CD63 | ENSG00000135404 | NCBI 967

Details for: CD63

Gene ID: 967

Symbol: CD63

Ensembl ID: ENSG00000135404

Description: CD63 molecule

Associated with

Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Azurophil granule membrane
(GO:0035577)
Cell-matrix adhesion
(GO:0007160)
Cell migration
(GO:0016477)
Cell surface
(GO:0009986)
Endosome lumen
(GO:0031904)
Endosome membrane
(GO:0010008)
Endosome to melanosome transport
(GO:0035646)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Intracellular membrane-bounded organelle
(GO:0043231)
Late endosome membrane
(GO:0031902)
Lysosomal membrane
(GO:0005765)
Melanosome
(GO:0042470)
Multivesicular body, internal vesicle
(GO:0097487)
Multivesicular body membrane
(GO:0032585)
Nucleoplasm
(GO:0005654)
Pigment granule maturation
(GO:0048757)
Plasma membrane
(GO:0005886)
Platelet dense granule membrane
(GO:0031088)
Positive regulation of integrin-mediated signaling pathway
(GO:2001046)
Positive regulation of receptor internalization
(GO:0002092)
Protein binding
(GO:0005515)
Protein transport
(GO:0015031)
Regulation of potassium ion transmembrane transport
(GO:1901379)
Regulation of vascular endothelial growth factor signaling pathway
(GO:1900746)

Other Information

Proteins

CD63 antigen

Genular Protein ID: 631187162

Symbol: CD63_HUMAN

Name: CD63 antigen

UniProtKB Accession Codes:

P08962 F8VZE2 Q5TZP3 Q8N6Z9 Q9UCG6

Database IDs:

Citations:

PubMed ID: 3365686

Title: Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression.

PubMed ID: 3365686

PubMed ID: 2171551

Title: Characterization of three abundant mRNAs from human ovarian granulosa cells.

PubMed ID: 2171551

DOI: 10.1089/dna.1990.9.479

PubMed ID: 1993697

Title: CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells.

PubMed ID: 1993697

DOI: 10.1016/s0021-9258(18)49980-2

PubMed ID: 1339263

Title: An ocular melanoma-associated antigen. Molecular characterization.

PubMed ID: 1339263

DOI: 10.1001/archopht.1992.01080150097036

PubMed ID: 1599482

Title: Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences.

PubMed ID: 1599482

DOI: 10.1016/s0006-291x(05)81004-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7682577

Title: The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin.

PubMed ID: 7682577

DOI: 10.1172/jci116388

PubMed ID: 4062294

Title: Isolation and amino terminal sequencing of a novel melanoma-associated antigen.

PubMed ID: 4062294

DOI: 10.1016/0003-9861(85)90241-3

PubMed ID: 1939168

Title: Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking.

PubMed ID: 1939168

DOI: 10.1016/s0021-9258(18)54636-6

PubMed ID: 10793155

Title: The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells.

PubMed ID: 10793155

DOI: 10.1091/mbc.11.5.1829

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15351990

Title: LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells.

PubMed ID: 15351990

DOI: 10.1002/cyto.a.20068

PubMed ID: 16917503

Title: Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein.

PubMed ID: 16917503

DOI: 10.1038/sj.emboj.7601281

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19640571

Title: Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets.

PubMed ID: 19640571

DOI: 10.1016/j.thromres.2009.07.005

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21803846

Title: CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin.

PubMed ID: 21803846

DOI: 10.1182/blood-2010-11-321489

PubMed ID: 21962903

Title: The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis.

PubMed ID: 21962903

DOI: 10.1016/j.devcel.2011.08.019

PubMed ID: 22431521

Title: The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting.

PubMed ID: 22431521

DOI: 10.1128/mcb.06726-11

PubMed ID: 22660413

Title: Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.

PubMed ID: 22660413

DOI: 10.1038/ncb2502

PubMed ID: 23632027

Title: Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-beta1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo.

PubMed ID: 23632027

DOI: 10.1074/jbc.m113.468199

PubMed ID: 24635319

Title: TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling.

PubMed ID: 24635319

DOI: 10.1042/bj20131119

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

Length: 238
Mass: 25637
Checksum: 85AC8E235C6E425F
Sequence:

MAVEGGMKCV KFLLYVLLLA FCACAVGLIA VGVGAQLVLS QTIIQGATPG SLLPVVIIAV 
GVFLFLVAFV GCCGACKENY CLMITFAIFL SLIMLVEVAA AIAGYVFRDK VMSEFNNNFR 
QQMENYPKNN HTASILDRMQ ADFKCCGAAN YTDWEKIPSM SKNRVPDSCC INVTVGCGIN 
FNEKAIHKEG CVEKIGGWLR KNVLVVAAAA LGIAFVEVLG IVFACCLVKS IRSGYEVM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD63

Associated with

Other Information

Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression. PubMed ID: 3365686

Characterization of three abundant mRNAs from human ovarian granulosa cells. PubMed ID: 2171551

CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. PubMed ID: 1993697

An ocular melanoma-associated antigen. Molecular characterization. PubMed ID: 1339263

Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences. PubMed ID: 1599482

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin. PubMed ID: 7682577

Isolation and amino terminal sequencing of a novel melanoma-associated antigen. PubMed ID: 4062294

Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking. PubMed ID: 1939168

The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells. PubMed ID: 10793155

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. PubMed ID: 12754519

LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells. PubMed ID: 15351990

Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. PubMed ID: 16917503

Integral and associated lysosomal membrane proteins. PubMed ID: 17897319

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets. PubMed ID: 19640571

Initial characterization of the human central proteome. PubMed ID: 21269460

CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin. PubMed ID: 21803846

The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. PubMed ID: 21962903

The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting. PubMed ID: 22431521

Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. PubMed ID: 22660413

Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-beta1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo. PubMed ID: 23632027

TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling. PubMed ID: 24635319

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712