Details for: CD69
Gene ID: 969
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CD69
Ensembl ID: ENSG00000110848
Description: CD69 molecule
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 106.5rCSI 80.56%PRS 95.47
-
CSI 54.71rCSI 54.02%PRS 94.04
-
CSI 54.21rCSI 40.28%PRS 94.09
-
CSI 51.75rCSI 44.38%PRS 90.79
-
CSI 47.21rCSI 27.88%PRS 97.25
-
CSI 44.86rCSI 33.64%PRS 96.6
-
CSI 44.26rCSI 33.26%PRS 90.91
-
CSI 43.61rCSI 34.62%PRS 97.41
-
CSI 42.39rCSI 76.52%PRS 96.04
-
CSI 41.27rCSI 33.35%PRS 92.87
-
CSI 40.6rCSI 49.19%PRS 67.01
-
CSI 40.21rCSI 31.27%PRS 95.77
-
CSI 39.47rCSI 36.49%PRS 96.54
-
CSI 39.3rCSI 28.21%PRS 95.94
-
CSI 38.96rCSI 43.85%PRS 95.51
-
CSI 38.27rCSI 36.8%PRS 95.14
-
CSI 37.76rCSI 26.28%PRS 96.4
-
CSI 36.01rCSI 25.29%PRS 95.09
-
CSI 35.96rCSI 37.56%PRS 94.76
-
CSI 33.65rCSI 57.56%PRS 94.78
-
CSI 33.53rCSI 32.96%PRS 95.43
-
CSI 33.41rCSI 100%PRS 86.05
-
CSI 33.09rCSI 29.88%PRS 85.27
-
CSI 32.85rCSI 24.59%PRS 95.43
-
CSI 32.77rCSI 28.7%PRS 91.64
-
CSI 31.82rCSI 27.67%PRS 93.61
-
CSI 31.73rCSI 37.26%PRS 93.59
-
CSI 31.64rCSI 40.48%PRS 91.9
-
CSI 31.11rCSI 41.63%PRS 89.6
-
CSI 30.7rCSI 39.29%PRS 91.88
-
CSI 29.77rCSI 40.56%PRS 97.17
-
CSI 29.37rCSI 36.91%PRS 95.7
-
CSI 28.5rCSI 18.99%PRS 93.84
-
CSI 28.46rCSI 54.82%PRS 97.07
-
CSI 28.22rCSI 23.37%PRS 88.56
-
CSI 27.85rCSI 21.19%PRS 95.93
-
CSI 27.4rCSI 33.76%PRS 87.4
-
CSI 26.88rCSI 27.52%PRS 90.47
-
CSI 26.78rCSI 56.66%PRS 93.63
-
CSI 26.66rCSI 48.19%PRS 88.92
-
CSI 25.65rCSI 30.06%PRS 95.72
-
CSI 25.32rCSI 21.3%PRS 95.7
-
CSI 25.24rCSI 16.78%PRS 88.53
-
CSI 25.03rCSI 48.93%PRS 95.14
-
CSI 24.75rCSI 29.55%PRS 96.51
-
CSI 21.12rCSI 21.52%PRS 93.33
-
CSI 19.85rCSI 37.6%PRS 97.76
-
CSI 19.75rCSI 43.47%PRS 89.47
-
CSI 18.85rCSI 40.71%PRS 87.12
-
CSI 18.63rCSI 13.91%PRS 94.87
-
CSI 18.34rCSI 12.75%PRS 95.32
-
CSI 18.11rCSI 37.38%PRS 81.89
-
CSI 17.6rCSI 63.99%PRS 95.22
-
CSI 16.26rCSI 10.95%PRS 95.94
-
CSI 16.1rCSI 14.14%PRS 90.36
-
CSI 15.86rCSI 14.44%PRS 95.23
-
CSI 15.85rCSI 51.89%PRS 96.04
-
CSI 15.25rCSI 23.3%PRS 91.95
-
CSI 14.98rCSI 20.02%PRS 96.39
-
CSI 14.35rCSI 10.02%PRS 90.01
-
