Details for: CD69

Gene ID: 969

Symbol: CD69

Ensembl ID: ENSG00000110848

Description: CD69 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 146.2919
    Cell Significance Index: -22.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.6384
    Cell Significance Index: -36.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 80.0664
    Cell Significance Index: -41.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.9799
    Cell Significance Index: -28.7900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.1579
    Cell Significance Index: -40.2500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 34.7085
    Cell Significance Index: 92.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.2651
    Cell Significance Index: -22.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 11.2819
    Cell Significance Index: 396.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 10.5266
    Cell Significance Index: -2.6700
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 8.9329
    Cell Significance Index: 27.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.6539
    Cell Significance Index: -26.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7257
    Cell Significance Index: -26.5400
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 5.1878
    Cell Significance Index: 23.2000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.9605
    Cell Significance Index: 61.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.5440
    Cell Significance Index: 228.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.2470
    Cell Significance Index: 95.3600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.9058
    Cell Significance Index: 18.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6528
    Cell Significance Index: 74.9200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.4671
    Cell Significance Index: 14.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2026
    Cell Significance Index: 228.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0162
    Cell Significance Index: 554.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9634
    Cell Significance Index: 95.3000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.9501
    Cell Significance Index: 8.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8384
    Cell Significance Index: 43.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8365
    Cell Significance Index: 755.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7705
    Cell Significance Index: 20.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5481
    Cell Significance Index: 64.6400
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.4373
    Cell Significance Index: 1.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3996
    Cell Significance Index: 64.9900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.3796
    Cell Significance Index: 2.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.2954
    Cell Significance Index: 62.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1762
    Cell Significance Index: 19.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.1608
    Cell Significance Index: 119.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0281
    Cell Significance Index: 17.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0001
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0003
    Cell Significance Index: -0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0105
    Cell Significance Index: -0.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0134
    Cell Significance Index: -25.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0179
    Cell Significance Index: -32.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0197
    Cell Significance Index: -30.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0244
    Cell Significance Index: -33.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0272
    Cell Significance Index: -1.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0491
    Cell Significance Index: -21.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0537
    Cell Significance Index: -39.3500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0537
    Cell Significance Index: -0.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0594
    Cell Significance Index: -1.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0610
    Cell Significance Index: -38.7600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0622
    Cell Significance Index: -0.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0705
    Cell Significance Index: -1.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0757
    Cell Significance Index: -34.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0764
    Cell Significance Index: -5.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0796
    Cell Significance Index: -28.5400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0955
    Cell Significance Index: -0.9900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1210
    Cell Significance Index: -5.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1292
    Cell Significance Index: -37.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1309
    Cell Significance Index: -25.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1355
    Cell Significance Index: -27.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1564
    Cell Significance Index: -3.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1599
    Cell Significance Index: -28.8300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1637
    Cell Significance Index: -2.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1674
    Cell Significance Index: -17.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1691
    Cell Significance Index: -23.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2093
    Cell Significance Index: -6.7100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2173
    Cell Significance Index: -24.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2313
    Cell Significance Index: -26.9600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2352
    Cell Significance Index: -2.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2401
    Cell Significance Index: -14.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2472
    Cell Significance Index: -30.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2502
    Cell Significance Index: -32.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2526
    Cell Significance Index: -26.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2602
    Cell Significance Index: -37.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2660
    Cell Significance Index: -5.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2754
    Cell Significance Index: -35.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2787
    Cell Significance Index: -13.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2788
    Cell Significance Index: -6.0400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.3220
    Cell Significance Index: -4.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3358
    Cell Significance Index: -23.7500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3620
    Cell Significance Index: -6.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3825
    Cell Significance Index: -29.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4328
    Cell Significance Index: -29.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4349
    Cell Significance Index: -26.1100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.4448
    Cell Significance Index: -3.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4922
    Cell Significance Index: -36.6800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.4978
    Cell Significance Index: -4.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5024
    Cell Significance Index: -28.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5032
    Cell Significance Index: -39.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5606
    Cell Significance Index: -34.4600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5767
    Cell Significance Index: -8.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5912
    Cell Significance Index: -30.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6219
    Cell Significance Index: -17.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6965
    Cell Significance Index: -32.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7061
    Cell Significance Index: -18.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7146
    Cell Significance Index: -31.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7265
    Cell Significance Index: -15.0700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.7326
    Cell Significance Index: -8.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7644
    Cell Significance Index: -26.7800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.7699
    Cell Significance Index: -5.5400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.7850
    Cell Significance Index: -5.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CD69 is a type II transmembrane protein, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. Its extracellular domain contains a carbohydrate-binding site, which allows it to interact with various ligands, including complement components and cytokines. The intracellular domain of CD69 contains a coiled-coil structure, which is involved in the regulation of gene expression and signaling pathways. CD69 is expressed on the surface of activated T cells, natural killer cells, and some subsets of B cells, but not on resting or naive cells. **Pathways and Functions:** CD69 is involved in various signaling pathways that regulate immune responses, including: 1. **Transmembrane Signaling Receptor Activity:** CD69 acts as a receptor for several ligands, including complement components and cytokines, which triggers a signaling cascade that leads to the activation and proliferation of immune cells. 2. **Cellular Response to Xenobiotic Stimulus:** CD69 is involved in the recognition and response to pathogens and other foreign substances, which is essential for the activation of immune cells. 3. **Protein Binding:** CD69 interacts with various proteins, including complement components, cytokines, and adhesion molecules, which regulates immune cell adhesion, migration, and activation. 4. **Transcriptional Regulation:** CD69 regulates the expression of genes involved in immune cell activation, proliferation, and differentiation, including the upregulation of cytokine genes and the downregulation of anti-inflammatory genes. **Clinical Significance:** CD69 has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases:** CD69 is involved in the regulation of immune responses in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** CD69 is overexpressed in certain types of cancer, including leukemia and lymphoma, where it promotes tumor progression and immune evasion. 3. **Infectious Diseases:** CD69 is involved in the recognition and response to pathogens, such as HIV and influenza, where it regulates immune cell activation and proliferation. 4. **Immunotherapy:** CD69 has been identified as a potential target for immunotherapeutic strategies, including cancer immunotherapy and vaccine development. In conclusion, CD69 is a critical molecule in the regulation of immune responses, particularly in the activation and proliferation of T cells. Its unique expression pattern and functional characteristics make it an essential component of the immune system, and its dysregulation has been implicated in various immune-related disorders. Further research is needed to fully elucidate the mechanisms of CD69 and its role in immune responses, as well as its potential as a therapeutic target.

