Details for: CD58

Gene ID: 965

Symbol: CD58

Ensembl ID: ENSG00000116815

Description: CD58 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.5963
    Cell Significance Index: -20.9500
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 80.4911
    Cell Significance Index: -12.5200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 65.6394
    Cell Significance Index: -27.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 56.5405
    Cell Significance Index: -22.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.9645
    Cell Significance Index: -25.9500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 49.1363
    Cell Significance Index: -25.2800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 38.7171
    Cell Significance Index: -25.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.2893
    Cell Significance Index: -23.1900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.2870
    Cell Significance Index: -23.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.5313
    Cell Significance Index: -20.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.5046
    Cell Significance Index: -23.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5509
    Cell Significance Index: -25.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6102
    Cell Significance Index: -12.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1167
    Cell Significance Index: 28.8800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.9920
    Cell Significance Index: 32.8300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.6256
    Cell Significance Index: 23.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.5644
    Cell Significance Index: 100.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4922
    Cell Significance Index: 43.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2360
    Cell Significance Index: 74.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0025
    Cell Significance Index: 116.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9733
    Cell Significance Index: 27.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9678
    Cell Significance Index: 74.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9015
    Cell Significance Index: 171.5700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.8364
    Cell Significance Index: 14.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8217
    Cell Significance Index: 15.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7472
    Cell Significance Index: 148.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7339
    Cell Significance Index: 19.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6006
    Cell Significance Index: 31.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5874
    Cell Significance Index: 40.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5638
    Cell Significance Index: 29.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5575
    Cell Significance Index: 10.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4238
    Cell Significance Index: 19.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4030
    Cell Significance Index: 18.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3620
    Cell Significance Index: 35.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3480
    Cell Significance Index: 8.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2579
    Cell Significance Index: 140.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2323
    Cell Significance Index: 10.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2321
    Cell Significance Index: 41.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2244
    Cell Significance Index: 202.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2182
    Cell Significance Index: 26.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2115
    Cell Significance Index: 10.6900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1915
    Cell Significance Index: 2.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1628
    Cell Significance Index: 19.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1431
    Cell Significance Index: 5.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1321
    Cell Significance Index: 58.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0818
    Cell Significance Index: 10.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0718
    Cell Significance Index: 1.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0636
    Cell Significance Index: 3.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0624
    Cell Significance Index: 12.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0544
    Cell Significance Index: 37.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0497
    Cell Significance Index: 6.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0310
    Cell Significance Index: 0.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0238
    Cell Significance Index: 36.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0196
    Cell Significance Index: 36.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0011
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0086
    Cell Significance Index: -16.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0102
    Cell Significance Index: -0.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0140
    Cell Significance Index: -10.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0156
    Cell Significance Index: -9.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0219
    Cell Significance Index: -16.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0263
    Cell Significance Index: -2.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0331
    Cell Significance Index: -15.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0362
    Cell Significance Index: -26.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0409
    Cell Significance Index: -6.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0438
    Cell Significance Index: -27.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0481
    Cell Significance Index: -27.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0618
    Cell Significance Index: -22.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0661
    Cell Significance Index: -9.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0727
    Cell Significance Index: -2.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0771
    Cell Significance Index: -22.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0820
    Cell Significance Index: -11.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1152
    Cell Significance Index: -13.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1209
    Cell Significance Index: -9.0100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1212
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1242
    Cell Significance Index: -21.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1256
    Cell Significance Index: -4.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1363
    Cell Significance Index: -28.7200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1440
    Cell Significance Index: -2.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1444
    Cell Significance Index: -10.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1539
    Cell Significance Index: -4.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1661
    Cell Significance Index: -4.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1738
    Cell Significance Index: -3.7700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2251
    Cell Significance Index: -1.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2406
    Cell Significance Index: -25.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2435
    Cell Significance Index: -6.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3001
    Cell Significance Index: -23.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3564
    Cell Significance Index: -21.8500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3569
    Cell Significance Index: -3.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3573
    Cell Significance Index: -21.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3630
    Cell Significance Index: -24.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3909
    Cell Significance Index: -3.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4282
    Cell Significance Index: -12.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4468
    Cell Significance Index: -11.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4977
    Cell Significance Index: -26.1300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5234
    Cell Significance Index: -7.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5508
    Cell Significance Index: -20.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5813
    Cell Significance Index: -8.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6109
    Cell Significance Index: -21.2300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.6332
    Cell Significance Index: -8.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Surface Expression:** CD58 is transmembrane glycoprotein that is expressed on the surface of various cell types, including immune cells, epithelial cells, and endothelial cells. 2. **Cell-Cell Adhesion:** CD58 is a key component in heterotypic cell-cell adhesion, facilitating interactions between different cell types, including immune cells and endothelial cells. 3. **Cytokine Regulation:** CD58 is involved in the regulation of cytokine production, including the production of interleukin-8 (IL-8), a pro-inflammatory cytokine. 4. **Neutrophil Degranulation:** CD58 is also involved in the regulation of neutrophil degranulation, a process that is crucial for the clearance of pathogens from the body. **Pathways and Functions:** 1. **Cell-Cell Adhesion:** CD58 interacts with CD2, a ligand on T cells, to facilitate cell-cell adhesion and interaction between immune cells and endothelial cells. 2. **Cytokine Signaling:** CD58 is involved in the regulation of cytokine signaling, including the production of IL-8, which is crucial for the recruitment of immune cells to sites of inflammation. 3. **Neutrophil Activation:** CD58 is also involved in the activation of neutrophils, a process that is crucial for the clearance of pathogens from the body. 4. **Immune Response:** CD58 is involved in the regulation of immune responses, including the activation of T cells and the production of cytokines. **Clinical Significance:** 1. **Inflammatory Diseases:** CD58 is involved in the pathogenesis of various inflammatory diseases, including rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. 2. **Cancer:** CD58 is also involved in the metastasis of cancer cells, making it a potential target for cancer therapy. 3. **Neurological Diseases:** CD58 is involved in the pathogenesis of various neurological diseases, including Alzheimer's disease and Parkinson's disease. 4. **Transplantation:** CD58 is also involved in the rejection of transplanted organs, making it a potential target for immunosuppressive therapy. In conclusion, CD58 is a vital component of the immune system, involved in the regulation of cell-cell adhesion, cytokine signaling, and neutrophil activation. Its dysregulation has been implicated in various diseases, including inflammatory diseases, cancer, and neurological diseases. Further research is needed to fully elucidate the mechanisms by which CD58 regulates immune cell interactions and tissue homeostasis.

