Details for: SOCS5

Gene ID: 9655

Symbol: SOCS5

Ensembl ID: ENSG00000171150

Description: suppressor of cytokine signaling 5

Associated with

  • Cytokine signaling in immune system
    (R-HSA-1280215)
  • Immune system
    (R-HSA-168256)
  • Interleukin-4 and interleukin-13 signaling
    (R-HSA-6785807)
  • Metabolism of proteins
    (R-HSA-392499)
  • Neddylation
    (R-HSA-8951664)
  • Post-translational protein modification
    (R-HSA-597592)
  • Signaling by interleukins
    (R-HSA-449147)
  • 1-phosphatidylinositol-3-kinase regulator activity
    (GO:0046935)
  • Cellular response to low-density lipoprotein particle stimulus
    (GO:0071404)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytosol
    (GO:0005829)
  • Epidermal growth factor receptor binding
    (GO:0005154)
  • Epidermal growth factor receptor signaling pathway
    (GO:0007173)
  • Intracellular signal transduction
    (GO:0035556)
  • Negative regulation of epidermal growth factor-activated receptor activity
    (GO:0007175)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of monocyte chemotactic protein-1 production
    (GO:0071638)
  • Negative regulation of signal transduction
    (GO:0009968)
  • Negative regulation of t-helper 2 cell differentiation
    (GO:0045629)
  • Phosphatidylinositol 3-kinase complex
    (GO:0005942)
  • Phosphatidylinositol phosphate biosynthetic process
    (GO:0046854)
  • Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
    (GO:0032436)
  • Positive regulation of t-helper 1 cell differentiation
    (GO:0045627)
  • Protein binding
    (GO:0005515)
  • Protein ubiquitination
    (GO:0016567)
  • Receptor signaling pathway via jak-stat
    (GO:0007259)
  • Receptor tyrosine kinase binding
    (GO:0030971)
  • Vascular endothelial cell response to fluid shear stress
    (GO:0097699)

Other Information

Genular Protein ID: 1668123281

Symbol: SOCS5_HUMAN

Name: Suppressor of cytokine signaling 5

UniProtKB Accession Codes:

O75159 Q53SD4 Q8IYZ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10773671

Title: Cloning and expression of CIS6, chromosomal assignment to 3p22 and 2p21 by in situ hybridization.

PubMed ID: 10773671

DOI: 10.1159/000015490

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15590694

Title: Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.

PubMed ID: 15590694

DOI: 10.1074/jbc.m408575200

Sequence Information:

  • Length: 536
  • Mass: 61246
  • Checksum: 0629CDCF2A97E9D8
  • Sequence:
    • MDKVGKMWNN FKYRCQNLFG HEGGSRSENV DMNSNRCLSV KEKNISIGDS TPQQQSSPLR 
ENIALQLGLS PSKNSSRRNQ NCATEIPQIV EISIEKDNDS CVTPGTRLAR RDSYSRHAPW 
GGKKKHSCST KTQSSLDADK KFGRTRSGLQ RRERRYGVSS VHDMDSVSSR TVGSRSLRQR 
LQDTVGLCFP MRTYSKQSKP LFSNKRKIHL SELMLEKCPF PAGSDLAQKW HLIKQHTAPV 
SPHSTFFDTF DPSLVSTEDE EDRLRERRRL SIEEGVDPPP NAQIHTFEAT AQVNPLYKLG 
PKLAPGMTEI SGDSSAIPQA NCDSEEDTTT LCLQSRRQKQ RQISGDSHTH VSRQGAWKVH 
TQIDYIHCLV PDLLQITGNP CYWGVMDRYE AEALLEGKPE GTFLLRDSAQ EDYLFSVSFR 
RYNRSLHARI EQWNHNFSFD AHDPCVFHSS TVTGLLEHYK DPSSCMFFEP LLTISLNRTF 
PFSLQYICRA VICRCTTYDG IDGLPLPSML QDFLKEYHYK QKVRVRWLER EPVKAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.