Details for: CD59
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 419.3636
Cell Significance Index: -65.2300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 284.8882
Cell Significance Index: -72.2600 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 213.5223
Cell Significance Index: -87.9600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 183.5646
Cell Significance Index: -86.6700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 129.9771
Cell Significance Index: -87.2200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 64.4305
Cell Significance Index: -79.4400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 28.8854
Cell Significance Index: -77.3800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 23.2300
Cell Significance Index: -71.3500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 22.0854
Cell Significance Index: -87.1500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 18.1761
Cell Significance Index: -39.7800 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 17.9284
Cell Significance Index: 128.7600 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 11.5170
Cell Significance Index: 203.5200 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 10.7832
Cell Significance Index: 114.5700 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 10.1297
Cell Significance Index: 62.3400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 7.7786
Cell Significance Index: 222.9800 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 6.6767
Cell Significance Index: 75.8500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 6.0438
Cell Significance Index: 450.4400 - Cell Name: lactocyte (CL0002325)
Fold Change: 5.3052
Cell Significance Index: 685.3900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.6705
Cell Significance Index: 217.7600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 4.3442
Cell Significance Index: 204.1800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.6085
Cell Significance Index: 650.5100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.3059
Cell Significance Index: 406.4900 - Cell Name: odontoblast (CL0000060)
Fold Change: 3.2561
Cell Significance Index: 417.4100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.8950
Cell Significance Index: 204.7500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.5067
Cell Significance Index: 68.2300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.3956
Cell Significance Index: 22.0600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.2178
Cell Significance Index: 304.5600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.9801
Cell Significance Index: 875.4600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.8923
Cell Significance Index: 1033.4100 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.7338
Cell Significance Index: 10.7300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.6382
Cell Significance Index: 471.3600 - Cell Name: perivascular cell (CL4033054)
Fold Change: 1.6081
Cell Significance Index: 7.4300 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.3360
Cell Significance Index: 19.2200 - Cell Name: peg cell (CL4033014)
Fold Change: 1.0561
Cell Significance Index: 24.4000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0435
Cell Significance Index: 113.5000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.8586
Cell Significance Index: 29.8400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8349
Cell Significance Index: 43.3700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.7241
Cell Significance Index: 82.6600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.6604
Cell Significance Index: 3.9900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6294
Cell Significance Index: 126.2500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5175
Cell Significance Index: 51.2000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4985
Cell Significance Index: 13.3100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.4826
Cell Significance Index: 365.2800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4651
Cell Significance Index: 166.8300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4114
Cell Significance Index: 21.6000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3220
Cell Significance Index: 22.2700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.3117
Cell Significance Index: 9.1600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.2946
Cell Significance Index: 216.0200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2686
Cell Significance Index: 5.8200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1965
Cell Significance Index: 33.5500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1933
Cell Significance Index: 5.1800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1651
Cell Significance Index: 31.4200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1539
Cell Significance Index: 138.9600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0687
Cell Significance Index: 1.9800 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0523
Cell Significance Index: 1.3700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0028
Cell Significance Index: 0.1000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0232
Cell Significance Index: -17.1600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0377
Cell Significance Index: -70.9000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0424
Cell Significance Index: -4.3300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0524
Cell Significance Index: -32.7200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0548
Cell Significance Index: -101.0500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0644
Cell Significance Index: -99.1800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0738
Cell Significance Index: -100.3300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0744
Cell Significance Index: -1.2500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1050
Cell Significance Index: -59.2100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1108
Cell Significance Index: -8.5000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1169
Cell Significance Index: -74.2500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1385
Cell Significance Index: -15.8700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1585
Cell Significance Index: -33.3900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1865
Cell Significance Index: -84.6300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.2261
Cell Significance Index: -36.7700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2393
Cell Significance Index: -27.8900 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2976
Cell Significance Index: -2.5000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.3579
Cell Significance Index: -71.0200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4498
Cell Significance Index: -53.0500 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.4828
Cell Significance Index: -3.0000 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.4868
Cell Significance Index: -9.5000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5523
Cell Significance Index: -17.6900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.5664
Cell Significance Index: -82.3400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.7315
Cell Significance Index: -44.9600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7980
Cell Significance Index: -63.2000 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.8161
Cell Significance Index: -17.0200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.8348
Cell Significance Index: -52.6200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.8430
Cell Significance Index: -23.5600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.8434
Cell Significance Index: -87.8200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.8693
Cell Significance Index: -43.9300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.9278
Cell Significance Index: -59.8600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9306
Cell Significance Index: -57.0600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.9882
Cell Significance Index: -55.4500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -1.0949
Cell Significance Index: -27.9700 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -1.2117
Cell Significance Index: -49.6500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.2741
Cell Significance Index: -85.6700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.3852
Cell Significance Index: -83.1600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.4210
Cell Significance Index: -64.4100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.4229
Cell Significance Index: -62.9400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.5223
Cell Significance Index: -32.4200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.5991
Cell Significance Index: -47.1000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.6430
Cell Significance Index: -34.3900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.6985
Cell Significance Index: -25.4500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.6999
Cell Significance Index: -64.3700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2132032314
Symbol: CD59_HUMAN
Name: CD59 glycoprotein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2475570
Title: CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.