Genular Protein ID: 3292455730

Symbol: CD69_HUMAN

Name: Early activation antigen CD69

UniProtKB Accession Codes:

Q07108

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8496594

Title: Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain.

PubMed ID: 8496594

PubMed ID: 8340758

Title: Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors.

PubMed ID: 8340758

DOI: 10.1084/jem.178.2.537

PubMed ID: 8100776

Title: Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens.

PubMed ID: 8100776

DOI: 10.1002/eji.1830230737

PubMed ID: 8026529

Title: Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors.

PubMed ID: 8026529

DOI: 10.1002/eji.1830240735

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24752896

Title: The leukocyte activation receptor CD69 controls T cell differentiation through its interaction with galectin-1.

PubMed ID: 24752896

DOI: 10.1128/mcb.00348-14

PubMed ID: 26296369

Title: Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation.

PubMed ID: 26296369

DOI: 10.1096/fj.15-273987

PubMed ID: 34841721

Title: CD69 mediates the protective role of adipose tissue-derived mesenchymal stem cells against Pseudomonas aeruginosa pulmonary infection.

PubMed ID: 34841721

DOI: 10.1002/ctm2.563

PubMed ID: 35930205

Title: CD69-oxLDL ligand engagement induces Programmed Cell Death 1 (PD-1) expression in human CD4 + T lymphocytes.

PubMed ID: 35930205

DOI: 10.1007/s00018-022-04481-1

PubMed ID: 11101293

Title: Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells.

PubMed ID: 11101293

DOI: 10.1021/bi0018180

PubMed ID: 11036086

Title: Crystal structure of the C-type lectin-like domain from the human hematopoietic cell receptor CD69.

PubMed ID: 11036086

DOI: 10.1074/jbc.m008573200

PubMed ID: 18959746

Title: Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemical stability display prolonged circulation and remain intact in the blood of mice.

PubMed ID: 18959746

DOI: 10.1111/j.1742-4658.2008.06683.x

PubMed ID: 37039481

Title: Transmembrane protein CD69 acts as an S1PR1 agonist.

PubMed ID: 37039481

DOI: 10.7554/elife.88204

Sequence Information:

  • Length: 199
  • Mass: 22559
  • Checksum: 172E2699D2FB8DFB
  • Sequence:
    • MSSENCFVAE NSSLHPESGQ ENDATSPHFS TRHEGSFQVP VLCAVMNVVF ITILIIALIA 
LSVGQYNCPG QYTFSMPSDS HVSSCSEDWV GYQRKCYFIS TVKRSWTSAQ NACSEHGATL 
AVIDSEKDMN FLKRYAGREE HWVGLKKEPG HPWKWSNGKE FNNWFNVTGS DKCVFLKNTE 
VSSMECEKNL YWICNKPYK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.