Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 1085.9221
Cell Significance Index: -168.9100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 603.4457
Cell Significance Index: -153.0600 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 420.1505
Cell Significance Index: -173.0800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 359.6099
Cell Significance Index: -169.7800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 308.1931
Cell Significance Index: -158.5300 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 254.8798
Cell Significance Index: -171.0300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 138.2937
Cell Significance Index: -170.5100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 43.6969
Cell Significance Index: -172.4300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 43.4843
Cell Significance Index: -133.5600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 27.5383
Cell Significance Index: -60.2700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 18.1682
Cell Significance Index: -48.6700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 11.3418
Cell Significance Index: 325.1200 - Cell Name: peg cell (CL4033014)
Fold Change: 9.3467
Cell Significance Index: 215.9400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 7.2274
Cell Significance Index: 339.6800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 6.9311
Cell Significance Index: 323.1600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 6.6194
Cell Significance Index: 909.0300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 6.3060
Cell Significance Index: 58.0700 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 6.0369
Cell Significance Index: 106.6800 - Cell Name: odontoblast (CL0000060)
Fold Change: 5.4241
Cell Significance Index: 695.3400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 5.4039
Cell Significance Index: 2951.2000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 5.3065
Cell Significance Index: 395.4900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 5.0764
Cell Significance Index: 57.6700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 5.0422
Cell Significance Index: 908.9500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 5.0311
Cell Significance Index: 105.3100 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 4.6017
Cell Significance Index: 28.3200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 4.4286
Cell Significance Index: 544.5400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.8561
Cell Significance Index: 104.9600 - Cell Name: lactocyte (CL0002325)
Fold Change: 3.7003
Cell Significance Index: 478.0600 - Cell Name: granulosa cell (CL0000501)
Fold Change: 3.2618
Cell Significance Index: 85.7700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.9760
Cell Significance Index: 294.3900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.6530
Cell Significance Index: 92.1900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.5617
Cell Significance Index: 1132.5800 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.5056
Cell Significance Index: 18.0000 - Cell Name: kidney cell (CL1000497)
Fold Change: 2.3885
Cell Significance Index: 19.0700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 2.2905
Cell Significance Index: 1733.6900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 2.0140
Cell Significance Index: 343.9100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.9104
Cell Significance Index: 51.0100 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.8107
Cell Significance Index: 35.3400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.6574
Cell Significance Index: 117.2200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.4946
Cell Significance Index: 77.6400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.4922
Cell Significance Index: 27.5800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.4520
Cell Significance Index: 65.8200 - Cell Name: perivascular cell (CL4033054)
Fold Change: 1.3720
Cell Significance Index: 6.3400 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.9882
Cell Significance Index: 6.1400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8472
Cell Significance Index: 168.1300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.6259
Cell Significance Index: 458.9200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.5239
Cell Significance Index: 33.8000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.2860
Cell Significance Index: 32.6500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2848
Cell Significance Index: 46.3200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1659
Cell Significance Index: 31.5700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1440
Cell Significance Index: 2.4100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0937
Cell Significance Index: 2.5100 - Cell Name: theca cell (CL0000503)
Fold Change: 0.0340
Cell Significance Index: 0.2000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0268
Cell Significance Index: 50.5000 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0232
Cell Significance Index: 0.1400 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.0074
Cell Significance Index: 0.0900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0259
Cell Significance Index: -2.6500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0523
Cell Significance Index: -38.7400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1067
Cell Significance Index: -196.8600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1230
Cell Significance Index: -189.3100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1466
Cell Significance Index: -199.3100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1511
Cell Significance Index: -95.9700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1517
Cell Significance Index: -94.7100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1533
Cell Significance Index: -8.0500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2145
Cell Significance Index: -120.9800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.2258
