Details for: CD63

Gene ID: 967

Symbol: CD63

Ensembl ID: ENSG00000135404

Description: CD63 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1085.9221
    Cell Significance Index: -168.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 603.4457
    Cell Significance Index: -153.0600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 420.1505
    Cell Significance Index: -173.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 359.6099
    Cell Significance Index: -169.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 308.1931
    Cell Significance Index: -158.5300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 254.8798
    Cell Significance Index: -171.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 138.2937
    Cell Significance Index: -170.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 43.6969
    Cell Significance Index: -172.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 43.4843
    Cell Significance Index: -133.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 27.5383
    Cell Significance Index: -60.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.1682
    Cell Significance Index: -48.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.3418
    Cell Significance Index: 325.1200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 9.3467
    Cell Significance Index: 215.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 7.2274
    Cell Significance Index: 339.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.9311
    Cell Significance Index: 323.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 6.6194
    Cell Significance Index: 909.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 6.3060
    Cell Significance Index: 58.0700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 6.0369
    Cell Significance Index: 106.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.4241
    Cell Significance Index: 695.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.4039
    Cell Significance Index: 2951.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 5.3065
    Cell Significance Index: 395.4900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 5.0764
    Cell Significance Index: 57.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.0422
    Cell Significance Index: 908.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.0311
    Cell Significance Index: 105.3100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.6017
    Cell Significance Index: 28.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.4286
    Cell Significance Index: 544.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.8561
    Cell Significance Index: 104.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.7003
    Cell Significance Index: 478.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.2618
    Cell Significance Index: 85.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.9760
    Cell Significance Index: 294.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.6530
    Cell Significance Index: 92.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.5617
    Cell Significance Index: 1132.5800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.5056
    Cell Significance Index: 18.0000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.3885
    Cell Significance Index: 19.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.2905
    Cell Significance Index: 1733.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.0140
    Cell Significance Index: 343.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9104
    Cell Significance Index: 51.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.8107
    Cell Significance Index: 35.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6574
    Cell Significance Index: 117.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4946
    Cell Significance Index: 77.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4922
    Cell Significance Index: 27.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4520
    Cell Significance Index: 65.8200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.3720
    Cell Significance Index: 6.3400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.9882
    Cell Significance Index: 6.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8472
    Cell Significance Index: 168.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.6259
    Cell Significance Index: 458.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5239
    Cell Significance Index: 33.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2860
    Cell Significance Index: 32.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2848
    Cell Significance Index: 46.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1659
    Cell Significance Index: 31.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1440
    Cell Significance Index: 2.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0937
    Cell Significance Index: 2.5100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.0340
    Cell Significance Index: 0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0268
    Cell Significance Index: 50.5000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0232
    Cell Significance Index: 0.1400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0074
    Cell Significance Index: 0.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0259
    Cell Significance Index: -2.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0523
    Cell Significance Index: -38.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1067
    Cell Significance Index: -196.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1230
    Cell Significance Index: -189.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1466
    Cell Significance Index: -199.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1511
    Cell Significance Index: -95.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1517
    Cell Significance Index: -94.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1533
    Cell Significance Index: -8.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2145
    Cell Significance Index: -120.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2258
    Cell Significance Index: -6.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2551
    Cell Significance Index: -51.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2641
    Cell Significance Index: -94.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2704
    Cell Significance Index: -122.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2861
    Cell Significance Index: -60.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4732
    Cell Significance Index: -136.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6939
    Cell Significance Index: -79.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7239
    Cell Significance Index: -21.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7766
    Cell Significance Index: -112.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.9383
    Cell Significance Index: -109.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.9450
    Cell Significance Index: -102.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0094
    Cell Significance Index: -63.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -1.1394
    Cell Significance Index: -134.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2510
    Cell Significance Index: -70.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.4481
    Cell Significance Index: -89.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.5298
    Cell Significance Index: -121.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.5799
    Cell Significance Index: -121.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.5895
    Cell Significance Index: -165.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.8673
    Cell Significance Index: -94.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.9234
    Cell Significance Index: -28.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.9419
    Cell Significance Index: -49.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.0448
    Cell Significance Index: -141.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.0847
    Cell Significance Index: -66.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -2.1133
    Cell Significance Index: -59.0600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -2.2656
    Cell Significance Index: -24.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.4081
    Cell Significance Index: -64.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.4084
    Cell Significance Index: -161.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.5089
    Cell Significance Index: -34.2300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.6227
    Cell Significance Index: -22.0300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -2.6426
    Cell Significance Index: -108.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.7355
    Cell Significance Index: -167.7100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -2.8692
    Cell Significance Index: -59.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -2.9331
    Cell Significance Index: -103.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.0916
    Cell Significance Index: -91.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.8263
    Cell Significance Index: -82.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transmembrane localization**: CD63 is a transmembrane protein, meaning it spans the lipid bilayer of the plasma membrane, with a portion of the protein exposed on the extracellular surface and another portion embedded within the membrane. 2. **Multifunctional**: CD63 is involved in multiple cellular processes, including cell migration, adhesion, signaling, and vesicle trafficking. 3. **Regulation of integrin-mediated signaling**: CD63 acts as a positive regulator of integrin-mediated signaling pathways, which are essential for cell adhesion, migration, and signaling. 4. **Protein binding**: CD63 interacts with various proteins, including integrins, receptors, and signaling molecules, to regulate cellular processes. **Pathways and Functions** 1. **Cell migration and adhesion**: CD63 plays a crucial role in cell migration and adhesion by regulating integrin-mediated signaling pathways. 2. **Vesicle trafficking**: CD63 is involved in the transport of proteins and lipids between vesicles, including late endosomes, multivesicular bodies, and melanosomes. 3. **Signaling and aggregation**: CD63 regulates signaling and aggregation of platelets, which is essential for hemostasis and wound healing. 4. **Immune system regulation**: CD63 is expressed on immune cells, including neutrophils and natural killer cells, and plays a role in regulating immune responses. **Clinical Significance** 1. **Cancer**: CD63 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Inflammatory diseases**: CD63 is involved in the regulation of immune responses and is associated with inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. 3. **Platelet disorders**: CD63 is involved in platelet activation and aggregation, and its dysregulation is associated with bleeding disorders, such as thrombocytopenia. 4. **Neurological disorders**: CD63 is expressed on neurons and plays a role in regulating synaptic transmission and neuroinflammation, which is associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CD63 is a versatile membrane protein that plays a critical role in multiple cellular processes, including immune responses, cell signaling, and vesicle trafficking. Its dysregulation is associated with various diseases, including cancer, inflammatory diseases, platelet disorders, and neurological disorders. Further research is needed to fully understand the mechanisms of CD63 and its clinical significance.