CSI 13.59rCSI 73.51%PRS 96.89
-
CSI 11.86rCSI 16.3%PRS 96.58
-
CSI 11.53rCSI 31.39%PRS 96.43
-
CSI 11.42rCSI 14.34%PRS 92.74
-
CSI 11.39rCSI 27.4%PRS 97.12
-
CSI 10.72rCSI 12.42%PRS 83.45
-
CSI 10.69rCSI 16.33%PRS 94.25
-
CSI 10.26rCSI 22.92%PRS 91.96
-
CSI 9.85rCSI 40.87%PRS 83.54
-
CSI 9.74rCSI 22.1%PRS 85.9
-
CSI 9.37rCSI 12.27%PRS 94.14
-
CSI 9.27rCSI 24%PRS 96.74
-
CSI 9.06rCSI 25.86%PRS 88.82
-
CSI 8.91rCSI 7.72%PRS 89.54
-
CSI 8.85rCSI 8.12%PRS 92.25
-
CSI 8.69rCSI 13.1%PRS 91.07
-
CSI 8.66rCSI 10.46%PRS 92.36
-
CSI 8.31rCSI 6.54%PRS 89.99
-
CSI 8rCSI 11.31%PRS 83.61
-
CSI 7.96rCSI 7.81%PRS 95.92
-
CSI 7.71rCSI 12.69%PRS 89.22
-
CSI 7.42rCSI 5.94%PRS 94.41
-
CSI 7.34rCSI 26.58%PRS 97.27
-
CSI 7.27rCSI 8.7%PRS 92.82
-
CSI 7.23rCSI 18.11%PRS 95.14
-
CSI 6.56rCSI 13.08%PRS 94.65
-
CSI 6.52rCSI 32.71%PRS 95.15
-
CSI 6.36rCSI 18.25%PRS 97.56
-
CSI 6.31rCSI 18.83%PRS 92.43
-
CSI 6.3rCSI 9.67%PRS 92.98
-
CSI 5.68rCSI 24.63%PRS 89.45
-
CSI 5.58rCSI 4.51%PRS 88.4
-
CSI 5.05rCSI 58.66%PRS 95.84
-
CSI 5.01rCSI 24.7%PRS 91.83
-
CSI 4.9rCSI 5.61%PRS 92.78
-
CSI 4.48rCSI 17.42%PRS 96.62
-
CSI 4.28rCSI 19.28%PRS 95.59
-
CSI 4.16rCSI 18.89%PRS 96.2
-
CSI 3.9rCSI 6.08%PRS 95.92
-
CSI 3.55rCSI 68.09%PRS 94.84
-
CSI 0.3rCSI 5.0%PRS 95.6%
-
CSI 0.3rCSI 7.6%PRS 98.1%
-
CSI 0.5rCSI 3.1%PRS 93.7%
-
CSI 0.8rCSI 3.0%PRS 88.7%
-
CSI 1.1rCSI 6.2%PRS 89.8%
-
CSI 1.3rCSI 26.7%PRS 94.2%
-
CSI 1.4rCSI 6.4%PRS 94.4%
-
CSI 1.4rCSI 36.5%PRS 95.8%
-
CSI 1.6rCSI 16.5%PRS 93.3%
-
CSI 1.7rCSI 2.3%PRS 83.2%
-
CSI 1.9rCSI 25.3%PRS 93.7%
-
CSI 1.9rCSI 9.8%PRS 96.1%
-
CSI 1.9rCSI 41.2%PRS 95.5%
-
CSI 2.0rCSI 13.1%PRS 96.2%
-
CSI 2.0rCSI 2.9%PRS 95.4%
-
CSI 2.1rCSI 38.8%PRS 97.0%
-
CSI 2.3rCSI 8.1%PRS 97.7%
-
CSI 2.4rCSI 75.7%PRS 96.5%
-
CSI 2.5rCSI 14.0%PRS 87.5%
-
CSI 2.7rCSI 3.9%PRS 90.2%
-
CSI 2.7rCSI 15.4%PRS 95.3%
-
CSI 3.1rCSI 44.0%PRS 98.6%
-
CSI 3.2rCSI 2.9%PRS 87.7%
-
CSI 3.6rCSI 68.1%PRS 94.8%
-
CSI 3.9rCSI 6.1%PRS 95.9%
-
CSI 4.2rCSI 18.9%PRS 96.2%
-
CSI 4.3rCSI 19.3%PRS 95.6%
-
CSI 4.5rCSI 17.4%PRS 96.6%
-
CSI 4.9rCSI 5.6%PRS 92.8%
-
CSI 5.0rCSI 24.7%PRS 91.8%
-
CSI 5.1rCSI 58.7%PRS 95.8%
-