Genular Protein ID: 4157349863

Symbol: LFA3_HUMAN

Name: Lymphocyte function-associated antigen 3

UniProtKB Accession Codes:

P19256 A8K7G5 Q5U053 Q6IB65 Q96KI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 21 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3309127

Title: Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein.

PubMed ID: 3309127

DOI: 10.1084/jem.166.4.923

PubMed ID: 3313052

Title: An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2.

PubMed ID: 3313052

DOI: 10.1038/329840a0

PubMed ID: 9510189

Title: Gene structure, promoter characterization, and basis for alternative mRNA splicing of the human CD58 gene.

PubMed ID: 9510189

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 17566972

Title: Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments.

PubMed ID: 17566972

DOI: 10.1002/pmic.200700068

PubMed ID: 28813417

Title: CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.

PubMed ID: 28813417

DOI: 10.1038/nature23643

PubMed ID: 29691324

Title: Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses.

PubMed ID: 29691324

DOI: 10.1073/pnas.1720950115

PubMed ID: 10380930

Title: Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors.

PubMed ID: 10380930

DOI: 10.1016/s0092-8674(00)80790-4

PubMed ID: 10200255

Title: Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-A resolution.

PubMed ID: 10200255

DOI: 10.1073/pnas.96.8.4289

Sequence Information:

  • Length: 250
  • Mass: 28147
  • Checksum: 34D635DF1D14FE2E
  • Sequence:
    • MVAGSDAGRA LGVLSVVCLL HCFGFISCFS QQIYGVVYGN VTFHVPSNVP LKEVLWKKQK 
DKVAELENSE FRAFSSFKNR VYLDTVSGSL TIYNLTSSDE DEYEMESPNI TDTMKFFLYV 
LESLPSPTLT CALTNGSIEV QCMIPEHYNS HRGLIMYSWD CPMEQCKRNS TSIYFKMEND 
LPQKIQCTLS NPLFNTTSSI ILTTCIPSSG HSRHRYALIP IPLAVITTCI VLYMNGILKC 
DRKPDRTNSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.