KDM4A | ENSG00000066135 | NCBI 9682

Details for: KDM4A

Gene ID: 9682

Symbol: KDM4A

Ensembl ID: ENSG00000066135

Description: lysine demethylase 4A

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna repair
(R-HSA-73894)
Hdms demethylate histones
(R-HSA-3214842)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Apoptotic chromosome condensation
(GO:0030263)
Cardiac muscle hypertrophy in response to stress
(GO:0014898)
Chromatin
(GO:0000785)
Chromatin remodeling
(GO:0006338)
Cytosol
(GO:0005829)
Fibrillar center
(GO:0001650)
Histone demethylase activity
(GO:0032452)
Histone h3k9 demethylase activity
(GO:0032454)
Histone h3k9me2/h3k9me3 demethylase activity
(GO:0140684)
Histone h3k36 demethylase activity
(GO:0051864)
Histone h3k36me2/h3k36me3 demethylase activity
(GO:0140681)
Methylated histone binding
(GO:0035064)
Negative regulation of astrocyte differentiation
(GO:0048712)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pericentric heterochromatin
(GO:0005721)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neuron differentiation
(GO:0045666)
Protein binding
(GO:0005515)
Regulation of gene expression
(GO:0010468)
Response to nutrient levels
(GO:0031667)
Ubiquitin protein ligase binding
(GO:0031625)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Lysine-specific demethylase 4A

Genular Protein ID: 1836288099

Symbol: KDM4A_HUMAN

Name: Lysine-specific demethylase 4A

UniProtKB Accession Codes:

O75164 Q5VVB1

Database IDs:

Citations:

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15927959

Title: Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.

PubMed ID: 15927959

DOI: 10.1074/jbc.m413687200

PubMed ID: 16024779

Title: JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2).

PubMed ID: 16024779

DOI: 10.1128/mcb.25.15.6404-6414.2005

PubMed ID: 16603238

Title: Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.

PubMed ID: 16603238

DOI: 10.1016/j.cell.2006.03.028

PubMed ID: 16415788

Title: Tudor, MBT and chromo domains gauge the degree of lysine methylation.

PubMed ID: 16415788

DOI: 10.1038/sj.embor.7400625

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22373579

Title: RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.

PubMed ID: 22373579

DOI: 10.1038/emboj.2012.47

PubMed ID: 21694756

Title: A new isoform of the histone demethylase JMJD2A/KDM4A is required for skeletal muscle differentiation.

PubMed ID: 21694756

DOI: 10.1371/journal.pgen.1001390

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 16677698

Title: Structural insights into histone demethylation by JMJD2 family members.

PubMed ID: 16677698

DOI: 10.1016/j.cell.2006.04.024

PubMed ID: 16601153

Title: Recognition of histone H3 lysine-4 methylation by the double Tudor domain of JMJD2A.

PubMed ID: 16601153

DOI: 10.1126/science.1125162

PubMed ID: 26741168

Title: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

PubMed ID: 26741168

DOI: 10.1021/acs.jmedchem.5b01635

PubMed ID: 27214403

Title: Structural analysis of human KDM5B guides histone demethylase inhibitor development.

PubMed ID: 27214403

DOI: 10.1038/nchembio.2087

Sequence Information:

Length: 1064
Mass: 120662
Checksum: 4A811BEECFEDC6B3
Sequence:

MASESETLNP SARIMTFYPT MEEFRNFSRY IAYIESQGAH RAGLAKVVPP KEWKPRASYD 
DIDDLVIPAP IQQLVTGQSG LFTQYNIQKK AMTVREFRKI ANSDKYCTPR YSEFEELERK 
YWKNLTFNPP IYGADVNGTL YEKHVDEWNI GRLRTILDLV EKESGITIEG VNTPYLYFGM 
WKTSFAWHTE DMDLYSINYL HFGEPKSWYS VPPEHGKRLE RLAKGFFPGS AQSCEAFLRH 
KMTLISPLML KKYGIPFDKV TQEAGEFMIT FPYGYHAGFN HGFNCAESTN FATRRWIEYG 
KQAVLCSCRK DMVKISMDVF VRKFQPERYK LWKAGKDNTV IDHTLPTPEA AEFLKESELP 
PRAGNEEECP EEDMEGVEDG EEGDLKTSLA KHRIGTKRHR VCLEIPQEVS QSELFPKEDL 
SSEQYEMTEC PAALAPVRPT HSSVRQVEDG LTFPDYSDST EVKFEELKNV KLEEEDEEEE 
QAAAALDLSV NPASVGGRLV FSGSKKKSSS SLGSGSSRDS ISSDSETSEP LSCRAQGQTG 
VLTVHSYAKG DGRVTVGEPC TRKKGSAARS FSERELAEVA DEYMFSLEEN KKSKGRRQPL 
SKLPRHHPLV LQECVSDDET SEQLTPEEEA EETEAWAKPL SQLWQNRPPN FEAEKEFNET 
MAQQAPHCAV CMIFQTYHQV EFGGFNQNCG NASDLAPQKQ RTKPLIPEMC FTSTGCSTDI 
NLSTPYLEED GTSILVSCKK CSVRVHASCY GVPPAKASED WMCSRCSANA LEEDCCLCSL 
RGGALQRAND DRWVHVSCAV AILEARFVNI AERSPVDVSK IPLPRFKLKC IFCKKRRKRT 
AGCCVQCSHG RCPTAFHVSC AQAAGVMMQP DDWPFVVFIT CFRHKIPNLE RAKGALQSIT 
AGQKVISKHK NGRFYQCEVV RLTTETFYEV NFDDGSFSDN LYPEDIVSQD CLQFGPPAEG 
EVVQVRWTDG QVYGAKFVAS HPIQMYQVEF EDGSQLVVKR DDVYTLDEEL PKRVKSRLSV 
ASDMRFNEIF TEKEVKQEKK RQRVINSRYR EDYIEPALYR AIME

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: KDM4A

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. PubMed ID: 9734811

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. PubMed ID: 15927959

JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). PubMed ID: 16024779

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. PubMed ID: 16603238

Tudor, MBT and chromo domains gauge the degree of lysine methylation. PubMed ID: 16415788

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. PubMed ID: 22373579

A new isoform of the histone demethylase JMJD2A/KDM4A is required for skeletal muscle differentiation. PubMed ID: 21694756

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Structural insights into histone demethylation by JMJD2 family members. PubMed ID: 16677698

Recognition of histone H3 lysine-4 methylation by the double Tudor domain of JMJD2A. PubMed ID: 16601153

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. PubMed ID: 26741168

Structural analysis of human KDM5B guides histone demethylase inhibitor development. PubMed ID: 27214403