CD59 | ENSG00000085063 | NCBI 966

Details for: CD59

Gene ID: 966

Symbol: CD59

Ensembl ID: ENSG00000085063

Description: CD59 molecule (CD59 blood group)

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Cargo concentration in the er
(R-HSA-5694530)
Complement cascade
(R-HSA-166658)
Copi-mediated anterograde transport
(R-HSA-6807878)
Copii-mediated vesicle transport
(R-HSA-204005)
Er to golgi anterograde transport
(R-HSA-199977)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Neutrophil degranulation
(R-HSA-6798695)
Post-translational protein modification
(R-HSA-597592)
Regulation of complement cascade
(R-HSA-977606)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Blood coagulation
(GO:0007596)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Complement binding
(GO:0001848)
Endoplasmic reticulum-golgi intermediate compartment membrane
(GO:0033116)
Endoplasmic reticulum membrane
(GO:0005789)
Er to golgi transport vesicle membrane
(GO:0012507)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Focal adhesion
(GO:0005925)
Golgi membrane
(GO:0000139)
Membrane
(GO:0016020)
Negative regulation of activation of membrane attack complex
(GO:0001971)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Regulation of complement-dependent cytotoxicity
(GO:1903659)
Regulation of complement activation
(GO:0030449)
Specific granule membrane
(GO:0035579)
Tertiary granule membrane
(GO:0070821)
Transport vesicle
(GO:0030133)
Vesicle
(GO:0031982)

Other Information

Proteins

CD59 glycoprotein

Genular Protein ID: 2132032314

Symbol: CD59_HUMAN

Name: CD59 glycoprotein

UniProtKB Accession Codes:

P13987 E9PR17

Database IDs:

Citations:

PubMed ID: 2475570

Title: CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.

PubMed ID: 2475570

DOI: 10.1084/jem.170.3.637

PubMed ID: 1689664

Title: The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility.

PubMed ID: 1689664

DOI: 10.1002/eji.1830200113

PubMed ID: 2475111

Title: 20 KDa homologous restriction factor of complement resembles T cell activating protein.

PubMed ID: 2475111

DOI: 10.1016/0006-291x(89)90852-8

PubMed ID: 2606909

Title: Molecular cloning and characterization of MACIF, an inhibitor of membrane channel formation of complement.

PubMed ID: 2606909

DOI: 10.1093/oxfordjournals.jbchem.a122893

PubMed ID: 1692709

Title: Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes.

PubMed ID: 1692709

DOI: 10.1089/dna.1990.9.213

PubMed ID: 1381503

Title: Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.

PubMed ID: 1381503

DOI: 10.1073/pnas.89.17.7876

PubMed ID: 1383553

Title: Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation.

PubMed ID: 1383553

DOI: 10.1016/0022-2836(92)90239-g

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2476718

Title: Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C.

PubMed ID: 2476718

DOI: 10.1093/nar/17.16.6728

PubMed ID: 8670172

Title: Structural composition and functional characterization of soluble CD59: heterogeneity of the oligosaccharide and glycophosphoinositol (GPI) anchor revealed by laser-desorption mass spectrometric analysis.

PubMed ID: 8670172

DOI: 10.1042/bj3160923

PubMed ID: 8276756

Title: Determination of carboxyl-terminal residue and disulfide bonds of MACIF (CD59), a glycosyl-phosphatidylinositol-anchored membrane protein.

PubMed ID: 8276756

DOI: 10.1093/oxfordjournals.jbchem.a124202

PubMed ID: 1377690

Title: The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the ''b'' domain of C9.

PubMed ID: 1377690

DOI: 10.1016/s0021-9258(18)42266-1

PubMed ID: 9235986

Title: Mapping the regions of the complement inhibitor CD59 responsible for its species selective activity.

PubMed ID: 9235986

DOI: 10.1021/bi970832i

PubMed ID: 9053451

Title: Mutational analysis of the active site and antibody epitopes of the complement-inhibitory glycoprotein, CD59.

PubMed ID: 9053451

DOI: 10.1084/jem.185.3.507

PubMed ID: 9054419

Title: The glycosylation of the complement regulatory protein, human erythrocyte CD59.

PubMed ID: 9054419

DOI: 10.1074/jbc.272.11.7229

PubMed ID: 10805801

Title: Molecular basis for a link between complement and the vascular complications of diabetes.

PubMed ID: 10805801

DOI: 10.1073/pnas.97.10.5450

PubMed ID: 17566972

Title: Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments.

PubMed ID: 17566972

DOI: 10.1002/pmic.200700068

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 7512825

Title: Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins.

PubMed ID: 7512825

DOI: 10.1021/bi00181a006

PubMed ID: 7520819

Title: Structure of a soluble, glycosylated form of the human complement regulatory protein CD59.

PubMed ID: 7520819

DOI: 10.1016/s0969-2126(00)00020-4

PubMed ID: 1382994

Title: Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene.

PubMed ID: 1382994

DOI: 10.1002/eji.1830221029

PubMed ID: 23149847

Title: CD59 deficiency is associated with chronic hemolysis and childhood relapsing immune-mediated polyneuropathy.

PubMed ID: 23149847

DOI: 10.1182/blood-2012-07-441857

Sequence Information:

Length: 128
Mass: 14177
Checksum: 2F0D29CBE3C28505
Sequence:

MGIQGGSVLF GLLLVLAVFC HSGHSLQCYN CPNPTADCKT AVNCSSDFDA CLITKAGLQV 
YNKCWKFEHC NFNDVTTRLR ENELTYYCCK KDLCNFNEQL ENGGTSLSEK TVLLLVTPFL 
AAAWSLHP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD59

Associated with

Other Information

CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. PubMed ID: 2475570

The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility. PubMed ID: 1689664

20 KDa homologous restriction factor of complement resembles T cell activating protein. PubMed ID: 2475111

Molecular cloning and characterization of MACIF, an inhibitor of membrane channel formation of complement. PubMed ID: 2606909

Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes. PubMed ID: 1692709

Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein. PubMed ID: 1381503

Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation. PubMed ID: 1383553

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C. PubMed ID: 2476718

Structural composition and functional characterization of soluble CD59: heterogeneity of the oligosaccharide and glycophosphoinositol (GPI) anchor revealed by laser-desorption mass spectrometric analysis. PubMed ID: 8670172

Determination of carboxyl-terminal residue and disulfide bonds of MACIF (CD59), a glycosyl-phosphatidylinositol-anchored membrane protein. PubMed ID: 8276756

The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the ''b'' domain of C9. PubMed ID: 1377690

Mapping the regions of the complement inhibitor CD59 responsible for its species selective activity. PubMed ID: 9235986

Mutational analysis of the active site and antibody epitopes of the complement-inhibitory glycoprotein, CD59. PubMed ID: 9053451

The glycosylation of the complement regulatory protein, human erythrocyte CD59. PubMed ID: 9054419

Molecular basis for a link between complement and the vascular complications of diabetes. PubMed ID: 10805801

Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments. PubMed ID: 17566972

Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. PubMed ID: 18780401

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins. PubMed ID: 7512825

Structure of a soluble, glycosylated form of the human complement regulatory protein CD59. PubMed ID: 7520819

Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene. PubMed ID: 1382994

CD59 deficiency is associated with chronic hemolysis and childhood relapsing immune-mediated polyneuropathy. PubMed ID: 23149847