CSI 5.6rCSI 4.5%PRS 88.4%
-
CSI 5.7rCSI 24.6%PRS 89.5%
-
CSI 6.3rCSI 9.7%PRS 93.0%
-
CSI 6.3rCSI 18.8%PRS 92.4%
-
CSI 6.4rCSI 18.3%PRS 97.6%
-
CSI 6.5rCSI 32.7%PRS 95.2%
-
CSI 6.6rCSI 13.1%PRS 94.7%
-
CSI 7.2rCSI 18.1%PRS 95.1%
-
CSI 7.3rCSI 8.7%PRS 92.8%
-
CSI 7.3rCSI 26.6%PRS 97.3%
-
CSI 7.4rCSI 5.9%PRS 94.4%
-
CSI 7.7rCSI 12.7%PRS 89.2%
-
CSI 8.0rCSI 7.8%PRS 95.9%
-
CSI 8.0rCSI 11.3%PRS 83.6%
-
CSI 8.3rCSI 6.5%PRS 90.0%
-
CSI 8.7rCSI 10.5%PRS 92.4%
-
CSI 8.7rCSI 13.1%PRS 91.1%
-
CSI 8.9rCSI 8.1%PRS 92.3%
-
CSI 8.9rCSI 7.7%PRS 89.5%
-
CSI 9.1rCSI 25.9%PRS 88.8%
-
CSI 9.3rCSI 24.0%PRS 96.7%
-
CSI 9.4rCSI 12.3%PRS 94.1%
-
CSI 9.7rCSI 22.1%PRS 85.9%
-
CSI 9.9rCSI 40.9%PRS 83.5%
-
CSI 10.3rCSI 22.9%PRS 92.0%
-
CSI 10.7rCSI 16.3%PRS 94.3%
-
CSI 10.7rCSI 12.4%PRS 83.5%
-
CSI 11.4rCSI 27.4%PRS 97.1%
-
CSI 11.4rCSI 14.3%PRS 92.7%
-
CSI 11.5rCSI 31.4%PRS 96.4%
-
CSI 11.9rCSI 16.3%PRS 96.6%
-
CSI 13.6rCSI 73.5%PRS 96.9%
-
CSI 14.4rCSI 10.0%PRS 90.0%
-
CSI 15.0rCSI 20.0%PRS 96.4%
-
CSI 15.3rCSI 23.3%PRS 92.0%
-
CSI 15.9rCSI 51.9%PRS 96.0%
-
CSI 15.9rCSI 14.4%PRS 95.2%
-
CSI 16.1rCSI 14.1%PRS 90.4%
-
CSI 16.3rCSI 11.0%PRS 95.9%
-
CSI 17.6rCSI 64.0%PRS 95.2%
-
CSI 18.1rCSI 37.4%PRS 81.9%
-
CSI 18.3rCSI 12.8%PRS 95.3%
-
CSI 18.6rCSI 13.9%PRS 94.9%
-
CSI 18.9rCSI 40.7%PRS 87.1%
-
CSI 19.8rCSI 43.5%PRS 89.5%
-
CSI 19.9rCSI 37.6%PRS 97.8%
-
CSI 21.1rCSI 21.5%PRS 93.3%
-
CSI 24.8rCSI 29.6%PRS 96.5%
-
CSI 25.0rCSI 48.9%PRS 95.1%
-
CSI 25.2rCSI 16.8%PRS 88.5%
-
CSI 25.3rCSI 21.3%PRS 95.7%
-
CSI 25.7rCSI 30.1%PRS 95.7%
-
CSI 26.7rCSI 48.2%PRS 88.9%
-
CSI 26.8rCSI 56.7%PRS 93.6%
-
CSI 26.9rCSI 27.5%PRS 90.5%
-
CSI 27.4rCSI 33.8%PRS 87.4%
-
CSI 27.9rCSI 21.2%PRS 95.9%
-
CSI 28.2rCSI 23.4%PRS 88.6%
-
CSI 28.5rCSI 54.8%PRS 97.1%
-
CSI 28.5rCSI 19.0%PRS 93.8%
-
CSI 29.4rCSI 36.9%PRS 95.7%
-
CSI 29.8rCSI 40.6%PRS 97.2%
-
CSI 30.7rCSI 39.3%PRS 91.9%
-
CSI 31.1rCSI 41.6%PRS 89.6%
-
CSI 31.6rCSI 40.5%PRS 91.9%
-
CSI 31.7rCSI 37.3%PRS 93.6%
-
CSI 31.8rCSI 27.7%PRS 93.6%
-
CSI 32.8rCSI 28.7%PRS 91.6%
-
CSI 32.9rCSI 24.6%PRS 95.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3292455730
Symbol: CD69_HUMAN