PubMed ID: 2475570
PubMed ID: 1689664
Title: The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility.
PubMed ID: 1689664
PubMed ID: 2475111
Title: 20 KDa homologous restriction factor of complement resembles T cell activating protein.
PubMed ID: 2475111
PubMed ID: 2606909
Title: Molecular cloning and characterization of MACIF, an inhibitor of membrane channel formation of complement.
PubMed ID: 2606909
PubMed ID: 1692709
Title: Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes.
PubMed ID: 1692709
PubMed ID: 1381503
Title: Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.
PubMed ID: 1381503
PubMed ID: 1383553
Title: Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation.
PubMed ID: 1383553
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2476718
Title: Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C.
PubMed ID: 2476718
PubMed ID: 8670172
Title: Structural composition and functional characterization of soluble CD59: heterogeneity of the oligosaccharide and glycophosphoinositol (GPI) anchor revealed by laser-desorption mass spectrometric analysis.
PubMed ID: 8670172
DOI: 10.1042/bj3160923
PubMed ID: 8276756
Title: Determination of carboxyl-terminal residue and disulfide bonds of MACIF (CD59), a glycosyl-phosphatidylinositol-anchored membrane protein.
PubMed ID: 8276756
PubMed ID: 1377690
Title: The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the ''b'' domain of C9.
PubMed ID: 1377690
PubMed ID: 9235986
Title: Mapping the regions of the complement inhibitor CD59 responsible for its species selective activity.
PubMed ID: 9235986
DOI: 10.1021/bi970832i
PubMed ID: 9053451
Title: Mutational analysis of the active site and antibody epitopes of the complement-inhibitory glycoprotein, CD59.
PubMed ID: 9053451
PubMed ID: 9054419
Title: The glycosylation of the complement regulatory protein, human erythrocyte CD59.
PubMed ID: 9054419
PubMed ID: 10805801
Title: Molecular basis for a link between complement and the vascular complications of diabetes.
PubMed ID: 10805801
PubMed ID: 17566972
Title: Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments.
PubMed ID: 17566972
PubMed ID: 18780401
Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.
PubMed ID: 18780401
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 7512825
Title: Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins.
PubMed ID: 7512825
DOI: 10.1021/bi00181a006
PubMed ID: 7520819
Title: Structure of a soluble, glycosylated form of the human complement regulatory protein CD59.
PubMed ID: 7520819
PubMed ID: 1382994
Title: Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene.
PubMed ID: 1382994
PubMed ID: 23149847
Title: CD59 deficiency is associated with chronic hemolysis and childhood relapsing immune-mediated polyneuropathy.
PubMed ID: 23149847
Sequence Information:
- Length: 128
- Mass: 14177
- Checksum: 2F0D29CBE3C28505
- Sequence:
MGIQGGSVLF GLLLVLAVFC HSGHSLQCYN CPNPTADCKT AVNCSSDFDA CLITKAGLQV YNKCWKFEHC NFNDVTTRLR ENELTYYCCK KDLCNFNEQL ENGGTSLSEK TVLLLVTPFL AAAWSLHP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.