Cell Significance Index: -6.5100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.2551
Cell Significance Index: -51.1800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.2641
Cell Significance Index: -94.7300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2704
Cell Significance Index: -122.7100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2861
Cell Significance Index: -60.2500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4732
Cell Significance Index: -136.1500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6939
Cell Significance Index: -79.5000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.7239
Cell Significance Index: -21.2600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.7766
Cell Significance Index: -112.8900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.9383
Cell Significance Index: -109.3500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.9450
Cell Significance Index: -102.7900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.0094
Cell Significance Index: -63.6200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -1.1394
Cell Significance Index: -134.3700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.2510
Cell Significance Index: -70.2000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.4481
Cell Significance Index: -89.0100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.5298
Cell Significance Index: -121.1600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.5799
Cell Significance Index: -121.2400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.5895
Cell Significance Index: -165.5000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -1.8673
Cell Significance Index: -94.3700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.9234
Cell Significance Index: -28.8200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -1.9419
Cell Significance Index: -49.6100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -2.0448
Cell Significance Index: -141.4100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.0847
Cell Significance Index: -66.7700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -2.1133
Cell Significance Index: -59.0600 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -2.2656
Cell Significance Index: -24.6300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -2.4081
Cell Significance Index: -64.4200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -2.4084
Cell Significance Index: -161.9500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -2.5089
Cell Significance Index: -34.2300 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -2.6227
Cell Significance Index: -22.0300 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -2.6426
Cell Significance Index: -108.2800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.7355
Cell Significance Index: -167.7100 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -2.8692
Cell Significance Index: -59.8400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -2.9331
Cell Significance Index: -103.0700 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -3.0916
Cell Significance Index: -91.0600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -3.8263
Cell Significance Index: -82.9000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 631187162
Symbol: CD63_HUMAN
Name: CD63 antigen
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3365686
Title: Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression.
PubMed ID: 3365686
PubMed ID: 2171551
Title: Characterization of three abundant mRNAs from human ovarian granulosa cells.
PubMed ID: 2171551
PubMed ID: 1993697
Title: CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells.
PubMed ID: 1993697
PubMed ID: 1339263
Title: An ocular melanoma-associated antigen. Molecular characterization.
PubMed ID: 1339263
PubMed ID: 1599482
Title: Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences.
PubMed ID: 1599482
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7682577
Title: The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin.
PubMed ID: 7682577
DOI: 10.1172/jci116388
PubMed ID: 4062294
Title: Isolation and amino terminal sequencing of a novel melanoma-associated antigen.
PubMed ID: 4062294
PubMed ID: 1939168
Title: Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking.
PubMed ID: 1939168
PubMed ID: 10793155
Title: The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells.
PubMed ID: 10793155
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 15351990
Title: LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells.
PubMed ID: 15351990
DOI: 10.1002/cyto.a.20068
PubMed ID: 16917503
Title: Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein.
PubMed ID: 16917503
PubMed ID: 17897319
Title: Integral and associated lysosomal membrane proteins.
PubMed ID: 17897319
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19640571
Title: Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets.
PubMed ID: 19640571
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21803846
Title: CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin.
PubMed ID: 21803846
PubMed ID: 21962903
Title: The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis.
PubMed ID: 21962903
PubMed ID: 22431521
Title: The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting.
PubMed ID: 22431521
DOI: 10.1128/mcb.06726-11
PubMed ID: 22660413
Title: Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.
PubMed ID: 22660413
DOI: 10.1038/ncb2502
PubMed ID: 23632027
Title: Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-beta1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo.
PubMed ID: 23632027
PubMed ID: 24635319
Title: TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling.
PubMed ID: 24635319
DOI: 10.1042/bj20131119
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 238
- Mass: 25637
- Checksum: 85AC8E235C6E425F
- Sequence:
MAVEGGMKCV KFLLYVLLLA FCACAVGLIA VGVGAQLVLS QTIIQGATPG SLLPVVIIAV GVFLFLVAFV GCCGACKENY CLMITFAIFL SLIMLVEVAA AIAGYVFRDK VMSEFNNNFR QQMENYPKNN HTASILDRMQ ADFKCCGAAN YTDWEKIPSM SKNRVPDSCC INVTVGCGIN FNEKAIHKEG CVEKIGGWLR KNVLVVAAAA LGIAFVEVLG IVFACCLVKS IRSGYEVM
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.