Name: Early activation antigen CD69
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8496594
Title: Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain.
PubMed ID: 8496594
PubMed ID: 8340758
Title: Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors.
PubMed ID: 8340758
PubMed ID: 8100776
Title: Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens.
PubMed ID: 8100776
PubMed ID: 8026529
Title: Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors.
PubMed ID: 8026529
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24752896
Title: The leukocyte activation receptor CD69 controls T cell differentiation through its interaction with galectin-1.
PubMed ID: 24752896
DOI: 10.1128/mcb.00348-14
PubMed ID: 26296369
Title: Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation.
PubMed ID: 26296369
DOI: 10.1096/fj.15-273987
PubMed ID: 34841721
Title: CD69 mediates the protective role of adipose tissue-derived mesenchymal stem cells against Pseudomonas aeruginosa pulmonary infection.
PubMed ID: 34841721
DOI: 10.1002/ctm2.563
PubMed ID: 35930205
Title: CD69-oxLDL ligand engagement induces Programmed Cell Death 1 (PD-1) expression in human CD4 + T lymphocytes.
PubMed ID: 35930205
PubMed ID: 11101293
Title: Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells.
PubMed ID: 11101293
DOI: 10.1021/bi0018180
PubMed ID: 11036086
Title: Crystal structure of the C-type lectin-like domain from the human hematopoietic cell receptor CD69.
PubMed ID: 11036086
PubMed ID: 18959746
Title: Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemical stability display prolonged circulation and remain intact in the blood of mice.
PubMed ID: 18959746
PubMed ID: 37039481
Title: Transmembrane protein CD69 acts as an S1PR1 agonist.
PubMed ID: 37039481
DOI: 10.7554/elife.88204
Sequence Information:
- Length: 199
- Mass: 22559
- Checksum: 172E2699D2FB8DFB
- Sequence:
MSSENCFVAE NSSLHPESGQ ENDATSPHFS TRHEGSFQVP VLCAVMNVVF ITILIIALIA LSVGQYNCPG QYTFSMPSDS HVSSCSEDWV GYQRKCYFIS TVKRSWTSAQ NACSEHGATL AVIDSEKDMN FLKRYAGREE HWVGLKKEPG HPWKWSNGKE FNNWFNVTGS DKCVFLKNTE VSSMECEKNL YWICNKPYK