Details for: TTI1

Gene ID: 9675

Symbol: TTI1

Ensembl ID: ENSG00000101407

Description: TELO2 interacting protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.19
    Marker Score: 2,081
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.18
    Marker Score: 2,786
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18,226
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.06
    Marker Score: 1,643
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.03
    Marker Score: 63,363
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.02
    Marker Score: 9,649
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,763
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,988
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,402
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,721
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.9
    Marker Score: 9,339
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.9
    Marker Score: 7,723
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.89
    Marker Score: 709
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.87
    Marker Score: 18,547
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.85
    Marker Score: 3,525
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.84
    Marker Score: 1,706
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.83
    Marker Score: 30,746
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.81
    Marker Score: 3,113
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.78
    Marker Score: 7,364
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.76
    Marker Score: 15,151
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 296
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 556
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.73
    Marker Score: 10,876
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,045
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.68
    Marker Score: 25,755
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.68
    Marker Score: 5,188
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.67
    Marker Score: 660
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 613
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.67
    Marker Score: 455
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.66
    Marker Score: 2,681
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.65
    Marker Score: 723
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.65
    Marker Score: 2,713
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.65
    Marker Score: 364
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.64
    Marker Score: 1,403
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.61
    Marker Score: 878
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.58
    Marker Score: 187
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 348
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.58
    Marker Score: 434
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.54
    Marker Score: 325
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.54
    Marker Score: 729
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.54
    Marker Score: 169
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.53
    Marker Score: 242
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.52
    Marker Score: 305
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.52
    Marker Score: 218
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.52
    Marker Score: 559
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.51
    Marker Score: 2,148
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.51
    Marker Score: 395
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.51
    Marker Score: 584
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 211
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5
    Marker Score: 3,027
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.5
    Marker Score: 174
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5
    Marker Score: 4,351
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.5
    Marker Score: 429
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.49
    Marker Score: 257
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.49
    Marker Score: 1,729
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.48
    Marker Score: 586
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.48
    Marker Score: 139
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.48
    Marker Score: 3,083
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.48
    Marker Score: 1,876
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.47
    Marker Score: 8,396
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.47
    Marker Score: 10,438
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.46
    Marker Score: 975
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.45
    Marker Score: 299
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 119
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.45
    Marker Score: 559
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.44
    Marker Score: 214
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.44
    Marker Score: 163
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.44
    Marker Score: 119
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.44
    Marker Score: 1,878
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.43
    Marker Score: 398
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.43
    Marker Score: 162
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.43
    Marker Score: 210
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.43
    Marker Score: 270
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.43
    Marker Score: 237
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 404
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 196
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.41
    Marker Score: 129
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.41
    Marker Score: 424
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.4
    Marker Score: 573
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.4
    Marker Score: 356
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.4
    Marker Score: 424
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.4
    Marker Score: 769
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.4
    Marker Score: 1,849
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.4
    Marker Score: 1,666
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.4
    Marker Score: 1,086
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.39
    Marker Score: 115
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.39
    Marker Score: 195
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.39
    Marker Score: 444
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.39
    Marker Score: 338
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.39
    Marker Score: 158

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TTI1 is a protein that interacts with TELO2, a protein involved in the regulation of telomere length and telomerase activity. The TTI1-TELO2 complex is also associated with the Ttt hsp90 cochaperone complex, which is involved in the regulation of protein stability and degradation. TTI1 has been identified in various cell types, including germ cells, kidney proximal straight tubule epithelial cells, cardiac muscle myoblasts, and neurons. Its expression is also notable in the cerebral cortex, where it is involved in the regulation of glutamatergic neurotransmission. **Pathways and Functions:** TTI1 is involved in several cellular pathways, including: 1. **Positive regulation of DNA damage checkpoint**: TTI1 interacts with TELO2 to regulate telomere length and telomerase activity, which is essential for maintaining genome stability. 2. **Protein binding**: TTI1 binds to various proteins, including TELO2, hsp90, and other chaperones, to regulate protein stability and degradation. 3. **Protein stabilization**: TTI1 helps to stabilize proteins, including those involved in DNA damage response and cell cycle regulation. 4. **Regulation of TOR signaling**: TTI1 interacts with the TOR complex to regulate protein synthesis and cell growth. **Clinical Significance:** TTI1 has been implicated in various human diseases, including: 1. **Cancer**: TTI1 expression is often upregulated in cancer cells, where it contributes to tumorigenesis and metastasis. 2. **Neurological disorders**: TTI1 has been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it may contribute to neuronal damage and death. 3. **Cardiovascular disease**: TTI1 expression is also elevated in cardiovascular disease, where it may contribute to cardiac remodeling and dysfunction. In conclusion, TTI1 is a multifunctional protein that plays a critical role in maintaining cellular homeostasis. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into the mechanisms of TTI1 and its potential therapeutic applications.

