CD58

Ensembl ID: ENSG00000116815

Description: CD58 molecule

Associated with

Other Information

Genular Protein ID: 4157349863

Symbol: LFA3_HUMAN

Name: Lymphocyte function-associated antigen 3

UniProtKB Accession Codes:

P19256 A8K7G5 Q5U053 Q6IB65 Q96KI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 21 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3309127

Title: Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein.

PubMed ID: 3309127

DOI: 10.1084/jem.166.4.923

PubMed ID: 3313052

Title: An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2.

PubMed ID: 3313052

DOI: 10.1038/329840a0

PubMed ID: 9510189

Title: Gene structure, promoter characterization, and basis for alternative mRNA splicing of the human CD58 gene.

PubMed ID: 9510189

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 17566972

Title: Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments.

PubMed ID: 17566972

DOI: 10.1002/pmic.200700068

PubMed ID: 28813417

Title: CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.

PubMed ID: 28813417

DOI: 10.1038/nature23643

PubMed ID: 29691324

Title: Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses.

PubMed ID: 29691324

DOI: 10.1073/pnas.1720950115

PubMed ID: 10380930

Title: Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors.

PubMed ID: 10380930

DOI: 10.1016/s0092-8674(00)80790-4

PubMed ID: 10200255

Title: Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-A resolution.

PubMed ID: 10200255

DOI: 10.1073/pnas.96.8.4289

Sequence Information:

  • Length: 250
  • Mass: 28147
  • Checksum: 34D635DF1D14FE2E
  • Sequence:
    • MVAGSDAGRA LGVLSVVCLL HCFGFISCFS QQIYGVVYGN VTFHVPSNVP LKEVLWKKQK 
DKVAELENSE FRAFSSFKNR VYLDTVSGSL TIYNLTSSDE DEYEMESPNI TDTMKFFLYV 
LESLPSPTLT CALTNGSIEV QCMIPEHYNS HRGLIMYSWD CPMEQCKRNS TSIYFKMEND 
LPQKIQCTLS NPLFNTTSSI ILTTCIPSSG HSRHRYALIP IPLAVITTCI VLYMNGILKC 
DRKPDRTNSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.