Details for: UBE3C
Associated with
Other Information
Genular Protein ID: 2598009412
Symbol: UBE3C_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7584026
Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.
PubMed ID: 7584026
PubMed ID: 12853948
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11278995
Title: A HECT domain E3 enzyme assembles novel polyubiquitin chains.
PubMed ID: 11278995
PubMed ID: 9575161
Title: Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7.
PubMed ID: 9575161
PubMed ID: 12692129
Title: Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase.
PubMed ID: 12692129
PubMed ID: 16341092
Title: Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis.
PubMed ID: 16341092
PubMed ID: 16601690
Title: Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligase.
PubMed ID: 16601690
PubMed ID: 17323924
Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.
PubMed ID: 17323924
DOI: 10.1021/bi061994u
PubMed ID: 21167755
Title: The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3.
PubMed ID: 21167755
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24811749
Title: Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.
PubMed ID: 24811749
PubMed ID: 24158444
Title: The E3 ubiquitin ligase UBE3C enhances proteasome processivity by ubiquitinating partially proteolyzed substrates.
PubMed ID: 24158444
PubMed ID: 25752573
Title: K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin.
PubMed ID: 25752573
PubMed ID: 25752577
Title: Assembly and specific recognition of K29- and K33-linked polyubiquitin.
PubMed ID: 25752577
PubMed ID: 28396413
Title: Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c.
PubMed ID: 28396413
PubMed ID: 31375563
Title: Acute unfolding of a single protein immediately stimulates recruitment of ubiquitin protein ligase E3C (UBE3C) to 26S proteasomes.
PubMed ID: 31375563
PubMed ID: 34239127
Title: K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.
PubMed ID: 34239127
PubMed ID: 33637724
Title: VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism.
PubMed ID: 33637724
PubMed ID: 32039437
Title: Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity.
PubMed ID: 32039437
DOI: 10.1042/bcj20200027
PubMed ID: 36401616
Title: Biallelic variants in HECT E3 paralogs, HECTD4 and UBE3C, encoding ubiquitin ligases cause neurodevelopmental disorders that overlap with Angelman syndrome.
PubMed ID: 36401616
Sequence Information:
- Length: 1083
- Mass: 123923
- Checksum: BD437ABA457A0DDA
- Sequence:
MFSFEGDFKT RPKVSLGGAS RKEEKASLLH RTQEERRKRE EERRRLKNAI IIQSFIRGYR DRKQQYSIQR SAFDRCATLS QSGGAFPIAN GPNLTLLVRQ LLFFYKQNED SKRLIWLYQN LIKHSSLFVK QLDGSERLTC LFQIKRLMSL CCRLLQNCND DSLNVALPMR MLEVFSSENT YLPVLQDASY VVSVIEQILH YMIHNGYYRS LYLLINSKLP SSIEYSDLSR VPIAKILLEN VLKPLHFTYN SCPEGARQQV FTAFTEEFLA APFTDQIFHF IIPALADAQT VFPYEPFLNA LLLIESRCSR KSGGAPWLFY FVLTVGENYL GALSEEGLLV YLRVLQTFLS QLPVSPASAS CHDSASDSEE ESEEADKPSS PEDGRLSVSY ITEECLKKLD TKQQTNTLLN LVWRDSASEE VFTTMASVCH TLMVQHRMMV PKVRLLYSLA FNARFLRHLW FLISSMSTRM ITGSMVPLLQ VISRGSPMSF EDSSRIIPLF YLFSSLFSHS LISIHDNEFF GDPIEVVGQR QSSMMPFTLE ELIMLSRCLR DACLGIIKLA YPETKPEVRE EYITAFQSIG VTTSSEMQQC IQMEQKRWIQ LFKVITNLVK MLKSRDTRRN FCPPNHWLSE QEDIKADKVT QLYVPASRHV WRFRRMGRIG PLQSTLDVGL ESPPLSVSEE RQLAVLTELP FVVPFEERVK IFQRLIYADK QEVQGDGPFL DGINVTIRRN YIYEDAYDKL SPENEPDLKK RIRVHLLNAH GLDEAGIDGG GIFREFLNEL LKSGFNPNQG FFKTTNEGLL YPNPAAQMLV GDSFARHYYF LGRMLGKALY ENMLVELPFA GFFLSKLLGT SADVDIHHLA SLDPEVYKNL LFLKSYEDDV EELGLNFTVV NNDLGEAQVV ELKFGGKDIP VTSANRIAYI HLVADYRLNR QIRQHCLAFR QGLANVVSLE WLRMFDQQEI QVLISGAQVP ISLEDLKSFT NYSGGYSADH PVIKVFWRVV EGFTDEEKRK LLKFVTSCSR PPLLGFKELY PAFCIHNGGS DLERLPTAST CMNLLKLPEF YDETLLRSKL LYAIECAAGF ELS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.