Genular Protein ID: 455255400

Symbol: TTI1_HUMAN

Name: TELO2-interacting protein 1 homolog

UniProtKB Accession Codes:

O43156 D6W4K3 Q5JX67 Q96A38 Q9BR47 Q9H4K0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 1 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 20427287

Title: Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

PubMed ID: 20427287

DOI: 10.1074/jbc.m110.121699

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 20810650

Title: A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

PubMed ID: 20810650

DOI: 10.1101/gad.1934210

PubMed ID: 20801936

Title: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.

PubMed ID: 20801936

DOI: 10.1101/gad.1956410

PubMed ID: 20371770

Title: AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.

PubMed ID: 20371770

DOI: 10.1126/scisignal.2000468

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23263282

Title: SCF(Fbxo9) and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.

PubMed ID: 23263282

DOI: 10.1038/ncb2651

PubMed ID: 26812014

Title: WAC regulates mTOR activity by acting as an adaptor for the TTT and Pontin/Reptin complexes.

PubMed ID: 26812014

DOI: 10.1016/j.devcel.2015.12.019

Sequence Information:

  • Length: 1089
  • Mass: 122069
  • Checksum: 27F4D3EFAC18A54E
  • Sequence:
    • MAVFDTPEEA FGVLRPVCVQ LTKTQTVENV EHLQTRLQAV SDSALQELQQ YILFPLRFTL 
KTPGPKRERL IQSVVECLTF VLSSTCVKEQ ELLQELFSEL SACLYSPSSQ KPAAVSEELK 
LAVIQGLSTL MHSAYGDIIL TFYEPSILPR LGFAVSLLLG LAEQEKSKQI KIAALKCLQV 
LLLQCDCQDH PRSLDELEQK QLGDLFASFL PGISTALTRL ITGDFKQGHS IVVSSLKIFY 
KTVSFIMADE QLKRISKVQA KPAVEHRVAE LMVYREADWV KKTGDKLTIL IKKIIECVSV 
HPHWKVRLEL VELVEDLLLK CSQSLVECAG PLLKALVGLV NDESPEIQAQ CNKVLRHFAD 
QKVVVGNKAL ADILSESLHS LATSLPRLMN SQDDQGKFST LSLLLGYLKL LGPKINFVLN 
SVAHLQRLSK ALIQVLELDV ADIKIVEERR WNSDDLNASP KTSATQPWNR IQRRYFRFFT 
DERIFMLLRQ VCQLLGYYGN LYLLVDHFME LYHQSVVYRK QAAMILNELV TGAAGLEVED 
LHEKHIKTNP EELREIVTSI LEEYTSQENW YLVTCLETEE MGEELMMEHP GLQAITSGEH 
TCQVTSFLAF SKPSPTICSM NSNIWQICIQ LEGIGQFAYA LGKDFCLLLM SALYPVLEKA 
GDQTLLISQV ATSTMMDVCR ACGYDSLQHL INQNSDYLVN GISLNLRHLA LHPHTPKVLE 
VMLRNSDANL LPLVADVVQD VLATLDQFYD KRAASFVSVL HALMAALAQW FPDTGNLGHL 
QEQSLGEEGS HLNQRPAALE KSTTTAEDIE QFLLNYLKEK DVADGNVSDF DNEEEEQSVP 
PKVDENDTRP DVEPPLPLQI QIAMDVMERC IHLLSDKNLQ IRLKVLDVLD LCVVVLQSHK 
NQLLPLAHQA WPSLVHRLTR DAPLAVLRAF KVLRTLGSKC GDFLRSRFCK DVLPKLAGSL 
VTQAPISARA GPVYSHTLAF KLQLAVLQGL GPLCERLDLG EGDLNKVADA CLIYLSVKQP 
VKLQEAARSV FLHLMKVDPD STWFLLNELY CPVQFTPPHP SLHPVQLHGA SGQQNPYTTN 
VLQLLKELQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.