Genular Protein ID: 631187162

Symbol: CD63_HUMAN

Name: CD63 antigen

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3365686

Title: Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression.

PubMed ID: 3365686

PubMed ID: 2171551

Title: Characterization of three abundant mRNAs from human ovarian granulosa cells.

PubMed ID: 2171551

DOI: 10.1089/dna.1990.9.479

PubMed ID: 1993697

Title: CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells.

PubMed ID: 1993697

DOI: 10.1016/s0021-9258(18)49980-2

PubMed ID: 1339263

Title: An ocular melanoma-associated antigen. Molecular characterization.

PubMed ID: 1339263

DOI: 10.1001/archopht.1992.01080150097036

PubMed ID: 1599482

Title: Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences.

PubMed ID: 1599482

DOI: 10.1016/s0006-291x(05)81004-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7682577

Title: The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin.

PubMed ID: 7682577

DOI: 10.1172/jci116388

PubMed ID: 4062294

Title: Isolation and amino terminal sequencing of a novel melanoma-associated antigen.

PubMed ID: 4062294

DOI: 10.1016/0003-9861(85)90241-3

PubMed ID: 1939168

Title: Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking.

PubMed ID: 1939168

DOI: 10.1016/s0021-9258(18)54636-6

PubMed ID: 10793155

Title: The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells.

PubMed ID: 10793155

DOI: 10.1091/mbc.11.5.1829

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15351990

Title: LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells.

PubMed ID: 15351990

DOI: 10.1002/cyto.a.20068

PubMed ID: 16917503

Title: Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein.

PubMed ID: 16917503

DOI: 10.1038/sj.emboj.7601281

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19640571

Title: Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets.

PubMed ID: 19640571

DOI: 10.1016/j.thromres.2009.07.005

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21803846

Title: CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin.

PubMed ID: 21803846

DOI: 10.1182/blood-2010-11-321489

PubMed ID: 21962903

Title: The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis.

PubMed ID: 21962903

DOI: 10.1016/j.devcel.2011.08.019

PubMed ID: 22431521

Title: The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting.

PubMed ID: 22431521

DOI: 10.1128/mcb.06726-11

PubMed ID: 22660413

Title: Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.

PubMed ID: 22660413

DOI: 10.1038/ncb2502

PubMed ID: 23632027

Title: Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-beta1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo.

PubMed ID: 23632027

DOI: 10.1074/jbc.m113.468199

PubMed ID: 24635319

Title: TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling.

PubMed ID: 24635319

DOI: 10.1042/bj20131119

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 238
  • Mass: 25637
  • Checksum: 85AC8E235C6E425F
  • Sequence:
  • MAVEGGMKCV KFLLYVLLLA FCACAVGLIA VGVGAQLVLS QTIIQGATPG SLLPVVIIAV 
    GVFLFLVAFV GCCGACKENY CLMITFAIFL SLIMLVEVAA AIAGYVFRDK VMSEFNNNFR 
    QQMENYPKNN HTASILDRMQ ADFKCCGAAN YTDWEKIPSM SKNRVPDSCC INVTVGCGIN 
    FNEKAIHKEG CVEKIGGWLR KNVLVVAAAA LGIAFVEVLG IVFACCLVKS IRSGYEVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.